Aliases for HIF1A Gene
- Hypoxia Inducible Factor 1, Alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) 2 3
- MOP1 3 4 6
- Class E Basic Helix-Loop-Helix Protein 78 3 4
- Basic-Helix-Loop-Helix-PAS Protein MOP1 3 4
- PAS Domain-Containing Protein 8 3 4
- ARNT-Interacting Protein 3 4
- Member Of PAS Protein 1 3 4
- HIF-1-Alpha 3 4
- HIF1-ALPHA 3 4
- BHLHe78 3 4
- PASD8 3 4
External Ids for HIF1A Gene
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]
GeneCards Summary for HIF1A Gene
HIF1A (Hypoxia Inducible Factor 1, Alpha Subunit (Basic Helix-Loop-Helix Transcription Factor)) is a Protein Coding gene. Diseases associated with HIF1A include supraglottic laryngeal cancer and breast fibroadenoma. Among its related pathways are Signaling by GPCR and Proteoglycans in cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is AHRR.
UniProtKB/Swiss-Prot for HIF1A Gene
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5-[AG]CGTG-3 within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP300. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.
Hypoxia Inducible Factors (HIFs) are transcription factors that are activated in response to decreased oxygen availability in the cellular environment. They influence cell metabolism, cell survival and angiogenesis to maintain biological homeostasis. The HIF family is made up of alpha subunits (HIF-1, HIF-2 and HIF-3) and a constitutively expressed beta subunit (ARNT; also known as Aryl hydrocarbon Receptor Nuclear Translocator).