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Aliases for HNRNPC Gene

Aliases for HNRNPC Gene

  • Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) 2 3
  • HNRPC 3 4 6
  • HnRNP C1/C2 3 4
  • Heterogeneous Nuclear Ribonucleoproteins C1/C2 3
  • Nuclear Ribonucleoprotein Particle C1 Protein 3
  • Nuclear Ribonucleoprotein Particle C2 Protein 3
  • HNRNP 3
  • SNRPC 3
  • C1 3
  • C2 3

External Ids for HNRNPC Gene

Previous HGNC Symbols for HNRNPC Gene

  • HNRPC

Previous GeneCards Identifiers for HNRNPC Gene

  • GC14M020747
  • GC14M021677
  • GC14M001797

Summaries for HNRNPC Gene

Entrez Gene Summary for HNRNPC Gene

  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPC Gene

HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C (C1/C2)) is a Protein Coding gene. Diseases associated with HNRNPC include oculopharyngeal muscular dystrophy. Among its related pathways are Complement and coagulation cascades and Complement and coagulation cascades. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is RALYL.

UniProtKB/Swiss-Prot for HNRNPC Gene

  • Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named m(6)A-switch to facilitate binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3-UTR or 5-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621).

Gene Wiki entry for HNRNPC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPC Gene

Genomics for HNRNPC Gene

Regulatory Elements for HNRNPC Gene

Genomic Location for HNRNPC Gene

Start:
21,209,136 bp from pter
End:
21,269,494 bp from pter
Size:
60,359 bases
Orientation:
Minus strand

Genomic View for HNRNPC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HNRNPC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPC Gene

Proteins for HNRNPC Gene

  • Protein details for HNRNPC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07910-HNRPC_HUMAN
    Recommended name:
    Heterogeneous nuclear ribonucleoproteins C1/C2
    Protein Accession:
    P07910
    Secondary Accessions:
    • D3DS19
    • D3DS22
    • P22628
    • Q53EX2
    • Q59FD3
    • Q5FWE8
    • Q86SF8
    • Q86U45
    • Q96HK7
    • Q96HM4
    • Q96IY5
    • Q9BTS3

    Protein attributes for HNRNPC Gene

    Size:
    306 amino acids
    Molecular mass:
    33670 Da
    Quaternary structure:
    • Tetramer composed of 3 copies of isoform C1 and 1 copy of isoform C2. Assembly of 3 tetramers with bound pre-mRNA gives rise to a 19S complex that interacts with HNRNPA2B1 tetramers. Component of the 40S hnRNP particle. Identified in the spliceosome C complex. Interacts with IGF2BP1.
    SequenceCaution:
    • Sequence=BAD92764.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HNRNPC Gene

    Alternative splice isoforms for HNRNPC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HNRNPC Gene

Proteomics data for HNRNPC Gene at MOPED

Post-translational modifications for HNRNPC Gene

  • Phosphorylated on Ser-260 and Ser-299 in resting cells. Phosphorylated on Ser-253 and on 1 serine residue in the poly-Ser stretch at position 238 in response to hydrogen peroxide.
  • Sumoylated. Sumoylation reduces affinity for mRNA.
  • Ubiquitination at Lys8, Lys29, Lys39, Lys42, Lys89, and Lys206
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HNRNPC Gene

Domains for HNRNPC Gene

Gene Families for HNRNPC Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for HNRNPC Gene

Graphical View of Domain Structure for InterPro Entry

P07910

UniProtKB/Swiss-Prot:

HNRPC_HUMAN :
  • P07910
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the RRM HNRPC family. RALY subfamily.
genes like me logo Genes that share domains with HNRNPC: view

Function for HNRNPC Gene

Molecular function for HNRNPC Gene

UniProtKB/Swiss-Prot Function: Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs that affects mRNA splicing, processing and stability. M6A alters the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named m(6)A-switch to facilitate binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3-UTR or 5-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621).

Gene Ontology (GO) - Molecular Function for HNRNPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 16217013
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA 16217013
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding NAS 9731529
genes like me logo Genes that share ontologies with HNRNPC: view
genes like me logo Genes that share phenotypes with HNRNPC: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HNRNPC Gene

Localization for HNRNPC Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPC Gene

Nucleus. Note=Component of ribonucleosomes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HNRNPC Gene COMPARTMENTS Subcellular localization image for HNRNPC gene
Compartment Confidence
nucleus 5
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for HNRNPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 16217013
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IDA 9731529
GO:0005829 cytosol IDA 16010978
genes like me logo Genes that share ontologies with HNRNPC: view

Pathways for HNRNPC Gene

genes like me logo Genes that share pathways with HNRNPC: view

Gene Ontology (GO) - Biological Process for HNRNPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0001649 osteoblast differentiation IDA 16210410
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
GO:0038032 termination of G-protein coupled receptor signaling pathway --
genes like me logo Genes that share ontologies with HNRNPC: view

Compounds for HNRNPC Gene

(6) Novoseek inferred chemical compound relationships for HNRNPC Gene

Compound -log(P) Hits PubMed IDs
poly c 53.4 1
poly u 49.5 1
adenylate 26.8 1
arginine 20.9 1
h2o2 8.99 5
genes like me logo Genes that share compounds with HNRNPC: view

