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Aliases for HMGN2 Gene

Aliases for HMGN2 Gene

  • High Mobility Group Nucleosomal Binding Domain 2 2 3
  • High Mobility Group Nucleosome-Binding Domain-Containing Protein 2 3 4
  • High-Mobility Group (Nonhistone Chromosomal) Protein 17 2 3
  • High-Mobility Group Nucleosomal Binding Domain 2 2 3
  • HMG17 3 4
  • Nonhistone Chromosomal Protein HMG-17 3
  • High Mobility Group Protein N2 3

External Ids for HMGN2 Gene

Previous HGNC Symbols for HMGN2 Gene

  • HMG17

Previous GeneCards Identifiers for HMGN2 Gene

  • GC01M028726
  • GC01P025819
  • GC01P026031
  • GC01P026404
  • GC01P026406
  • GC01P026671
  • GC01P026800
  • GC01P025053

Summaries for HMGN2 Gene

Entrez Gene Summary for HMGN2 Gene

  • The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMGN1, the encoded protein may help maintain an open chromatin configuration around transcribable genes. The protein has also been found to have antimicrobial activity against bacteria, viruses and fungi. [provided by RefSeq, Oct 2014]

GeneCards Summary for HMGN2 Gene

HMGN2 (High Mobility Group Nucleosomal Binding Domain 2) is a Protein Coding gene. Diseases associated with HMGN2 include limited scleroderma. Among its related pathways are Chromatin Regulation / Acetylation. GO annotations related to this gene include poly(A) RNA binding and nucleosomal DNA binding. An important paralog of this gene is HMGN4.

UniProtKB/Swiss-Prot for HMGN2 Gene

  • Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).

Gene Wiki entry for HMGN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGN2 Gene

Genomics for HMGN2 Gene

Regulatory Elements for HMGN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HMGN2 Gene

Chromosome:
1
Start:
26,472,411 bp from pter
End:
26,476,642 bp from pter
Size:
4,232 bases
Orientation:
Plus strand

Genomic View for HMGN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for HMGN2 Gene

Proteins for HMGN2 Gene

  • Protein details for HMGN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05204-HMGN2_HUMAN
    Recommended name:
    Non-histone chromosomal protein HMG-17
    Protein Accession:
    P05204
    Secondary Accessions:
    • Q0VGD5
    • Q6FGI5
    • Q96C64

    Protein attributes for HMGN2 Gene

    Size:
    90 amino acids
    Molecular mass:
    9393 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HMGN2 Gene

Proteomics data for HMGN2 Gene at MOPED

Post-translational modifications for HMGN2 Gene

  • Phosphorylation favors cytoplasmic localization.
  • Ubiquitination at Lys 59, Lys 64, and Lys 82
  • Modification sites at PhosphoSitePlus

Other Protein References for HMGN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HMGN2 (HMGN2)
  • Cloud-Clone Corp. Antibodies for HMGN2

No data available for DME Specific Peptides for HMGN2 Gene

Domains & Families for HMGN2 Gene

Gene Families for HMGN2 Gene

Protein Domains for HMGN2 Gene

Graphical View of Domain Structure for InterPro Entry

P05204

UniProtKB/Swiss-Prot:

HMGN2_HUMAN :
  • Belongs to the HMGN family.
Family:
  • Belongs to the HMGN family.
genes like me logo Genes that share domains with HMGN2: view

Function for HMGN2 Gene

Molecular function for HMGN2 Gene

UniProtKB/Swiss-Prot Function:
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).

Gene Ontology (GO) - Molecular Function for HMGN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031492 nucleosomal DNA binding IEA --
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with HMGN2: view
genes like me logo Genes that share phenotypes with HMGN2: view

Animal Models for HMGN2 Gene

MGI Knock Outs for HMGN2:

Animal Model Products

miRNA for HMGN2 Gene

miRTarBase miRNAs that target HMGN2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HMGN2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for HMGN2 Gene

Localization for HMGN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMGN2 Gene

Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HMGN2 Gene COMPARTMENTS Subcellular localization image for HMGN2 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for HMGN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HMGN2: view

Pathways & Interactions for HMGN2 Gene

genes like me logo Genes that share pathways with HMGN2: view

Pathways by source for HMGN2 Gene

1 Cell Signaling Technology pathway for HMGN2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Polycomb & Trithorax Target Genes in human,mouse,rat

SIGNOR curated interactions for HMGN2 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for HMGN2 Gene

None

Drugs & Compounds for HMGN2 Gene

(1) Drugs for HMGN2 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
lysine Nutra 70
genes like me logo Genes that share compounds with HMGN2: view

Transcripts for HMGN2 Gene

mRNA/cDNA for HMGN2 Gene

Unigene Clusters for HMGN2 Gene

High mobility group nucleosomal binding domain 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HMGN2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HMGN2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5
SP1: - -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for HMGN2 Gene

GeneLoc Exon Structure for
HMGN2
ECgene alternative splicing isoforms for
HMGN2

Expression for HMGN2 Gene

mRNA expression in normal human tissues for HMGN2 Gene

Protein differential expression in normal tissues from HIPED for HMGN2 Gene

This gene is overexpressed in Stomach (23.0), Peripheral blood mononuclear cells (18.4), and Urine (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HMGN2 Gene



SOURCE GeneReport for Unigene cluster for HMGN2 Gene Hs.181163

genes like me logo Genes that share expression patterns with HMGN2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HMGN2 Gene

Orthologs for HMGN2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HMGN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HMGN2 35
  • 100 (n)
  • 100 (a)
HMGN2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hmgn2 16
Gm6594 36
  • 84 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 99 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 72 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6669 35
Species with no ortholog for HMGN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HMGN2 Gene

ENSEMBL:
Gene Tree for HMGN2 (if available)
TreeFam:
Gene Tree for HMGN2 (if available)

Paralogs for HMGN2 Gene

Paralogs for HMGN2 Gene

(1) SIMAP similar genes for HMGN2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for HMGN2 Gene

genes like me logo Genes that share paralogs with HMGN2: view

Variants for HMGN2 Gene

Sequence variations from dbSNP and Humsavar for HMGN2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1058934 -- 26,473,119(-) GAACT(A/C)GTGGG intron-variant
rs1064616 -- 26,472,561(+) CGCGC(C/T)GCTGC utr-variant-5-prime
rs1064617 -- 26,472,584(+) GCACC(C/T)ACGTC utr-variant-5-prime
rs1064621 -- 26,472,594(+) CCCGC(C/T)GCCGT utr-variant-5-prime
rs1064622 -- 26,472,599(+) TGCCG(C/T)CGCCG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for HMGN2 Gene

Variant ID Type Subtype PubMed ID
dgv202n71 CNV Loss 21882294

Variation tolerance for HMGN2 Gene

Residual Variation Intolerance Score: 44.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.03; 0.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HMGN2 Gene

HapMap Linkage Disequilibrium report
HMGN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMGN2 Gene

Disorders for HMGN2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for HMGN2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
limited scleroderma
  • systemic sclerosis, limited
- elite association
Search HMGN2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for HMGN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HMGN2
genes like me logo Genes that share disorders with HMGN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HMGN2 Gene

Publications for HMGN2 Gene

  1. Reconstitution of nucleosomal arrays using recombinant Drosophila ACF and NAP1. (PMID: 20147123) Peterson C.L. (Cold Spring Harb Protoc 2009) 23 67
  2. HMGN proteins act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility. (PMID: 19524541) Rattner B.P. … Kadonaga J.T. (Mol. Cell 2009) 23 67
  3. [Production of HMGN2 polyclonal antibody by immunization with recombinant GST-HMGN2 fusion protein and its application to analysis of HMGN2 distribution in human monocytes]. (PMID: 16078558) Xiong W.B. … Wang B.Y. (Sichuan Da Xue Xue Bao Yi Xue Ban 2005) 23 67
  4. Modulation of HMG-N2 binding to chromatin by butyrate-induced acetylation in human colon adenocarcinoma cells. (PMID: 11807779) LA1hrs H. … Menzel T. (Int. J. Cancer 2002) 23 67
  5. HMGN3a and HMGN3b, two protein isoforms with a tissue-specific expression pattern, expand the cellular repertoire of nucleosome- binding proteins. (PMID: 11356838) West K.L. … Bustin M. (J. Biol. Chem. 2001) 23 67

Products for HMGN2 Gene

Sources for HMGN2 Gene

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