Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FOXA3 Gene

Aliases for FOXA3 Gene

  • Forkhead Box A3 2 3 5
  • Fork Head-Related Protein FKH H3 3 4
  • Forkhead Box Protein A3 3 4
  • Transcription Factor 3G 3 4
  • HNF-3-Gamma 3 4
  • HNF-3G 3 4
  • TCF-3G 3 4
  • HNF3G 3 4
  • TCF3G 3 4
  • Hepatocyte Nuclear Factor 3, Gamma 2
  • Hepatocyte Nuclear Factor 3-Gamma 3
  • FKHH3 3

External Ids for FOXA3 Gene

Previous HGNC Symbols for FOXA3 Gene

  • HNF3G

Previous GeneCards Identifiers for FOXA3 Gene

  • GC19P047011
  • GC19P046758
  • GC19P051043
  • GC19P051059
  • GC19P046368
  • GC19P042796

Summaries for FOXA3 Gene

Entrez Gene Summary for FOXA3 Gene

  • This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXA3 Gene

FOXA3 (Forkhead Box A3) is a Protein Coding gene. Among its related pathways are Regulation of beta-cell development and FOXA1 transcription factor network. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription factor binding. An important paralog of this gene is FOXA1.

UniProtKB/Swiss-Prot for FOXA3 Gene

  • Transcription factor that is thought to act as a pioneer factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis.

Gene Wiki entry for FOXA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXA3 Gene

Genomics for FOXA3 Gene

Regulatory Elements for FOXA3 Gene

Enhancers for FOXA3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F045798 1 Ensembl ENCODE 11.3 -64.2 -64241 1.7 PKNOX1 KLF17 ZNF2 RAD21 ZEB1 GLIS2 ZNF143 FOS EGR2 ZNF654 DMWD SIX5 SYMPK FOXA3 GC19M045805 PIR50651
GH19F045774 0.2 ENCODE 11.1 -89.0 -89032 0.2 ZBTB10 CTCF POLR2A ARID4B ZNF600 PRDM1 FBXO46 BHMG1 FOXA3 SYMPK GC19M045770 DMPK
GH19F045763 0.4 ENCODE 11 -95.1 -95148 10.2 HDGF PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 FBXO46 BHMG1 SYMPK DMWD RPS16P9 CCDC61 ENSG00000269148 DMPK FOXA3 ENSG00000266958
GH19F045999 1.3 FANTOM5 Ensembl ENCODE 11 +136.4 136354 1.9 ATF1 ZNF2 GLIS2 ZNF548 SP3 YY2 NCOA1 TSHZ1 ZNF518A ZNF610 CCDC61 FOXA3 SYMPK ENSG00000268810 PNMAL1 EML2 PNMAL2 NOVA2 GC19M045998
GH19F045952 0.9 Ensembl ENCODE 11 +90.7 90700 4.7 ATF1 ZNF133 ARID4B SIN3A GLI4 ZNF2 GLIS2 CBX5 ZNF143 SP3 IGFL4 CCDC61 LOC105372421 PPP5D1 MYPOP MIR769 PGLYRP1 FOXA3 SYMPK HIF3A
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FOXA3 on UCSC Golden Path with GeneCards custom track

Promoters for FOXA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000347487 -289 3801 HDGF PKNOX1 ARNT CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for FOXA3 Gene

Chromosome:
19
Start:
45,863,989 bp from pter
End:
45,873,797 bp from pter
Size:
9,809 bases
Orientation:
Plus strand

Genomic View for FOXA3 Gene

Genes around FOXA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXA3 Gene

Proteins for FOXA3 Gene

  • Protein details for FOXA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55318-FOXA3_HUMAN
    Recommended name:
    Hepatocyte nuclear factor 3-gamma
    Protein Accession:
    P55318
    Secondary Accessions:
    • A9LYI5
    • Q53F16
    • Q9UMW9

    Protein attributes for FOXA3 Gene

    Size:
    350 amino acids
    Molecular mass:
    37140 Da
    Quaternary structure:
    • Interacts with FOXA2.

    Three dimensional structures from OCA and Proteopedia for FOXA3 Gene

neXtProt entry for FOXA3 Gene

Post-translational modifications for FOXA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXA3 Gene

Domains & Families for FOXA3 Gene

Gene Families for FOXA3 Gene

Suggested Antigen Peptide Sequences for FOXA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P55318

UniProtKB/Swiss-Prot:

FOXA3_HUMAN :
  • Contains 1 fork-head DNA-binding domain.
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXA3: view

Function for FOXA3 Gene

Molecular function for FOXA3 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that is thought to act as a pioneer factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis.

