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Aliases for HMGN1 Gene

Aliases for HMGN1 Gene

  • High Mobility Group Nucleosome Binding Domain 1 2 3 5
  • High Mobility Group Nucleosome-Binding Domain-Containing Protein 1 3 4
  • High-Mobility Group (Nonhistone Chromosomal) Protein 14 2 3
  • High-Mobility Group Nucleosome Binding 1 2 3
  • Nonhistone Chromosomal Protein HMG-14 2 3
  • HMG14 3 4
  • High-Mobility Group Nucleosome Binding Domain 1 2
  • Non-Histone Chromosomal Protein HMG-14 3

External Ids for HMGN1 Gene

Previous HGNC Symbols for HMGN1 Gene

  • HMG14

Previous GeneCards Identifiers for HMGN1 Gene

  • GC21M037290
  • GC21M039634
  • GC21M039637
  • GC21M040714
  • GC21M026182

Summaries for HMGN1 Gene

Entrez Gene Summary for HMGN1 Gene

  • The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes. [provided by RefSeq, Aug 2011]

GeneCards Summary for HMGN1 Gene

HMGN1 (High Mobility Group Nucleosome Binding Domain 1) is a Protein Coding gene. Among its related pathways are MAPK-Erk Pathway and Transcription-Coupled Nucleotide Excision Repair (TC-NER). GO annotations related to this gene include chromatin binding and nucleosomal DNA binding.

UniProtKB/Swiss-Prot for HMGN1 Gene

  • Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity).

Gene Wiki entry for HMGN1 Gene

Additional gene information for HMGN1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGN1 Gene

Genomics for HMGN1 Gene

Regulatory Elements for HMGN1 Gene

Enhancers for HMGN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH21H039311 1.2 ENCODE 142.3 +36.2 36169 3 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 NFYC HMGN1 PSMG1 WRB RNF6P1 MYL6P2 BRWD1 LCA5L BRWD1-AS1 SH3BGR BRWD1-AS2
GH21H038906 2 FANTOM5 Ensembl ENCODE dbSUPER 81.8 +438.2 438218 9 HDGF PKNOX1 FOXA2 MLX SIN3A YBX1 ZBTB7B YY1 ZNF302 ZNF207 HMGN1 LCA5L RNF6P1 DSCR4 MYL6P2 DSCR10 LOC100288590 DSCR4-IT1 PSMG1 DSCR8
GH21H038983 2.5 VISTA FANTOM5 Ensembl ENCODE dbSUPER 48.5 +360.2 360223 11 PKNOX1 FOXA2 MLX ARNT ARID4B YBX1 FEZF1 ZNF2 ZNF766 CBX5 HMGN1 RNF6P1 MYL6P2 DSCR10 LOC100288590 DSCR4 DSCR4-IT1 DSCR8 ETS2 ENSG00000235888
GH21H038800 2 FANTOM5 Ensembl ENCODE dbSUPER 41 +541.9 541874 15 MLX FEZF1 YY1 SLC30A9 ZNF143 ZNF548 SP3 MEF2D ZNF610 GLIS1 HMGN1 ETS2 ERG ENSG00000229986
GH21H039104 1.7 FANTOM5 Ensembl ENCODE dbSUPER 46.9 +244.4 244410 2 PKNOX1 DMAP1 ZNF155 ZNF366 ZNF207 FOS ZNF680 ZBTB2 ZNF114 CEBPB HMGN1 ETS2 BRWD1 RPL23AP12 ENSG00000237609
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around HMGN1 on UCSC Golden Path with GeneCards custom track

Promoters for HMGN1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000142470 947 3001 HDGF ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF143 ZNF207

Genomic Location for HMGN1 Gene

Chromosome:
21
Start:
39,342,315 bp from pter
End:
39,349,647 bp from pter
Size:
7,333 bases
Orientation:
Minus strand

Genomic View for HMGN1 Gene

Genes around HMGN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HMGN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HMGN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMGN1 Gene

Proteins for HMGN1 Gene

  • Protein details for HMGN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05114-HMGN1_HUMAN
    Recommended name:
    Non-histone chromosomal protein HMG-14
    Protein Accession:
    P05114
    Secondary Accessions:
    • Q3KQR8

    Protein attributes for HMGN1 Gene

    Size:
    100 amino acids
    Molecular mass:
    10659 Da
    Quaternary structure:
    No Data Available

neXtProt entry for HMGN1 Gene

Post-translational modifications for HMGN1 Gene

  • Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By similarity). Phosphorylation favors cytoplasmic localization.
  • Ubiquitination at posLast=55 and posLast=1414
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HMGN1 (HMGN1)

No data available for DME Specific Peptides for HMGN1 Gene

Domains & Families for HMGN1 Gene

Gene Families for HMGN1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for HMGN1 Gene

Graphical View of Domain Structure for InterPro Entry

P05114

UniProtKB/Swiss-Prot:

HMGN1_HUMAN :
  • Belongs to the HMGN family.
Family:
  • Belongs to the HMGN family.
genes like me logo Genes that share domains with HMGN1: view

Function for HMGN1 Gene

Molecular function for HMGN1 Gene

UniProtKB/Swiss-Prot Function:
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity).

Phenotypes From GWAS Catalog for HMGN1 Gene

Gene Ontology (GO) - Molecular Function for HMGN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 8047885
GO:0003682 chromatin binding IEA --
GO:0031492 nucleosomal DNA binding IEA --
genes like me logo Genes that share ontologies with HMGN1: view
genes like me logo Genes that share phenotypes with HMGN1: view

Animal Models for HMGN1 Gene

MGI Knock Outs for HMGN1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HMGN1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HMGN1 Gene

Localization for HMGN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMGN1 Gene

Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for HMGN1 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for HMGN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0005634 nucleus IDA,IEA 16780588
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with HMGN1: view

Pathways & Interactions for HMGN1 Gene

genes like me logo Genes that share pathways with HMGN1: view

Pathways by source for HMGN1 Gene

2 Sino Biological pathways for HMGN1 Gene
1 Cell Signaling Technology pathway for HMGN1 Gene

SIGNOR curated interactions for HMGN1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for HMGN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000720 pyrimidine dimer repair by nucleotide-excision repair IEA --
GO:0006283 transcription-coupled nucleotide-excision repair TAS,IEA --
GO:0006325 chromatin organization IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0010224 response to UV-B IEA --
genes like me logo Genes that share ontologies with HMGN1: view

Drugs & Compounds for HMGN1 Gene

(3) Drugs for HMGN1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HMGN1: view

Transcripts for HMGN1 Gene

Unigene Clusters for HMGN1 Gene

High mobility group nucleosome binding domain 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for HMGN1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for HMGN1 Gene

No ASD Table

Relevant External Links for HMGN1 Gene

GeneLoc Exon Structure for
HMGN1
ECgene alternative splicing isoforms for
HMGN1

Expression for HMGN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for HMGN1 Gene

Protein differential expression in normal tissues from HIPED for HMGN1 Gene

This gene is overexpressed in Stomach (13.4), Lavage (13.0), and Nasal epithelium (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for HMGN1 Gene



Protein tissue co-expression partners for HMGN1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of HMGN1 Gene:

HMGN1

SOURCE GeneReport for Unigene cluster for HMGN1 Gene:

Hs.356285

Evidence on tissue expression from TISSUES for HMGN1 Gene

  • Nervous system(4.9)
  • Liver(4.6)
  • Blood(4.5)
  • Bone marrow(4.4)
  • Lung(3.5)
  • Eye(3.3)
  • Intestine(2.7)
  • Spleen(2.5)
  • Thyroid gland(2.5)
  • Kidney(2.2)
  • Pancreas(2.2)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with HMGN1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for HMGN1 Gene

Orthologs for HMGN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HMGN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HMGN1 33 34
  • 99.67 (n)
dog
(Canis familiaris)
Mammalia HMGN1 33 34
  • 92.67 (n)
cow
(Bos Taurus)
Mammalia HMGN1 33 34
  • 90.33 (n)
-- 34
  • 83 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Hmgn1 33 16 34
  • 81.05 (n)
rat
(Rattus norvegicus)
Mammalia LOC100911295 33
  • 80.35 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia HMGN1 34
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 75 (a)
OneToMany
-- 34
  • 74 (a)
OneToMany
-- 34
  • 74 (a)
OneToMany
-- 34
  • 68 (a)
OneToMany
-- 34
  • 67 (a)
OneToMany
-- 34
  • 40 (a)
OneToMany
chicken
(Gallus gallus)
Aves HMGN1 33 34
  • 72.57 (n)
lizard
(Anolis carolinensis)
Reptilia HMGN1 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75785 33
African clawed frog
(Xenopus laevis)
Amphibia hmgn1-prov 33
Species where no ortholog for HMGN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for HMGN1 Gene

ENSEMBL:
Gene Tree for HMGN1 (if available)
TreeFam:
Gene Tree for HMGN1 (if available)

Paralogs for HMGN1 Gene

(2) SIMAP similar genes for HMGN1 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with HMGN1: view

No data available for Paralogs for HMGN1 Gene

Variants for HMGN1 Gene

Sequence variations from dbSNP and Humsavar for HMGN1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1000433303 -- 39,348,761(+) CGAGC(A/G)CTCGC intron-variant, upstream-variant-2KB
rs1000697562 -- 39,343,010(+) CTAGA(C/G)CTACT downstream-variant-500B, reference, missense, utr-variant-3-prime
rs1000868318 -- 39,347,932(+) CTCCT(A/G)GCCTC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001153863 -- 39,342,273(+) TTCTG(A/T)AAATA downstream-variant-500B
rs1001207425 -- 39,348,072(+) TCGTC(C/T)TAAGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for HMGN1 Gene

Variant ID Type Subtype PubMed ID
dgv2389n106 CNV deletion 24896259
nsv1073129 CNV deletion 25765185
nsv587483 CNV loss 21841781
nsv979537 CNV duplication 23825009

Variation tolerance for HMGN1 Gene

Residual Variation Intolerance Score: 87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.26; 62.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HMGN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
HMGN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HMGN1 Gene

Disorders for HMGN1 Gene

Relevant External Links for HMGN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HMGN1

No disorders were found for HMGN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HMGN1 Gene

Publications for HMGN1 Gene

  1. Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry. (PMID: 10739259) Louie DF … Ahn NG (Protein science : a publication of the Protein Society 2000) 3 4 22 60
  2. Chromosomal protein HMG-14. Identification, characterization, and chromosome localization of a functional gene from the large human multigene family. (PMID: 2563381) Landsman D … Bustin M (The Journal of biological chemistry 1989) 2 3 4 60
  3. Chromosomal protein HMG-14. Complete human cDNA sequence and evidence for a multigene family. (PMID: 3782107) Landsman D … Bustin M (The Journal of biological chemistry 1986) 2 3 4 60
  4. Serine ADP-Ribosylation Depends on HPF1. (PMID: 28190768) Bonfiglio JJ … Matic I (Molecular cell 2017) 3 4 60
  5. HMGN proteins act in opposition to ATP-dependent chromatin remodeling factors to restrict nucleosome mobility. (PMID: 19524541) Rattner BP … Kadonaga JT (Molecular cell 2009) 3 22 60

Products for HMGN1 Gene

Sources for HMGN1 Gene

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