Aliases for HMMR Gene
External Ids for HMMR Gene
Previous GeneCards Identifiers for HMMR Gene
The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008]
GeneCards Summary for HMMR Gene
HMMR (Hyaluronan Mediated Motility Receptor) is a Protein Coding gene. Diseases associated with HMMR include breast cancer and chronic lymphocytic leukemia. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include hyaluronic acid binding.
UniProtKB/Swiss-Prot for HMMR Gene
Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular-regulated kinase (ERK) activity.