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Aliases for HLA-B Gene

Aliases for HLA-B Gene

  • Major Histocompatibility Complex, Class I, B 2 3 5
  • MHC Class I Antigen B*47 3 4
  • MHC Class I Antigen B*50 3 4
  • MHC Class I Antigen B*82 3 4
  • Bw-47 3 4
  • Bw-50 3 4
  • HLAB 3 4
  • HLA Class I Histocompatibility Antigen, B-47 Alpha Chain 3
  • HLA Class I Histocompatibility Antigen, B-50 Alpha Chain 3
  • HLA Class I Histocompatibility Antigen, B-82 Alpha Chain 3
  • HLA Class I Histocompatibility Antigen, B-12 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, B-21 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, B-5 Alpha Chain 4
  • HLA Class I Histocompatibility Antigen, B Alpha Chain 3
  • MHC Class I Antigen HLA-B Heavy Chain 3
  • MHC HLA-B Transmembrane Glycoprotein 3
  • MHC HLA-B Cell Surface Glycoprotein 3
  • Truncated MHC Class I Antigen 3
  • MHC Class I Antigen GN00104 3
  • Leukocyte Antigen Class I-B 3
  • MHC Class I Antigen SHCHA 3
  • MHC Class I Antigen B*13 4
  • MHC Class I Antigen B*14 4
  • MHC Class I Antigen B*15 4
  • MHC Class I Antigen B*18 4
  • MHC Class I Antigen B*27 4
  • MHC Class I Antigen B*35 4
  • MHC Class I Antigen B*37 4
  • MHC Class I Antigen B*38 4
  • MHC Class I Antigen B*39 4
  • MHC Class I Antigen B*40 4
  • MHC Class I Antigen B*41 4
  • MHC Class I Antigen B*42 4
  • MHC Class I Antigen B*44 4
  • MHC Class I Antigen B*45 4
  • MHC Class I Antigen B*46 4
  • MHC Class I Antigen B*48 4
  • MHC Class I Antigen B*49 4
  • MHC Class I Antigen B*51 4
  • MHC Class I Antigen B*52 4
  • MHC Class I Antigen B*53 4
  • MHC Class I Antigen B*54 4
  • MHC Class I Antigen B*55 4
  • MHC Class I Antigen B*56 4
  • MHC Class I Antigen B*57 4
  • MHC Class I Antigen B*58 4
  • MHC Class I Antigen B*59 4
  • MHC Class I Antigen B*67 4
  • MHC Class I Antigen B*73 4
  • MHC Class I Antigen B*78 4
  • MHC Class I Antigen B*81 4
  • MHC Class I Antigen B*7 4
  • MHC Class I Antigen B*8 4
  • Ankylosing Spondylitis 2
  • Lymphocyte Antigen 3
  • SPDA1 3
  • Bw-22 4
  • Bw-41 4
  • Bw-44 4
  • Bw-45 4
  • Bw-46 4
  • Bw-48 4
  • Bw-52 4
  • Bw-53 4
  • Bw-54 4
  • Bw-55 4
  • Bw-56 4
  • Bw-57 4
  • Bw-58 4
  • Bw-60 4
  • Bw-4 4
  • BDT 4
  • AS 3

External Ids for HLA-B Gene

Previous HGNC Symbols for HLA-B Gene

  • AS

Previous GeneCards Identifiers for HLA-B Gene

  • GC06M031376
  • GC06M031426
  • GC06M031342
  • GC06M031429
  • GC06M031345
  • GC06M031321
  • GC06M031112

Summaries for HLA-B Gene

Entrez Gene Summary for HLA-B Gene

  • HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for HLA-B Gene

HLA-B (Major Histocompatibility Complex, Class I, B) is a Protein Coding gene. Diseases associated with HLA-B include hypersensitivity syndrome, carbamazepine-induced and spondyloarthropathy 1. Among its related pathways are Immune System and Interferon gamma signaling. GO annotations related to this gene include receptor binding and peptide antigen binding. An important paralog of this gene is MR1.

Gene Wiki entry for HLA-B Gene

PharmGKB "VIP" Summary for HLA-B Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for HLA-B Gene

Genomics for HLA-B Gene

Regulatory Elements for HLA-B Gene

Promoters for HLA-B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HLA-B on UCSC Golden Path with GeneCards custom track

Genomic Location for HLA-B Gene

Chromosome:
6
Start:
31,353,868 bp from pter
End:
31,357,212 bp from pter
Size:
3,345 bases
Orientation:
Minus strand

Genomic View for HLA-B Gene

Genes around HLA-B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HLA-B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HLA-B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for HLA-B Gene

  • Protein details for HLA-B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01889-1B07_HUMAN
    Recommended name:
    HLA class I histocompatibility antigen, B-7 alpha chain
    Protein Accession:
    P01889
    Secondary Accessions:
    • Q29638
    • Q29681
    • Q29854
    • Q29861
    • Q31613
    • Q5SRJ2
    • Q9GIX1
    • Q9TP95

    Protein attributes for HLA-B Gene

    Size:
    362 amino acids
    Molecular mass:
    40460 Da
    Quaternary structure:
    • Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin). Interacts with human herpesvirus 8 MIR1 protein (By similarity). Interacts with HTLV-1 accessory protein p12I.

