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Aliases for FOXA2 Gene

Aliases for FOXA2 Gene

  • Forkhead Box A2 2 3
  • HNF3B 3 4 6
  • Hepatocyte Nuclear Factor 3, Beta 2 3
  • Forkhead Box Protein A2 3 4
  • Transcription Factor 3B 3 4
  • HNF-3-Beta 3 4
  • HNF-3B 3 4
  • TCF-3B 3 4
  • TCF3B 3 4
  • Hepatocyte Nuclear Factor 3-Beta 3
  • Hepatic Nuclear Factor-3-Beta 3

External Ids for FOXA2 Gene

Previous HGNC Symbols for FOXA2 Gene

  • HNF3B

Previous GeneCards Identifiers for FOXA2 Gene

  • GC20M022550
  • GC20M022556
  • GC20M022509
  • GC20M022561
  • GC20M022523

Summaries for FOXA2 Gene

Entrez Gene Summary for FOXA2 Gene

  • This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for FOXA2 Gene

FOXA2 (Forkhead Box A2) is a Protein Coding gene. Diseases associated with FOXA2 include meckel's diverticulum and maturity-onset diabetes of the young. Among its related pathways are L1CAM interactions and Regulation of beta-cell development. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is FOXE3.

UniProtKB/Swiss-Prot for FOXA2 Gene

  • Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a pioneer factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3 (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.

Gene Wiki entry for FOXA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXA2 Gene

Genomics for FOXA2 Gene

Regulatory Elements for FOXA2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FOXA2 Gene

Start:
22,581,004 bp from pter
End:
22,585,463 bp from pter
Size:
4,460 bases
Orientation:
Minus strand

Genomic View for FOXA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FOXA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXA2 Gene

Proteins for FOXA2 Gene

  • Protein details for FOXA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y261-FOXA2_HUMAN
    Recommended name:
    Hepatocyte nuclear factor 3-beta
    Protein Accession:
    Q9Y261
    Secondary Accessions:
    • Q8WUW4
    • Q96DF7

    Protein attributes for FOXA2 Gene

    Size:
    457 amino acids
    Molecular mass:
    48306 Da
    Quaternary structure:
    • Binds DNA as a monomer. Binds TLE1 (By similarity). Interacts with FOXA1 and FOXA3. Interacts with PRKDC.
    SequenceCaution:
    • Sequence=AAH11780.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for FOXA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXA2 Gene

Proteomics data for FOXA2 Gene at MOPED

Post-translational modifications for FOXA2 Gene

  • Phosphorylation on Thr-156 abolishes binding to target promoters and subsequent transcription activation upon insulin stimulation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXA2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for FOXA2 (HNF-3 beta/FoxA2)
  • Cell Signaling Technology (CST) Antibodies for FOXA2 (FOXA2)

No data available for DME Specific Peptides for FOXA2 Gene

Domains for FOXA2 Gene

Gene Families for FOXA2 Gene

HGNC:
  • FOX :Forkhead boxes

Protein Domains for FOXA2 Gene

Suggested Antigen Peptide Sequences for FOXA2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y261

UniProtKB/Swiss-Prot:

FOXA2_HUMAN :
  • Q9Y261
Domain:
  • Contains 1 fork-head DNA-binding domain.
genes like me logo Genes that share domains with FOXA2: view

Function for FOXA2 Gene

Molecular function for FOXA2 Gene

UniProtKB/Swiss-Prot Function: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a pioneer factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3 (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.

Gene Ontology (GO) - Molecular Function for FOXA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 12642491
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003677 DNA binding IDA 9931457
GO:0003700 sequence-specific DNA binding transcription factor activity IDA 12124776
genes like me logo Genes that share ontologies with FOXA2: view
genes like me logo Genes that share phenotypes with FOXA2: view

Animal Models for FOXA2 Gene

MGI Knock Outs for FOXA2:

Animal Model Products

CRISPR Products

miRNA for FOXA2 Gene

miRTarBase miRNAs that target FOXA2
Targeting motifs for FOXA2 Gene
HOMER Transcription Factor Regulatory Elements motif FOXA2
  • Consensus sequence: CTTGTTTACATA Submotif: canonical Cell Type: Liver GeoId: GSE25694

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for FOXA2 Gene

Localization for FOXA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXA2 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FOXA2 Gene COMPARTMENTS Subcellular localization image for FOXA2 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for FOXA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 20160041
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with FOXA2: view

Pathways for FOXA2 Gene

genes like me logo Genes that share pathways with FOXA2: view

PCR Array Products

Interacting Proteins for FOXA2 Gene

Selected Interacting proteins: Q9Y261-FOXA2_HUMAN for FOXA2 Gene via MINT I2D

Gene Ontology (GO) - Biological Process for FOXA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000432 positive regulation of transcription from RNA polymerase II promoter by glucose ISS --
GO:0000433 negative regulation of transcription from RNA polymerase II promoter by glucose ISS --
GO:0001701 in utero embryonic development IEA --
GO:0001705 ectoderm formation IEA --
GO:0001708 cell fate specification ISS --
genes like me logo Genes that share ontologies with FOXA2: view

