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Aliases for HMGB2 Gene

Aliases for HMGB2 Gene

  • High Mobility Group Box 2 2 3
  • HMG2 3 4 6
  • High-Mobility Group (Nonhistone Chromosomal) Protein 2 2 3
  • High Mobility Group Protein 2 3 4
  • High-Mobility Group Box 2 2 3
  • HMG-2 3 4
  • High Mobility Group Protein B2 3

External Ids for HMGB2 Gene

Previous Symbols for HMGB2 Gene

  • HMG2

Summaries for HMGB2 Gene

Entrez Gene Summary for HMGB2 Gene

  • This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]

GeneCards Summary for HMGB2 Gene

HMGB2 (High Mobility Group Box 2) is a Protein Coding gene. Among its related pathways are RB in Cancer and Chromatin Regulation / Acetylation. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein domain specific binding. An important paralog of this gene is HMGB4.

UniProtKB/Swiss-Prot for HMGB2 Gene

  • DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity).

Gene Wiki entry for HMGB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HMGB2 Gene

Genomics for HMGB2 Gene

Genomic Location for HMGB2 Gene

Start:
173,331,376 bp from pter
End:
173,335,125 bp from pter
Size:
3,750 bases
Orientation:
Minus strand

Genomic View for HMGB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HMGB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HMGB2 Gene

Regulatory Elements for HMGB2 Gene

Proteins for HMGB2 Gene

  • Protein details for HMGB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26583-HMGB2_HUMAN
    Recommended name:
    High mobility group protein B2
    Protein Accession:
    P26583
    Secondary Accessions:
    • B2R4K8
    • D3DP37
    • Q5U072

    Protein attributes for HMGB2 Gene

    Size:
    209 amino acids
    Molecular mass:
    24034 Da
    Quaternary structure:
    • Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Component of the SET complex, composed of at least ANP32A, APEX1, HMGB2, NME1, SET and TREX1. Directly interacts with SET.

neXtProt entry for HMGB2 Gene

Proteomics data for HMGB2 Gene at MOPED

Post-translational modifications for HMGB2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys12, Lys50, Lys114, Lys147, and Lys157

Other Protein References for HMGB2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HMGB2 Gene

Domains for HMGB2 Gene

Gene Families for HMGB2 Gene

HGNC:
  • HMG :High-mobility group / Canonical

Protein Domains for HMGB2 Gene

UniProtKB/Swiss-Prot:

HMGB2_HUMAN
Domain:
  • Contains 2 HMG box DNA-binding domains.:
    • P26583
Family:
  • Belongs to the HMGB family.:
    • P26583
genes like me logo Genes that share domains with HMGB2: view

Function for HMGB2 Gene

Molecular function for HMGB2 Gene

UniProtKB/Swiss-Prot Function: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity).

Gene Ontology (GO) - Molecular Function for HMGB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IMP 11909973
GO:0003682 chromatin binding IBA --
GO:0003684 damaged DNA binding IDA 8226934
GO:0003690 double-stranded DNA binding ISS --
GO:0003697 single-stranded DNA binding ISS --
genes like me logo Genes that share ontologies with HMGB2: view

Phenotypes for HMGB2 Gene

genes like me logo Genes that share phenotypes with HMGB2: view

miRNA for HMGB2 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for HMGB2 Gene

Localization for HMGB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HMGB2 Gene

Nucleus. Chromosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HMGB2 Gene COMPARTMENTS Subcellular localization image for HMGB2 gene
Compartment Confidence
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for HMGB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000793 condensed chromosome IDA 12925773
GO:0005615 extracellular space IDA 19811285
GO:0005634 nucleus IDA 11909973
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 11909973
genes like me logo Genes that share ontologies with HMGB2: view

Pathways for HMGB2 Gene

genes like me logo Genes that share pathways with HMGB2: view

Pathways by source for HMGB2 Gene

2 Qiagen pathways for HMGB2 Gene
1 Cell Signaling Technology pathway for HMGB2 Gene

Gene Ontology (GO) - Biological Process for HMGB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001938 positive regulation of endothelial cell proliferation IDA 19811285
GO:0006265 DNA topological change ISS --
GO:0006288 base-excision repair, DNA ligation IDA 9600082
GO:0006309 apoptotic DNA fragmentation TAS --
GO:0006325 chromatin organization NAS 11909973
genes like me logo Genes that share ontologies with HMGB2: view

Compounds for HMGB2 Gene

(3) Novoseek inferred chemical compound relationships for HMGB2 Gene

Compound -log(P) Hits PubMed IDs
cisplatin 33 7
estrogen 0.701 1
atp 0 1
genes like me logo Genes that share compounds with HMGB2: view

