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Aliases for HNRNPD Gene

Aliases for HNRNPD Gene

  • Heterogeneous Nuclear Ribonucleoprotein D (AU-Rich Element RNA Binding Protein 1, 37kDa) 2 3
  • HNRPD 3 4 6
  • AUF1 3 4 6
  • HnRNP D0 3 4
  • AUF1A 3 6
  • Heterogeneous Nuclear Ribonucleoprotein D (AU-Rich Element RNA-Binding Protein 1, 37kD) 2
  • Heterogeneous Nuclear Ribonucleoprotein D0 3
  • AU-Rich Element RNA-Binding Protein 1 4
  • ARE-Binding Protein AUFI, Type A 3
  • HnRNPD0 3
  • P37 3

External Ids for HNRNPD Gene

Previous HGNC Symbols for HNRNPD Gene

  • AUF1
  • HNRPD

Previous GeneCards Identifiers for HNRNPD Gene

  • GC04M083494
  • GC04M083274
  • GC04M079015

Summaries for HNRNPD Gene

Entrez Gene Summary for HNRNPD Gene

  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability. Alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPD Gene

HNRNPD (Heterogeneous Nuclear Ribonucleoprotein D (AU-Rich Element RNA Binding Protein 1, 37kDa)) is a Protein Coding gene. Among its related pathways are Translational Control and Gene Expression. GO annotations related to this gene include RNA binding and telomeric DNA binding. An important paralog of this gene is HNRNPA0.

UniProtKB/Swiss-Prot for HNRNPD Gene

  • Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5-UUAG-3 sequence and also weaker to the single-stranded 5-TTAGGG-3 telomeric DNA repeat. Binds RNA oligonucleotides with 5-UUAGGG-3 repeats more tightly than the telomeric single-stranded DNA 5-TTAGGG-3 repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.

Gene Wiki entry for HNRNPD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPD Gene

Genomics for HNRNPD Gene

Regulatory Elements for HNRNPD Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HNRNPD Gene

Start:
82,352,498 bp from pter
End:
82,374,503 bp from pter
Size:
22,006 bases
Orientation:
Minus strand

Genomic View for HNRNPD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HNRNPD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPD Gene

Proteins for HNRNPD Gene

  • Protein details for HNRNPD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14103-HNRPD_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein D0
    Protein Accession:
    Q14103
    Secondary Accessions:
    • A8K9J2
    • P07029
    • Q01858
    • Q14100
    • Q14101
    • Q14102
    • Q4W5A1
    • Q9UCE8
    • Q9UCE9

    Protein attributes for HNRNPD Gene

    Size:
    355 amino acids
    Molecular mass:
    38434 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Part of a complex associated with the FOS mCRD domain and consisting of PABPC1, PAIP1, CSDE1/UNR and SYNCRIP. Interacts with IGF2BP2. Interacts with GTPBP1. Interacts with EIF4G1; the interaction requires RNA. Interacts with EIF3B and RPS3.
    SequenceCaution:
    • Sequence=AAA35781.1; Type=Frameshift; Positions=45, 59, 355; Evidence={ECO:0000305}; Sequence=AAA35781.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=CAA27544.1; Type=Miscellaneous discrepancy; Note=Several sequence conflicts.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HNRNPD Gene

    Alternative splice isoforms for HNRNPD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPD Gene

Proteomics data for HNRNPD Gene at MOPED

Post-translational modifications for HNRNPD Gene

  • Arg-345 is dimethylated, probably to asymmetric dimethylarginine
  • Methylated by PRMT1, in an insulin-dependent manner. The PRMT1-mediated methylation regulates tyrosine phosphorylation (By similarity).
  • Ubiquitination at Lys114, Lys119, Lys129, Lys183, Lys197, Lys231, Lys260, and Lys292
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HNRNPD (hnRNP D0)

No data available for DME Specific Peptides for HNRNPD Gene

Domains for HNRNPD Gene

Gene Families for HNRNPD Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Suggested Antigen Peptide Sequences for HNRNPD Gene

Graphical View of Domain Structure for InterPro Entry

Q14103

UniProtKB/Swiss-Prot:

HNRPD_HUMAN :
  • Q14103
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with HNRNPD: view

Function for HNRNPD Gene

Molecular function for HNRNPD Gene

UniProtKB/Swiss-Prot Function: Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5-UUAG-3 sequence and also weaker to the single-stranded 5-TTAGGG-3 telomeric DNA repeat. Binds RNA oligonucleotides with 5-UUAGGG-3 repeats more tightly than the telomeric single-stranded DNA 5-TTAGGG-3 repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation.

