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Aliases for HIF1A Gene

Aliases for HIF1A Gene

  • Hypoxia Inducible Factor 1, Alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) 2 3
  • MOP1 3 4 6
  • Class E Basic Helix-Loop-Helix Protein 78 3 4
  • Basic-Helix-Loop-Helix-PAS Protein MOP1 3 4
  • PAS Domain-Containing Protein 8 3 4
  • ARNT-Interacting Protein 3 4
  • Member Of PAS Protein 1 3 4
  • HIF-1-Alpha 3 4
  • HIF1-ALPHA 3 4
  • BHLHe78 3 4
  • PASD8 3 4
  • Hypoxia-Inducible Factor 1, Alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) 3
  • Hypoxia-Inducible Factor 1 Alpha Isoform I.3 3
  • Hypoxia-Inducible Factor 1-Alpha 3
  • Hypoxia-Inducible Factor1alpha 3
  • Member Of PAS Superfamily 1 3
  • ARNT Interacting Protein 3
  • HIF-1alpha 3
  • HIF-1A 3
  • HIF1 3

External Ids for HIF1A Gene

Previous GeneCards Identifiers for HIF1A Gene

  • GC14P059488
  • GC14P055956
  • GC14P060152
  • GC14P061231
  • GC14P062162
  • GC14P042326

Summaries for HIF1A Gene

Entrez Gene Summary for HIF1A Gene

  • This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]

GeneCards Summary for HIF1A Gene

HIF1A (Hypoxia Inducible Factor 1, Alpha Subunit (Basic Helix-Loop-Helix Transcription Factor)) is a Protein Coding gene. Diseases associated with HIF1A include breast fibroadenoma and supraglottic laryngeal cancer. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is AHRR.

UniProtKB/Swiss-Prot for HIF1A Gene

  • Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5-[AG]CGTG-3 within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.

Tocris Summary for HIF1A Gene

  • Hypoxia Inducible Factors (HIFs) are transcription factors that are activated in response to decreased oxygen availability in the cellular environment. They influence cell metabolism, cell survival and angiogenesis to maintain biological homeostasis. The HIF family is made up of alpha subunits (HIF-1, HIF-2 and HIF-3) and a constitutively expressed beta subunit (ARNT; also known as Aryl hydrocarbon Receptor Nuclear Translocator)

Gene Wiki entry for HIF1A Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HIF1A Gene

Genomics for HIF1A Gene

Regulatory Elements for HIF1A Gene

Transcription factor binding sites by QIAGEN in the HIF1A gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for HIF1A Gene

Start:
61,695,401 bp from pter
End:
61,748,259 bp from pter
Size:
52,859 bases
Orientation:
Plus strand

Genomic View for HIF1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HIF1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HIF1A Gene

Proteins for HIF1A Gene

  • Protein details for HIF1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16665-HIF1A_HUMAN
    Recommended name:
    Hypoxia-inducible factor 1-alpha
    Protein Accession:
    Q16665
    Secondary Accessions:
    • C0LZJ3
    • Q53XP6
    • Q96PT9
    • Q9UPB1

    Protein attributes for HIF1A Gene

    Size:
    826 amino acids
    Molecular mass:
    92670 Da
    Quaternary structure:
    • Interacts with the HIF1A beta/ARNT subunit; heterodimerization is required for DNA binding. Interacts with COPS5; the interaction increases the transcriptional activity of HIF1A through increased stability (By similarity). Interacts with EP300 (via TAZ-type 1 domains); the interaction is stimulated in response to hypoxia and inhibited by CITED2. Interacts with CREBBP (via TAZ-type 1 domains). Interacts with NCOA1, NCOA2, APEX and HSP90. Interacts (hydroxylated within the ODD domain) with VHLL (via beta domain); the interaction, leads to polyubiquitination and subsequent HIF1A proteasomal degradation. During hypoxia, sumoylated HIF1A also binds VHL; the interaction promotes the ubiquitination of HIF1A. Interacts with SENP1; the interaction desumoylates HIF1A resulting in stabilization and activation of transcription. Interacts (Via the ODD domain) with ARD1A; the interaction appears not to acetylate HIF1A nor have any affect on protein stability, during hypoxia. Interacts with RWDD3; the interaction enhances HIF1A sumoylation. Interacts with TSGA10 (By similarity). Interacts with HIF3A (By similarity). Interacts with RORA (via the DNA binding domain); the interaction enhances HIF1A transcription under hypoxia through increasing protein stability. Interaction with PSMA7 inhibits the transactivation activity of HIF1A under both normoxic and hypoxia-mimicking conditions. Interacts with USP20. Interacts with GNB2L1/RACK1; promotes HIF1A ubiquitination and proteasome-mediated degradation. Interacts (via N-terminus) with USP19. Interacts with SIRT2. Interacts (deacetylated form) with EGLN1.

