Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HOXA13 Gene

Aliases for HOXA13 Gene

  • Homeobox A13 2 3
  • Homeobox Protein Hox-1J 3 4
  • Homeo Box A13 2 3
  • HOX1J 3 4
  • Transcription Factor HOXA13 3
  • Homeobox Protein HOXA13 3
  • Homeo Box 1J 3
  • HOX1 3

External Ids for HOXA13 Gene

Previous HGNC Symbols for HOXA13 Gene

  • HOX1J
  • HOX1

Previous GeneCards Identifiers for HOXA13 Gene

  • GC07M026880
  • GC07M026944
  • GC07M026978
  • GC07M027009
  • GC07M027203
  • GC07M027235
  • GC07M027246
  • GC07M027256

Summaries for HOXA13 Gene

Entrez Gene Summary for HOXA13 Gene

  • In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Expansion of a polyalanine tract in the encoded protein can cause hand-foot-uterus syndrome, also known as hand-foot-genital syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXA13 Gene

HOXA13 (Homeobox A13) is a Protein Coding gene. Diseases associated with HOXA13 include guttmacher syndrome and hand-foot-uterus syndrome. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is HOXD10.

UniProtKB/Swiss-Prot for HOXA13 Gene

  • Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Wiki entry for HOXA13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXA13 Gene

Genomics for HOXA13 Gene

Regulatory Elements for HOXA13 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HOXA13 Gene

Chromosome:
7
Start:
27,193,419 bp from pter
End:
27,200,266 bp from pter
Size:
6,848 bases
Orientation:
Minus strand

Genomic View for HOXA13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for HOXA13 Gene

Proteins for HOXA13 Gene

  • Protein details for HOXA13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31271-HXA13_HUMAN
    Recommended name:
    Homeobox protein Hox-A13
    Protein Accession:
    P31271
    Secondary Accessions:
    • A4D188
    • O43371

    Protein attributes for HOXA13 Gene

    Size:
    388 amino acids
    Molecular mass:
    39727 Da
    Quaternary structure:
    • Binds DNA as a homodimer. Interacts with MEIS1, MEIS2 and MEIS3 (By similarity).

    Three dimensional structures from OCA and Proteopedia for HOXA13 Gene

neXtProt entry for HOXA13 Gene

Proteomics data for HOXA13 Gene at MOPED

Post-translational modifications for HOXA13 Gene

  • Ubiquitination at Lys 303
  • Modification sites at PhosphoSitePlus

Other Protein References for HOXA13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXA13 Gene

Domains & Families for HOXA13 Gene

Gene Families for HOXA13 Gene

Protein Domains for HOXA13 Gene

Suggested Antigen Peptide Sequences for HOXA13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31271

UniProtKB/Swiss-Prot:

HXA13_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Abd-B homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Abd-B homeobox family.
genes like me logo Genes that share domains with HOXA13: view

Function for HOXA13 Gene

Molecular function for HOXA13 Gene

GENATLAS Biochemistry:
homeo box A13(1J),homologous to mouse Hox-1.10 (hypodactyly),expressed in the developing lower genitourinary tract (abnormal seminal vesicle and prostate development),altered in hypodactyly mutants
UniProtKB/Swiss-Prot Function:
Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Gene Ontology (GO) - Molecular Function for HOXA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 9020844
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0005515 protein binding --
GO:0043565 sequence-specific DNA binding IEA --
GO:0044212 transcription regulatory region DNA binding IEA --
genes like me logo Genes that share ontologies with HOXA13: view
genes like me logo Genes that share phenotypes with HOXA13: view

Animal Models for HOXA13 Gene

MGI Knock Outs for HOXA13:

Animal Model Products

miRNA for HOXA13 Gene

miRTarBase miRNAs that target HOXA13

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOXA13

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HOXA13 Gene

Localization for HOXA13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXA13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXA13 Gene COMPARTMENTS Subcellular localization image for HOXA13 gene
Compartment Confidence
nucleus 5
cytoskeleton 4

