Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HLF Gene

Aliases for HLF Gene

  • HLF, PAR BZIP Transcription Factor 2 3
  • Hepatic Leukemia Factor 2 5
  • PAR BZIP Transcription Factor 2

External Ids for HLF Gene

Previous GeneCards Identifiers for HLF Gene

  • GC17P053073
  • GC17P055823
  • GC17P053684
  • GC17P053817
  • GC17P050697
  • GC17P053342
  • GC17P048701

Summaries for HLF Gene

Entrez Gene Summary for HLF Gene

  • This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLF Gene

HLF (HLF, PAR BZIP Transcription Factor) is a Protein Coding gene. Diseases associated with HLF include Precursor B-Cell Acute Lymphoblastic Leukemia and Leukemia. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and double-stranded DNA binding. An important paralog of this gene is DBP.

Gene Wiki entry for HLF Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HLF Gene

Genomics for HLF Gene

Regulatory Elements for HLF Gene

Enhancers for HLF Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HLF on UCSC Golden Path with GeneCards custom track

Genomic Location for HLF Gene

55,264,960 bp from pter
55,325,065 bp from pter
60,106 bases
Plus strand

Genomic View for HLF Gene

Genes around HLF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HLF Gene

Proteins for HLF Gene

  • Protein details for HLF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hepatic leukemia factor
    Protein Accession:
    Secondary Accessions:
    • A8K1X8
    • Q6FHS9

    Protein attributes for HLF Gene

    295 amino acids
    Molecular mass:
    33199 Da
    Quaternary structure:
    • Binds DNA specifically as homodimer or heterodimer with other PAR factors.
    • Sequence=AAA58445.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for HLF Gene


neXtProt entry for HLF Gene

Proteomics data for HLF Gene at MOPED

Post-translational modifications for HLF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HLF Gene

No data available for DME Specific Peptides for HLF Gene

Domains & Families for HLF Gene

Gene Families for HLF Gene

Protein Domains for HLF Gene


Suggested Antigen Peptide Sequences for HLF Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. PAR subfamily.
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. PAR subfamily.
genes like me logo Genes that share domains with HLF: view

Function for HLF Gene

Molecular function for HLF Gene

GENATLAS Biochemistry:
hepatic leukemia factor,rearranged in acute B-cell leukemia,with translocation t(17;19)
UniProtKB/Swiss-Prot Induction:
Accumulates according to a robust circadian rhythm.

Gene Ontology (GO) - Molecular Function for HLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 8639829
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with HLF: view
genes like me logo Genes that share phenotypes with HLF: view

Animal Models for HLF Gene

MGI Knock Outs for HLF:

Animal Model Products

Transcription Factor Targets for HLF Gene

Selected GeneGlobe predicted Target genes for HLF

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for HLF Gene

Localization for HLF Gene

Subcellular locations from UniProtKB/Swiss-Prot for HLF Gene


Subcellular locations from

Jensen Localization Image for HLF Gene COMPARTMENTS Subcellular localization image for HLF gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for HLF Gene

Pathways & Interactions for HLF Gene

SuperPathways for HLF Gene

No Data Available

Gene Ontology (GO) - Biological Process for HLF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035914 skeletal muscle cell differentiation IEA --
GO:0048511 rhythmic process IEA --
genes like me logo Genes that share ontologies with HLF: view

No data available for Pathways by source and SIGNOR curated interactions for HLF Gene

Drugs & Compounds for HLF Gene

(1) Drugs for HLF Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with HLF: view

Transcripts for HLF Gene

Unigene Clusters for HLF Gene

Hepatic leukemia factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HLF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e ^ 10 ^ 11a · 11b · 11c
SP1: - - - - - - - - - - - -
SP2: - - -
SP3: - - - - -
SP4: -
SP5: - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - -
SP11: - - - - - - - -

Relevant External Links for HLF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HLF Gene

mRNA expression in normal human tissues for HLF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for HLF Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HLF Gene

SOURCE GeneReport for Unigene cluster for HLF Gene Hs.196952

mRNA Expression by UniProt/SwissProt for HLF Gene

Tissue specificity: Highly expressed in liver; lower levels in lung and kidney.
genes like me logo Genes that share expression patterns with HLF: view

Protein tissue co-expression partners for HLF Gene

Primer Products

No data available for mRNA differential expression in normal tissues for HLF Gene

Orthologs for HLF Gene

This gene was present in the common ancestor of animals.