    Three dimensional structures from OCA and Proteopedia for HIF1A Gene

    Alternative splice isoforms for HIF1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HIF1A Gene

Proteomics data for HIF1A Gene at MOPED

Post-translational modifications for HIF1A Gene

  • Acetylation of Lys-532 by ARD1 increases interaction with VHL and stimulates subsequent proteasomal degradation. Deacetylation of Lys-709 by SIRT2 increases its interaction with and hydroxylation by EGLN1 thereby inactivating HIF1A activity by inducing its proteasomal degradation.
  • In normoxia, is hydroxylated on Asn-803 by HIF1AN, thus abrogating interaction with CREBBP and EP300 and preventing transcriptional activation. This hydroxylation is inhibited by the Cu/Zn-chelator, Clioquinol.
  • In normoxia, is hydroxylated on Pro-402 and Pro-564 in the oxygen-dependent degradation domain (ODD) by EGLN1/PHD1 and EGLN2/PHD2. EGLN3/PHD3 has also been shown to hydroxylate Pro-564. The hydroxylated prolines promote interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation. Deubiquitinated by USP20. Under hypoxia, proline hydroxylation is impaired and ubiquitination is attenuated, resulting in stabilization.
  • Polyubiquitinated; in normoxia, following hydroxylation and interaction with VHL. Lys-532 appears to be the principal site of ubiquitination. Clioquinol, the Cu/Zn-chelator, inhibits ubiquitination through preventing hydroxylation at Asn-803. Ubiquitinated by a CUL2-based E3 ligase.
  • Requires phosphorylation for DNA-binding. Phosphorylation at Ser-247 by CSNK1D/CK1 represses kinase activity and impairs ARNT binding. Phosphorylation by GSK3-beta and PLK3 promote degradation by the proteasome.
  • S-nitrosylation of Cys-800 may be responsible for increased recruitment of p300 coactivator necessary for transcriptional activity of HIF-1 complex.
  • Sumoylated; with SUMO1 under hypoxia. Sumoylation is enhanced through interaction with RWDD3. Both sumoylation and desumoylation seem to be involved in the regulation of its stability during hypoxia. Sumoylation can promote either its stabilization or its VHL-dependent degradation by promoting hydroxyproline-independent HIF1A-VHL complex binding, thus leading to HIF1A ubiquitination and proteasomal degradation. Desumoylation by SENP1 increases its stability amd transcriptional activity. There is a disaccord between various publications on the effect of sumoylation and desumoylation on its stability and transcriptional activity.
  • The iron and 2-oxoglutarate dependent 3-hydroxylation of asparagine is (S) stereospecific within HIF CTAD domains
  • Ubiquitination at Lys185, Lys251, Lys297, Lys377, Lys532, Lys538, Lys547, and Lys709
  • Modification sites at PhosphoSitePlus

Other Protein References for HIF1A Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for HIF1A (HIF1A)

No data available for DME Specific Peptides for HIF1A Gene

Domains for HIF1A Gene

Gene Families for HIF1A Gene

HGNC:
  • bHLH :Basic helix-loop-helix proteins

Graphical View of Domain Structure for InterPro Entry

Q16665

UniProtKB/Swiss-Prot:

HIF1A_HUMAN :
  • Q16665
Domain:
  • Contains two independent C-terminal transactivation domains, NTAD and CTAD, which function synergistically. Their transcriptional activity is repressed by an intervening inhibitory domain (ID)
  • Contains 1 bHLH (basic helix-loop-helix) domain.
  • Contains 1 PAC (PAS-associated C-terminal) domain.
  • Contains 2 PAS (PER-ARNT-SIM) domains.
genes like me logo Genes that share domains with HIF1A: view

Function for HIF1A Gene

Molecular function for HIF1A Gene

GENATLAS Biochemistry: hypoxia-inducible factor 1,alpha subunit,complexing with HIF2A and HIF2B (ANRT) for activation of genes involved in metabolism,angiogenesis,erythropoiesis and glycolysis through the recruitement of the CBP/p300 co-activator,rapidly degraded by proteasome under normoxic conditions,binding to VHL,involved (essential) in cardiovascular development and systemic 02 homeostasis
UniProtKB/Swiss-Prot Function: Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5-[AG]CGTG-3 within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.
UniProtKB/Swiss-Prot Induction: Under reduced oxygen tension. Induced also by various receptor-mediated factors such as growth factors, cytokines, and circulatory factors such as PDGF, EGF, FGF2, IGF2, TGFB1, HGF, TNF, IL1B/interleukin-1 beta, angiotensin-2 and thrombin. However, this induction is less intense than that stimulated by hypoxia. Repressed by HIPK2 and LIMD1.

Gene Ontology (GO) - Molecular Function for HIF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000989 transcription factor binding transcription factor activity IDA 22735262
GO:0001076 RNA polymerase II transcription factor binding transcription factor activity IEA --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 15261140
genes like me logo Genes that share ontologies with HIF1A: view
genes like me logo Genes that share phenotypes with HIF1A: view

Animal Models for HIF1A Gene

MGI Knock Outs for HIF1A:

Animal Model Products

CRISPR Products

Targeting motifs for HIF1A Gene
HOMER Transcription Factor Regulatory Elements motif HIF1A
  • Consensus sequence: TACGTGCV Submotif: canonical Cell Type: MCF7 GeoId: GSE28352

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for HIF1A Gene

Localization for HIF1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for HIF1A Gene

Cytoplasm. Nucleus. Nucleus speckle. Note=Colocalizes with HIF3A in the nucleus and speckles (By similarity). Cytoplasmic in normoxia, nuclear translocation in response to hypoxia. Colocalizes with SUMO1 in the nucleus, under hypoxia. {ECO:0000250 UniProtKB:Q61221}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HIF1A Gene COMPARTMENTS Subcellular localization image for HIF1A gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for HIF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IPI 9576906
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with HIF1A: view

Pathways for HIF1A Gene

genes like me logo Genes that share pathways with HIF1A: view

PCR Array Products

Gene Ontology (GO) - Biological Process for HIF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001568 blood vessel development --
GO:0001666 response to hypoxia IMP 12411310
GO:0001755 neural crest cell migration IEA --
GO:0001837 epithelial to mesenchymal transition ISS 18037992
genes like me logo Genes that share ontologies with HIF1A: view

Compounds for HIF1A Gene

Compound Products

(7) ApexBio Compounds for HIF1A Gene

Compound Action Cas Number
Chetomin inhibits interaction of HIF-1alpha, HIF-2alpha and STAT2 [1403-36-7]
DMOG inhibits HIF-alpha prolyl hydroxylase (HIF-PH). [89464-63-1]
FG-4592 (ASP1517) a potent small molecule inhibitor of HIF-PH [808118-40-3]
IOX2(Glycine) potent inhibitor of HIF-1alfa prolyll hydroxylase-2 (PHD2) [931398-72-0]
KC7F2 Inhibitor of HIF-1alpha. [927822-86-4]
ML 228 HIF pathway activator [1357171-62-0]
PX 12 attenuates expression of HIF-1alpha, VEGF and iNOS [141400-58-0]

(3) Tocris Compounds for HIF1A Gene

Compound Action Cas Number
DMOG Prolyl hydroxylase inhibitor [89464-63-1]
KC7F2 HIF-1alpha inhibitor; down-regulates HIF-1alpha protein synthesis [927822-86-4]
ML 228 HIF pathway activator [1357171-62-0]

(1) Drugbank Compounds for HIF1A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE
target

(132) Novoseek inferred chemical compound relationships for HIF1A Gene

Compound -log(P) Hits PubMed IDs
vegf 92.5 555
cobalt chloride 84.7 32
cocl2 79 50
oxygen 78.4 172
pimonidazole 74.4 17

(1) PharmGKB related drug/compound annotations for HIF1A Gene

Drug/compound Annotation
everolimus
genes like me logo Genes that share compounds with HIF1A: view

Transcripts for HIF1A Gene

mRNA/cDNA for HIF1A Gene

(21) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HIF1A Gene

Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor):
Representative Sequences:

CRISPR Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HIF1A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: -
SP2: -
SP3: - -
SP4:

Relevant External Links for HIF1A Gene

GeneLoc Exon Structure for
HIF1A
ECgene alternative splicing isoforms for
HIF1A

Expression for HIF1A Gene

mRNA expression in normal human tissues for HIF1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for HIF1A Gene Hs.597216

mRNA Expression by UniProt/SwissProt for HIF1A Gene

Q16665-HIF1A_HUMAN
Tissue specificity: Expressed in most tissues with highest levels in kidney and heart. Overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumor suppressors. A higher level expression seen in pituitary tumors as compared to the pituitary gland.
genes like me logo Genes that share expressions with HIF1A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein expression for HIF1A Gene

Orthologs for HIF1A Gene

This gene was present in the common ancestor of animals.

Orthologs for HIF1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HIF1A 35
  • 99.92 (n)
  • 99.88 (a)
HIF1A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HIF1A 35
  • 94.21 (n)
  • 95.63 (a)
HIF1A 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HIF1A 35
  • 94.29 (n)
  • 95.87 (a)
HIF1A 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hif1a 35
  • 88.79 (n)
  • 90.38 (a)
Hif1a 16
Hif1a 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HIF1A 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HIF1A 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hif1a 35
  • 88.63 (n)
  • 90.74 (a)
chicken
(Gallus gallus)
Aves HIF1A 35
  • 79.2 (n)
  • 79.65 (a)
HIF1A 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HIF1A 36
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia hif1a-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10694 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8039 35
zebrafish
(Danio rerio)
Actinopterygii hif1ab 35
  • 67.87 (n)
  • 72.91 (a)
hif1ab 36
  • 61 (a)
OneToOne
zgc55405 35
fruit fly
(Drosophila melanogaster)
Insecta sima 36
  • 16 (a)
OneToMany
sima 37
  • 41 (a)
worm
(Caenorhabditis elegans)
Secernentea hif-1 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for HIF1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HIF1A Gene

ENSEMBL:
Gene Tree for HIF1A (if available)
TreeFam:
Gene Tree for HIF1A (if available)

Paralogs for HIF1A Gene

Paralogs for HIF1A Gene

Selected SIMAP similar genes for HIF1A Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for HIF1A Gene

genes like me logo Genes that share paralogs with HIF1A: view

Variants for HIF1A Gene

Sequence variations from dbSNP and Humsavar for HIF1A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs962962 -- 61,718,281(+) GCCTG(A/G)AATGA intron-variant
rs966824 -- 61,733,800(+) TATTG(C/T)GGCAC intron-variant
rs1040995 -- 61,698,292(+) agcat(A/G)tggtg intron-variant
rs1555584 -- 61,740,088(+) TTTGA(C/G)ATGGA intron-variant
rs1555585 -- 61,740,129(+) TGGCA(A/C/T)GATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HIF1A Gene

Variant ID Type Subtype PubMed ID
nsv902008 CNV Loss 21882294
nsv1300 CNV Loss 18451855

Relevant External Links for HIF1A Gene

HapMap Linkage Disequilibrium report
HIF1A
Human Gene Mutation Database (HGMD)
HIF1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HIF1A Gene

Disorders for HIF1A Gene

(3) University of Copenhagen DISEASES for HIF1A Gene

(97) Novoseek inferred disease relationships for HIF1A Gene

Disease -log(P) Hits PubMed IDs
tumors 76.9 332
cancer 70.5 172
solid tumor 68.7 30
renal clear cell carcinoma 68.5 23
carcinoma renal cell 64.5 60

Relevant External Links for HIF1A

Genetic Association Database (GAD)
HIF1A
Human Genome Epidemiology (HuGE) Navigator
HIF1A
genes like me logo Genes that share disorders with HIF1A: view

No data available for UniProtKB/Swiss-Prot for HIF1A Gene

Publications for HIF1A Gene

  1. Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension. (PMID: 9235919) Jiang B.H. … Semenza G.L. (J. Biol. Chem. 1997) 3 4 23
  2. Redox-regulated recruitment of the transcriptional coactivators CREB- binding protein and SRC-1 to hypoxia-inducible factor 1alpha. (PMID: 10594042) Carrero P. … Poellinger L. (Mol. Cell. Biol. 2000) 3 4 23
  3. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. (PMID: 10944113) Tanimoto K. … Poellinger L. (EMBO J. 2000) 3 4 23
  4. Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha. (PMID: 11959990) Freedman S.J. … Eck M.J. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4 23
  5. Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha. (PMID: 12446723) Elkins J.M. … Schofield C.J. (J. Biol. Chem. 2003) 3 4 23

Products for HIF1A Gene

  • Addgene plasmids for HIF1A

Sources for HIF1A Gene

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