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Aliases for NR4A1 Gene

Aliases for NR4A1 Gene

  • Nuclear Receptor Subfamily 4 Group A Member 1 2 3 5
  • Nuclear Receptor Subfamily 4, Group A, Member 1 2 3
  • Nuclear Hormone Receptor NUR/77 3 4
  • Early Response Protein NAK1 3 4
  • Orphan Nuclear Receptor HMR 3 4
  • Orphan Nuclear Receptor TR3 3 4
  • Testicular Receptor 3 3 4
  • NUR77 3 4
  • GFRP1 3 4
  • ST-59 3 4
  • HMR 3 4
  • Nerve Growth Factor IB Nuclear Receptor Variant 1 3
  • Growth Factor-Inducible Nuclear Protein N10 3
  • Steroid Receptor TR3 3
  • TR3 Orphan Receptor 3
  • Hormone Receptor 3
  • NAK-1 3
  • NGFIB 3
  • NP10 3
  • NAK1 4
  • N10 3
  • TR3 3

External Ids for NR4A1 Gene

Previous HGNC Symbols for NR4A1 Gene

  • HMR
  • GFRP1

Previous GeneCards Identifiers for NR4A1 Gene

  • GC12M052494
  • GC12P052474
  • GC12P052154
  • GC12P050723
  • GC12P050717
  • GC12P052432
  • GC12P049478
  • GC12P052416

Summaries for NR4A1 Gene

Entrez Gene Summary for NR4A1 Gene

  • This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for NR4A1 Gene

NR4A1 (Nuclear Receptor Subfamily 4 Group A Member 1) is a Protein Coding gene. Diseases associated with NR4A1 include Fetal Adenoma and Pyruvate Dehydrogenase E1-Alpha Deficiency. Among its related pathways are Constitutive Signaling by AKT1 E17K in Cancer and Gene Expression. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is NR4A2.

UniProtKB/Swiss-Prot for NR4A1 Gene

  • Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5-AAAAGGTCA-3 (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation.

Tocris Summary for NR4A1 Gene

Gene Wiki entry for NR4A1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NR4A1 Gene

Genomics for NR4A1 Gene

Regulatory Elements for NR4A1 Gene

Enhancers for NR4A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NR4A1 on UCSC Golden Path with GeneCards custom track

Promoters for NR4A1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NR4A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for NR4A1 Gene

Chromosome:
12
Start:
52,022,832 bp from pter
End:
52,059,507 bp from pter
Size:
36,676 bases
Orientation:
Plus strand

Genomic View for NR4A1 Gene

Genes around NR4A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NR4A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NR4A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NR4A1 Gene

Proteins for NR4A1 Gene

  • Protein details for NR4A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22736-NR4A1_HUMAN
    Recommended name:
    Nuclear receptor subfamily 4 group A member 1
    Protein Accession:
    P22736
    Secondary Accessions:
    • B4DML7
    • Q15627
    • Q53Y00
    • Q6IBU8

    Protein attributes for NR4A1 Gene

    Size:
    598 amino acids
    Molecular mass:
    64463 Da
    Quaternary structure:
    • Binds DNA as a monomer (By similarity). Interacts with GADD45GIP1. Interacts with STK11.

    Three dimensional structures from OCA and Proteopedia for NR4A1 Gene

    Alternative splice isoforms for NR4A1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NR4A1 Gene

Proteomics data for NR4A1 Gene at MOPED

Post-translational modifications for NR4A1 Gene

  • Acetylated by p300/CBP, acetylation increases stability. Deacetylated by HDAC1.
  • Phosphorylated at Ser-351 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for NR4A1 Gene

Domains & Families for NR4A1 Gene

Gene Families for NR4A1 Gene

Graphical View of Domain Structure for InterPro Entry

P22736

UniProtKB/Swiss-Prot:

NR4A1_HUMAN :
  • Contains 1 nuclear receptor DNA-binding domain.
  • Belongs to the nuclear hormone receptor family. NR4 subfamily.
Domain:
  • Contains 1 nuclear receptor DNA-binding domain.
Family:
  • Belongs to the nuclear hormone receptor family. NR4 subfamily.
genes like me logo Genes that share domains with NR4A1: view

Function for NR4A1 Gene

Molecular function for NR4A1 Gene

GENATLAS Biochemistry:
nuclear receptor subfamily 4,group A,member 1,steroid/thyroid receptor superfamily,likely functionning as a general coactivation of gene transcription
UniProtKB/Swiss-Prot Function:
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5-AAAAGGTCA-3 (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation.
UniProtKB/Swiss-Prot Induction:
By growth-stimulating agents.

Gene Ontology (GO) - Molecular Function for NR4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with NR4A1: view
genes like me logo Genes that share phenotypes with NR4A1: view

Animal Models for NR4A1 Gene

MGI Knock Outs for NR4A1:

Animal Model Products

  • Taconic Biosciences Mouse Models for NR4A1
Targeted motifs for NR4A1 Gene
HOMER Transcription Factor Regulatory Elements motif NR4A1
  • Consensus sequence: TGACCTTTNCNT Submotif: canonical Cell Type: K562 GEO ID: GSE31363

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for NR4A1 Gene

Localization for NR4A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NR4A1 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NR4A1 Gene COMPARTMENTS Subcellular localization image for NR4A1 gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for NR4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with NR4A1: view

Pathways & Interactions for NR4A1 Gene

genes like me logo Genes that share pathways with NR4A1: view

SIGNOR curated interactions for NR4A1 Gene

Inactivates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for NR4A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IMP 18059339
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with NR4A1: view