Transcripts for HNRNPC Gene

Unigene Clusters for HNRNPC Gene

Heterogeneous nuclear ribonucleoprotein C (C1/C2):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPC Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10a · 10b · 10c · 10d · 10e · 10f ^ 11a · 11b · 11c ^ 12a ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - - - - - - -
SP8: - -
SP9: - -
SP10: - -
SP11: -
SP12: - - -
SP13: - -
SP14:
SP15: - - - - - - - - - - - -
SP16:

ExUns: 12b · 12c · 12d · 12e ^ 13a · 13b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for HNRNPC Gene

GeneLoc Exon Structure for
HNRNPC
ECgene alternative splicing isoforms for
HNRNPC

Expression for HNRNPC Gene

mRNA expression in normal human tissues for HNRNPC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for HNRNPC Gene

SOURCE GeneReport for Unigene cluster for HNRNPC Gene Hs.508848

genes like me logo Genes that share expressions with HNRNPC: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HNRNPC Gene

Orthologs for HNRNPC Gene

This gene was present in the common ancestor of animals.

Orthologs for HNRNPC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HNRNPC 35
  • 99.66 (n)
  • 100 (a)
HNRNPC 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HNRPC 36
  • 98 (a)
OneToMany
LOC510852 35
  • 96.47 (n)
  • 98.63 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 95 (a)
ManyToMany
LOC475399 35
  • 96.28 (n)
  • 98.36 (a)
mouse
(Mus musculus)
Mammalia Hnrnpc 35
  • 93.55 (n)
  • 98.03 (a)
Hnrnpc 16
Ralyl 36
  • 71 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 98 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 98 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Hnrnpc 35
  • 93.33 (n)
  • 98.03 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 89 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia LOC397793 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6109 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3917 35
zebrafish
(Danio rerio)
Actinopterygii hnrnpc 36
  • 59 (a)
ManyToMany
zgc55733 35
zgc:55733 36
  • 65 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG42458 36
  • 12 (a)
OneToMany
Species with no ortholog for HNRNPC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HNRNPC Gene

ENSEMBL:
Gene Tree for HNRNPC (if available)
TreeFam:
Gene Tree for HNRNPC (if available)

Paralogs for HNRNPC Gene

Paralogs for HNRNPC Gene

genes like me logo Genes that share paralogs with HNRNPC: view

Variants for HNRNPC Gene

Sequence variations from dbSNP and Humsavar for HNRNPC Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs7495 -- 21,209,535(+) TTGAC(C/T)GAATT utr-variant-3-prime
rs1064879 -- 21,210,938(-) GTTTT(A/T)ATCAA utr-variant-3-prime, downstream-variant-500B
rs1064971 -- 21,211,128(-) AGTAT(C/T)TTCAG utr-variant-3-prime, downstream-variant-500B
rs1142288 -- 21,263,848(-) AATCT(C/G)TTCTC intron-variant
rs1957415 -- 21,215,825(+) ATCTG(C/G)AAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HNRNPC Gene

Variant ID Type Subtype PubMed ID
dgv1852n71 CNV Gain 21882294
esv2656744 CNV Deletion 23128226
esv2748453 CNV Deletion 23290073
nsv509527 CNV Insertion 20534489
esv1560508 CNV Insertion 17803354

Relevant External Links for HNRNPC Gene

HapMap Linkage Disequilibrium report
HNRNPC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNRNPC Gene

Disorders for HNRNPC Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for HNRNPC Gene including...

Search for HNRNPC Gene in MalaCards »

(1) University of Copenhagen DISEASES for HNRNPC Gene

(7) Novoseek inferred disease relationships for HNRNPC Gene

Disease -log(P) Hits PubMed IDs
mixed connective tissue disease 64.7 1
rheumatic diseases 38.3 2
lupus erythematosus systemic 23.2 1
rheumatoid arthritis 11.7 1
cancer lung 0 5

Relevant External Links for HNRNPC

Genetic Association Database (GAD)
HNRNPC
genes like me logo Genes that share disorders with HNRNPC: view

No data available for UniProtKB/Swiss-Prot for HNRNPC Gene

Publications for HNRNPC Gene

  1. 1H, 13C, and 15N NMR assignments and global folding pattern of the RNA-binding domain of the human hnRNP C proteins. (PMID: 1385725) Witteking M. … Mueller L. (Biochemistry 1992) 3 4 23
  2. Heterogeneous nuclear ribonucleoprotein C modulates translation of c- myc mRNA in a cell cycle phase-dependent manner. (PMID: 12509468) Kim J.H. … Jang S.K. (Mol. Cell. Biol. 2003) 3 4 23
  3. Basal and hydrogen peroxide stimulated sites of phosphorylation in heterogeneous nuclear ribonucleoprotein C1/C2. (PMID: 12564933) Stone J.R. … Collins T. (Biochemistry 2003) 3 4 23
  4. Regulation of urokinase receptor mRNA stability by hnRNP C in lung epithelial cells. (PMID: 16010978) Shetty S. (Mol. Cell. Biochem. 2005) 3 4 23
  5. Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region. (PMID: 16217013) Mahajan M.C. … Weissman S.M. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 23

Products for HNRNPC Gene

Sources for HNRNPC Gene

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