Compounds for FOXA2 Gene

(5) Novoseek inferred chemical compound relationships for FOXA2 Gene

Compound -log(P) Hits PubMed IDs
glucose 24.1 11
glycogen 19.8 1
katp 19.1 2
c-peptide 18 1
fatty acid 0 3
genes like me logo Genes that share compounds with FOXA2: view

Transcripts for FOXA2 Gene

Unigene Clusters for FOXA2 Gene

Forkhead box A2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FOXA2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXA2 Gene

No ASD Table

Relevant External Links for FOXA2 Gene

GeneLoc Exon Structure for
FOXA2
ECgene alternative splicing isoforms for
FOXA2

Expression for FOXA2 Gene

mRNA expression in normal human tissues for FOXA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXA2 Gene

This gene is overexpressed in Liver (15.7), Pancreas (12.5), Stomach (10.2), and Lung (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for FOXA2 Gene

SOURCE GeneReport for Unigene cluster for FOXA2 Gene Hs.155651

genes like me logo Genes that share expressions with FOXA2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FOXA2 Gene

Orthologs for FOXA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FOXA2 35
  • 94.1 (n)
  • 97.01 (a)
FOXA2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXA2 35
  • 94.38 (n)
  • 97.59 (a)
FOXA2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxa2 35
  • 90.23 (n)
  • 97.37 (a)
Foxa2 16
Foxa2 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FOXA2 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOXA2 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxa2 35
  • 89.18 (n)
  • 96.05 (a)
chicken
(Gallus gallus)
Aves FOXA2 35
  • 78.78 (n)
  • 77.31 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia foxa2 35
  • 71.6 (n)
  • 73.15 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
foxa2 35
  • 68.63 (n)
  • 70.34 (a)
foxa2 36
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta fkh 36
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
ManyToMany
CSA.7421 36
  • 29 (a)
ManyToMany
Species with no ortholog for FOXA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXA2 Gene

ENSEMBL:
Gene Tree for FOXA2 (if available)
TreeFam:
Gene Tree for FOXA2 (if available)

Paralogs for FOXA2 Gene

Selected SIMAP similar genes for FOXA2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FOXA2: view

Variants for FOXA2 Gene

Sequence variations from dbSNP and Humsavar for FOXA2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1974 -- 22,581,673(+) GGAAC(A/G)GCTGC utr-variant-3-prime
rs1055080 -- 22,581,800(+) CACTT(A/G)TCCTC utr-variant-3-prime
rs1203908 -- 22,580,759(+) TAACC(A/C)CCAAA downstream-variant-500B
rs1203909 -- 22,580,841(+) TACTG(G/T)TATCT downstream-variant-500B
rs1203910 -- 22,582,387(+) TGGGC(C/T)CCGGC reference, synonymous-codon

Relevant External Links for FOXA2 Gene

HapMap Linkage Disequilibrium report
FOXA2
Human Gene Mutation Database (HGMD)
FOXA2

PCR Panel Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FOXA2 Gene

Disorders for FOXA2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for FOXA2 Gene including...

Search for FOXA2 Gene in MalaCards »

(4) Novoseek inferred disease relationships for FOXA2 Gene

Disease -log(P) Hits PubMed IDs
niddm 22.9 3
insulin resistance 0 1
tumors 0 3
obesity 0 1

Relevant External Links for FOXA2

Genetic Association Database (GAD)
FOXA2
Human Genome Epidemiology (HuGE) Navigator
FOXA2
genes like me logo Genes that share disorders with FOXA2: view

No data available for UniProtKB/Swiss-Prot for FOXA2 Gene

Publications for FOXA2 Gene

  1. Beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the hepatocyte nuclear factor-3beta gene (HNF3B) in Japanese patients with maturity-onset diabetes of the young. (PMID: 10868948) Hinokio Y. … Bell G.I. (Diabetes 2000) 3 23 48
  2. Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release. (PMID: 11875061) Wang H. … Wollheim C.B. (J. Biol. Chem. 2002) 2 3 23
  3. Insulin regulates the activity of forkhead transcription factor Hnf- 3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization. (PMID: 14500912) Wolfrum C. … Stoffel M. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 23
  4. Genetic predictors of interindividual variability in hepatic CYP3A4 expression. (PMID: 19934400) Lamba V. … Schuetz E.G. (J. Pharmacol. Exp. Ther. 2010) 3 23 48
  5. Foxa2 and Nurr1 synergistically yield A9 nigral dopamine neurons exhibiting improved differentiation, function, and cell survival. (PMID: 20049900) Lee H.S. … Lee S.H. (Stem Cells 2010) 3 23

Products for FOXA2 Gene

Sources for FOXA2 Gene

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