Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HOXA6 Gene

Aliases for HOXA6 Gene

  • Homeobox A6 2 3 5
  • Homeobox Protein Hox-1B 3 4
  • Homeo Box A6 2 3
  • HOX1B 3 4
  • Homeobox Protein HOXA6 3
  • Homeo Box 1B 3
  • HOX1.2 3
  • HOX1 3

External Ids for HOXA6 Gene

Previous HGNC Symbols for HOXA6 Gene

  • HOX1B
  • HOX1

Previous GeneCards Identifiers for HOXA6 Gene

  • GC07M026827
  • GC07M026927
  • GC07M026958
  • GC07M027151
  • GC07M027065
  • GC07M027185

Summaries for HOXA6 Gene

Entrez Gene Summary for HOXA6 Gene

  • In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXA6 Gene

HOXA6 (Homeobox A6) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot for HOXA6 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Gene Wiki entry for HOXA6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXA6 Gene

Genomics for HOXA6 Gene

Regulatory Elements for HOXA6 Gene

Promoters for HOXA6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HOXA6 on UCSC Golden Path with GeneCards custom track

Genomic Location for HOXA6 Gene

27,145,396 bp from pter
27,150,603 bp from pter
5,208 bases
Minus strand

Genomic View for HOXA6 Gene

Genes around HOXA6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXA6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXA6 Gene

Proteins for HOXA6 Gene

  • Protein details for HOXA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein Hox-A6
    Protein Accession:
    Secondary Accessions:
    • A4D192
    • Q2M3G3
    • Q9UPM0

    Protein attributes for HOXA6 Gene

    233 amino acids
    Molecular mass:
    26339 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXA6 Gene

Proteomics data for HOXA6 Gene at MOPED

Post-translational modifications for HOXA6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXA6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HOXA6 Gene

Domains & Families for HOXA6 Gene

Gene Families for HOXA6 Gene

Suggested Antigen Peptide Sequences for HOXA6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Antp homeobox family.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Antp homeobox family.
genes like me logo Genes that share domains with HOXA6: view

Function for HOXA6 Gene

Molecular function for HOXA6 Gene

GENATLAS Biochemistry:
homeo box A6(1B),homologous to mouse Hox-1.2,Drosophila Antp,Ubx,abd-A
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
genes like me logo Genes that share phenotypes with HOXA6: view

Animal Models for HOXA6 Gene

MGI Knock Outs for HOXA6:

Animal Model Products

miRNA for HOXA6 Gene

miRTarBase miRNAs that target HOXA6

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HOXA6 Gene

Localization for HOXA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXA6 Gene

Subcellular locations from

Jensen Localization Image for HOXA6 Gene COMPARTMENTS Subcellular localization image for HOXA6 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for HOXA6 Gene

Pathways & Interactions for HOXA6 Gene

SuperPathways for HOXA6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for HOXA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009952 anterior/posterior pattern specification IEA --
GO:0048704 embryonic skeletal system morphogenesis IEA --
genes like me logo Genes that share ontologies with HOXA6: view

No data available for Pathways by source and SIGNOR curated interactions for HOXA6 Gene

Drugs & Compounds for HOXA6 Gene

No Compound Related Data Available

Transcripts for HOXA6 Gene

mRNA/cDNA for HOXA6 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HOXA6 Gene

Homeobox A6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOXA6 Gene

No ASD Table

Relevant External Links for HOXA6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HOXA6 Gene

mRNA expression in normal human tissues for HOXA6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXA6 Gene

This gene is overexpressed in Fallopian Tube (x7.1) and Colon - Transverse (x5.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXA6 Gene

SOURCE GeneReport for Unigene cluster for HOXA6 Gene Hs.679517

genes like me logo Genes that share expression patterns with HOXA6: view

Primer Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HOXA6 Gene

Orthologs for HOXA6 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXA6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HOXA6 35
  • 95.85 (n)
  • 97.85 (a)
HOXA6 36
  • 91 (a)
(Canis familiaris)
Mammalia HOXA6 35
  • 97.14 (n)
  • 97.85 (a)
HOXA6 36
  • 98 (a)
(Mus musculus)
Mammalia Hoxa6 35
  • 92.96 (n)
  • 96.55 (a)
Hoxa6 16
Hoxa6 36
  • 97 (a)
(Pan troglodytes)
Mammalia HOXA6 35
  • 99.86 (n)
  • 100 (a)
HOXA6 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Hoxa6 35
  • 94.56 (n)
  • 97 (a)
(Monodelphis domestica)
Mammalia HOXA6 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia HOXA6 36
  • 91 (a)
(Gallus gallus)
Aves LOC100858434 35
  • 81.39 (n)
  • 87.01 (a)
HOXA6 36
  • 87 (a)
HOXA6 36
  • 87 (a)
HOXA6 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxa6 35
  • 68.54 (n)
  • 72.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta Antp 37
  • 70 (a)
Antp 36
  • 22 (a)
Species with no ortholog for HOXA6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HOXA6 Gene

Gene Tree for HOXA6 (if available)
Gene Tree for HOXA6 (if available)

Paralogs for HOXA6 Gene

(12) SIMAP similar genes for HOXA6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HOXA6: view

Variants for HOXA6 Gene

Structural Variations from Database of Genomic Variants (DGV) for HOXA6 Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
nsv887856 CNV Loss 21882294
dgv1094n67 CNV Gain 20364138
dgv7231n71 CNV Loss 21882294
dgv7232n71 CNV Loss 21882294
dgv7233n71 CNV Loss 21882294
dgv7234n71 CNV Loss 21882294
dgv7235n71 CNV Loss 21882294
nsv5674 CNV Loss 18451855
nsv887876 CNV Loss 21882294
nsv824042 CNV Gain 20364138
dgv7236n71 CNV Loss 21882294
nsv526526 CNV Loss 19592680

Variation tolerance for HOXA6 Gene

Residual Variation Intolerance Score: 26.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.47% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for HOXA6 Gene

Disorders for HOXA6 Gene

Relevant External Links for HOXA6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HOXA6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HOXA6 Gene

Publications for HOXA6 Gene

  1. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 48 67
  2. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3
  3. Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3
  4. DNA methylation in the malignant transformation of meningiomas. (PMID: 23349797) Gao F. … Wang K. (PLoS ONE 2013) 3
  5. HOXA/PBX3 knockdown impairs growth and sensitizes cytogenetically normal acute myeloid leukemia cells to chemotherapy. (PMID: 23539541) Dickson G.J. … Thompson A. (Haematologica 2013) 3

Products for HOXA6 Gene

Sources for HOXA6 Gene