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Aliases for HNRNPL Gene

Aliases for HNRNPL Gene

  • Heterogeneous Nuclear Ribonucleoprotein L 2 3
  • HnRNP L 3 4
  • HNRPL 3 4
  • P/OKcl.14 3
  • HnRNP-L 3

External Ids for HNRNPL Gene

Previous HGNC Symbols for HNRNPL Gene

  • HNRPL

Previous GeneCards Identifiers for HNRNPL Gene

  • GC19M044022
  • GC19M039327
  • GC19M035773

Summaries for HNRNPL Gene

Entrez Gene Summary for HNRNPL Gene

  • Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPL Gene

HNRNPL (Heterogeneous Nuclear Ribonucleoprotein L) is a Protein Coding gene. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include RNA binding and transcription regulatory region DNA binding. An important paralog of this gene is ENSG00000268083.

UniProtKB/Swiss-Prot for HNRNPL Gene

  • Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.

Gene Wiki entry for HNRNPL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPL Gene

Genomics for HNRNPL Gene

Regulatory Elements for HNRNPL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HNRNPL Gene

Start:
38,836,388 bp from pter
End:
38,852,347 bp from pter
Size:
15,960 bases
Orientation:
Minus strand

Genomic View for HNRNPL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HNRNPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPL Gene

Proteins for HNRNPL Gene

  • Protein details for HNRNPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14866-HNRPL_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein L
    Protein Accession:
    P14866
    Secondary Accessions:
    • A6ND69
    • A6NIT8
    • Q9H3P3

    Protein attributes for HNRNPL Gene

    Size:
    589 amino acids
    Molecular mass:
    64133 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with HNRNPLL. Interacts with APEX1; the interaction is DNA-dependent. Component of a complex with SETD2.
    Miscellaneous:
    • Excess hnRNP L activates NMD of its own mRNA by promoting the inclusion of a poison exon containing a premature stop codon and leading to nonsense-mediated decay. It also cross-regulates inclusion of an analogous poison exon in the hnRNP L-like pre-mRNA (PubMed:19124611).
    SequenceCaution:
    • Sequence=CAA34261.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HNRNPL Gene

    Alternative splice isoforms for HNRNPL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPL Gene

Proteomics data for HNRNPL Gene at MOPED

Post-translational modifications for HNRNPL Gene

  • Phosphorylation at Ser-544 by CaMK4 enhances interaction with a CaMK4-responsive RNA element (CaRRE1), and prevents inclusion of the stress axis-regulated exon (STREX) of the KCNMA1 potassium channel transcripts upon membrane depolarization.
  • Several isoelectric forms of the L protein are probably the results of post-translational modifications
  • Ubiquitination at Lys59, Lys97, Lys229, Lys248, Lys264, Lys277, Lys302, Lys455, Lys493, Lys533, and Lys568
  • Modification sites at PhosphoSitePlus

Other Protein References for HNRNPL Gene

Antibody Products

No data available for DME Specific Peptides for HNRNPL Gene

Domains for HNRNPL Gene

Gene Families for HNRNPL Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for HNRNPL Gene

Graphical View of Domain Structure for InterPro Entry

P14866

UniProtKB/Swiss-Prot:

HNRPL_HUMAN :
  • P14866
Domain:
  • RRM domain 2 has moderate RNA-binding affinity. RRM domains 3 and 4 may facilitate RNA looping when binding to two appropriately separated binding sites within the same target pre-mRNA (PubMed:23782695).
  • Contains 4 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with HNRNPL: view

Function for HNRNPL Gene

Molecular function for HNRNPL Gene

UniProtKB/Swiss-Prot Function:
Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter.

Gene Ontology (GO) - Molecular Function for HNRNPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding TAS 2687284
GO:0005515 protein binding IPI 11809897
GO:0044212 transcription regulatory region DNA binding IDA 11809897
genes like me logo Genes that share ontologies with HNRNPL: view

Phenotypes for HNRNPL Gene

genes like me logo Genes that share phenotypes with HNRNPL: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HNRNPL Gene

Localization for HNRNPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPL Gene

Nucleus, nucleoplasm. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPL Gene COMPARTMENTS Subcellular localization image for HNRNPL gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for HNRNPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15798186
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IDA 19946888
GO:0019013 viral nucleocapsid --
genes like me logo Genes that share ontologies with HNRNPL: view

Pathways for HNRNPL Gene

genes like me logo Genes that share pathways with HNRNPL: view

Pathways by source for HNRNPL Gene

Gene Ontology (GO) - Biological Process for HNRNPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006396 RNA processing TAS 2687284
GO:0006397 mRNA processing --
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with HNRNPL: view

