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Aliases for HLX Gene

Aliases for HLX Gene

  • H2.0 Like Homeobox 2 3
  • Homeobox Protein HB24 3 4
  • Homeobox Protein HLX1 3 4
  • H2.0-Like Homeobox 1 2 3
  • H2.0-Like Homeobox 2 5
  • HLX1 3 4
  • H2.0 (Drosophila)-Like Homeo Box 1 2
  • H2.0-Like Homeobox 1 (Drosophila) 2
  • H2.0-Like Homeo Box 1 3
  • H2.0-Like Homeo Box-1 3
  • HB24 3

External Ids for HLX Gene

Previous HGNC Symbols for HLX Gene

  • HLX1

Previous GeneCards Identifiers for HLX Gene

  • GC01P219120
  • GC01P221052
  • GC01P191727

Summaries for HLX Gene

GeneCards Summary for HLX Gene

HLX (H2.0 Like Homeobox) is a Protein Coding gene. Diseases associated with HLX include Ovarian Endodermal Sinus Tumor and Ovarian Primitive Germ Cell Tumor. Among its related pathways are IL12-mediated signaling events. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is BARX2.

UniProtKB/Swiss-Prot for HLX Gene

  • Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity).

Gene Wiki entry for HLX Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLX Gene

Genomics for HLX Gene

Regulatory Elements for HLX Gene

Enhancers for HLX Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HLX on UCSC Golden Path with GeneCards custom track

Promoters for HLX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HLX on UCSC Golden Path with GeneCards custom track

Genomic Location for HLX Gene

220,879,400 bp from pter
220,885,059 bp from pter
5,660 bases
Plus strand

Genomic View for HLX Gene

Genes around HLX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HLX Gene

Proteins for HLX Gene

  • Protein details for HLX Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    H2.0-like homeobox protein
    Protein Accession:
    Secondary Accessions:
    • B2R8A8
    • Q15988
    • Q59HE7
    • Q9NZ75

    Protein attributes for HLX Gene

    488 amino acids
    Molecular mass:
    50789 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAD92049.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAD92049.1; Type=Frameshift; Positions=198, 259, 321; Evidence={ECO:0000305}; Sequence=M60721; Type=Frameshift; Positions=69, 115, 152, 167; Evidence={ECO:0000305};

neXtProt entry for HLX Gene

Proteomics data for HLX Gene at MOPED

Post-translational modifications for HLX Gene

  • Ubiquitination at Lys 175
  • Modification sites at PhosphoSitePlus

Other Protein References for HLX Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HLX Gene

Domains & Families for HLX Gene

Gene Families for HLX Gene

Suggested Antigen Peptide Sequences for HLX Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the H2.0 homeobox family.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the H2.0 homeobox family.
genes like me logo Genes that share domains with HLX: view

Function for HLX Gene

Molecular function for HLX Gene

UniProtKB/Swiss-Prot Function:
Transcription factor required for TBX21/T-bet-dependent maturation of Th1 cells as well as maintenance of Th1-specific gene expression. Involved in embryogenesis and hematopoiesis (By similarity).
genes like me logo Genes that share phenotypes with HLX: view

Animal Models for HLX Gene

MGI Knock Outs for HLX:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for HLX Gene

Localization for HLX Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLX Gene


Subcellular locations from

Jensen Localization Image for HLX Gene COMPARTMENTS Subcellular localization image for HLX gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for HLX Gene

Pathways & Interactions for HLX Gene

SuperPathways for HLX Gene

genes like me logo Genes that share pathways with HLX: view

Pathways by source for HLX Gene

1 BioSystems pathway for HLX Gene

Gene Ontology (GO) - Biological Process for HLX Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0007275 multicellular organism development TAS 8094082
GO:0007519 skeletal muscle tissue development IEA --
GO:0008284 positive regulation of cell proliferation IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with HLX: view

No data available for SIGNOR curated interactions for HLX Gene

Drugs & Compounds for HLX Gene

No Compound Related Data Available

Transcripts for HLX Gene

mRNA/cDNA for HLX Gene

Unigene Clusters for HLX Gene

H2.0-like homeobox:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HLX Gene

No ASD Table

Relevant External Links for HLX Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HLX Gene

mRNA expression in normal human tissues for HLX Gene

mRNA differential expression in normal tissues according to GTEx for HLX Gene

This gene is overexpressed in Whole Blood (x8.1) and Colon - Sigmoid (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HLX Gene

SOURCE GeneReport for Unigene cluster for HLX Gene Hs.74870

mRNA Expression by UniProt/SwissProt for HLX Gene

Tissue specificity: Low level in normal B and T-cells, high level in activated lymphocytes and monocytes. Also found in thymus, tonsil, bone marrow, developing vessels, and fetal brain.
genes like me logo Genes that share expression patterns with HLX: view

Protein tissue co-expression partners for HLX Gene

- Elite partner

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein differential expression in normal tissues for HLX Gene

Orthologs for HLX Gene

This gene was present in the common ancestor of animals.

Orthologs for HLX Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HLX 35
  • 85.46 (n)
  • 88.89 (a)
HLX 36
  • 91 (a)
(Canis familiaris)
Mammalia HLX 35
  • 89.84 (n)
  • 92.93 (a)
HLX 36
  • 88 (a)
(Mus musculus)
Mammalia Hlx 35
  • 84.31 (n)
  • 87.82 (a)
Hlx 16
Hlx 36
  • 89 (a)
(Pan troglodytes)
Mammalia HLX 35
  • 99.11 (n)
  • 98.98 (a)
HLX 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Hlx 35
  • 84.73 (n)
  • 88.45 (a)
(Monodelphis domestica)
Mammalia HLX 36
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia HLX 36
  • 81 (a)
(Gallus gallus)
Aves HLX 36
  • 66 (a)
(Anolis carolinensis)
Reptilia HLX 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hlx 35
  • 67.86 (n)
  • 68.68 (a)
(Danio rerio)
Actinopterygii hlx1 35
  • 65.51 (n)
  • 69.5 (a)
hlx1 36
  • 57 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2656 35
fruit fly
(Drosophila melanogaster)
Insecta H2.0 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
Species with no ortholog for HLX:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HLX Gene

Gene Tree for HLX (if available)
Gene Tree for HLX (if available)

Paralogs for HLX Gene

genes like me logo Genes that share paralogs with HLX: view

Variants for HLX Gene

Sequence variations from dbSNP and Humsavar for HLX Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_037162 -
rs2738755 - 220,884,304(+) AGCCC(C/G/T)GGCTG reference, missense
rs11578466 - 220,884,397(+) CATGG(C/G)CCCCA reference, missense
rs868058 -- 220,883,048(-) AATTA(A/T)TTCAG intron-variant
rs945446 -- 220,882,977(+) GAATA(C/T)CCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HLX Gene

Variant ID Type Subtype PubMed ID
nsv819685 CNV Gain 19587683

Variation tolerance for HLX Gene

Residual Variation Intolerance Score: 55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.70; 94.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HLX Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HLX Gene

Disorders for HLX Gene

MalaCards: The human disease database

(3) MalaCards diseases for HLX Gene - From: DISEASES

Disorder Aliases PubMed IDs
ovarian endodermal sinus tumor
  • endodermal sinus tumor of ovary
ovarian primitive germ cell tumor
diaphragm disease
  • disease of diaphragm
- elite association - COSMIC cancer census association via MalaCards
Search HLX in MalaCards View complete list of genes associated with diseases

Relevant External Links for HLX

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HLX: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HLX Gene

Publications for HLX Gene

  1. Cloning of a human homeobox gene that resembles a diverged Drosophila homeobox gene and is expressed in activated lymphocytes. (PMID: 1676597) Deguchi Y. … Kehrl J.H. (New Biol. 1991) 2 3 4 23 67
  2. Genomic structure, promoter sequence, and revised translation of human homeobox gene HLX1. (PMID: 7806220) Kennedy M.A. … Morris C.M. (Genomics 1994) 2 3
  3. Linkage localization of TGFB2 and the human homeobox gene HLX1 to chromosome 1q. (PMID: 8095486) Nishimura D.Y. … Murray J.C. (Genomics 1993) 3 23
  4. Interplay between Homeobox proteins and Polycomb repressive complexes in p16INKa8'a regulation. (PMID: 23455154) Martin N. … Gil J. (EMBO J. 2013) 3
  5. Functional polymorphisms in TBX21 and HLX are associated with development and prognosis of Graves' disease. (PMID: 22014209) Morita M. … Iwatani Y. (Autoimmunity 2012) 3

Products for HLX Gene

Sources for HLX Gene