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Aliases for HOXA4 Gene

Aliases for HOXA4 Gene

  • Homeobox A4 2 3 5
  • Homeobox Protein Hox-1.4 3 4
  • Homeobox Protein Hox-1D 3 4
  • Homeo Box A4 2 3
  • HOX1D 3 4
  • Hox-1.4-Like Protein 3
  • Dfd-Like Protein 3
  • HOX1 3

External Ids for HOXA4 Gene

Previous HGNC Symbols for HOXA4 Gene

  • HOX1D
  • HOX1

Previous GeneCards Identifiers for HOXA4 Gene

  • GC07M026810
  • GC07M026911
  • GC07M026912
  • GC07M026941
  • GC07M027134
  • GC07M027048
  • GC07M027170

Summaries for HOXA4 Gene

Entrez Gene Summary for HOXA4 Gene

  • In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for HOXA4 Gene

HOXA4 (Homeobox A4) is a Protein Coding gene. Diseases associated with HOXA4 include hypospadias. Among its related pathways are Developmental Biology and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is HOXA7.

UniProtKB/Swiss-Prot for HOXA4 Gene

  • Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5-TAATGA[CG]-3 and 5-CTAATTTT-3.

Gene Wiki entry for HOXA4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HOXA4 Gene

Genomics for HOXA4 Gene

Regulatory Elements for HOXA4 Gene

Promoters for HOXA4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HOXA4 on UCSC Golden Path with GeneCards custom track

Genomic Location for HOXA4 Gene

Chromosome:
7
Start:
27,128,507 bp from pter
End:
27,130,799 bp from pter
Size:
2,293 bases
Orientation:
Minus strand

Genomic View for HOXA4 Gene

Genes around HOXA4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HOXA4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HOXA4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HOXA4 Gene

Proteins for HOXA4 Gene

  • Protein details for HOXA4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00056-HXA4_HUMAN
    Recommended name:
    Homeobox protein Hox-A4
    Protein Accession:
    Q00056
    Secondary Accessions:
    • A4D180
    • O43366

    Protein attributes for HOXA4 Gene

    Size:
    320 amino acids
    Molecular mass:
    34499 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HOXA4 Gene

Proteomics data for HOXA4 Gene at MOPED

Post-translational modifications for HOXA4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HOXA4 Gene

Antibody Products

No data available for DME Specific Peptides for HOXA4 Gene

Domains & Families for HOXA4 Gene

Gene Families for HOXA4 Gene

Suggested Antigen Peptide Sequences for HOXA4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q00056

UniProtKB/Swiss-Prot:

HXA4_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Antp homeobox family. Deformed subfamily.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the Antp homeobox family. Deformed subfamily.
genes like me logo Genes that share domains with HOXA4: view

Function for HOXA4 Gene

Molecular function for HOXA4 Gene

GENATLAS Biochemistry:
homeo box A4(1D),homologous to mouse Hox-1.4,Drosophila Dfd
UniProtKB/Swiss-Prot Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5-TAATGA[CG]-3 and 5-CTAATTTT-3.
genes like me logo Genes that share phenotypes with HOXA4: view

Animal Models for HOXA4 Gene

MGI Knock Outs for HOXA4:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for HOXA4 Gene

Localization for HOXA4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HOXA4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HOXA4 Gene COMPARTMENTS Subcellular localization image for HOXA4 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for HOXA4 Gene

Pathways & Interactions for HOXA4 Gene

genes like me logo Genes that share pathways with HOXA4: view

Interacting Proteins for HOXA4 Gene

Gene Ontology (GO) - Biological Process for HOXA4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009653 anatomical structure morphogenesis TAS 1675427
genes like me logo Genes that share ontologies with HOXA4: view

No data available for SIGNOR curated interactions for HOXA4 Gene

Drugs & Compounds for HOXA4 Gene

No Compound Related Data Available

Transcripts for HOXA4 Gene

mRNA/cDNA for HOXA4 Gene

Unigene Clusters for HOXA4 Gene

Homeobox A4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HOXA4 Gene

No ASD Table

Relevant External Links for HOXA4 Gene

GeneLoc Exon Structure for
HOXA4
ECgene alternative splicing isoforms for
HOXA4

Expression for HOXA4 Gene

mRNA expression in normal human tissues for HOXA4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HOXA4 Gene

This gene is overexpressed in Esophagus - Muscularis (x7.3) and Esophagus - Gastroesophageal Junction (x6.8).

