Aliases for HMGA1 Gene
External Ids for HMGA1 Gene
Previous Symbols for HMGA1 Gene
This gene encodes a non-histone protein involved in many cellular processes, including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It has little secondary structure in solution but assumes distinct conformations when bound to substrates such as DNA or other proteins. The encoded protein is frequently acetylated and is found in the nucleus. At least seven transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for HMGA1 Gene
HMGA1 (High Mobility Group AT-Hook 1) is a Protein Coding gene. Diseases associated with HMGA1 include pelvic lipomatosis and ring chromosome 1. Among its related pathways are Disease and IL4-mediated signaling events. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and enzyme binding.
UniProtKB/Swiss-Prot for HMGA1 Gene
HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions