Free for academic non-profit institutions. Other users need a Commercial license

Aliases for EHD4 Gene

Aliases for EHD4 Gene

  • EH-Domain Containing 4 2 3
  • Hepatocellular Carcinoma-Associated Protein 10/11 3 4
  • PAST Homolog 4 3 4
  • PAST4 3 4
  • Hepatocellular Carcinoma-Associated Protein HCA11 3
  • EH Domain-Containing Protein 4 3
  • Ortholog Of Rat Pincher 3
  • EH Domain Containing 4 3
  • HCA10 4
  • HCA11 4

External Ids for EHD4 Gene

Previous HGNC Symbols for EHD4 Gene

  • PAST4

Previous GeneCards Identifiers for EHD4 Gene

  • GC15M037559
  • GC15M035087
  • GC15M039770
  • GC15M039907
  • GC15M039978
  • GC15M042190
  • GC15M019040

Summaries for EHD4 Gene

GeneCards Summary for EHD4 Gene

EHD4 (EH-Domain Containing 4) is a Protein Coding gene. Diseases associated with EHD4 include hepatocellular carcinoma. Among its related pathways are Endocytosis and Trk receptor signaling mediated by the MAPK pathway. GO annotations related to this gene include calcium ion binding and nucleic acid binding. An important paralog of this gene is EHD1.

UniProtKB/Swiss-Prot for EHD4 Gene

  • Plays a role in early endosomal transport.

Gene Wiki entry for EHD4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EHD4 Gene

Genomics for EHD4 Gene

Regulatory Elements for EHD4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EHD4 Gene

41,895,939 bp from pter
41,972,578 bp from pter
76,640 bases
Minus strand

Genomic View for EHD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EHD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EHD4 Gene

Proteins for EHD4 Gene

  • Protein details for EHD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    EH domain-containing protein 4
    Protein Accession:
    Secondary Accessions:
    • Q9HAR1
    • Q9NZN2

    Protein attributes for EHD4 Gene

    541 amino acids
    Molecular mass:
    61175 Da
    Quaternary structure:
    • Homooligomer, and heterooligomer with EHD1, EHD2 and EHD3.

neXtProt entry for EHD4 Gene

Proteomics data for EHD4 Gene at MOPED

Post-translational modifications for EHD4 Gene

  • Ubiquitination at Lys35
  • Modification sites at PhosphoSitePlus

Other Protein References for EHD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for EHD4 Gene

Domains for EHD4 Gene

Gene Families for EHD4 Gene

  • EFHAND :EF-hand domain containing

Suggested Antigen Peptide Sequences for EHD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9H223
  • The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins.
  • Contains 1 dynamin-type G (guanine nucleotide-binding) domain.
  • Contains 1 EF-hand domain.
  • Contains 1 EH domain.
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily.
genes like me logo Genes that share domains with EHD4: view

Function for EHD4 Gene

Molecular function for EHD4 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in early endosomal transport.

Gene Ontology (GO) - Molecular Function for EHD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding TAS 10673336
GO:0003924 GTPase activity --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 17233914
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with EHD4: view
genes like me logo Genes that share phenotypes with EHD4: view

Animal Models for EHD4 Gene

MGI Knock Outs for EHD4:

Animal Model Products

miRNA for EHD4 Gene

miRTarBase miRNAs that target EHD4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EHD4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for EHD4 Gene

Localization for EHD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for EHD4 Gene

Cell membrane. Early endosome membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein.

Subcellular locations from

Jensen Localization Image for EHD4 Gene COMPARTMENTS Subcellular localization image for EHD4 gene
Compartment Confidence
endosome 5
endoplasmic reticulum 4
nucleus 4
cytosol 3
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for EHD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 10673336
GO:0005783 endoplasmic reticulum IDA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0031901 early endosome membrane IEA --
genes like me logo Genes that share ontologies with EHD4: view

Pathways for EHD4 Gene

genes like me logo Genes that share pathways with EHD4: view

Pathways by source for EHD4 Gene

Gene Ontology (GO) - Biological Process for EHD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006907 pinocytosis IEA --
GO:0030100 regulation of endocytosis IEA --
GO:0032456 endocytic recycling IGI 17233914
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA --
genes like me logo Genes that share ontologies with EHD4: view

Transcripts for EHD4 Gene

mRNA/cDNA for EHD4 Gene

Unigene Clusters for EHD4 Gene

EH-domain containing 4:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EHD4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EHD4 Gene

No ASD Table

Relevant External Links for EHD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for EHD4 Gene

mRNA expression in normal human tissues for EHD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for EHD4 Gene

This gene is overexpressed in Uterus (9.9) and Adipocyte (8.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EHD4 Gene

SOURCE GeneReport for Unigene cluster for EHD4 Gene Hs.143703

mRNA Expression by UniProt/SwissProt for EHD4 Gene

Tissue specificity: Highly expressed in pancreas and heart
genes like me logo Genes that share expressions with EHD4: view

Expression partners for EHD4 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for EHD4 Gene

Orthologs for EHD4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EHD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia EHD4 35
  • 91.17 (n)
  • 94.81 (a)
EHD4 36
  • 95 (a)
(Canis familiaris)
Mammalia EHD4 35
  • 92.91 (n)
  • 98.52 (a)
EHD4 36
  • 99 (a)
(Mus musculus)
Mammalia Ehd4 35
  • 90.76 (n)
  • 97.04 (a)
Ehd4 16
Ehd4 36
  • 97 (a)
(Pan troglodytes)
Mammalia EHD4 35
  • 99.82 (n)
  • 99.82 (a)
EHD4 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ehd4 35
  • 89.9 (n)
  • 97.23 (a)
(Monodelphis domestica)
Mammalia EHD4 36
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia EHD4 36
  • 93 (a)
(Gallus gallus)
Aves LOC100859860 35
  • 77.07 (n)
  • 89.45 (a)
EHD4 36
  • 89 (a)
(Anolis carolinensis)
Reptilia EHD4 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ehd4 35
  • 74.08 (n)
  • 85.05 (a)
(Danio rerio)
Actinopterygii im:7147183 35
  • 71.31 (n)
  • 77.32 (a)
EHD4 36
  • 67 (a)
fruit fly
(Drosophila melanogaster)
Insecta Past1 37
  • 49 (a)
(Caenorhabditis elegans)
Secernentea rme-1 37
  • 65 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1591 35
(Zea mays)
Liliopsida Zm.3719 35
Species with no ortholog for EHD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EHD4 Gene

Gene Tree for EHD4 (if available)
Gene Tree for EHD4 (if available)

Paralogs for EHD4 Gene

Paralogs for EHD4 Gene

Selected SIMAP similar genes for EHD4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with EHD4: view

Variants for EHD4 Gene

Sequence variations from dbSNP and Humsavar for EHD4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs764319 -- 41,951,737(-) GAGGG(C/G)AAGTA intron-variant
rs890500 -- 41,909,504(+) TGTGT(C/T)TCCTT intron-variant
rs890501 -- 41,909,765(+) ATGTA(A/G)ATTTC reference, synonymous-codon
rs890502 -- 41,912,753(+) TCATG(A/G)AATAC intron-variant
rs979421 -- 41,929,886(-) TCTTA(A/G)GCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EHD4 Gene

Variant ID Type Subtype PubMed ID
nsv904116 CNV Loss 21882294
dgv2364n71 CNV Loss 21882294
nsv9244 CNV Gain 18304495
dgv2366n71 CNV Loss 21882294
nsv904129 CNV Loss 21882294
nsv519577 CNV Loss 19592680
esv273033 CNV Insertion 20981092

Relevant External Links for EHD4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EHD4 Gene

Disorders for EHD4 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for EHD4 Gene in MalaCards »

(1) Diseases for EHD4 Gene including...

Relevant External Links for EHD4

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with EHD4: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for EHD4 Gene

Publications for EHD4 Gene

  1. EHD2, EHD3, and EHD4 encode novel members of a highly conserved family of EH domain-containing proteins. (PMID: 10673336) Pohl U. … Louis D.N. (Genomics 2000) 2 3 4
  2. Characterization of EHD4, an EH domain-containing protein expressed in the extracellular matrix. (PMID: 11533061) Kuo H.J. … Glanville R.W. (J. Biol. Chem. 2001) 2 3
  3. Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies. (PMID: 12097419) Wang Y. … Chen W.-F. (J. Immunol. 2002) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4

Products for EHD4 Gene

Sources for EHD4 Gene

Back to Top