Aliases for EHD2 Gene
External Ids for EHD2 Gene
Previous HGNC Symbols for EHD2 Gene
Previous GeneCards Identifiers for EHD2 Gene
This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway. [provided by RefSeq, Jul 2008]
GeneCards Summary for EHD2 Gene
EHD2 (EH Domain Containing 2) is a Protein Coding gene. Among its related pathways are Angiopoietin Like Protein 8 Regulatory Pathway and Endocytosis. GO annotations related to this gene include nucleic acid binding and GTP binding. An important paralog of this gene is EHD3.
UniProtKB/Swiss-Prot for EHD2 Gene
ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (By similarity). Plays a role in membrane trafficking between the plasma membrane and endosomes (PubMed:17233914). Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane (By similarity).