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Aliases for HGF Gene

Aliases for HGF Gene

  • Hepatocyte Growth Factor 2 3
  • Hepatocyte Growth Factor (Hepapoietin A; Scatter Factor) 2 3
  • Fibroblast-Derived Tumor Cytotoxic Factor 2 3
  • Lung Fibroblast-Derived Mitogen 2 3
  • Hepatopoietin-A 3 4
  • Scatter Factor 2 4
  • HPTA 3 4
  • SF 3 4
  • Hepatocyte Growth Factor (Hepapoietin A Scatter Factor) 5
  • Deafness, Autosomal Recessive 39 2
  • Hepatopoietin A 2
  • EC 63
  • EC 3.4.21 63
  • DFNB39 3
  • F-TCF 3
  • HGFB 3

External Ids for HGF Gene

Previous HGNC Symbols for HGF Gene

  • DFNB39

Previous GeneCards Identifiers for HGF Gene

  • GC07M079863
  • GC07M080926
  • GC07M080940
  • GC07M080943
  • GC07M080976
  • GC07M081166
  • GC07M081328
  • GC07M075935

Summaries for HGF Gene

Entrez Gene Summary for HGF Gene

  • This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]

GeneCards Summary for HGF Gene

HGF (Hepatocyte Growth Factor) is a Protein Coding gene. Diseases associated with HGF include Deafness, Autosomal Recessive 39 and Kaposi Sarcoma. Among its related pathways are Glioma and p70S6K Signaling. GO annotations related to this gene include identical protein binding and serine-type endopeptidase activity. An important paralog of this gene is PLAT.

UniProtKB/Swiss-Prot for HGF Gene

  • Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

Tocris Summary for HGF Gene

  • The MET receptor, also known as hepatocyte growth factor receptor (HGFR), is a proto-oncogenic receptor tyrosine kinase. The endogenous ligand for MET is hepatocyte growth factor/scatter factor (HGF), a disulfide-linked heterodimeric molecule.

Gene Wiki entry for HGF Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HGF Gene

Genomics for HGF Gene

Regulatory Elements for HGF Gene

Enhancers for HGF Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around HGF on UCSC Golden Path with GeneCards custom track

Promoters for HGF Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around HGF on UCSC Golden Path with GeneCards custom track

Genomic Location for HGF Gene

81,699,006 bp from pter
81,770,438 bp from pter
71,433 bases
Minus strand

Genomic View for HGF Gene

Genes around HGF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
HGF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for HGF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HGF Gene

Proteins for HGF Gene

  • Protein details for HGF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Hepatocyte growth factor
    Protein Accession:
    Secondary Accessions:
    • A1L3U6
    • Q02935
    • Q13494
    • Q14519
    • Q3KRB2
    • Q8TCE2
    • Q9BYL9
    • Q9BYM0
    • Q9UDU6

    Protein attributes for HGF Gene

    728 amino acids
    Molecular mass:
    83134 Da
    Quaternary structure:
    • Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.

    Three dimensional structures from OCA and Proteopedia for HGF Gene

    Alternative splice isoforms for HGF Gene

neXtProt entry for HGF Gene

Proteomics data for HGF Gene at MOPED

Selected DME Specific Peptides for HGF Gene

Post-translational modifications for HGF Gene

  • Glycosylation at Asn 294, Asn 402, Thr 476, Asn 566, and Asn 653
  • Modification sites at PhosphoSitePlus

Domains & Families for HGF Gene

Suggested Antigen Peptide Sequences for HGF Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 4 kringle domains.
  • Belongs to the peptidase S1 family. Plasminogen subfamily.
  • Contains 4 kringle domains.
  • Contains 1 PAN domain.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Plasminogen subfamily.
genes like me logo Genes that share domains with HGF: view

No data available for Gene Families for HGF Gene

Function for HGF Gene

Molecular function for HGF Gene

GENATLAS Biochemistry:
hepatocyte growth factor,precursor of chains alpha and beta,expressed in platelets,fibroblast,macrophage,endothelial and smooth muscle cells
UniProtKB/Swiss-Prot Function:
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.

Enzyme Numbers (IUBMB) for HGF Gene

LifeMap Function Summary for HGF Gene

genes like me logo Genes that share phenotypes with HGF: view

Human Phenotype Ontology for HGF Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for HGF Gene

MGI Knock Outs for HGF:

miRNA for HGF Gene

miRTarBase miRNAs that target HGF

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for HGF Gene

Localization for HGF Gene

Subcellular locations from

Jensen Localization Image for HGF Gene COMPARTMENTS Subcellular localization image for HGF gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
lysosome 2
nucleus 2
vacuole 2
endosome 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for HGF Gene

Pathways & Interactions for HGF Gene

genes like me logo Genes that share pathways with HGF: view

SIGNOR curated interactions for HGF Gene


Gene Ontology (GO) - Biological Process for HGF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IEA --
GO:0000902 cell morphogenesis IEA --
GO:0001837 epithelial to mesenchymal transition TAS 14679171
GO:0001889 liver development IEA --
GO:0002576 platelet degranulation TAS --
genes like me logo Genes that share ontologies with HGF: view

Drugs & Compounds for HGF Gene

(101) Drugs for HGF Gene - From: DrugBank, ClinicalTrials, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phenytoin Approved Pharma Pore Blocker 74
N,O6-Disulfo-Glucosamine Experimental Pharma Target 0
O2-Sulfo-Glucuronic Acid Experimental Pharma Target 0
ABT-510 Investigational Pharma Target 0
XL880 Investigational Pharma Target 0

(63) Additional Compounds for HGF Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
K 252a
PF 04217903 mesylate

(5) Tocris Compounds for HGF Gene

Compound Action Cas Number
K 252a Protein kinase inhibitor 99533-80-9
PF 04217903 mesylate Highly selective MET inhibitor 956906-93-7
PHA 665752 Potent and selective MET inhibitor 477575-56-7
SU 11274 Selective inhibitor of MET kinase activity 658084-23-2
SU 5416 VEGFR inhibitor. Also inhibits KIT, RET, MET and FLT3 204005-46-9
genes like me logo Genes that share compounds with HGF: view

Transcripts for HGF Gene

Unigene Clusters for HGF Gene

Hepatocyte growth factor (hepapoietin A; scatter factor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HGF Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2: -

Relevant External Links for HGF Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for HGF Gene

mRNA expression in normal human tissues for HGF Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HGF Gene

This gene is overexpressed in Liver (x5.3).

Protein differential expression in normal tissues from HIPED for HGF Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (27.1), Amniocyte (24.6), and Placenta (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for HGF Gene

SOURCE GeneReport for Unigene cluster for HGF Gene Hs.396530

genes like me logo Genes that share expression patterns with HGF: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HGF Gene

Orthologs for HGF Gene

This gene was present in the common ancestor of animals.

Orthologs for HGF Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia HGF 35
  • 92.76 (n)
  • 93.4 (a)
HGF 36
  • 93 (a)
(Canis familiaris)
Mammalia HGF 35
  • 92.49 (n)
  • 92.72 (a)
HGF 36
  • 92 (a)
(Mus musculus)
Mammalia Hgf 35
  • 88.51 (n)
  • 91.03 (a)
Hgf 16
Hgf 36
  • 91 (a)
(Pan troglodytes)
Mammalia HGF 35
  • 99.91 (n)
  • 99.86 (a)
HGF 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Hgf 35
  • 88.09 (n)
  • 90.62 (a)
(Monodelphis domestica)
Mammalia HGF 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia HGF 36
  • 80 (a)
(Gallus gallus)
Aves HGF 35
  • 76.87 (n)
  • 75.35 (a)
  • 75 (a)
(Anolis carolinensis)
Reptilia HGF 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia hgf 35
  • 70.63 (n)
  • 68.77 (a)
(Danio rerio)
Actinopterygii hgfa 35
  • 55.29 (n)
  • 49.55 (a)
HGF (2 of 2) 36
  • 53 (a)
hgfa 36
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tequila 36
  • 5 (a)
(Caenorhabditis elegans)
Secernentea svh-1 36
  • 13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
-- 36
  • 20 (a)
Species with no ortholog for HGF:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HGF Gene

Gene Tree for HGF (if available)
Gene Tree for HGF (if available)

Paralogs for HGF Gene

Paralogs for HGF Gene

(7) SIMAP similar genes for HGF Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with HGF: view

Variants for HGF Gene

Sequence variations from dbSNP and Humsavar for HGF Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs17566 - 81,757,213(-) CTGGA(G/T)TTCCA reference, missense
rs5745687 - 81,729,735(-) CAACT(A/G)AATGC reference, missense
rs5745688 - 81,729,657(-) GTTGG(G/T)ATTCT reference, missense
rs767889 -- 81,711,429(+) CTTCT(C/G)ACACA intron-variant
rs769292 -- 81,762,376(+) GAAAA(A/G)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HGF Gene

Variant ID Type Subtype PubMed ID
nsv888562 CNV Loss 21882294
esv2618632 CNV Deletion 19546169
esv2384607 CNV Deletion 18987734
dgv1149e201 CNV Deletion 23290073
esv3807 CNV Deletion 18987735
esv8642 CNV Loss 19470904
nsv366332 CNV Loss 16902084
esv2734743 CNV Deletion 23290073
nsv464609 CNV Loss 19166990

Variation tolerance for HGF Gene

Residual Variation Intolerance Score: 8.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HGF Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HGF Gene

Disorders for HGF Gene

MalaCards: The human disease database

(57) MalaCards diseases for HGF Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
deafness, autosomal recessive 39
  • deafness, autosomal recessive, 39
kaposi sarcoma
  • human herpesvirus 8
fibromatosis, gingival, 1
  • hereditary gingival fibromatosis
intracranial hemorrhage in brain cerebrovascular malformations
  • intracranial hemorrhage in brain cerebrovascular malformations, susceptibility to
inflammatory bowel disease 1
  • crohn disease-associated growth failure
- elite association - COSMIC cancer census association via MalaCards
Search HGF in MalaCards View complete list of genes associated with diseases


  • Deafness, autosomal recessive, 39 (DFNB39) [MIM:608265]: A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269 PubMed:19576567}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for HGF

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with HGF: view

No data available for Genatlas for HGF Gene

Publications for HGF Gene

  1. Noncoding mutations of HGF are associated with nonsyndromic hearing loss, DFNB39. (PMID: 19576567) Schultz J.M. … Morell R.J. (Am. J. Hum. Genet. 2009) 2 3 4 67
  2. Combined and sequential delivery of bioactive VEGF165 and HGF from poly(trimethylene carbonate) based photo-cross-linked elastomers. (PMID: 19961885) Chapanian R. … Amsden B.G. (J Control Release 2010) 3 23
  3. High concentrations of HGF inhibit skeletal muscle satellite cell proliferation in vitro by inducing expression of myostatin: a possible mechanism for reestablishing satellite cell quiescence in vivo. (PMID: 20007454) Yamada M. … Allen R.E. (Am. J. Physiol., Cell Physiol. 2010) 3 23
  4. Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA. (PMID: 20015050) Owen K.A. … Ellis V. (Biochem. J. 2010) 3 23
  5. Co-treatment with hepatocyte growth factor and TGF-beta1 enhances migration of HaCaT cells through NADPH oxidase-dependent ROS generation. (PMID: 20177149) Nam H.J. … Lee J.H. (Exp. Mol. Med. 2010) 3 23

Products for HGF Gene

  • Addgene plasmids for HGF

Sources for HGF Gene