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Aliases for HOXB2 Gene

Aliases for HOXB2 Gene

  • Homeobox B2 2 3
  • HOX2H 3 4 6
  • Homeobox Protein Hox-2.8 3 4
  • Homeobox Protein Hox-2H 3 4
  • Homeo Box B2 2 3
  • K8 3 4
  • Homeobox Protein Hox-B2 3
  • K8 Home Protein 3
  • Homeo Box 2H 3
  • Hox-2.8 3
  • HOX2 3

External Ids for HOXB2 Gene

Previous HGNC Symbols for HOXB2 Gene

  • HOX2
  • HOX2H

Previous GeneCards Identifiers for HOXB2 Gene

  • GC17M046331
  • GC17M049100
  • GC17M046962
  • GC17M047094
  • GC17M043975
  • GC17M046620
  • GC17M041989

Summaries for HOXB2 Gene

Entrez Gene Summary for HOXB2 Gene

  • This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXB2 Gene

HOXB2 (Homeobox B2) is a Protein Coding gene. Diseases associated with HOXB2 include bamforth-lazarus syndrome and pancreatic cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is EVX1.

UniProtKB/Swiss-Prot for HOXB2 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXB2 Gene

Genomics for HOXB2 Gene

Regulatory Elements for HOXB2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HOXB2 Gene

Start:
48,540,894 bp from pter
End:
48,545,031 bp from pter
Size:
4,138 bases
Orientation:
Minus strand

Genomic View for HOXB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HOXB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXB2 Gene

Proteins for HOXB2 Gene

  • Protein details for HOXB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14652-HXB2_HUMAN
    Recommended name:
    Homeobox protein Hox-B2
    Protein Accession:
    P14652
    Secondary Accessions:
    • P10913
    • P17485

    Protein attributes for HOXB2 Gene

    Size:
    356 amino acids
    Molecular mass:
    37914 Da
    Quaternary structure:
    • Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least by SATB1 and HOXB2

neXtProt entry for HOXB2 Gene

Proteomics data for HOXB2 Gene at MOPED

Post-translational modifications for HOXB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HOXB2 Gene

Domains for HOXB2 Gene

Gene Families for HOXB2 Gene

HGNC:
  • HOXL :Homeoboxes / ANTP class : HOXL subclass

Suggested Antigen Peptide Sequences for HOXB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P14652

UniProtKB/Swiss-Prot:

HXB2_HUMAN :
  • P14652
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Antp homeobox family. Proboscipedia subfamily.
genes like me logo Genes that share domains with HOXB2: view

Function for HOXB2 Gene

Molecular function for HOXB2 Gene

GENATLAS Biochemistry:
homeo box B2(2H),homologous to mouse Hox-2.8,Drosophila pb
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Ontology (GO) - Molecular Function for HOXB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXB2: view
genes like me logo Genes that share phenotypes with HOXB2: view

Animal Models for HOXB2 Gene

MGI Knock Outs for HOXB2:

Animal Model Products

miRNA for HOXB2 Gene

miRTarBase miRNAs that target HOXB2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOXB2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HOXB2 Gene

Localization for HOXB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXB2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXB2 Gene COMPARTMENTS Subcellular localization image for HOXB2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HOXB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with HOXB2: view

Pathways for HOXB2 Gene

SuperPathways for HOXB2 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HOXB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002011 morphogenesis of an epithelial sheet IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organismal development TAS 7876223
GO:0008015 blood circulation TAS 7876223
genes like me logo Genes that share ontologies with HOXB2: view

No data available for Pathways by source for HOXB2 Gene

Compounds for HOXB2 Gene

(3) Novoseek inferred chemical compound relationships for HOXB2 Gene

Compound -log(P) Hits PubMed IDs
phosphorothioate 62.8 1
retinoic acid 38.8 4
vegf 13 2
genes like me logo Genes that share compounds with HOXB2: view

Transcripts for HOXB2 Gene

Unigene Clusters for HOXB2 Gene

Homeobox B2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOXB2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXB2 Gene

