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Aliases for HPCA Gene

Aliases for HPCA Gene

  • Hippocalcin 2 3
  • Calcium-Binding Protein BDR-2 3 4
  • BDR2 3 4
  • Neuron Specific Calcium-Binding Protein Hippocalcin 3
  • Neuron-Specific Calcium-Binding Protein Hippocalcin 3

External Ids for HPCA Gene

Previous GeneCards Identifiers for HPCA Gene

  • GC01P033171
  • GC01P032307
  • GC01P032778
  • GC01P033021
  • GC01P033124
  • GC01P033351
  • GC01P031469

Summaries for HPCA Gene

Entrez Gene Summary for HPCA Gene

  • The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. This protein is associated with the plasma membrane. It has similarities to proteins located in the photoreceptor cells that regulate photosignal transduction in a calcium-sensitive manner. This protein displays recoverin activity and a calcium-dependent inhibition of rhodopsin kinase. It is identical to the rat and mouse hippocalcin proteins and thought to play an important role in neurons of the central nervous system in a number of species. [provided by RefSeq, Jul 2008]

GeneCards Summary for HPCA Gene

HPCA (Hippocalcin) is a Protein Coding gene. Diseases associated with HPCA include ascending cholangitis. GO annotations related to this gene include calcium ion binding and actin binding. An important paralog of this gene is KCNIP3.

UniProtKB/Swiss-Prot for HPCA Gene

  • May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds two calcium ions

Gene Wiki entry for HPCA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HPCA Gene

Genomics for HPCA Gene

Regulatory Elements for HPCA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HPCA Gene

32,885,994 bp from pter
32,898,441 bp from pter
12,448 bases
Plus strand

Genomic View for HPCA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HPCA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HPCA Gene

Proteins for HPCA Gene

  • Protein details for HPCA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Neuron-specific calcium-binding protein hippocalcin
    Protein Accession:
    Secondary Accessions:
    • B2R9T3
    • D3DPQ7
    • P32076
    • P41211
    • P70510

    Protein attributes for HPCA Gene

    193 amino acids
    Molecular mass:
    22427 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HPCA Gene

Proteomics data for HPCA Gene at MOPED

Post-translational modifications for HPCA Gene

  • Myristoylation facilitates interaction with membranes.
  • Ubiquitination at Lys63 and Lys174
  • Modification sites at PhosphoSitePlus

Other Protein References for HPCA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for HPCA Gene

Domains for HPCA Gene

Gene Families for HPCA Gene

  • EFHAND :EF-hand domain containing

Protein Domains for HPCA Gene

Suggested Antigen Peptide Sequences for HPCA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P84074
  • Contains 4 EF-hand domains.
  • Belongs to the recoverin family.
genes like me logo Genes that share domains with HPCA: view

Function for HPCA Gene

Molecular function for HPCA Gene

GENATLAS Biochemistry:
hippocalcin,23kDa,calcium binding protein expressed in hippocampus
UniProtKB/Swiss-Prot Function:
May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds two calcium ions

Gene Ontology (GO) - Molecular Function for HPCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IDA 11964161
GO:0005509 calcium ion binding NAS 8387172
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with HPCA: view
genes like me logo Genes that share phenotypes with HPCA: view

Animal Models for HPCA Gene

MGI Knock Outs for HPCA:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HPCA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for HPCA Gene

Localization for HPCA Gene

Subcellular locations from

Jensen Localization Image for HPCA Gene COMPARTMENTS Subcellular localization image for HPCA gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HPCA Gene

Pathways for HPCA Gene

SuperPathways for HPCA Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HPCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048839 inner ear development IEA --
genes like me logo Genes that share ontologies with HPCA: view

No data available for Pathways by source for HPCA Gene

Compounds for HPCA Gene

(1) HMDB Compounds for HPCA Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(1) Novoseek inferred chemical compound relationships for HPCA Gene

Compound -log(P) Hits PubMed IDs
calcium 42.9 18
genes like me logo Genes that share compounds with HPCA: view

Transcripts for HPCA Gene

Unigene Clusters for HPCA Gene

Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HPCA

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HPCA Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP2: - - -
SP3: - -
SP4: -

Relevant External Links for HPCA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HPCA Gene

mRNA expression in normal human tissues for HPCA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HPCA Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (13.8), Brain - Caudate (basal ganglia) (11.0), Brain - Nucleus accumbens (basal ganglia) (10.9), and Brain - Hippocampus (4.8).

