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Aliases for HOXA9 Gene

Aliases for HOXA9 Gene

  • Homeobox A9 2 3 5
  • Homeobox Protein Hox-1G 3 4
  • HOX1G 3 4
  • Homeodomain Protein HOXA9 3
  • Homeobox Protein Hox-A9 3
  • Homeo Box A9 2
  • HOX1.7 3
  • ABD-B 3
  • HOX1 3

External Ids for HOXA9 Gene

Previous HGNC Symbols for HOXA9 Gene

  • HOX1G
  • HOX1

Previous GeneCards Identifiers for HOXA9 Gene

  • GC07U990049
  • GC07M026844
  • GC07M026910
  • GC07M026945
  • GC07M026946
  • GC07M026975
  • GC07M027168
  • GC07M027213
  • GC07M027214
  • GC07M027219
  • GC07M027230
  • GC07M027254

Summaries for HOXA9 Gene

Entrez Gene Summary for HOXA9 Gene

  • In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011]

GeneCards Summary for HOXA9 Gene

HOXA9 (Homeobox A9) is a Protein Coding gene. Diseases associated with HOXA9 include Myeloid Leukemia and Myelodysplastic Syndrome. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include sequence-specific DNA binding and enzyme binding. An important paralog of this gene is HOXB9.

UniProtKB/Swiss-Prot for HOXA9 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation.

Gene Wiki entry for HOXA9 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXA9 Gene

Genomics for HOXA9 Gene

Regulatory Elements for HOXA9 Gene

Enhancers for HOXA9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G027095 3.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 18 +37.0 36985 86.3 MLX ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 HOTAIRM1 HOXA10-AS HOXA2 HOXA-AS2 HOXA9 HOXA11-AS HOXA10 HOXA11 EIF4HP1 SKAP2
GH07G026372 2.1 ENCODE 12 +800.2 800188 5.5 HDGF PKNOX1 ARID4B FEZF1 ZNF2 ZNF302 ZNF143 ZNF548 SP3 REST HOXA10-AS HOXA9 CBX3 HNRNPA2B1 KIAA0087 C7orf71 SNX10 LOC105375304 LOC441204
GH07G026862 1.4 ENCODE dbSUPER 10.7 +311.1 311066 3.1 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 HOTAIRM1 HOXA-AS3 HOXA4 HOXA3 HOXA6 HOXA5 HOXA1 HOXA2 HOXA10-AS HOXA9
GH07G028082 1.3 FANTOM5 Ensembl ENCODE 9.6 -908.5 -908504 2.6 BHLHE40 CEBPB NR3C1 EP300 RFX5 YY1 FOXA1 JUND ATF3 STAT3 JAZF1 JAZF1-AS1 HOXA11-AS HOXA11 HOXA9 HOXA10 ENSG00000253508 HOXA13 HOTTIP EVX1-AS
GH07G027920 1.1 Ensembl ENCODE 10.7 -746.1 -746135 0.6 SIN3A ZNF76 BMI1 FEZF1 ZNF2 RAD21 RFX5 ZSCAN5C FOS RELB HOTTIP HOXA13 ENSG00000253508 HOXA11 HOXA11-AS HOXA10 HOXA9 EVX1 ENSG00000253308 EVX1-AS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HOXA9 on UCSC Golden Path with GeneCards custom track

Promoters for HOXA9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000209849 1480 1401 KLF17 FEZF1 GLIS2 ZNF366 ZSCAN5C KLF7 ZNF391 EGR2 SP3 ZNF362

Transcription factor binding sites by QIAGEN in the HOXA9 gene promoter:

Genomic Location for HOXA9 Gene

Chromosome:
7
Start:
27,162,435 bp from pter
End:
27,175,180 bp from pter
Size:
12,746 bases
Orientation:
Minus strand

Genomic View for HOXA9 Gene

Genes around HOXA9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXA9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXA9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXA9 Gene

