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Aliases for HNF4G Gene

Aliases for HNF4G Gene

  • Hepatocyte Nuclear Factor 4 Gamma 2 3 5
  • Nuclear Receptor Subfamily 2 Group A Member 2 3 4
  • HNF-4-Gamma 3 4
  • NR2A2 3 4
  • Hepatocyte Nuclear Factor 4-Gamma 3
  • NR2A3 3

External Ids for HNF4G Gene

Previous GeneCards Identifiers for HNF4G Gene

  • GC08P075350
  • GC08P076308
  • GC08P076043
  • GC08P076370
  • GC08P076502
  • GC08P076482
  • GC08P076614
  • GC08P071939

Summaries for HNF4G Gene

GeneCards Summary for HNF4G Gene

HNF4G (Hepatocyte Nuclear Factor 4 Gamma) is a Protein Coding gene. Diseases associated with HNF4G include Maturity-Onset Diabetes Of The Young. Among its related pathways are Gene Expression and Developmental Biology. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and steroid hormone receptor activity. An important paralog of this gene is HNF4A.

UniProtKB/Swiss-Prot for HNF4G Gene

  • Transcription factor. Has a lower transcription activation potential than HNF4-alpha.

Gene Wiki entry for HNF4G Gene

Additional gene information for HNF4G Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HNF4G Gene

Genomics for HNF4G Gene

GeneHancer (GH) Regulatory Elements for HNF4G Gene

Promoters and enhancers for HNF4G Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I075402 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 557.3 +0.2 205 11.5 HDGF FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 ETS1 HNF4G GC08M075436
GH08I075538 Promoter/Enhancer 0.9 EPDnew ENCODE 554.2 +133.5 133474 5.3 ZNF133 MLLT1 HNF4G GC08M075604 GC08P075474
GH08I075418 Enhancer 0.9 ENCODE dbSUPER 5.2 +13.2 13202 4.9 FOXA2 MAX GATA3 ZNF316 ATF7 FOS MAFK FOXA3 MAFG REST HNF4G GC08M075436
GH08I075552 Enhancer 0.5 ENCODE 4.2 +146.2 146224 3.2 HDGF JUND IKZF1 CEBPB HNF4G GC08M075604 GC08P075474
GH08I075425 Enhancer 0.4 ENCODE dbSUPER 4.5 +19.4 19387 2.8 HNF4G GC08M075436
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around HNF4G on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the HNF4G gene promoter:

Genomic Locations for HNF4G Gene

Genomic Locations for HNF4G Gene
159,163 bases
Plus strand

Genomic View for HNF4G Gene

Genes around HNF4G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HNF4G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HNF4G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HNF4G Gene

Proteins for HNF4G Gene

  • Protein details for HNF4G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hepatocyte nuclear factor 4-gamma
    Protein Accession:
    Secondary Accessions:
    • Q7Z2V9
    • Q9UH81
    • Q9UIS6

    Protein attributes for HNF4G Gene

    408 amino acids
    Molecular mass:
    45877 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAE11875.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for HNF4G Gene

    Alternative splice isoforms for HNF4G Gene


neXtProt entry for HNF4G Gene

Post-translational modifications for HNF4G Gene

No Post-translational modifications

Other Protein References for HNF4G Gene

No data available for DME Specific Peptides for HNF4G Gene

Domains & Families for HNF4G Gene

Gene Families for HNF4G Gene

Human Protein Atlas (HPA):
  • Nuclear receptors
  • Predicted intracellular proteins
  • Transcription factors

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
genes like me logo Genes that share domains with HNF4G: view

Function for HNF4G Gene

Molecular function for HNF4G Gene

GENATLAS Biochemistry:
hepatocyte nuclear factor 4 gamma,steroid/thyroid receptor superfamily,expressed in kidney,pancreas,small intestine,testis,colon,not in the liver,involved in differential transcriptional regulation,not playing a major role in the etiology of early onst autosomal dominant,non insulin dependent type 2,diabetes
UniProtKB/Swiss-Prot Function:
Transcription factor. Has a lower transcription activation potential than HNF4-alpha.

Phenotypes From GWAS Catalog for HNF4G Gene

Gene Ontology (GO) - Molecular Function for HNF4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 12220531
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IC --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity TAS 8622695
GO:0003707 steroid hormone receptor activity IEA --
genes like me logo Genes that share ontologies with HNF4G: view
genes like me logo Genes that share phenotypes with HNF4G: view

Animal Models for HNF4G Gene

MGI Knock Outs for HNF4G:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HNF4G Gene

Localization for HNF4G Gene

Subcellular locations from UniProtKB/Swiss-Prot for HNF4G Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HNF4G gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for HNF4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with HNF4G: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for HNF4G Gene

Pathways & Interactions for HNF4G Gene

genes like me logo Genes that share pathways with HNF4G: view

Pathways by source for HNF4G Gene

Gene Ontology (GO) - Biological Process for HNF4G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II TAS 8622695
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0030522 intracellular receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with HNF4G: view

No data available for SIGNOR curated interactions for HNF4G Gene

Drugs & Compounds for HNF4G Gene

(1) Drugs for HNF4G Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Palmitic Acid Approved, Experimental Pharma Full agonist, Agonist, Target 23
genes like me logo Genes that share compounds with HNF4G: view

Transcripts for HNF4G Gene

Unigene Clusters for HNF4G Gene

Hepatocyte nuclear factor 4, gamma:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for HNF4G Gene

No ASD Table

Relevant External Links for HNF4G Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HNF4G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HNF4G Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HNF4G Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x19.9), Colon - Transverse (x10.9), and Liver (x5.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HNF4G Gene

NURSA nuclear receptor signaling pathways regulating expression of HNF4G Gene:


SOURCE GeneReport for Unigene cluster for HNF4G Gene:


mRNA Expression by UniProt/SwissProt for HNF4G Gene:

Tissue specificity: Expressed in pancreas, kidney, small intestine and testis. Weakly expressed in colon. Not expressed in liver, skeletal muscle, lung, placenta, brain, heart, peripheral blood, ovary, prostate, thymus and spleen.

Evidence on tissue expression from TISSUES for HNF4G Gene

  • Liver(4.4)
  • Kidney(4.2)
genes like me logo Genes that share expression patterns with HNF4G: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for HNF4G Gene

Orthologs for HNF4G Gene

This gene was present in the common ancestor of animals.

Orthologs for HNF4G Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia HNF4G 33 34
  • 99.7 (n)
(Canis familiaris)
Mammalia HNF4G 33 34
  • 92.88 (n)
(Bos Taurus)
Mammalia HNF4G 33 34
  • 92.06 (n)
(Monodelphis domestica)
Mammalia HNF4G 34
  • 89 (a)
(Mus musculus)
Mammalia Hnf4g 33 16 34
  • 87.02 (n)
(Rattus norvegicus)
Mammalia Hnf4g 33
  • 86.7 (n)
(Ornithorhynchus anatinus)
Mammalia HNF4G 34
  • 74 (a)
(Gallus gallus)
Aves HNF4G 33 34
  • 80.93 (n)
(Anolis carolinensis)
Reptilia HNF4G 34
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hnf4g 33
  • 74.74 (n)
(Danio rerio)
Actinopterygii hnf4g 33 34
  • 65.13 (n)
fruit fly
(Drosophila melanogaster)
Insecta Hnf4 35 34
  • 66 (a)
(Caenorhabditis elegans)
Secernentea nhr-64 35 33 34
  • 48.89 (n)
nhr-69 35 34
  • 38 (a)
nhr-14 35
  • 32 (a)
nhr-35 34
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3727 33
Species where no ortholog for HNF4G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HNF4G Gene

Gene Tree for HNF4G (if available)
Gene Tree for HNF4G (if available)

Paralogs for HNF4G Gene

Variants for HNF4G Gene

Sequence variations from dbSNP and Humsavar for HNF4G Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000010739 -- 75,555,352(+) A/G intron_variant
rs1000030992 -- 75,413,010(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000042192 -- 75,417,239(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000050079 -- 75,564,051(+) A/T coding_sequence_variant, synonymous_variant
rs1000056007 -- 75,485,563(+) T/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for HNF4G Gene

Variant ID Type Subtype PubMed ID
esv3891416 CNV gain 25118596
nsv465718 CNV loss 19166990
nsv465719 CNV loss 19166990
nsv611561 CNV gain 21841781
nsv611562 CNV loss 21841781
nsv611563 CNV loss 21841781
nsv611564 CNV loss 21841781
nsv831357 CNV loss 17160897

Variation tolerance for HNF4G Gene

Residual Variation Intolerance Score: 24.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.48% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for HNF4G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HNF4G Gene

Disorders for HNF4G Gene

MalaCards: The human disease database

(1) MalaCards diseases for HNF4G Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
maturity-onset diabetes of the young
  • mody
- elite association - COSMIC cancer census association via MalaCards
Search HNF4G in MalaCards View complete list of genes associated with diseases

Additional Disease Information for HNF4G

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with HNF4G: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HNF4G Gene

Publications for HNF4G Gene

  1. Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids. (PMID: 12220494) Wisely GB … Williams SP (Structure (London, England : 1993) 2002) 2 3 4 58
  2. Hepatocyte nuclear factor-4gamma: cDNA sequence, gene organization, and mutation screening in early-onset autosomal-dominant type 2 diabetes. (PMID: 10512380) Plengvidhya N … Doria A (Diabetes 1999) 3 4 22 58
  3. Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes. (PMID: 8622695) Drewes T … Ryffel GU (Molecular and cellular biology 1996) 2 3 4 58
  4. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PMID: 20935630) Speliotes EK … Loos RJ (Nature genetics 2010) 3 44 58
  5. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 3 4 58

Products for HNF4G Gene

Sources for HNF4G Gene

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