No ASD Table

Relevant External Links for HOXB2 Gene

GeneLoc Exon Structure for
HOXB2
ECgene alternative splicing isoforms for
HOXB2

Expression for HOXB2 Gene

mRNA expression in normal human tissues for HOXB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HOXB2 Gene

SOURCE GeneReport for Unigene cluster for HOXB2 Gene Hs.514289

genes like me logo Genes that share expressions with HOXB2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for HOXB2 Gene

Orthologs for HOXB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HOXB2 35
  • 88.01 (n)
  • 86.97 (a)
HOXB2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOXB2 35
  • 88.11 (n)
  • 87.72 (a)
HOXB2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxb2 35
  • 82.72 (n)
  • 80.45 (a)
Hoxb2 16
Hoxb2 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HOXB2 35
  • 99.34 (n)
  • 99.16 (a)
HOXB2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hoxb2 35
  • 82.44 (n)
  • 81.02 (a)
oppossum
(Monodelphis domestica)
Mammalia HOXB2 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOXB2 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves HOXB2 35
  • 68.91 (n)
  • 69.87 (a)
HOXB2 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HOXB2 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxb2 35
  • 64.55 (n)
  • 63.44 (a)
zebrafish
(Danio rerio)
Actinopterygii hoxb2a 35
  • 63.38 (n)
  • 62.32 (a)
hoxb2a 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pb 36
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for HOXB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXB2 Gene

ENSEMBL:
Gene Tree for HOXB2 (if available)
TreeFam:
Gene Tree for HOXB2 (if available)

Paralogs for HOXB2 Gene

Selected SIMAP similar genes for HOXB2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HOXB2: view

Variants for HOXB2 Gene

Sequence variations from dbSNP and Humsavar for HOXB2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs72829845 -- 48,542,329(+) CACCC(C/T)CCTCT downstream-variant-500B
rs370429896 -- 48,542,177(+) CGTCC(C/T)TAGGC downstream-variant-500B
rs373273880 -- 48,542,313(+) AGGCT(C/T)CCTCT downstream-variant-500B
rs542538666 -- 48,542,237(+) AAAGC(C/T)TAGGA downstream-variant-500B
rs544717262 -- 48,542,336(+) CTCTG(A/T)TCGCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HOXB2 Gene

Variant ID Type Subtype PubMed ID
nsv833469 CNV Loss 17160897
dgv3222n71 CNV Loss 21882294
dgv3223n71 CNV Loss 21882294
dgv988e1 CNV Complex 17122850
dgv3224n71 CNV Loss 21882294
nsv833471 CNV Gain 17160897
dgv369n27 CNV Loss 19166990

Relevant External Links for HOXB2 Gene

HapMap Linkage Disequilibrium report
HOXB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXB2 Gene

Disorders for HOXB2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for HOXB2 Gene in MalaCards »

(3) Diseases for HOXB2 Gene including...

(1) University of Copenhagen DISEASES for HOXB2 Gene

(1) Novoseek inferred disease relationships for HOXB2 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 4

Relevant External Links for HOXB2

Genetic Association Database (GAD)
HOXB2
Human Genome Epidemiology (HuGE) Navigator
HOXB2
genes like me logo Genes that share disorders with HOXB2: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for HOXB2 Gene

Publications for HOXB2 Gene

  1. Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells. (PMID: 7876223) Vieille-Grosjean I. … Huber P. (J. Biol. Chem. 1995) 3 4 23
  2. The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation. (PMID: 10595394) Case S.S. … Lloyd J.A. (DNA Cell Biol. 1999) 3 4 23
  3. Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. (PMID: 20195514) Pillas D. … Jarvelin M.R. (PLoS Genet. 2010) 3 23 48
  4. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3
  5. Regulation of Hoxb2 by APL-associated PLZF protein. (PMID: 12802276) Ivins S. … Zelent A. (Oncogene 2003) 3 23

Products for HOXB2 Gene

Sources for HOXB2 Gene

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