Proteins for HOXA9 Gene

  • Protein details for HOXA9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31269-HXA9_HUMAN
    Recommended name:
    Homeobox protein Hox-A9
    Protein Accession:
    P31269
    Secondary Accessions:
    • O43369
    • O43429
    • Q99820

    Protein attributes for HOXA9 Gene

    Size:
    272 amino acids
    Molecular mass:
    30172 Da
    Quaternary structure:
    • Transiently interacts with PRMT5 in TNF-alpha stimulated endothelial cells.
    SequenceCaution:
    • Sequence=AAC50364.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for HOXA9 Gene

Post-translational modifications for HOXA9 Gene

  • Methylated on Arg-140 by PRMT5; methylation is critical for E-selectin induction.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXA9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXA9 Gene

Domains & Families for HOXA9 Gene

Gene Families for HOXA9 Gene

Suggested Antigen Peptide Sequences for HOXA9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P31269

UniProtKB/Swiss-Prot:

HXA9_HUMAN :
  • Belongs to the Abd-B homeobox family.
Family:
  • Belongs to the Abd-B homeobox family.
genes like me logo Genes that share domains with HOXA9: view

Function for HOXA9 Gene

Molecular function for HOXA9 Gene

GENATLAS Biochemistry:
homeo box A9(1G),with two alternatively spliced isoforms,including either exon AB or CD,homologous to mouse Hox-1.7,Drosophila abd-B,fused with NUP98 in acute myeloid leukemia with translocation t(7;11),see AML2
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation.

Gene Ontology (GO) - Molecular Function for HOXA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0019899 enzyme binding IPI 22269951
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HOXA9: view
genes like me logo Genes that share phenotypes with HOXA9: view

Animal Models for HOXA9 Gene

MGI Knock Outs for HOXA9:

Animal Model Products

CRISPR Products

miRNA for HOXA9 Gene

miRTarBase miRNAs that target HOXA9

Transcription Factor Targets for HOXA9 Gene

Selected GeneGlobe predicted Target genes for HOXA9
Targeted motifs for HOXA9 Gene
HOMER Transcription Factor Regulatory Elements motif HOXA9
  • Consensus sequence: GGCCATAAATCA Submotif: canonical Cell Type: HSC GEO ID: GSE33509

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HOXA9

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for HOXA9 Gene

Localization for HOXA9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXA9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HOXA9 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1

Gene Ontology (GO) - Cellular Components for HOXA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA --
genes like me logo Genes that share ontologies with HOXA9: view

Pathways & Interactions for HOXA9 Gene

genes like me logo Genes that share pathways with HOXA9: view

Pathways by source for HOXA9 Gene

1 KEGG pathway for HOXA9 Gene

SIGNOR curated interactions for HOXA9 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for HOXA9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007275 multicellular organism development IEA,TAS --
GO:0042118 endothelial cell activation IMP 22269951
GO:0045638 negative regulation of myeloid cell differentiation ISS --
genes like me logo Genes that share ontologies with HOXA9: view

Drugs & Compounds for HOXA9 Gene

(2) Drugs for HOXA9 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HOXA9: view

Transcripts for HOXA9 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for HOXA9

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HOXA9 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: - -
SP2:
SP3:

Relevant External Links for HOXA9 Gene

GeneLoc Exon Structure for
HOXA9
ECgene alternative splicing isoforms for
HOXA9

Expression for HOXA9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HOXA9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXA9 Gene

This gene is overexpressed in Kidney - Cortex (x5.8) and Fallopian Tube (x5.4).