Compounds for HNRNPL Gene

(1) Novoseek inferred chemical compound relationships for HNRNPL Gene

Compound -log(P) Hits PubMed IDs
vegf 37.8 1
genes like me logo Genes that share compounds with HNRNPL: view

Transcripts for HNRNPL Gene

Unigene Clusters for HNRNPL Gene

Heterogeneous nuclear ribonucleoprotein L:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HNRNPL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPL Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11
SP1: -
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:

Relevant External Links for HNRNPL Gene

GeneLoc Exon Structure for
HNRNPL
ECgene alternative splicing isoforms for
HNRNPL

Expression for HNRNPL Gene

mRNA expression in normal human tissues for HNRNPL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNRNPL Gene

SOURCE GeneReport for Unigene cluster for HNRNPL Gene Hs.644906

genes like me logo Genes that share expressions with HNRNPL: view

Expression partners for HNRNPL Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPL Gene

Orthologs for HNRNPL Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HNRNPL 35
  • 94.84 (n)
  • 100 (a)
HNRNPL 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HNRNPL 35
  • 94.51 (n)
  • 100 (a)
HNRNPL 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hnrnpl 35
  • 91.07 (n)
  • 97.95 (a)
Hnrnpl 16
Hnrnpl 36
  • 98 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia HNRNPL 35
  • 99.66 (n)
  • 100 (a)
HNRNPL 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hnrnpl 35
  • 91.87 (n)
  • 97.95 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 98 (a)
ManyToMany
-- 36
  • 89 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 92 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnpl 35
  • 77.71 (n)
  • 88.37 (a)
Str.5918 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.1324 35
zebrafish
(Danio rerio)
Actinopterygii hnrpl 35
  • 73.6 (n)
  • 79.8 (a)
zgc55429 35
CABZ01100304.1 36
  • 52 (a)
ManyToMany
hnrnpl2 36
  • 77 (a)
ManyToMany
hnrpl 36
  • 77 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8682 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012054 35
  • 54 (n)
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta sm 35
  • 54.13 (n)
  • 48.53 (a)
sm 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C44B7.2 35
  • 48.82 (n)
  • 43.68 (a)
C44B7.2 36
  • 34 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2266 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToMany
Species with no ortholog for HNRNPL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HNRNPL Gene

ENSEMBL:
Gene Tree for HNRNPL (if available)
TreeFam:
Gene Tree for HNRNPL (if available)

Paralogs for HNRNPL Gene

Paralogs for HNRNPL Gene

Selected SIMAP similar genes for HNRNPL Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for HNRNPL Gene

genes like me logo Genes that share paralogs with HNRNPL: view

Variants for HNRNPL Gene

Sequence variations from dbSNP and Humsavar for HNRNPL Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs862454 -- 38,847,485(+) ATGAC(A/G)CCCCA intron-variant
rs862455 -- 38,847,502(+) TCTGT(A/G)CTGTT intron-variant
rs862456 -- 38,848,023(+) GAATC(A/G)CCCTC intron-variant
rs862457 -- 38,848,225(+) AGCTG(C/G)AATTA intron-variant
rs862458 -- 38,850,542(+) AATGG(G/T)GAGCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HNRNPL Gene

Variant ID Type Subtype PubMed ID
nsv911673 CNV Loss 21882294
esv29388 CNV Loss 19812545

Relevant External Links for HNRNPL Gene

HapMap Linkage Disequilibrium report
HNRNPL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPL Gene

Disorders for HNRNPL Gene

No disorders were found for HNRNPL Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for HNRNPL Gene

Publications for HNRNPL Gene

  1. Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter. (PMID: 11809897) Kuninger D.T. … Mitra S. (Nucleic Acids Res. 2002) 3 4 23
  2. Heterogeneous nuclear ribonucleoprotein L Is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo. (PMID: 19332550) Yuan W. … Reinberg D. (J. Biol. Chem. 2009) 3 4 23
  3. A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts. (PMID: 2687284) Pinol-Roma S. … Dreyfuss G. (J. Cell Biol. 1989) 2 3 4
  4. Molecular basis of T cell-mediated recognition of pancreatic cancer cells. (PMID: 11280764) Ito M. … Itoh K. (Cancer Res. 2001) 3 4
  5. Proteomic identification of heterogeneous nuclear ribonucleoprotein L as a novel component of SLM/Sam68 Nuclear Bodies. (PMID: 19912651) Rajan P. … Elliott D.J. (BMC Cell Biol. 2009) 3 23

Products for HNRNPL Gene

Sources for HNRNPL Gene

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