Gene Ontology (GO) - Molecular Function for HNRNPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding NAS 3754960
GO:0005515 protein binding IPI 12107167
GO:0042162 telomeric DNA binding IDA 8321232
genes like me logo Genes that share ontologies with HNRNPD: view
genes like me logo Genes that share phenotypes with HNRNPD: view

Animal Models for HNRNPD Gene

MGI Knock Outs for HNRNPD:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HNRNPD

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for HNRNPD Gene

Localization for HNRNPD Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPD Gene

Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Cytoplasmic localization oscillates diurnally.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPD Gene COMPARTMENTS Subcellular localization image for HNRNPD gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 1

Gene Ontology (GO) - Cellular Components for HNRNPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 1433497
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0030529 ribonucleoprotein complex IDA 17289661
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with HNRNPD: view

Pathways for HNRNPD Gene

genes like me logo Genes that share pathways with HNRNPD: view

Pathways by source for HNRNPD Gene

1 Qiagen pathway for HNRNPD Gene
1 Cell Signaling Technology pathway for HNRNPD Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for HNRNPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 1433497
GO:0006396 RNA processing TAS 10205060
GO:0006401 RNA catabolic process TAS 10205060
genes like me logo Genes that share ontologies with HNRNPD: view

Compounds for HNRNPD Gene

(5) Novoseek inferred chemical compound relationships for HNRNPD Gene

Compound -log(P) Hits PubMed IDs
adenylate 11 7
oligonucleotide 0 1
calcium 0 4
tyrosine 0 1
cyclosporin a 0 1
genes like me logo Genes that share compounds with HNRNPD: view

Transcripts for HNRNPD Gene

Unigene Clusters for HNRNPD Gene

Heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HNRNPD

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPD Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b
SP1: - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - -
SP6:
SP7: - - -
SP8: - - -
SP9:
SP10:
SP11: - -

Relevant External Links for HNRNPD Gene

GeneLoc Exon Structure for
HNRNPD
ECgene alternative splicing isoforms for
HNRNPD

Expression for HNRNPD Gene

mRNA expression in normal human tissues for HNRNPD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNRNPD Gene

SOURCE GeneReport for Unigene cluster for HNRNPD Gene Hs.480073

genes like me logo Genes that share expressions with HNRNPD: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPD Gene

Orthologs for HNRNPD Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HNRNPD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPD 35
  • 99.91 (n)
  • 100 (a)
HNRNPD 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HNRPD 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HNRNPD 35
  • 98.03 (n)
  • 99.44 (a)
HNRNPD 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hnrnpd 35
  • 93.99 (n)
  • 95.49 (a)
Hnrnpd 16
Hnrnpd 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HNRNPD 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HNRNPD 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hnrpd 35
  • 93.01 (n)
  • 94.9 (a)
chicken
(Gallus gallus)
Aves HNRNPD 35
  • 88.85 (n)
  • 98.83 (a)
HNRNPD 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HNRNPD 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnpd 35
  • 75.12 (n)
  • 82.25 (a)
Str.8893 35
zebrafish
(Danio rerio)
Actinopterygii hnrnpd 35
  • 74.91 (n)
  • 86.91 (a)
hnrnpd 36
  • 82 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta sqd 36
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRP1 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10292 36
  • 37 (a)
ManyToMany
CSA.5495 36
  • 41 (a)
ManyToMany
Species with no ortholog for HNRNPD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HNRNPD Gene

ENSEMBL:
Gene Tree for HNRNPD (if available)
TreeFam:
Gene Tree for HNRNPD (if available)

Paralogs for HNRNPD Gene

Paralogs for HNRNPD Gene

Pseudogenes.org Pseudogenes for HNRNPD Gene

genes like me logo Genes that share paralogs with HNRNPD: view

Variants for HNRNPD Gene

Sequence variations from dbSNP and Humsavar for HNRNPD Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs3944 -- 82,353,646(+) AAGTC(A/G)TTCCC utr-variant-3-prime
rs11074 -- 82,353,330(+) CATAA(A/T)CACGG utr-variant-3-prime
rs1045146 -- 82,370,779(-) GTCTT(C/T)CTGCT intron-variant
rs1045147 -- 82,370,683(-) TCTTT(A/C)CAAGC intron-variant
rs1050811 -- 82,354,545(-) TTTTT(C/T)TTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPD Gene

Variant ID Type Subtype PubMed ID
nsv829988 CNV Loss 17160897

Relevant External Links for HNRNPD Gene

HapMap Linkage Disequilibrium report
HNRNPD
Human Gene Mutation Database (HGMD)
HNRNPD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPD Gene

Disorders for HNRNPD Gene

(4) Novoseek inferred disease relationships for HNRNPD Gene

Disease -log(P) Hits PubMed IDs
shock 18.2 5
necrosis 7.61 2
tumors 0 4
heart failure 0 1

Relevant External Links for HNRNPD

Genetic Association Database (GAD)
HNRNPD
genes like me logo Genes that share disorders with HNRNPD: view

No data available for UniProtKB/Swiss-Prot for HNRNPD Gene

Publications for HNRNPD Gene

  1. The UUAG-specific RNA binding protein, heterogeneous nuclear ribonucleoprotein D0. Common modular structure and binding properties of the 2xRBD-Gly family. (PMID: 7673195) Kajita Y. … Ishikawa F. (J. Biol. Chem. 1995) 3 4 23
  2. Structure and interactions with RNA of the N-terminal UUAG-specific RNA-binding domain of hnRNP D0. (PMID: 10080887) Nagata T. … Katahira M. (J. Mol. Biol. 1999) 3 4 23
  3. Structure and genomic organization of the human AUF1 gene: alternative pre-mRNA splicing generates four protein isoforms. (PMID: 9521873) Wagner B.J. … Brewer G. (Genomics 1998) 3 4 23
  4. The human HNRPD locus maps to 4q21 and encodes a highly conserved protein. (PMID: 9615222) Dempsey L.A. … Maizels N. (Genomics 1998) 2 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for HNRNPD Gene

Sources for HNRNPD Gene

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