Gene Ontology (GO) - Cellular Components for HOXA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0045111 intermediate filament cytoskeleton IDA --
genes like me logo Genes that share ontologies with HOXA13: view

Pathways & Interactions for HOXA13 Gene

SuperPathways for HOXA13 Gene

No Data Available

SIGNOR curated interactions for HOXA13 Gene

Activates:

Gene Ontology (GO) - Biological Process for HOXA13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001501 skeletal system development TAS 9020844
GO:0001570 vasculogenesis IEA --
GO:0001886 endothelial cell morphogenesis IEA --
GO:0001894 tissue homeostasis IEA --
GO:0003281 ventricular septum development IEA --
genes like me logo Genes that share ontologies with HOXA13: view

No data available for Pathways by source for HOXA13 Gene

Drugs & Compounds for HOXA13 Gene

(1) Drugs for HOXA13 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
alanine Nutra 97
genes like me logo Genes that share compounds with HOXA13: view

Transcripts for HOXA13 Gene

mRNA/cDNA for HOXA13 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(47) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOXA13 Gene

Homeobox A13:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HOXA13

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXA13 Gene

No ASD Table

Relevant External Links for HOXA13 Gene

GeneLoc Exon Structure for
HOXA13
ECgene alternative splicing isoforms for
HOXA13

Expression for HOXA13 Gene

mRNA expression in normal human tissues for HOXA13 Gene

mRNA differential expression in normal tissues according to GTEx for HOXA13 Gene

This gene is overexpressed in Cervix - Ectocervix (x11.5), Cervix - Endocervix (x11.2), Vagina (x7.6), Bladder (x7.0), Prostate (x4.9), and Colon - Transverse (x4.5).

Protein differential expression in normal tissues from HIPED for HOXA13 Gene

This gene is overexpressed in Cervix (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXA13 Gene



SOURCE GeneReport for Unigene cluster for HOXA13 Gene Hs.592172

genes like me logo Genes that share expression patterns with HOXA13: view

Protein tissue co-expression partners for HOXA13 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HOXA13 Gene

Orthologs for HOXA13 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXA13 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HOXA13 35
  • 89.25 (n)
  • 91.43 (a)
HOXA13 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOXA13 35
  • 93.73 (n)
  • 97.68 (a)
HOXA13 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxa13 35
  • 91.02 (n)
  • 98.19 (a)
Hoxa13 16
Hoxa13 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HOXA13 35
  • 99.31 (n)
  • 99.74 (a)
HOXA13 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hoxa13 35
  • 90.33 (n)
  • 97.93 (a)
oppossum
(Monodelphis domestica)
Mammalia HOXA13 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOXA13 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100859005 35
  • 81.31 (n)
  • 83.93 (a)
HOXA13 36
  • 84 (a)
OneToMany
HOXA13 36
  • 84 (a)
OneToMany
HOXA13 36
  • 84 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia HOXA13 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxa13 35
  • 72.66 (n)
  • 75.93 (a)
African clawed frog
(Xenopus laevis)
Amphibia hoxa13-A 35
zebrafish
(Danio rerio)
Actinopterygii hoxa13b 35
  • 65.61 (n)
  • 67.37 (a)
hoxa13a 36
  • 65 (a)
OneToMany
hoxa13b 36
  • 70 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Abd-B 36
  • 16 (a)
OneToMany
Species with no ortholog for HOXA13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXA13 Gene

ENSEMBL:
Gene Tree for HOXA13 (if available)
TreeFam:
Gene Tree for HOXA13 (if available)

Paralogs for HOXA13 Gene

(5) SIMAP similar genes for HOXA13 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with HOXA13: view