Transcripts for HMGB2 Gene

Unigene Clusters for HMGB2 Gene

High mobility group box 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HMGB2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - - - -
SP2: - - - - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - - -
SP7: -
SP8: - - -
SP9:
SP10: - - - -

Relevant External Links for HMGB2 Gene

GeneLoc Exon Structure for
HMGB2
ECgene alternative splicing isoforms for
HMGB2

Expression for HMGB2 Gene

mRNA expression in normal human tissues for HMGB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HMGB2 Gene

This gene is overexpressed in Whole Blood (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HMGB2 Gene

SOURCE GeneReport for Unigene cluster for HMGB2 Gene Hs.434953

genes like me logo Genes that share expressions with HMGB2: view

Orthologs for HMGB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HMGB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HMGB2 36
  • 99.84 (n)
  • 100 (a)
HMGB2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 95 (a)
OneToMany
HMGB2 36
  • 91.07 (n)
  • 100 (a)
HMGB2 37
  • 100 (a)
OneToMany
dog
(Canis familiaris)
Mammalia HMGB2 36
  • 94.65 (n)
  • 100 (a)
HMGB2 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hmgb2 36
  • 90.55 (n)
  • 98.4 (a)
Hmgb2 16
Hmgb2 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HMGB2 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HMGB2 37
  • 52 (a)
OneToOne
chicken
(Gallus gallus)
Aves HMGB2 36
  • 83.96 (n)
  • 92.51 (a)
HMGB2 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HMGB2 37
  • 88 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii hmgb2a 36
  • 76.06 (n)
  • 79.56 (a)
hmgb2a 37
  • 77 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000005 36
  • 59.24 (n)
  • 57.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dsp1 36
  • 58.54 (n)
  • 56.25 (a)
worm
(Caenorhabditis elegans)
Secernentea hmg-1.2 36
  • 51.1 (n)
  • 43.11 (a)
Species with no ortholog for HMGB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for HMGB2 Gene

ENSEMBL:
Gene Tree for HMGB2 (if available)
TreeFam:
Gene Tree for HMGB2 (if available)

Paralogs for HMGB2 Gene

Paralogs for HMGB2 Gene

Selected SIMAP similar genes for HMGB2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with HMGB2: view

Variants for HMGB2 Gene

Sequence variations from dbSNP and Humsavar for HMGB2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs3733476 -- 173,335,349(-) GGTGC(A/G)GCGTG upstream-variant-2KB
rs6821844 -- 173,331,290(+) ggatc(C/G)tgcca downstream-variant-500B
rs6853427 -- 173,331,394(+) tatat(A/G)tgtat utr-variant-3-prime
rs7676013 -- 173,335,897(+) ATCTT(A/T)AAAAA upstream-variant-2KB
rs10632983 -- 173,331,375(+) TATAC(-/AT)ATATA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for HMGB2 Gene

Variant ID Type Subtype PubMed ID
nsv4610 CNV Loss 18451855

Relevant External Links for HMGB2 Gene

HapMap Linkage Disequilibrium report
HMGB2

Disorders for HMGB2 Gene

(5) Novoseek inferred disease relationships for HMGB2 Gene

Disease -log(P) Hits PubMed IDs
arthritis juvenile rheumatoid 36.3 2
hepatitis autoimmune 35.5 2
colitis ulcerative 31.5 3
rheumatic diseases 24.9 3
cancer 0 1

Relevant External Links for HMGB2

Genetic Association Database (GAD)
HMGB2
Human Genome Epidemiology (HuGE) Navigator
HMGB2
genes like me logo Genes that share disorders with HMGB2: view

No data available for UniProtKB/Swiss-Prot for HMGB2 Gene

Publications for HMGB2 Gene

  1. Sequence of human HMG2 cDNA. (PMID: 1754403) Majumdar A. … Seidman M.M. (Nucleic Acids Res. 1991) 2 3 4
  2. HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha. (PMID: 19223331) Stros M. … PospA-silovA! S. (Nucleic Acids Res. 2009) 3 23
  3. HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter. (PMID: 11748232) Stros M. … Nakagawara A. (J. Biol. Chem. 2002) 3 23
  4. A human HMG2 cDNA with a novel 3'-untranslated region. (PMID: 1475204) Alexandre S. … Lee A.S. (Nucleic Acids Res. 1992) 3 4
  5. Structure of a gene coding for human HMG2 protein. (PMID: 1551873) Shirakawa H. … Yoshida M. (J. Biol. Chem. 1992) 3 4

Products for HMGB2 Gene

Sources for HMGB2 Gene

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