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Aliases for HNRNPAB Gene

Aliases for HNRNPAB Gene

  • Heterogeneous Nuclear Ribonucleoprotein A/B 2 3 5
  • APOBEC1-Binding Protein 1 3 4
  • HnRNP A/B 3 4
  • HNRPAB 3 4
  • ABBP-1 3 4
  • ABBP1 3 4
  • Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide 1-Binding Protein 1 3
  • Apobec-1 Binding Protein 1 3
  • HnRNP Type A/B Protein 3

External Ids for HNRNPAB Gene

Previous HGNC Symbols for HNRNPAB Gene


Previous GeneCards Identifiers for HNRNPAB Gene

  • GC05P177565
  • GC05P177631
  • GC05P172357

Summaries for HNRNPAB Gene

Entrez Gene Summary for HNRNPAB Gene

  • This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for HNRNPAB Gene

HNRNPAB (Heterogeneous Nuclear Ribonucleoprotein A/B) is a Protein Coding gene. Diseases associated with HNRNPAB include Hay-Wells Syndrome and Wells Syndrome. Among its related pathways are mRNA Splicing - Major Pathway and Telomere Extension by Telomerase. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is HNRNPA0.

UniProtKB/Swiss-Prot for HNRNPAB Gene

  • Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.

Gene Wiki entry for HNRNPAB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNRNPAB Gene

Genomics for HNRNPAB Gene

Regulatory Elements for HNRNPAB Gene

Enhancers for HNRNPAB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HNRNPAB on UCSC Golden Path with GeneCards custom track

Promoters for HNRNPAB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HNRNPAB on UCSC Golden Path with GeneCards custom track

Genomic Location for HNRNPAB Gene

178,204,507 bp from pter
178,211,183 bp from pter
6,677 bases
Plus strand

Genomic View for HNRNPAB Gene

Genes around HNRNPAB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNRNPAB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNRNPAB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNRNPAB Gene

Proteins for HNRNPAB Gene

  • Protein details for HNRNPAB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein A/B
    Protein Accession:
    Secondary Accessions:
    • B3KNN5
    • D3DWP7
    • Q04150
    • Q8N7U3
    • Q9BQ99

    Protein attributes for HNRNPAB Gene

    332 amino acids
    Molecular mass:
    36225 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with APOBEC1.
    • Sequence=AAC50956.1; Type=Frameshift; Positions=296, 307, 330; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HNRNPAB Gene

    Alternative splice isoforms for HNRNPAB Gene


neXtProt entry for HNRNPAB Gene

Proteomics data for HNRNPAB Gene at MOPED

Post-translational modifications for HNRNPAB Gene

  • Dimethylation at Arg-322 is probably asymmetric.
  • Ubiquitination at Lys 86, Lys 91, Lys 101, Lys 118, Lys 125, Lys 130, Lys 232, Lys 155, Lys 169, and Lys 271
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for HNRNPAB Gene

Domains & Families for HNRNPAB Gene

Gene Families for HNRNPAB Gene

Suggested Antigen Peptide Sequences for HNRNPAB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 RRM (RNA recognition motif) domains.
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with HNRNPAB: view

Function for HNRNPAB Gene

Molecular function for HNRNPAB Gene

UniProtKB/Swiss-Prot Function:
Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site.

Gene Ontology (GO) - Molecular Function for HNRNPAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003729 mRNA binding TAS 8999813
GO:0005515 protein binding IPI 24965446
GO:0043565 contributes_to sequence-specific DNA binding ISS --
genes like me logo Genes that share ontologies with HNRNPAB: view
genes like me logo Genes that share phenotypes with HNRNPAB: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for HNRNPAB Gene

Localization for HNRNPAB Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNRNPAB Gene

Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

Jensen Localization Image for HNRNPAB Gene COMPARTMENTS Subcellular localization image for HNRNPAB gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for HNRNPAB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0090575 RNA polymerase II transcription factor complex ISS --
genes like me logo Genes that share ontologies with HNRNPAB: view

Pathways & Interactions for HNRNPAB Gene

genes like me logo Genes that share pathways with HNRNPAB: view

Pathways by source for HNRNPAB Gene

1 BioSystems pathway for HNRNPAB Gene
1 Qiagen pathway for HNRNPAB Gene

Gene Ontology (GO) - Biological Process for HNRNPAB Gene


No data available for SIGNOR curated interactions for HNRNPAB Gene

Drugs & Compounds for HNRNPAB Gene

No Compound Related Data Available

Transcripts for HNRNPAB Gene

Unigene Clusters for HNRNPAB Gene

Heterogeneous nuclear ribonucleoprotein A/B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HNRNPAB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP2: -
SP5: - - - -

Relevant External Links for HNRNPAB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HNRNPAB Gene

mRNA expression in normal human tissues for HNRNPAB Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HNRNPAB Gene

SOURCE GeneReport for Unigene cluster for HNRNPAB Gene Hs.591731

mRNA Expression by UniProt/SwissProt for HNRNPAB Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with HNRNPAB: view

Protein tissue co-expression partners for HNRNPAB Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for HNRNPAB Gene

Orthologs for HNRNPAB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HNRNPAB Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HNRNPAB 35
  • 91.11 (n)
  • 95.83 (a)
  • 96 (a)
(Mus musculus)
Mammalia Hnrnpab 35
  • 88.38 (n)
  • 91.13 (a)
Hnrnpab 16
Hnrnpab 36
  • 92 (a)
(Rattus norvegicus)
Mammalia LOC100910156 35
  • 88.89 (n)
  • 91.74 (a)
(Canis familiaris)
Mammalia HNRNPAB 36
  • 90 (a)
(Monodelphis domestica)
Mammalia HNRNPAB 36
  • 64 (a)
(Ornithorhynchus anatinus)
Mammalia HNRNPAB 36
  • 87 (a)
(Pan troglodytes)
Mammalia HNRNPAB 36
  • 100 (a)
(Gallus gallus)
  • 77.65 (n)
  • 84.67 (a)
  • 87 (a)
(Anolis carolinensis)
Reptilia HNRNPAB 36
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hnrnpab 35
  • 71.34 (n)
  • 76.55 (a)
African clawed frog
(Xenopus laevis)
Amphibia hnrpab-prov 35
(Danio rerio)
Actinopterygii Dr.18836 35
hnrnpabb 35
  • 69.83 (n)
  • 72.99 (a)
hnrnpaba 36
  • 67 (a)
hnrnpabb 36
  • 74 (a)
fruit fly
(Drosophila melanogaster)
Insecta sqd 36
  • 36 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HRP1 36
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10292 36
  • 40 (a)
CSA.5495 36
  • 40 (a)
Species with no ortholog for HNRNPAB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HNRNPAB Gene

Gene Tree for HNRNPAB (if available)
Gene Tree for HNRNPAB (if available)

Paralogs for HNRNPAB Gene

Paralogs for HNRNPAB Gene Pseudogenes for HNRNPAB Gene

genes like me logo Genes that share paralogs with HNRNPAB: view

Variants for HNRNPAB Gene

Sequence variations from dbSNP and Humsavar for HNRNPAB Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs2913753 -- 178,204,307(-) GCGCC(A/G)GGTCC upstream-variant-2KB
rs2913817 -- 178,203,039(+) CCTTG(A/G)GGCCC upstream-variant-2KB
rs2961673 -- 178,202,800(+) GTGAT(C/G/T)GTGCC upstream-variant-2KB
rs2961674 -- 178,205,526(+) TGGTG(A/G)AGACG intron-variant
rs1131347 -- 178,206,812(+) CCGGT(A/C/G)AAGAA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for HNRNPAB Gene

Variant ID Type Subtype PubMed ID
nsv820182 CNV Gain 19587683

Variation tolerance for HNRNPAB Gene

Residual Variation Intolerance Score: 35.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.77; 16.18% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HNRNPAB Gene

Disorders for HNRNPAB Gene

MalaCards: The human disease database

(2) MalaCards diseases for HNRNPAB Gene - From: GeneCards

Disorder Aliases PubMed IDs
hay-wells syndrome
  • aec syndrome
wells syndrome
  • bullous cellulitis with eosinophilia
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for HNRNPAB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HNRNPAB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNRNPAB Gene

Publications for HNRNPAB Gene

  1. Cloning and sequence analysis of a human type A/B hnRNP protein. (PMID: 1717314) Khan F. … Szer W. (FEBS Lett. 1991) 2 3 4 67
  2. P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells syndrome. (PMID: 12692135) Fomenkov A. … Ratovitski E. (J. Biol. Chem. 2003) 3 23
  3. Cloning of an Apobec-1-binding protein that also interacts with apolipoprotein B mRNA and evidence for its involvement in RNA editing. (PMID: 8999813) Lau P.P. … Chan L. (J. Biol. Chem. 1997) 3 23
  4. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3
  5. BioID-based Identification of Skp Cullin F-box (SCF)I^-TrCP1/2 E3 Ligase Substrates. (PMID: 25900982) Coyaud E. … Raught B. (Mol. Cell Proteomics 2015) 3

Products for HNRNPAB Gene

Sources for HNRNPAB Gene