Free for academic non-profit institutions. Other users need a Commercial license

Aliases for AOAH Gene

Aliases for AOAH Gene

  • Acyloxyacyl Hydrolase (Neutrophil) 2 3
  • EC 3.1.1.77 4

External Ids for AOAH Gene

Previous GeneCards Identifiers for AOAH Gene

  • GC07M036199
  • GC07M036293
  • GC07M036325

Summaries for AOAH Gene

Entrez Gene Summary for AOAH Gene

  • This locus encodes both the light and heavy subunits of acyloxyacyl hydrolase. The encoded enzyme catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides, effectively detoxifying these molecules. The encoded protein may play a role in modulating host inflammatory response to gram-negative bacteria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Apr 2010]

GeneCards Summary for AOAH Gene

AOAH (Acyloxyacyl Hydrolase (Neutrophil)) is a Protein Coding gene. GO annotations related to this gene include lipoprotein lipase activity and acyloxyacyl hydrolase activity.

UniProtKB/Swiss-Prot for AOAH Gene

  • Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides

Gene Wiki entry for AOAH Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AOAH Gene

Genomics for AOAH Gene

Regulatory Elements for AOAH Gene

Genomic Location for AOAH Gene

Start:
36,512,941 bp from pter
End:
36,724,549 bp from pter
Size:
211,609 bases
Orientation:
Minus strand

Genomic View for AOAH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AOAH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AOAH Gene

Proteins for AOAH Gene

  • Protein details for AOAH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28039-AOAH_HUMAN
    Recommended name:
    Acyloxyacyl hydrolase
    Protein Accession:
    P28039
    Secondary Accessions:
    • A4D1Y5
    • B7Z490
    • Q53F13

    Protein attributes for AOAH Gene

    Size:
    575 amino acids
    Molecular mass:
    65105 Da
    Quaternary structure:
    • Heterodimer

    Alternative splice isoforms for AOAH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AOAH Gene

Proteomics data for AOAH Gene at MOPED

Post-translational modifications for AOAH Gene

  • Both subunits contain a number of cysteine residues that may form disulfide bridges
  • Glycosylation at Asn59, Asn207, Asn336, Asn409, and Asn466
  • Modification sites at PhosphoSitePlus

Other Protein References for AOAH Gene

No data available for DME Specific Peptides for AOAH Gene

Domains for AOAH Gene

Protein Domains for AOAH Gene

Graphical View of Domain Structure for InterPro Entry

P28039

UniProtKB/Swiss-Prot:

AOAH_HUMAN :
  • P28039
Domain:
  • Contains 1 saposin B-type domain.
genes like me logo Genes that share domains with AOAH: view

No data available for Gene Families for AOAH Gene

Function for AOAH Gene

Molecular function for AOAH Gene

GENATLAS Biochemistry: acyloxyacyl hydrolase,two-subunit lipase expressed in phagocytic cells,specifically hydrolyzing the secondary acyl chains of the liposaccharide found in the walls of gram-negative bacteria
UniProtKB/Swiss-Prot CatalyticActivity: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid
UniProtKB/Swiss-Prot Function: Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides

Enzyme Numbers (IUBMB) for AOAH Gene

Gene Ontology (GO) - Molecular Function for AOAH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity TAS 1883828
GO:0004465 lipoprotein lipase activity TAS 1883828
GO:0016788 hydrolase activity, acting on ester bonds --
GO:0050528 acyloxyacyl hydrolase activity IEA --
genes like me logo Genes that share ontologies with AOAH: view

Phenotypes for AOAH Gene

MGI mutant phenotypes for AOAH:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with AOAH: view

Animal Models for AOAH Gene

MGI Knock Outs for AOAH:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for AOAH Gene

Localization for AOAH Gene

Subcellular locations from UniProtKB/Swiss-Prot for AOAH Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AOAH Gene COMPARTMENTS Subcellular localization image for AOAH gene
Compartment Confidence
extracellular 5
plasma membrane 2
lysosome 1

Gene Ontology (GO) - Cellular Components for AOAH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with AOAH: view

Pathways for AOAH Gene

SuperPathways for AOAH Gene

No Data Available

Interacting Proteins for AOAH Gene

Selected Interacting proteins: P28039-AOAH_HUMAN for AOAH Gene via I2D

Symbol External ID(s) Details
IGHG1

Gene Ontology (GO) - Biological Process for AOAH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 1883828
GO:0006954 inflammatory response TAS 1883828
GO:0008653 lipopolysaccharide metabolic process --
GO:0050728 negative regulation of inflammatory response --
genes like me logo Genes that share ontologies with AOAH: view

No data available for Pathways by source for AOAH Gene

Compounds for AOAH Gene

(1) HMDB Compounds for AOAH Gene

Compound Synonyms Cas Number PubMed IDs
Water
  • Dihydrogen oxide
7732-18-5

(1) Novoseek inferred chemical compound relationships for AOAH Gene

Compound -log(P) Hits PubMed IDs
endotoxin 38.8 2
genes like me logo Genes that share compounds with AOAH: view

Transcripts for AOAH Gene

Unigene Clusters for AOAH Gene

Acyloxyacyl hydrolase (neutrophil):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AOAH Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24a · 24b
SP1: - - - -
SP2:
SP3:

Relevant External Links for AOAH Gene

GeneLoc Exon Structure for
AOAH
ECgene alternative splicing isoforms for
AOAH

Expression for AOAH Gene

mRNA expression in normal human tissues for AOAH Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for AOAH Gene

This gene is overexpressed in Whole Blood (29.7) and Spleen (7.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for AOAH Gene

SOURCE GeneReport for Unigene cluster for AOAH Gene Hs.488007

genes like me logo Genes that share expressions with AOAH: view

No data available for mRNA Expression by UniProt/SwissProt for AOAH Gene

Orthologs for AOAH Gene

This gene was present in the common ancestor of chordates.

Orthologs for AOAH Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AOAH 35
  • 99.3 (n)
  • 98.78 (a)
AOAH 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AOAH 35
  • 84.93 (n)
  • 80.52 (a)
AOAH 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AOAH 35
  • 86.84 (n)
  • 84.35 (a)
AOAH 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aoah 35
  • 81.3 (n)
  • 76.13 (a)
Aoah 16
Aoah 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AOAH 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AOAH 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aoah 35
  • 82.42 (n)
  • 78.1 (a)
chicken
(Gallus gallus)
Aves AOAH 35
  • 68.09 (n)
  • 63.82 (a)
AOAH 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AOAH 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia aoah 35
  • 59.84 (n)
  • 55.12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for AOAH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AOAH Gene

ENSEMBL:
Gene Tree for AOAH (if available)
TreeFam:
Gene Tree for AOAH (if available)

Paralogs for AOAH Gene

No data available for Paralogs for AOAH Gene

Variants for AOAH Gene

Sequence variations from dbSNP and Humsavar for AOAH Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs7986 -- 36,513,048(-) CCTTC(C/T)GCTGT reference, missense, utr-variant-3-prime
rs1962101 -- 36,632,099(-) ATATT(A/C)TAGAA missense, reference
rs1962611 -- 36,621,362(-) TCTCC(A/G)TGCAG intron-variant
rs1962612 -- 36,621,004(-) TGGAG(C/G)CTTCT intron-variant
rs1986468 -- 36,530,578(-) TGCCT(A/G)AATTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AOAH Gene

Variant ID Type Subtype PubMed ID
nsv830957 CNV Gain 17160897
esv2676624 CNV Deletion 23128226
esv2613811 CNV Deletion 19546169
nsv366801 CNV Loss 16902084
nsv830958 CNV Gain 17160897
nsv464427 CNV Loss 19166990
nsv5700 CNV Insertion 18451855
esv33783 CNV Gain 17666407
nsv830960 CNV Loss 17160897
nsv470199 CNV Loss 18288195

Relevant External Links for AOAH Gene

HapMap Linkage Disequilibrium report
AOAH
Human Gene Mutation Database (HGMD)
AOAH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AOAH Gene

Disorders for AOAH Gene

Relevant External Links for AOAH

Genetic Association Database (GAD)
AOAH
Human Genome Epidemiology (HuGE) Navigator
AOAH
genes like me logo Genes that share disorders with AOAH: view

No data available for UniProtKB/Swiss-Prot for AOAH Gene

Publications for AOAH Gene

  1. Expression and characterization of recombinant human acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides. (PMID: 1883828) Hagen F.S. … Munford R.S. (Biochemistry 1991) 2 3 4 23
  2. Polymorphisms in the novel gene acyloxyacyl hydroxylase (AOAH) are associated with asthma and associated phenotypes. (PMID: 16815140) Barnes K.C. … Mathias R.A. (J. Allergy Clin. Immunol. 2006) 3 23 48
  3. Intracellular and extracellular enzymatic deacylation of bacterial endotoxin during localized inflammation induced by Escherichia coli. (PMID: 1987068) McDermott C.M. … Fenwick B.W. (Infect. Immun. 1991) 3 23
  4. Chromosomal localization of the acyloxyacyl hydrolase (AOAH) gene to 7p14-p12 using fluorescence in situ hybridization. (PMID: 8088847) Whitmore T.E. … Durnam D.M. (Genomics 1994) 3 23
  5. Adenovirus-mediated transfer of a gene encoding acyloxyacyl hydrolase (AOAH) into mice increases tissue and plasma AOAH activity. (PMID: 8613354) Coulthard M.G. … Meidell R.S. (Infect. Immun. 1996) 3 23

Products for AOAH Gene

Sources for AOAH Gene

Back to Top

Content