    Three dimensional structures from OCA and Proteopedia for HLA-B Gene

neXtProt entry for HLA-B Gene

Proteomics data for HLA-B Gene at MOPED

Other Protein References for HLA-B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for HLA-B Gene

Domains & Families for HLA-B Gene

Graphical View of Domain Structure for InterPro Entry

P01889

UniProtKB/Swiss-Prot:

1B38_HUMAN :
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
  • Belongs to the MHC class I family.
Domain:
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with HLA-B: view

Function for HLA-B Gene

Gene Ontology (GO) - Molecular Function for HLA-B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IPI 8046333
GO:0042605 peptide antigen binding IEA,ISS --
genes like me logo Genes that share ontologies with HLA-B: view
genes like me logo Genes that share phenotypes with HLA-B: view

Human Phenotype Ontology for HLA-B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for HLA-B

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HLA-B Gene

Localization for HLA-B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HLA-B Gene COMPARTMENTS Subcellular localization image for HLA-B gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
golgi apparatus 5
plasma membrane 5
endosome 4
cytoskeleton 2
cytosol 2
lysosome 2
nucleus 2
vacuole 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for HLA-B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009986 cell surface ISS --
genes like me logo Genes that share ontologies with HLA-B: view

Pathways & Interactions for HLA-B Gene

genes like me logo Genes that share pathways with HLA-B: view

Gene Ontology (GO) - Biological Process for HLA-B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001916 positive regulation of T cell mediated cytotoxicity IDA 2420472
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I IEA,TAS --
GO:0006952 defense response TAS 3011411
GO:0016032 viral process IEA --
GO:0019882 antigen processing and presentation IEA,IBA --
genes like me logo Genes that share ontologies with HLA-B: view

No data available for SIGNOR curated interactions for HLA-B Gene

Drugs & Compounds for HLA-B Gene

(50) Drugs for HLA-B Gene - From: Novoseek, PharmGKB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carbamazepine Approved, Investigational Pharma 118
Abacavir Approved, Investigational Pharma 203
Acetazolamide Approved Pharma 67
Allopurinol Approved Pharma 129
Carbimazole Approved Pharma 2

(47) Additional Compounds for HLA-B Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Glycerylphosphorylethanolamine
  • 2-Aminoethyl ester 1-Glycerophosphoric acid
  • a-Glycerophosphorylethanolamine
  • alpha-Glycerophosphorylethanolamine
  • Glycerol 3-phosphoethanolamine
  • Glycerol 3-phosphorylethanolamine
1190-00-7
genes like me logo Genes that share compounds with HLA-B: view

Transcripts for HLA-B Gene

Unigene Clusters for HLA-B Gene

Major histocompatibility complex, class I, B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HLA-B Gene

No ASD Table

Relevant External Links for HLA-B Gene

GeneLoc Exon Structure for
HLA-B
ECgene alternative splicing isoforms for
HLA-B

Expression for HLA-B Gene

mRNA expression in normal human tissues for HLA-B Gene

mRNA differential expression in normal tissues according to GTEx for HLA-B Gene

This gene is overexpressed in Whole Blood (x15.6).

Protein differential expression in normal tissues from HIPED for HLA-B Gene

This gene is overexpressed in Amniocyte (36.4) and Oral epithelium (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HLA-B Gene



SOURCE GeneReport for Unigene cluster for HLA-B Gene Hs.77961

genes like me logo Genes that share expression patterns with HLA-B: view

Protein tissue co-expression partners for HLA-B Gene

- Elite partner

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for HLA-B Gene

Orthologs for HLA-B Gene

This gene was present in the common ancestor of chordates.

Orthologs for HLA-B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BOLA-A 35
  • 82.96 (n)
  • 76.12 (a)
dog
(Canis familiaris)
Mammalia DLA88 35
  • 82.59 (n)
  • 76.26 (a)
chimpanzee
(Pan troglodytes)
Mammalia PATR-B 35
  • 96.13 (n)
  • 93.09 (a)
PATR-B 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100217322 35
  • 52.61 (n)
  • 42.16 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC796419 35
  • 44.14 (n)
  • 34.36 (a)
Species with no ortholog for HLA-B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HLA-B Gene

ENSEMBL:
Gene Tree for HLA-B (if available)
TreeFam:
Gene Tree for HLA-B (if available)

Paralogs for HLA-B Gene

Paralogs for HLA-B Gene

(147) SIMAP similar genes for HLA-B Gene using alignment to 6308 proteins: