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HMGN1 Gene(Protein Coding)

High Mobility Group Nucleosome Binding Domain 1

GCID:
GC21M039342
GIFtS:
59
Genes Participants
UDN Logo

Aliases for HMGN1 Gene

Aliases for HMGN1 Gene

  • High Mobility Group Nucleosome Binding Domain 1 2 3 5
  • High Mobility Group Nucleosome-Binding Domain-Containing Protein 1 3 4
  • High-Mobility Group (Nonhistone Chromosomal) Protein 14 2 3
  • High-Mobility Group Nucleosome Binding Domain 1 2 3
  • High-Mobility Group Nucleosome Binding 1 2 3
  • Nonhistone Chromosomal Protein HMG-14 2 3
  • HMG14 3 4

External Ids for HMGN1 Gene

Previous HGNC Symbols for HMGN1 Gene

  • HMG14

Previous GeneCards Identifiers for HMGN1 Gene

  • GC21M037290
  • GC21M039634
  • GC21M039637
  • GC21M040714
  • GC21M026182

Summaries for HMGN1 Gene

Entrez Gene Summary for HMGN1 Gene

  • The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes. [provided by RefSeq, Aug 2011]

GeneCards Summary for HMGN1 Gene

HMGN1 (High Mobility Group Nucleosome Binding Domain 1) is a Protein Coding gene. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and DNA Double-Strand Break Repair. GO annotations related to this gene include chromatin binding and nucleosomal DNA binding.

UniProtKB/Swiss-Prot for HMGN1 Gene

  • Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity).

Gene Wiki entry for HMGN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGN1 Gene

Genomics for HMGN1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for HMGN1 Gene

Enhancers for HMGN1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HMGN1 on UCSC Golden Path with GeneCards custom track

Promoters for HMGN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HMGN1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the HMGN1 gene promoter:

Genomic Location for HMGN1 Gene

Chromosome:
21
Start:
39,342,315 bp from pter
End:
39,349,647 bp from pter
Size:
7,333 bases
Orientation:
Minus strand

Genomic View for HMGN1 Gene

Genes around HMGN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HMGN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HMGN1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for HMGN1 Gene

Proteins for HMGN1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for HMGN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05114-HMGN1_HUMAN
    Recommended name:
    Non-histone chromosomal protein HMG-14
    Protein Accession:
    P05114
    Secondary Accessions:
    • Q3KQR8

    Protein attributes for HMGN1 Gene

    Size:
    100 amino acids
    Molecular mass:
    10659 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HMGN1 Gene

Proteomics data for HMGN1 Gene at MOPED

Protein Expression for HMGN1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for HMGN1 Gene

  • Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By similarity). Phosphorylation favors cytoplasmic localization.
  • Ubiquitination at Lys 5 and Lys 14
  • Modification sites at PhosphoSitePlus

Other Protein References for HMGN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HMGN1 Gene

Domains & Families for HMGN1 Gene

Gene Families for HMGN1 Gene

HGNC:

Protein Domains for HMGN1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for HMGN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P05114

UniProtKB/Swiss-Prot:

HMGN1_HUMAN :
  • Belongs to the HMGN family.
Family:
  • Belongs to the HMGN family.
genes like me logo Genes that share domains with HMGN1: view

Function for HMGN1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for HMGN1 Gene

UniProtKB/Swiss-Prot Function:
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity).

Phenotypes for HMGN1 Gene

MGI mutant phenotypes for HMGN1:
inferred from 1 alleles
GenomeRNAi human phenotypes for HMGN1:
genes like me logo Genes that share phenotypes with HMGN1: view

Animal Models for HMGN1 Gene

MGI Knock Outs for HMGN1:

Animal Model Products

miRNA for HMGN1 Gene

miRTarBase miRNAs that target HMGN1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HMGN1 Gene

Localization for HMGN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMGN1 Gene

Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HMGN1 Gene COMPARTMENTS Subcellular localization image for HMGN1 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for HMGN1 Gene

Pathways & Interactions for HMGN1 Gene

genes like me logo Genes that share pathways with HMGN1: view

Pathways by source for HMGN1 Gene

1 Cell Signaling Technology pathway for HMGN1 Gene
1 BioSystems pathway for HMGN1 Gene
1 KEGG pathway for HMGN1 Gene
1 Qiagen pathway for HMGN1 Gene

SIGNOR curated interactions for HMGN1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for HMGN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032786 positive regulation of DNA-templated transcription, elongation TAS 8047885
genes like me logo Genes that share ontologies with HMGN1: view

Drugs & Compounds for HMGN1 Gene

Products:

  1. Drug

(3) Drugs for HMGN1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HMGN1: view

Transcripts for HMGN1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for HMGN1 Gene

(8) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(792) Selected AceView cDNA sequences:
(20) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HMGN1 Gene

High mobility group nucleosome binding domain 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HMGN1 Gene

No ASD Table

Relevant External Links for HMGN1 Gene

GeneLoc Exon Structure for
HMGN1
ECgene alternative splicing isoforms for
HMGN1

Expression for HMGN1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for HMGN1 Gene

mRNA expression in normal human tissues for HMGN1 Gene
mRNA expression by BioGPS for HMGN1 GenemRNA expression by GTEx for HMGN1 Gene

Protein differential expression in normal tissues from HIPED for HMGN1 Gene

This gene is overexpressed in Stomach (13.4), Lavage (13.0), and Nasal epithelium (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HMGN1 Gene



SOURCE GeneReport for Unigene cluster for HMGN1 Gene Hs.356285

genes like me logo Genes that share expression patterns with HMGN1: view

Protein tissue co-expression partners for HMGN1 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for HMGN1 Gene

Orthologs for HMGN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HMGN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia HMGN1 35
  • 90.33 (n)
  • 96 (a)
-- 36
  • 83 (a)
 OneToMany
HMGN1 36
  • 95 (a)
 OneToMany
dog
(Canis familiaris)
 Mammalia HMGN1 35
  • 92.67 (n)
  • 97 (a)
HMGN1 36
  • 96 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Hmgn1 35
  • 81.05 (n)
  • 85.26 (a)
Hmgn1 16
Hmgn1 36
  • 83 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia HMGN1 35
  • 99.67 (n)
  • 100 (a)
HMGN1 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Hmgn1 35
  • 80.35 (n)
  • 85.26 (a)
oppossum
(Monodelphis domestica)
 Mammalia -- 36
  • 74 (a)
 OneToMany
-- 36
  • 74 (a)
 OneToMany
-- 36
  • 75 (a)
 OneToMany
-- 36
  • 68 (a)
 OneToMany
-- 36
  • 67 (a)
 OneToMany
-- 36
  • 40 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia HMGN1 36
  • 77 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves HMGN1 35
  • 72.57 (n)
  • 68.75 (a)
HMGN1 36
  • 62 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia HMGN1 36
  • 73 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia MGC75785 35
African clawed frog
(Xenopus laevis)
 Amphibia hmgn1-prov 35
Species with no ortholog for HMGN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HMGN1 Gene

ENSEMBL:
Gene Tree for HMGN1 (if available)
TreeFam:
Gene Tree for HMGN1 (if available)

Paralogs for HMGN1 Gene

(2) SIMAP similar genes for HMGN1 Gene using alignment to 9 proteins:

Pseudogenes.org Pseudogenes for HMGN1 Gene

genes like me logo Genes that share paralogs with HMGN1: view

No data available for Paralogs for HMGN1 Gene

Variants for HMGN1 Gene

Sequence variations from dbSNP and Humsavar for HMGN1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs2249651 -- 39,347,101(+) TAATA(A/G)TATAC intron-variant
rs2249666 -- 39,347,315(+) GTTAA(C/T)ATTTT intron-variant
rs1474490 -- 39,344,210(+) aagat(A/C)ccacc intron-variant
rs1474491 -- 39,344,382(+) ATCAA(A/C)TATAA intron-variant
rs2735308 -- 39,342,234(+) ACAGG(G/T)TTTCA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HMGN1 Gene

Variant ID Type Subtype PubMed ID
nsv913744 CNV Loss 21882294

Variation tolerance for HMGN1 Gene

Residual Variation Intolerance Score: 87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.26; 62.53% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HMGN1 Gene

Disorders for HMGN1 Gene

Relevant External Links for HMGN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HMGN1

No disorders were found for HMGN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HMGN1 Gene

Publications for HMGN1 Gene

  1. Chromosomal protein HMG-14. Identification, characterization, and chromosome localization of a functional gene from the large human multigene family. (PMID: 2563381) Landsman D. … Bustin M. (J. Biol. Chem. 1989) 2 3 4 67
  2. HMGN proteins act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility. (PMID: 19524541) Rattner B.P. … Kadonaga J.T. (Mol. Cell 2009) 3 23
  3. Phosphorylation of human high mobility group N1 protein by protein kinase CK2. (PMID: 16729963) Jiang X.G. … Wang Y. (Biochem. Biophys. Res. Commun. 2006) 3 23
  4. Identification of novel in vivo phosphorylation sites in high mobility group N1 protein from the MCF-7 human breast cancer cells. (PMID: 15147216) Zou Y. … Wang Y. (Biochemistry 2004) 3 23
  5. Mitotic phosphorylation of chromosomal protein HMGN1 inhibits nuclear import and promotes interaction with 14.3.3 proteins. (PMID: 12215538) Prymakowska-Bosak M. … Bustin M. (Mol. Cell. Biol. 2002) 3 23

Products for HMGN1 Gene

Sources for HMGN1 Gene

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