Aliases for NR4A1 Gene
External Ids for NR4A1 Gene
Previous HGNC Symbols for NR4A1 Gene
Previous GeneCards Identifiers for NR4A1 Gene
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for NR4A1 Gene
NR4A1 (Nuclear Receptor Subfamily 4, Group A, Member 1) is a Protein Coding gene. Diseases associated with NR4A1 include fetal adenoma and pyruvate dehydrogenase e1-alpha deficiency. Among its related pathways are PI3K-Akt signaling pathway and PI3K/AKT Signaling in Cancer. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is AR.
UniProtKB/Swiss-Prot for NR4A1 Gene
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5-AAAAGGTCA-3 (By similarity). May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation.