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Aliases for HK3 Gene

Aliases for HK3 Gene

  • Hexokinase 3 2 3
  • Hexokinase 3 (White Cell) 2 3 5
  • Hexokinase Type III 3 4
  • EC 4 63
  • HK III 3 4
  • ATP:D-Hexose 6-Phosphotransferase 3
  • EC 2.7.1 63
  • HKIII 3
  • HXK3 3

External Ids for HK3 Gene

Previous GeneCards Identifiers for HK3 Gene

  • GC05M176681
  • GC05M177150
  • GC05M176243
  • GC05M176288
  • GC05M176240
  • GC05M171230

Summaries for HK3 Gene

Entrez Gene Summary for HK3 Gene

  • Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009]

GeneCards Summary for HK3 Gene

HK3 (Hexokinase 3) is a Protein Coding gene. Among its related pathways are Glycosaminoglycan metabolism and Glucose metabolism. GO annotations related to this gene include enzyme binding and phosphotransferase activity, alcohol group as acceptor. An important paralog of this gene is HK2.

Gene Wiki entry for HK3 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HK3 Gene

Genomics for HK3 Gene

Regulatory Elements for HK3 Gene

Enhancers for HK3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HK3 on UCSC Golden Path with GeneCards custom track

Promoters for HK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HK3 on UCSC Golden Path with GeneCards custom track

Genomic Location for HK3 Gene

176,880,869 bp from pter
176,899,373 bp from pter
18,505 bases
Minus strand

Genomic View for HK3 Gene

Genes around HK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HK3 Gene

Proteins for HK3 Gene

  • Protein details for HK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q8N1E7

    Protein attributes for HK3 Gene

    923 amino acids
    Molecular mass:
    99025 Da
    Quaternary structure:
    • Monomer.
    • In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase).

    Three dimensional structures from OCA and Proteopedia for HK3 Gene

neXtProt entry for HK3 Gene

Proteomics data for HK3 Gene at MOPED

Post-translational modifications for HK3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HK3 Gene

Antibody Products

Domains & Families for HK3 Gene

Protein Domains for HK3 Gene

Suggested Antigen Peptide Sequences for HK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus.
  • Belongs to the hexokinase family.
  • The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus.
  • Contains 2 hexokinase domains.
  • Belongs to the hexokinase family.
genes like me logo Genes that share domains with HK3: view

No data available for Gene Families for HK3 Gene

Function for HK3 Gene

Molecular function for HK3 Gene

GENATLAS Biochemistry:
hexokinase 3,108kDa,expressed in liver,lung,spleen,glycolysis,gluconeogenesis,energy pathways
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + D-hexose = ADP + D-hexose 6-phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P.

Enzyme Numbers (IUBMB) for HK3 Gene

Gene Ontology (GO) - Molecular Function for HK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004340 glucokinase activity IBA,TAS --
GO:0004396 hexokinase activity IEA,IDA 8717435
GO:0008865 fructokinase activity IBA --
genes like me logo Genes that share ontologies with HK3: view
genes like me logo Genes that share phenotypes with HK3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for HK3

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for HK3 Gene

Localization for HK3 Gene

Subcellular locations from

Jensen Localization Image for HK3 Gene COMPARTMENTS Subcellular localization image for HK3 gene
Compartment Confidence
cytosol 5
mitochondrion 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HK3 Gene

Pathways & Interactions for HK3 Gene

genes like me logo Genes that share pathways with HK3: view

UniProtKB/Swiss-Prot P52790-HXK3_HUMAN

  • Pathway: Carbohydrate metabolism; hexose metabolism.

Gene Ontology (GO) - Biological Process for HK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001678 cellular glucose homeostasis IBA --
GO:0006006 glucose metabolic process TAS --
GO:0006096 glycolytic process IEA,IBA --
GO:0008645 hexose transport TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with HK3: view

No data available for SIGNOR curated interactions for HK3 Gene

Drugs & Compounds for HK3 Gene

(9) Drugs for HK3 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Glucosamine Approved Nutra 158
Beta-D-Glucose Experimental Pharma 0
Deoxyadenosine triphosphate Experimental Pharma 0
glucosamine 6-phosphate Experimental Pharma 0

(13) Additional Compounds for HK3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
  • a-D-Glucopyranose
  • a-D-Glucose
  • a-Dextrose
  • a-Glucose
  • alpha-D-Glucopyranose
Beta-D-Fructose 6-phosphate
  • beta-D-Fructose 6-phosphate
Beta-D-Glucose 6-phosphate
  • beta-D-Glucose 6-(dihydrogen phosphate)
  • beta-D-Glucose 6-phosphate
  • 2'-Deoxyadenosine-5'-diphosphate
  • dADP
  • Deoxyadenosine diphosphate

(1) ApexBio Compounds for HK3 Gene

Compound Action Cas Number
Lonidamine 50264-69-2
genes like me logo Genes that share compounds with HK3: view

Transcripts for HK3 Gene

Unigene Clusters for HK3 Gene

Hexokinase 3 (white cell):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HK3 Gene

No ASD Table

Relevant External Links for HK3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HK3 Gene

mRNA expression in normal human tissues for HK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HK3 Gene

This gene is overexpressed in Whole Blood (x38.4) and Spleen (x5.8).

Protein differential expression in normal tissues from HIPED for HK3 Gene

This gene is overexpressed in Neutrophil (15.2), Peripheral blood mononuclear cells (11.4), Monocytes (7.9), and Cervix (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HK3 Gene

SOURCE GeneReport for Unigene cluster for HK3 Gene Hs.411695

genes like me logo Genes that share expression patterns with HK3: view

Protein tissue co-expression partners for HK3 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for HK3 Gene

Orthologs for HK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for HK3 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia HK3 35
  • 88.01 (n)
  • 90.14 (a)
HK3 36
  • 86 (a)
(Mus musculus)
Mammalia Hk3 35
  • 84.08 (n)
  • 85.67 (a)
Hk3 16
Hk3 36
  • 85 (a)
(Pan troglodytes)
Mammalia HK3 35
  • 99.24 (n)
  • 99.24 (a)
HK3 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Hk3 35
  • 83.8 (n)
  • 85.54 (a)
(Bos Taurus)
Mammalia HK3 36
  • 91 (a)
(Monodelphis domestica)
Mammalia HK3 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia HK3 36
  • 56 (a)
(Gallus gallus)
Aves HK3 35
  • 63.07 (n)
  • 56.07 (a)
HK3 36
  • 53 (a)
(Anolis carolinensis)
Reptilia HK3 36
  • 54 (a)
fruit fly
(Drosophila melanogaster)
Insecta Hex-A 37
  • 47 (a)
Hex-C 37
  • 41 (a)
Hex-t1 37
  • 31 (a)
Hex-t2 37
  • 42 (a)
Hex-A 36
  • 35 (a)
Hex-C 36
  • 37 (a)
Hex-t2 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea F14B4.2 37
  • 46 (a)
H25P06.1 37
  • 41 (a)
Y77E11A.1 37
  • 36 (a)
F14B4.2 36
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes EMI2 36
  • 29 (a)
GLK1 36
  • 29 (a)
HXK1 36
  • 28 (a)
HXK2 36
  • 27 (a)
HXK1 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11095 36
  • 40 (a)
Species with no ortholog for HK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for HK3 Gene

Gene Tree for HK3 (if available)
Gene Tree for HK3 (if available)

Paralogs for HK3 Gene

Paralogs for HK3 Gene

(5) SIMAP similar genes for HK3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with HK3: view

Variants for HK3 Gene

Sequence variations from dbSNP and Humsavar for HK3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs35610191 - 176,889,454(-) ATGAT(A/G)GGGCG nc-transcript-variant, reference, missense
VAR_036186 A colorectal cancer sample
VAR_036187 A breast cancer sample
rs812246 -- 176,900,643(-) CTCCA(C/T)TGGCC upstream-variant-2KB
rs6861925 -- 176,897,728(+) TTTCT(C/G)TTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HK3 Gene

Variant ID Type Subtype PubMed ID
dgv6376n71 CNV Loss 21882294
dgv6377n71 CNV Loss 21882294
dgv6378n71 CNV Loss 21882294
dgv732n27 CNV Loss 19166990
nsv883155 CNV Loss 21882294
nsv462562 CNV Loss 19166990
dgv362n21 CNV Loss 19592680
nsv519416 CNV Gain 19592680
esv270879 CNV Insertion 20981092
esv273198 CNV Insertion 20981092

Variation tolerance for HK3 Gene

Residual Variation Intolerance Score: 80.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.19; 69.72% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for HK3 Gene

Disorders for HK3 Gene

Relevant External Links for HK3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for HK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for HK3 Gene

Publications for HK3 Gene

  1. Sequence of human hexokinase III cDNA and assignment of the human hexokinase III gene (HK3) to chromosome band 5q35.2 by fluorescence in situ hybridization. (PMID: 8812439) Furuta H. … Bell G.I. (Genomics 1996) 2 3 4 23 67
  2. Hexokinase III, cyclin A and galectin-3 are overexpressed in malignant follicular thyroid nodules. (PMID: 17868400) Hooft L. … van Diest P.J. (Clin. Endocrinol. (Oxf) 2008) 3 23
  3. Hexokinase isoenzymes in normal and cirrhotic human liver: suppression of glucokinase in cirrhosis. (PMID: 9468341) Lowes W. … Agius L. (Biochim. Biophys. Acta 1998) 3 23
  4. Purification and characterization of the carboxyl-domain of human hexokinase type III expressed as fusion protein. (PMID: 8717435) Palma F. … Stocchi V. (Mol. Cell. Biochem. 1996) 3 23
  5. Assignment of the hexokinase type 3 gene (HK3) to human chromosome band 5q35.3 by somatic cell hybrids and in situ hybridization. (PMID: 8941369) Colosimo A. … Dallapiccola B. (Cytogenet. Cell Genet. 1996) 3 23

Products for HK3 Gene

Sources for HK3 Gene