Aliases for SLC29A2 Gene
- Solute Carrier Family 29 (Equilibrative Nucleoside Transporter), Member 2 2 3
- HNP36 3 4 6
- DER12 3 4 6
- Equilibrative Nitrobenzylmercaptopurine Riboside-Insensitive Nucleoside Transporter 3 4
- Solute Carrier Family 29 (Nucleoside Transporters), Member 2 2 3
- Equilibrative NBMPR-Insensitive Nucleoside Transporter 3 4
- Hydrophobic Nucleolar Protein, 36 KDa 3 4
- Delayed-Early Response Protein 12 3 4
External Ids for SLC29A2 Gene
Previous HGNC Symbols for SLC29A2 Gene
Previous GeneCards Identifiers for SLC29A2 Gene
The uptake of nucleosides by transporters, such as SLC29A2, is essential for nucleotide synthesis by salvage pathways in cells that lack de novo biosynthetic pathways. Nucleoside transport also plays a key role in the regulation of many physiologic processes through its effect on adenosine concentration at the cell surface (Griffiths et al., 1997 [PubMed 9396714]).[supplied by OMIM, Nov 2008]
GeneCards Summary for SLC29A2 Gene
SLC29A2 (Solute Carrier Family 29 (Equilibrative Nucleoside Transporter), Member 2) is a Protein Coding gene. Diseases associated with SLC29A2 include hyperglycemia and chronic lymphocytic leukemia. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and One carbon pool by folate. GO annotations related to this gene include nucleoside transmembrane transporter activity. An important paralog of this gene is SLC29A3.
UniProtKB/Swiss-Prot for SLC29A2 Gene
Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine.
Nucleoside transporters are divided into two families; the Na+-dependent solute carrier family 28 (SLC28) and the equilibrative solute carrier family 29 (SLC29). SLC28 family transporters (CNT1-3) display subtype-selective expression patterns; CNT1 is localized primarily to epithelial tissue whereas CNT2 and CNT3 have more widespread distributions. SLC29 family transporters (ENT1-4) are glycosylated proteins, localized to the plasma and mitochondrial membranes. They are expressed in the heart, brain, mammary gland, erythrocytes and placenta, and also in fetal liver and spleen. They mediate nucleoside influx and efflux and exhibit highest affinity for adenosine. CNT and ENT transporters play critical roles in nucleoside salvage pathways where they mediate the first step of nucleotide biosynthesis. In addition, these transporters work in concert to terminate adenosine signaling and are vital determinants in the response to a variety of anticancer and antiviral treatments, as they modulate the entry of these nucleoside analogs into target tissues.