Protein differential expression in normal tissues from HIPED for HOXA4 Gene

This gene is overexpressed in Neutrophil (23.8), Tlymphocyte (12.9), Nasal epithelium (10.8), and Blymphocyte (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HOXA4 Gene



SOURCE GeneReport for Unigene cluster for HOXA4 Gene Hs.533357

mRNA Expression by UniProt/SwissProt for HOXA4 Gene

Q00056-HXA4_HUMAN
Tissue specificity: Embryonic nervous system.
genes like me logo Genes that share expression patterns with HOXA4: view

Protein tissue co-expression partners for HOXA4 Gene

Primer Products

In Situ Assay Products

Orthologs for HOXA4 Gene

This gene was present in the common ancestor of animals.

Orthologs for HOXA4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HOXA4 35
  • 90.22 (n)
  • 88.96 (a)
HOXA4 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HOXA4 35
  • 91.59 (n)
  • 90.54 (a)
HOXA4 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hoxa4 35
  • 83.27 (n)
  • 77.54 (a)
Hoxa4 16
Hoxa4 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HOXA4 35
  • 99.37 (n)
  • 99.06 (a)
HOXA4 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100360577 35
  • 83.99 (n)
  • 79.72 (a)
oppossum
(Monodelphis domestica)
Mammalia HOXA4 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HOXA4 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100858429 35
  • 94.44 (n)
  • 91.67 (a)
HOXA4 36
  • 60 (a)
OneToMany
HOXA4 36
  • 60 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia HOXA4 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hoxa4 35
  • 66.67 (n)
  • 65.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dfd 37
  • 73 (a)
Scr 37
  • 60 (a)
Dfd 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for HOXA4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HOXA4 Gene

ENSEMBL:
Gene Tree for HOXA4 (if available)
TreeFam:
Gene Tree for HOXA4 (if available)

Paralogs for HOXA4 Gene

genes like me logo Genes that share paralogs with HOXA4: view

Variants for HOXA4 Gene

Sequence variations from dbSNP and Humsavar for HOXA4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
VAR_028414 -
VAR_028415 -
VAR_028416 -
VAR_028417 -
VAR_028418 -

Structural Variations from Database of Genomic Variants (DGV) for HOXA4 Gene

Variant ID Type Subtype PubMed ID
nsv7393 OTHER Inversion 18451855
nsv887856 CNV Loss 21882294
dgv1094n67 CNV Gain 20364138
dgv7231n71 CNV Loss 21882294
dgv7232n71 CNV Loss 21882294
dgv7233n71 CNV Loss 21882294
dgv7234n71 CNV Loss 21882294
dgv7235n71 CNV Loss 21882294
nsv5674 CNV Loss 18451855
nsv887876 CNV Loss 21882294
nsv824042 CNV Gain 20364138
dgv7236n71 CNV Loss 21882294

Variation tolerance for HOXA4 Gene

Residual Variation Intolerance Score: 73.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.09; 80.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HOXA4 Gene

HapMap Linkage Disequilibrium report
HOXA4
Human Gene Mutation Database (HGMD)
HOXA4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HOXA4 Gene

Disorders for HOXA4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HOXA4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hypospadias
  • familial hypospadias
- elite association - COSMIC cancer census association via MalaCards
Search HOXA4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HOXA4

Genetic Association Database (GAD)
HOXA4
Human Genome Epidemiology (HuGE) Navigator
HOXA4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HOXA4
genes like me logo Genes that share disorders with HOXA4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HOXA4 Gene

Publications for HOXA4 Gene

  1. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 48 67
  2. Vertebrate homeobox gene nomenclature. (PMID: 1358459) Scott M.P. (Cell 1992) 2 3
  3. Nomenclature for human homeobox genes. (PMID: 1973146) McAlpine P.J. … Shows T.B. (Genomics 1990) 2 3
  4. Tat predominantly associates with host promoter elements in HIV-1-infected T-cells - regulatory basis of transcriptional repression of c-Rel. (PMID: 25472883) Dhamija N. … Mitra D. (FEBS J. 2015) 3
  5. Genome-wide association analyses identify variants in developmental genes associated with hypospadias. (PMID: 25108383) Geller F. … Melbye M. (Nat. Genet. 2014) 3

Products for HOXA4 Gene

Sources for HOXA4 Gene

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