Protein differential expression in normal tissues for HPCA Gene

This gene is overexpressed in Bone (29.2), Frontal cortex (11.9), and Breast (11.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HPCA Gene

SOURCE GeneReport for Unigene cluster for HPCA Gene Hs.632391

mRNA Expression by UniProt/SwissProt for HPCA Gene

Tissue specificity: Brain specific.
genes like me logo Genes that share expressions with HPCA: view

In Situ Assay Products

No data available for Expression partners for HPCA Gene

Orthologs for HPCA Gene

This gene was present in the common ancestor of animals.

Orthologs for HPCA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HPCA 35
  • 95.51 (n)
  • 100 (a)
  • 100 (a)
(Canis familiaris)
Mammalia HPCA 35
  • 93.96 (n)
  • 100 (a)
  • 64 (a)
(Mus musculus)
Mammalia Hpca 35
  • 94.47 (n)
  • 100 (a)
Hpca 16
Hpca 36
  • 100 (a)
(Pan troglodytes)
Mammalia HPCA 35
  • 99.31 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Hpca 35
  • 92.92 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia HPCA 36
  • 97 (a)
(Gallus gallus)
Aves HPCA 35
  • 86.18 (n)
  • 94.3 (a)
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hpca 35
  • 79.45 (n)
  • 95.34 (a)
(Danio rerio)
Actinopterygii hpca 35
  • 82.38 (n)
  • 93.78 (a)
hpca 36
  • 94 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7646 37
  • 46 (a)
Nca 37
  • 85 (a)
(Caenorhabditis elegans)
Secernentea ncs-2 37
  • 50 (a)
ncs-3 37
  • 55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 78 (a)
Species with no ortholog for HPCA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HPCA Gene

Gene Tree for HPCA (if available)
Gene Tree for HPCA (if available)

Paralogs for HPCA Gene

Selected SIMAP similar genes for HPCA Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HPCA: view

Variants for HPCA Gene

Sequence variations from dbSNP and Humsavar for HPCA Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs942243 -- 32,888,049(-) CTTAC(A/G)TATAC intron-variant
rs942244 -- 32,887,995(+) GTTAT(C/G)GGTAT intron-variant
rs946026 -- 32,893,264(-) AGGTG(A/G)AAGCT intron-variant
rs1284371 -- 32,887,170(-) GTCAC(A/T)TGCAT intron-variant
rs1284372 -- 32,889,622(+) ataag(C/G)acatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HPCA Gene

Variant ID Type Subtype PubMed ID
nsv516302 CNV Loss 19592680
dgv212n71 CNV Loss 21882294

Relevant External Links for HPCA Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HPCA Gene

Disorders for HPCA Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for HPCA Gene in MalaCards »

(1) Diseases for HPCA Gene including...

(1) University of Copenhagen DISEASES for HPCA Gene

Relevant External Links for HPCA

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with HPCA: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for HPCA Gene

Publications for HPCA Gene

  1. Molecular cloning of human hippocalcin cDNA and chromosomal mapping of its gene. (PMID: 8166736) Takamatsu K. … Noguchi T. (Biochem. Biophys. Res. Commun. 1994) 2 3 4 23
  2. Genomic structure and chromosomal mapping of the human and mouse hippocalcin genes. (PMID: 9931466) Masaki T. … Takamatsu K. (Gene 1998) 2 3 4 23
  3. NAIP interacts with hippocalcin and protects neurons against calcium-induced cell death through caspase-3-dependent and -independent pathways. (PMID: 10899114) Mercer E.A. … Lindholm D. (EMBO J. 2000) 3 23
  4. Dynamics and calcium sensitivity of the Ca2+/myristoyl switch protein hippocalcin in living cells. (PMID: 14638856) O'Callaghan D.W. … Burgoyne R.D. (J. Cell Biol. 2003) 3 23
  5. High-affinity interaction of the N-terminal myristoylation motif of the neuronal calcium sensor protein hippocalcin with phosphatidylinositol 4,5-bisphosphate. (PMID: 16053445) O'Callaghan D.W. … Burgoyne R.D. (Biochem. J. 2005) 3 23

Products for HPCA Gene

Sources for HPCA Gene

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