Aliases for SLC29A2 Gene
- Solute Carrier Family 29 Member 2 2 3 4 5
- Equilibrative Nitrobenzylmercaptopurine Riboside-Insensitive Nucleoside Transporter 3 4
- Solute Carrier Family 29 (Equilibrative Nucleoside Transporter), Member 2 2 3
- Equilibrative NBMPR-Insensitive Nucleoside Transporter 3 4
- Hydrophobic Nucleolar Protein, 36 KDa 3 4
- Delayed-Early Response Protein 12 3 4
- Nucleoside Transporter, Ei-Type 3 4
- 36 KDa Nucleolar Protein HNP36 3 4
External Ids for SLC29A2 Gene
Previous HGNC Symbols for SLC29A2 Gene
Previous GeneCards Identifiers for SLC29A2 Gene
The uptake of nucleosides by transporters, such as SLC29A2, is essential for nucleotide synthesis by salvage pathways in cells that lack de novo biosynthetic pathways. Nucleoside transport also plays a key role in the regulation of many physiologic processes through its effect on adenosine concentration at the cell surface (Griffiths et al., 1997 [PubMed 9396714]).[supplied by OMIM, Nov 2008]
GeneCards Summary for SLC29A2 Gene
SLC29A2 (Solute Carrier Family 29 Member 2) is a Protein Coding gene. Diseases associated with SLC29A2 include Chronic Lymphocytic Leukemia. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics. GO annotations related to this gene include nucleoside transmembrane transporter activity. An important paralog of this gene is SLC29A1.
UniProtKB/Swiss-Prot for SLC29A2 Gene
Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine.
Nucleoside transporters are divided into two families: the Na+-dependent solute carrier family 28 (SLC28) and the equilibrative solute carrier family 29 (SLC29). SLC28 family transporters (CNT1, 2 and 3) display subtype-selective tissue expression patterns.