Variants for HOXA13 Gene

Sequence variations from dbSNP and Humsavar for HOXA13 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs757181 -- 27,197,339(+) TCCAT(C/T)ATGTT utr-variant-3-prime
rs2189239 -- 27,197,834(+) AACTT(C/T)CAGAT utr-variant-3-prime
rs2391397 -- 27,196,939(+) AAGGG(G/T)TTTTT utr-variant-3-prime
rs3735532 -- 27,195,158(+) GAGAC(A/C)TTTCG utr-variant-3-prime
rs11984297 -- 27,196,874(+) CAGAT(G/T)TTAAT downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HOXA13 Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
nsv887856 CNV Loss 21882294
dgv1094n67 CNV Gain 20364138
dgv7231n71 CNV Loss 21882294
dgv7234n71 CNV Loss 21882294
nsv824042 CNV Gain 20364138
dgv7237n71 CNV Loss 21882294
dgv7238n71 CNV Loss 21882294
dgv7239n71 CNV Loss 21882294
nsv5675 CNV Insertion 18451855
nsv887891 CNV Loss 21882294

Variation tolerance for HOXA13 Gene

Residual Variation Intolerance Score: 51.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOXA13 Gene

HapMap Linkage Disequilibrium report
HOXA13
Human Gene Mutation Database (HGMD)
HOXA13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXA13 Gene

Disorders for HOXA13 Gene

MalaCards: The human disease database

(8) MalaCards diseases for HOXA13 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
guttmacher syndrome
  • preaxial deficiency, postaxial polydactyly and hypospadias
hand-foot-uterus syndrome
  • hand-foot-genital syndrome
hypospadias
  • familial hypospadias
invasive bladder transitional cell carcinoma
  • invasive bladder urothelial carcinoma
triphalangeal thumb
- elite association

UniProtKB/Swiss-Prot

HXA13_HUMAN
  • Guttmacher syndrome (GUTTS) [MIM:176305]: Dominantly inherited combination of distal limb and genital tract abnormalities. It has several features in common with hand-foot-genital syndrome, including hypoplastic first digits and hypospadias. Typical features not seen in hand-foot-genital syndrome include postaxial polydactyly of the hands and uniphalangeal second toes with absent nails. {ECO:0000269 PubMed:11968094}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Hand-foot-genital syndrome (HFG) [MIM:140000]: A disorder characterized by limb and genitourinary anomalies. Clinical features include small feet with unusually short great toes and abnormal thumbs. Females with the disorder have duplication of the genital tract. {ECO:0000269 PubMed:10839976, ECO:0000269 PubMed:12073020}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for HOXA13

Genetic Association Database (GAD)
HOXA13
Human Genome Epidemiology (HuGE) Navigator
HOXA13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOXA13
genes like me logo Genes that share disorders with HOXA13: view

No data available for Genatlas for HOXA13 Gene

Publications for HOXA13 Gene

  1. Diminished vaginal HOXA13 expression in women with pelvic organ prolapse. (PMID: 19423998) Connell K.A. … Taylor H.S. (Menopause 2009) 23 67
  2. A tumorigenic homeobox (HOX) gene expressing human gastric cell line derived from putative gastric stem cell. (PMID: 19424076) Yang Y.C. … Wu D.C. (Eur J Gastroenterol Hepatol 2009) 23 67
  3. HOXA13 promotes cancer cell growth and predicts poor survival of patients with esophageal squamous cell carcinoma. (PMID: 19491265) Gu Z.D. … Chen K.N. (Cancer Res. 2009) 23 67
  4. Breaking the seals: efficient mRNA detection from human archival paraffin-embedded tissue. (PMID: 19549718) Illig R. … Schwarzer C. (RNA 2009) 23 67
  5. HOXD13 binds DNA replication origins to promote origin licensing and is inhibited by geminin. (PMID: 19703996) Salsi V. … Zappavigna V. (Mol. Cell. Biol. 2009) 23 67

Products for HOXA13 Gene

Sources for HOXA13 Gene

Back to Top

Content