Drugs & Compounds for NR4A1 Gene

(28) Drugs for NR4A1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(27) Additional Compounds for NR4A1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with NR4A1: view

Transcripts for NR4A1 Gene

Unigene Clusters for NR4A1 Gene

Nuclear receptor subfamily 4, group A, member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NR4A1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b ·
SP1: - -
SP2: - - - - - - - - - - - -
SP3: - - - -
SP4: - -
SP5: -
SP6: -
SP7:
SP8:
SP9: - - - - - - - -
SP10: - - - - -
SP11: - - -
SP12:
SP13: - - - - - -

ExUns: 13c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for NR4A1 Gene

GeneLoc Exon Structure for
NR4A1
ECgene alternative splicing isoforms for
NR4A1

Expression for NR4A1 Gene

mRNA expression in normal human tissues for NR4A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NR4A1 Gene

This gene is overexpressed in Ovary (x4.8).

Protein differential expression in normal tissues from HIPED for NR4A1 Gene

This gene is overexpressed in Ovary (38.3) and Islet of Langerhans (30.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for NR4A1 Gene



SOURCE GeneReport for Unigene cluster for NR4A1 Gene Hs.524430

mRNA Expression by UniProt/SwissProt for NR4A1 Gene

P22736-NR4A1_HUMAN
Tissue specificity: Fetal muscle and adult liver, brain and thyroid.
genes like me logo Genes that share expression patterns with NR4A1: view

Protein tissue co-expression partners for NR4A1 Gene

Primer Products

Orthologs for NR4A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for NR4A1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NR4A1 35
  • 90.64 (n)
  • 94.65 (a)
NR4A1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NR4A1 35
  • 89.8 (n)
  • 95.82 (a)
NR4A1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nr4a1 35
  • 86.01 (n)
  • 91.14 (a)
Nr4a1 16
Nr4a1 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NR4A1 35
  • 99.35 (n)
  • 99.18 (a)
NR4A1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nr4a1 35
  • 86.07 (n)
  • 90.44 (a)
lizard
(Anolis carolinensis)
Reptilia NR4A1 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nr4a1 35
  • 67.02 (n)
  • 69.73 (a)
zebrafish
(Danio rerio)
Actinopterygii nr4a1 35
  • 61.3 (n)
  • 60.18 (a)
nr4a1 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hr38 37
  • 64 (a)
Hr38 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nhr-6 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToMany
Species with no ortholog for NR4A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for NR4A1 Gene

ENSEMBL:
Gene Tree for NR4A1 (if available)
TreeFam:
Gene Tree for NR4A1 (if available)

Paralogs for NR4A1 Gene

Paralogs for NR4A1 Gene

genes like me logo Genes that share paralogs with NR4A1: view

Variants for NR4A1 Gene

Sequence variations from dbSNP and Humsavar for NR4A1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1882118 - 52,054,404(-) GGTCA(A/C/G)GGGGT reference, missense
rs1976255 -- 52,048,572(+) ctggg(C/T)gacag intron-variant
rs2001714 -- 52,048,467(-) acagg(C/T)gcctg intron-variant
rs2001715 -- 52,048,463(-) gtgcc(C/T)gccac intron-variant
rs2087978 -- 52,052,088(+) TTCCC(C/T)ACCCT intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for NR4A1 Gene

Variant ID Type Subtype PubMed ID
nsv899079 CNV Loss 21882294
dgv1424n71 CNV Loss 21882294
nsv469378 CNV Loss 19166990
nsv899082 CNV Loss 21882294
dgv1425n71 CNV Loss 21882294
nsv518451 CNV Loss 19592680
esv2656525 CNV Deletion 23128226
nsv832409 CNV Loss 17160897

Variation tolerance for NR4A1 Gene

Residual Variation Intolerance Score: 11.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.37; 63.44% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NR4A1 Gene

Disorders for NR4A1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for NR4A1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fetal adenoma
  • microfollicular adenoma
pyruvate dehydrogenase e1-alpha deficiency
  • pyruvate decarboxylase deficiency
- elite association - COSMIC cancer census association via MalaCards
Search NR4A1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for NR4A1

Genetic Association Database (GAD)
NR4A1
Human Genome Epidemiology (HuGE) Navigator
NR4A1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NR4A1
genes like me logo Genes that share disorders with NR4A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NR4A1 Gene

Publications for NR4A1 Gene

  1. Isolation and characterization of human TR3 receptor: a member of steroid receptor superfamily. (PMID: 2626032) Chang C. … Chang Y. (J. Steroid Biochem. 1989) 2 3 4 67
  2. Association of the orphan nuclear receptor NR4A1 with tardive dyskinesia. (PMID: 20010315) Novak G. … Le Foll B. (Psychiatr. Genet. 2010) 3 23
  3. Orphan nuclear receptor Nur77 participates in human apolipoprotein A5 gene expression. (PMID: 20059973) Song K.H. (Biochem. Biophys. Res. Commun. 2010) 3 23
  4. The orphan nuclear receptor NR4A1 regulates transcription of key steroidogenic enzymes in ovarian theca cells. (PMID: 20083153) Li M. … Liu J.Y. (Mol. Cell. Endocrinol. 2010) 3 23
  5. The orphan nuclear receptor Nur77 suppresses endothelial cell activation through induction of IkappaBalpha expression. (PMID: 19213954) You B. … Sun J. (Circ. Res. 2009) 3 23

Products for NR4A1 Gene

Sources for NR4A1 Gene

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