NURSA nuclear receptor signaling pathways regulating expression of HOXA9 Gene:

HOXA9

Evidence on tissue expression from TISSUES for HOXA9 Gene

  • Bone marrow(4.6)
  • Intestine(4.3)
  • Blood(2)
genes like me logo Genes that share expression patterns with HOXA9: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HOXA9 Gene

Orthologs for HOXA9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HOXA9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HOXA9 34 35
  • 99.14 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 97 (a)
OneToMany
HOXA9 34
  • 94.24 (n)
cow
(Bos Taurus)
Mammalia HOXA9 34 35
  • 93.87 (n)
mouse
(Mus musculus)
Mammalia Hoxa9 34 16 35
  • 92.87 (n)
rat
(Rattus norvegicus)
Mammalia LOC100909740 34
  • 92.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 71 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 89 (a)
ManyToMany
-- 35
  • 81 (a)
ManyToMany
-- 35
  • 81 (a)
ManyToMany
LOC100858551 34
  • 79.23 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 95 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxa9 34
  • 71.79 (n)
African clawed frog
(Xenopus laevis)
Amphibia hoxa9-A 34
zebrafish
(Danio rerio)
Actinopterygii hoxa9b 35
  • 48 (a)
ManyToMany
hoxa9a 35 35
  • 42 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 18 (a)
OneToMany
Species where no ortholog for HOXA9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HOXA9 Gene

ENSEMBL:
Gene Tree for HOXA9 (if available)
TreeFam:
Gene Tree for HOXA9 (if available)

Paralogs for HOXA9 Gene

(5) SIMAP similar genes for HOXA9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HOXA9: view

Variants for HOXA9 Gene

Sequence variations from dbSNP and Humsavar for HOXA9 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000950303 -- 27,165,162(+) CCGCC(A/G)CCACG intron-variant, reference, missense
rs1001052090 -- 27,167,291(+) GCCGC(A/G)CGGAT intron-variant, upstream-variant-2KB
rs1001381193 -- 27,165,360(+) GGGTC(C/G)CCGGC intron-variant, reference, missense
rs1002348742 -- 27,163,080(+) ACAAT(C/T)ACAAT nc-transcript-variant, utr-variant-3-prime
rs1003015066 -- 27,165,521(+) TTTCA(C/T)GTAAC intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for HOXA9 Gene

Variant ID Type Subtype PubMed ID
dgv1094n67 CNV gain 20364138
nsv606465 CNV loss 21841781
nsv606468 CNV loss 21841781
nsv7393 OTHER inversion 18451855
nsv824042 CNV gain 20364138

Variation tolerance for HOXA9 Gene

Residual Variation Intolerance Score: 61.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOXA9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HOXA9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXA9 Gene

Disorders for HOXA9 Gene

MalaCards: The human disease database

(5) MalaCards diseases for HOXA9 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
myeloid leukemia
  • leukemia myelogenous
myelodysplastic syndrome
  • myelodysplastic syndrome, somatic
leukemia, chronic myeloid, somatic
  • leukemia, chronic myeloid
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
clivus chordoma
  • chordoma of clivus
- elite association - COSMIC cancer census association via MalaCards
Search HOXA9 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

HXA9_HUMAN
  • Note=A chromosomal aberration involving HOXA9 is found in a form of acute myeloid leukemia. Translocation t(7;11)(p15;p15) with NUP98.
  • Note=A chromosomal aberration involving HOXA9 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with MSI2.

Relevant External Links for HOXA9

Genetic Association Database (GAD)
HOXA9
Human Genome Epidemiology (HuGE) Navigator
HOXA9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOXA9
genes like me logo Genes that share disorders with HOXA9: view

No data available for Genatlas for HOXA9 Gene

Publications for HOXA9 Gene

  1. A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease progression of chronic myeloid leukemia and forms a fusion gene with HOXA9 as a result of the cryptic t(7;17)(p15;q23). (PMID: 12649177) Barbouti A. … Fioretos T. (Cancer Res. 2003) 3 4 22 64
  2. The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. (PMID: 8563754) Borrow J. … Housman D.E. (Nat. Genet. 1996) 3 4 22 64
  3. HOXA9 methylation by PRMT5 is essential for endothelial cell expression of leukocyte adhesion molecules. (PMID: 22269951) Bandyopadhyay S. … Dicorleto P.E. (Mol. Cell. Biol. 2012) 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma. (PMID: 20068170) Costa B.M. … Costello J.F. (Cancer Res. 2010) 3 22 64

Products for HOXA9 Gene

Sources for HOXA9 Gene

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