Gene Ontology (GO) - Molecular Function for FOXA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003677 DNA binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9369482
GO:0008134 transcription factor binding IEA --
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with FOXA3: view
genes like me logo Genes that share phenotypes with FOXA3: view

Animal Models for FOXA3 Gene

MGI Knock Outs for FOXA3:

Animal Model Products

miRNA for FOXA3 Gene

miRTarBase miRNAs that target FOXA3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXA3 Gene

Localization for FOXA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXA3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXA3 Gene COMPARTMENTS Subcellular localization image for FOXA3 gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for FOXA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,TAS --
genes like me logo Genes that share ontologies with FOXA3: view

Pathways & Interactions for FOXA3 Gene

genes like me logo Genes that share pathways with FOXA3: view

Gene Ontology (GO) - Biological Process for FOXA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001678 cellular glucose homeostasis TAS 9369482
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with FOXA3: view

No data available for SIGNOR curated interactions for FOXA3 Gene

Transcripts for FOXA3 Gene

mRNA/cDNA for FOXA3 Gene

Unigene Clusters for FOXA3 Gene

Forkhead box A3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXA3 Gene

No ASD Table

Relevant External Links for FOXA3 Gene

GeneLoc Exon Structure for
FOXA3
ECgene alternative splicing isoforms for
FOXA3

Expression for FOXA3 Gene

mRNA expression in normal human tissues for FOXA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXA3 Gene

This gene is overexpressed in Liver (x20.2), Pancreas (x12.7), Stomach (x8.3), and Colon - Transverse (x5.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FOXA3 Gene



NURSA nuclear receptor signaling pathways regulating expression of FOXA3 Gene:

FOXA3

SOURCE GeneReport for Unigene cluster for FOXA3 Gene:

Hs.36137

mRNA Expression by UniProt/SwissProt for FOXA3 Gene:

P55318-FOXA3_HUMAN
Tissue specificity: Expressed in erythroleukemia and hepatoma cell lines and in liver and pancreas. Not expressed in any other cell lines or tissues examined.
genes like me logo Genes that share expression patterns with FOXA3: view

Primer Products

No data available for Protein differential expression in normal tissues and Protein tissue co-expression partners for FOXA3 Gene

Orthologs for FOXA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXA3 34 35
  • 99.05 (n)
dog
(Canis familiaris)
Mammalia FOXA3 34 35
  • 88.54 (n)
cow
(Bos Taurus)
Mammalia FOXA3 34 35
  • 87.11 (n)
rat
(Rattus norvegicus)
Mammalia Foxa3 34
  • 83.09 (n)
mouse
(Mus musculus)
Mammalia Foxa3 34 16 35
  • 81.95 (n)
oppossum
(Monodelphis domestica)
Mammalia FOXA3 35
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXA3 35
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii foxa3 34 35
  • 59.81 (n)
fruit fly
(Drosophila melanogaster)
Insecta fkh 35
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
ManyToMany
CSA.7421 35
  • 23 (a)
ManyToMany
Species where no ortholog for FOXA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXA3 Gene

ENSEMBL:
Gene Tree for FOXA3 (if available)
TreeFam:
Gene Tree for FOXA3 (if available)

Paralogs for FOXA3 Gene

(9) SIMAP similar genes for FOXA3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FOXA3: view

Variants for FOXA3 Gene

Sequence variations from dbSNP and Humsavar for FOXA3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10410870 -- 45,864,007(+) CCGCC(A/G)CGGTC upstream-variant-2KB
rs10411638 -- 45,864,075(+) GAAAG(C/G)CTCCA upstream-variant-2KB
rs10412574 -- 45,863,948(+) GACCT(C/T)TTACG upstream-variant-2KB
rs10416919 -- 45,869,609(+) CAGTG(C/T)CCTAT intron-variant
rs10417903 -- 45,864,726(+) AGCCT(C/G/T)GCCGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FOXA3 Gene

Variant ID Type Subtype PubMed ID
nsv510770 CNV deletion 20534489
nsv523029 CNV loss 19592680

Variation tolerance for FOXA3 Gene

Residual Variation Intolerance Score: 33.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FOXA3 Gene

Human Gene Mutation Database (HGMD)
FOXA3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXA3 Gene

Disorders for FOXA3 Gene

Relevant External Links for FOXA3

Genetic Association Database (GAD)
FOXA3
Human Genome Epidemiology (HuGE) Navigator
FOXA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FOXA3

No disorders were found for FOXA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXA3 Gene

Publications for FOXA3 Gene

  1. Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq. (PMID: 19919681) Motallebipour M. … Wadelius C. (Genome Biol. 2009) 3 4 22 64
  2. Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma. (PMID: 12695546) Rodriguez-Antona C. … Castell J.V. (Mol. Pharmacol. 2003) 3 4 22 64
  3. Genetic predictors of interindividual variability in hepatic CYP3A4 expression. (PMID: 19934400) Lamba V. … Schuetz E.G. (J. Pharmacol. Exp. Ther. 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis. (PMID: 10899756) Navas M.A. … Stoffel M. (Hum. Hered. 2000) 3 4 64

Products for FOXA3 Gene

Sources for FOXA3 Gene

Content
Loading form....