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Aliases for MNX1 Gene

Aliases for MNX1 Gene

  • Motor Neuron And Pancreas Homeobox 1 2 3
  • HLXB9 3 4 6
  • Homeobox Protein HB9 3 4
  • Homeobox HB9 2 3
  • HOXHB9 3 6
  • SCRA1 3 6
  • Motor Neuron And Pancreas Homeobox Protein 1 3
  • Homeo Box HB9 2
  • HB9 3

External Ids for MNX1 Gene

Previous HGNC Symbols for MNX1 Gene

  • HLXB9

Previous GeneCards Identifiers for MNX1 Gene

  • GC07M156491
  • GC07M156786
  • GC07M150530

Summaries for MNX1 Gene

Entrez Gene Summary for MNX1 Gene

  • This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for MNX1 Gene

MNX1 (Motor Neuron And Pancreas Homeobox 1) is a Protein Coding gene. Diseases associated with MNX1 include currarino syndrome and currarino triad. Among its related pathways are Regulation of beta-cell development. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is DLX5.

UniProtKB/Swiss-Prot for MNX1 Gene

  • Putative transcription factor involved in pancreas development and function

Gene Wiki entry for MNX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MNX1 Gene

Genomics for MNX1 Gene

Regulatory Elements for MNX1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MNX1 Gene

Start:
156,994,051 bp from pter
End:
157,010,653 bp from pter
Size:
16,603 bases
Orientation:
Minus strand

Genomic View for MNX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MNX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MNX1 Gene

Proteins for MNX1 Gene

  • Protein details for MNX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P50219-MNX1_HUMAN
    Recommended name:
    Motor neuron and pancreas homeobox protein 1
    Protein Accession:
    P50219
    Secondary Accessions:
    • F5H401
    • Q9Y648

    Protein attributes for MNX1 Gene

    Size:
    401 amino acids
    Molecular mass:
    40569 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for MNX1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MNX1 Gene

Proteomics data for MNX1 Gene at MOPED

Post-translational modifications for MNX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for MNX1 Gene

Domains for MNX1 Gene

Gene Families for MNX1 Gene

HGNC:
  • HOXL :Homeoboxes / ANTP class : HOXL subclass

Protein Domains for MNX1 Gene

Suggested Antigen Peptide Sequences for MNX1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P50219

UniProtKB/Swiss-Prot:

MNX1_HUMAN :
  • P50219
Domain:
  • Contains 1 homeobox DNA-binding domain.
genes like me logo Genes that share domains with MNX1: view

Function for MNX1 Gene

Molecular function for MNX1 Gene

UniProtKB/Swiss-Prot Function: Putative transcription factor involved in pancreas development and function

Gene Ontology (GO) - Molecular Function for MNX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 9843207
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with MNX1: view
genes like me logo Genes that share phenotypes with MNX1: view

Animal Models for MNX1 Gene

MGI Knock Outs for MNX1:

Animal Model Products

CRISPR Products

miRNA for MNX1 Gene

miRTarBase miRNAs that target MNX1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for MNX1 Gene

Localization for MNX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MNX1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MNX1 Gene COMPARTMENTS Subcellular localization image for MNX1 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for MNX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with MNX1: view

Pathways for MNX1 Gene

genes like me logo Genes that share pathways with MNX1: view

Pathways by source for MNX1 Gene

1 KEGG pathway for MNX1 Gene

Interacting Proteins for MNX1 Gene

Gene Ontology (GO) - Biological Process for MNX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9843207
GO:0006959 humoral immune response TAS 7914194
GO:0008045 motor neuron axon guidance IEA --
genes like me logo Genes that share ontologies with MNX1: view

Compounds for MNX1 Gene

(2) Novoseek inferred chemical compound relationships for MNX1 Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 20.6 3
alanine 0 2
genes like me logo Genes that share compounds with MNX1: view

Transcripts for MNX1 Gene

mRNA/cDNA for MNX1 Gene

Unigene Clusters for MNX1 Gene

Motor neuron and pancreas homeobox 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MNX1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MNX1 Gene

No ASD Table

Relevant External Links for MNX1 Gene

GeneLoc Exon Structure for
MNX1
ECgene alternative splicing isoforms for
MNX1

Expression for MNX1 Gene

mRNA expression in normal human tissues for MNX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MNX1 Gene

This gene is overexpressed in Pancreas (24.8), Colon - Transverse (6.1), and Small Intestine - Terminal Ileum (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MNX1 Gene

SOURCE GeneReport for Unigene cluster for MNX1 Gene Hs.37035

mRNA Expression by UniProt/SwissProt for MNX1 Gene

P50219-MNX1_HUMAN
Tissue specificity: Expressed in lymphoid and pancreatic tissues
genes like me logo Genes that share expressions with MNX1: view

In Situ Assay Products

Orthologs for MNX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for MNX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MNX1 35
  • 96.73 (n)
  • 96.73 (a)
MNX1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MNX1 35
  • 88.3 (n)
  • 84.8 (a)
MNX1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MNX1 35
  • 86.03 (n)
  • 86.98 (a)
MNX1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mnx1 35
  • 82.33 (n)
  • 86.5 (a)
Mnx1 16
Mnx1 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MNX1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MNX1 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mnx1 35
  • 82.29 (n)
  • 86.47 (a)
chicken
(Gallus gallus)
Aves MNX1 35
  • 84.23 (n)
  • 88.17 (a)
MNX1 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MNX1 36
  • 66 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia hlxb9-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia mnx1 35
  • 73.3 (n)
  • 77.18 (a)
zebrafish
(Danio rerio)
Actinopterygii mnx1 35
  • 66.67 (n)
  • 70.41 (a)
mnx1 36
  • 68 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta exex 36
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToOne
Species with no ortholog for MNX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MNX1 Gene

ENSEMBL:
Gene Tree for MNX1 (if available)
TreeFam:
Gene Tree for MNX1 (if available)

Paralogs for MNX1 Gene

genes like me logo Genes that share paralogs with MNX1: view

Variants for MNX1 Gene

Sequence variations from dbSNP and Humsavar for MNX1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs887607 -- 157,006,010(-) CATTC(C/T)GCTTC intron-variant
rs1047240 -- 157,005,088(-) GGAGC(C/T)GCCAT utr-variant-3-prime
rs2270210 -- 157,006,387(-) CATCT(A/G)GCGCT intron-variant
rs3793333 -- 157,008,329(-) AACCC(A/G)GGGTG intron-variant
rs6951967 -- 157,008,772(+) ACTCA(A/T)AAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MNX1 Gene

Variant ID Type Subtype PubMed ID
nsv889569 CNV Loss 21882294
nsv465249 CNV Loss 19166990
nsv6022 CNV Insertion 18451855
nsv889570 CNV Loss 21882294
dgv1150n67 CNV Gain 20364138
dgv7560n71 CNV Loss 21882294
nsv824418 CNV Gain 20364138

Relevant External Links for MNX1 Gene

HapMap Linkage Disequilibrium report
MNX1
Human Gene Mutation Database (HGMD)
MNX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MNX1 Gene

Disorders for MNX1 Gene

(1) OMIM Diseases for MNX1 Gene (142994)

UniProtKB/Swiss-Prot

MNX1_HUMAN
  • Currarino syndrome (CURRAS) [MIM:176450]: The triad of a presacral tumor, sacral agenesis and anorectal malformation constitutes the Currarino syndrome which is caused by dorsal-ventral patterning defects during embryonic development. The syndrome occurs in the majority of patients as an autosomal dominant trait. {ECO:0000269 PubMed:10631160, ECO:0000269 PubMed:10749657, ECO:0000269 PubMed:19853743, ECO:0000269 PubMed:22820079}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for MNX1 Gene

(11) Novoseek inferred disease relationships for MNX1 Gene

Disease -log(P) Hits PubMed IDs
anorectal anomalies 86.3 3
meningocele 76 1
leukemogenesis 57.6 2
teratoma 54.9 1
chromosome deletion 54.8 1

Relevant External Links for MNX1

Genetic Association Database (GAD)
MNX1
Human Genome Epidemiology (HuGE) Navigator
MNX1
genes like me logo Genes that share disorders with MNX1: view

Publications for MNX1 Gene

  1. A novel human homeobox gene distantly related to proboscipedia is expressed in lymphoid and pancreatic tissues. (PMID: 7914194) Harrison K.A. … Kehrl J.H. (J. Biol. Chem. 1994) 3 4 23
  2. Mutation analysis and embryonic expression of the HLXB9 Currarino syndrome gene. (PMID: 10749657) Hagan D.M. … Lindsay S. (Am. J. Hum. Genet. 2000) 3 4 23
  3. A homeobox gene, HLXB9, is the major locus for dominantly inherited sacral agenesis. (PMID: 9843207) Ross A.J. … Strachan T. (Nat. Genet. 1998) 2 3 23
  4. MNX1 (HLXB9) mutations in Currarino patients. (PMID: 19853743) Garcia-Barcelo M.M. … Tam P.K. (J. Pediatr. Surg. 2009) 3 4 23
  5. Ectopic expression of the HLXB9 gene is associated with an altered nuclear position in t(7;12) leukaemias. (PMID: 19212340) Ballabio E. … Tosi S. (Leukemia 2009) 3 23

Products for MNX1 Gene

Sources for MNX1 Gene

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