Orthologs for HLF Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HLF 35
  • 89.94 (n)
  • 97.97 (a)
HLF 36
  • 98 (a)
(Canis familiaris)
Mammalia HLF 35
  • 95.25 (n)
  • 99.32 (a)
HLF 36
  • 99 (a)
(Mus musculus)
Mammalia Hlf 35
  • 91.64 (n)
  • 97.63 (a)
Hlf 16
Hlf 36
  • 98 (a)
(Pan troglodytes)
Mammalia HLF 35
  • 99.77 (n)
  • 100 (a)
HLF 36
  • 100 (a)
(Rattus norvegicus)
Mammalia LOC690286 35
  • 91.75 (n)
  • 97.29 (a)
(Monodelphis domestica)
Mammalia HLF 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia HLF 36
  • 83 (a)
(Gallus gallus)
Aves HLF 35
  • 83.33 (n)
  • 90.41 (a)
HLF 36
  • 90 (a)
(Anolis carolinensis)
Reptilia HLF 36
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hlf 35
  • 77.18 (n)
  • 84.41 (a)
(Danio rerio)
Actinopterygii hlfa 35
  • 73.15 (n)
  • 75.09 (a)
hlfb 36
  • 71 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3939 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006376 35
  • 57.35 (n)
  • 57.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pdp1 35
  • 54.43 (n)
  • 55.56 (a)
Pdp1 36
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6834 36
  • 13 (a)
Species with no ortholog for HLF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HLF Gene

Gene Tree for HLF (if available)
Gene Tree for HLF (if available)

Paralogs for HLF Gene

Paralogs for HLF Gene

(2) SIMAP similar genes for HLF Gene using alignment to 3 proteins: Pseudogenes for HLF Gene

genes like me logo Genes that share paralogs with HLF: view

Variants for HLF Gene

Sequence variations from dbSNP and Humsavar for HLF Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_008515 -
rs13761 -- 55,322,073(+) GTGGT(C/G)TCATT utr-variant-3-prime
rs955734 -- 55,289,862(+) TCCTA(A/G)CACTT intron-variant
rs963955 -- 55,309,465(+) TCATC(A/G)AGGGA intron-variant
rs1065478 -- 55,322,796(+) CAGTT(C/T)TTTTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for HLF Gene

Variant ID Type Subtype PubMed ID
nsv908620 CNV Loss 21882294
nsv908628 CNV Gain 21882294

Variation tolerance for HLF Gene

Residual Variation Intolerance Score: 17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.11% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HLF Gene

Disorders for HLF Gene

MalaCards: The human disease database

(3) MalaCards diseases for HLF Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
precursor b-cell acute lymphoblastic leukemia
  • b-all
lymphoblastic leukemia
  • acute lymphocytic leukemia
- elite association - COSMIC cancer census association via MalaCards
Search HLF in MalaCards View complete list of genes associated with diseases


  • Note=A chromosomal aberration involving HLF is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(17;19)(q22;p13.3) with TCF3.

Genatlas disease for HLF Gene

acute lymphoblastic leukemia,preB-cell,with t(17;19)(q22;p13) translocation (see TCF3),associated with CDNK2A and/or CDKN2B deletion

Relevant External Links for HLF

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HLF: view

Publications for HLF Gene

  1. Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia. (PMID: 1386162) Inaba T. … Look A.T. (Science 1992) 2 3 4 23 67
  2. Thyroid hormone induces hypoxia-inducible factor 1alpha gene expression through thyroid hormone receptor beta/retinoid x receptor alpha-dependent activation of hepatic leukemia factor. (PMID: 18239067) Otto T. … Fandrey J. (Endocrinology 2008) 3 23
  3. E2A basic helix-loop-helix transcription factors in human leukemia. (PMID: 12700034) LeBrun D.P. (Front. Biosci. 2003) 3 23
  4. The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties. (PMID: 8639829) Hunger S.P. … Cleary M.L. (Blood 1996) 3 23
  5. The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences. (PMID: 7556072) Falvey E. … Schibler U. (EMBO J. 1995) 3 23

Products for HLF Gene

Sources for HLF Gene