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Aliases for ANXA5 Gene

Aliases for ANXA5 Gene

  • Annexin A5 2 3
  • ENX2 3 4 6
  • Placental Anticoagulant Protein 4 3 4
  • Placental Anticoagulant Protein I 3 4
  • Vascular Anticoagulant-Alpha 3 4
  • Thromboplastin Inhibitor 3 4
  • Calphobindin I 3 4
  • Anchorin CII 3 4
  • Endonexin II 3 4
  • Lipocortin V 3 4
  • Annexin V 3 4
  • Annexin-5 3 4
  • VAC-Alpha 3 4
  • RPRGL3 3 6
  • CBP-I 3 4
  • PAP-I 3 4
  • ANX5 3 4
  • PP4 3 4
  • Epididymis Secretory Protein Li 7 3
  • HEL-S-7 3

External Ids for ANXA5 Gene

Previous HGNC Symbols for ANXA5 Gene

  • ENX2
  • ANX5

Previous GeneCards Identifiers for ANXA5 Gene

  • GC04M123513
  • GC04M122868
  • GC04M122982
  • GC04M123047
  • GC04M122946
  • GC04M122589
  • GC04M118316

Summaries for ANXA5 Gene

Entrez Gene Summary for ANXA5 Gene

  • The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANXA5 Gene

ANXA5 (Annexin A5) is a Protein Coding gene. Diseases associated with ANXA5 include pregnancy loss, recurrent 3 and amelanotic melanoma. Among its related pathways are Ca, cAMP and Lipid Signaling and Regulation of CFTR activity (norm and CF). GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is ANXA9.

UniProtKB/Swiss-Prot for ANXA5 Gene

  • This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade

Gene Wiki entry for ANXA5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA5 Gene

Genomics for ANXA5 Gene

Regulatory Elements for ANXA5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ANXA5 Gene

121,667,955 bp from pter
121,697,113 bp from pter
29,159 bases
Minus strand

Genomic View for ANXA5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANXA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA5 Gene

Proteins for ANXA5 Gene

  • Protein details for ANXA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Annexin A5
    Protein Accession:
    Secondary Accessions:
    • D3DNW7
    • Q6FHB3
    • Q6FI16
    • Q8WV69
    • Q9UDH9

    Protein attributes for ANXA5 Gene

    320 amino acids
    Molecular mass:
    35937 Da
    Quaternary structure:
    • Monomer. Binds ATRX and EIF5B (By similarity). Interacts with hepatitis B virus (HBV).

    Three dimensional structures from OCA and Proteopedia for ANXA5 Gene

neXtProt entry for ANXA5 Gene

Proteomics data for ANXA5 Gene at MOPED

Post-translational modifications for ANXA5 Gene

  • S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.
  • Ubiquitination at Lys29, Lys58, Lys76, Lys79, Lys86, Lys97, Lys108, Lys193, Lys290, and Lys301
  • Modification sites at PhosphoSitePlus

Other Protein References for ANXA5 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ANXA5 (ANXA5)

No data available for DME Specific Peptides for ANXA5 Gene

Domains for ANXA5 Gene

Gene Families for ANXA5 Gene


Protein Domains for ANXA5 Gene

Suggested Antigen Peptide Sequences for ANXA5 Gene

Graphical View of Domain Structure for InterPro Entry



  • P08758
  • The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
  • A pair of annexin repeats may form one binding site for calcium and phospholipid
  • Belongs to the annexin family.
  • Contains 4 annexin repeats.
genes like me logo Genes that share domains with ANXA5: view

Function for ANXA5 Gene

Molecular function for ANXA5 Gene

GENATLAS Biochemistry:
annexin A5,calcium and phospholipid binding protein,endonexin 2,placental protein 4,anchorin CII collagen receptor of chondrocytes,predominantly expressed in major constituent of growth plate chondrocytes,down-regulated in adult articular cartilage
UniProtKB/Swiss-Prot Function:
This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade

Gene Ontology (GO) - Molecular Function for ANXA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004859 phospholipase inhibitor activity TAS 2967495
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
GO:0005543 phospholipid binding TAS 2967291
GO:0005544 calcium-dependent phospholipid binding IDA 2138016
genes like me logo Genes that share ontologies with ANXA5: view
genes like me logo Genes that share phenotypes with ANXA5: view

miRNA for ANXA5 Gene

miRTarBase miRNAs that target ANXA5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANXA5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANXA5 Gene

Localization for ANXA5 Gene

Subcellular locations from

Jensen Localization Image for ANXA5 Gene COMPARTMENTS Subcellular localization image for ANXA5 gene
Compartment Confidence
extracellular 5
cytosol 3
mitochondrion 3
nucleus 3
plasma membrane 3
cytoskeleton 2
endoplasmic reticulum 2
vacuole 2
lysosome 1

Gene Ontology (GO) - Cellular Components for ANXA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm TAS 16130169
GO:0005925 focal adhesion IDA 21423176
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ANXA5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANXA5 Gene

Pathways for ANXA5 Gene

genes like me logo Genes that share pathways with ANXA5: view

Pathways by source for ANXA5 Gene

1 Cell Signaling Technology pathway for ANXA5 Gene
1 BioSystems pathway for ANXA5 Gene
1 GeneGo (Thomson Reuters) pathway for ANXA5 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for ANXA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0007165 signal transduction TAS 16130169
GO:0007596 blood coagulation IEA --
GO:0010033 response to organic substance IEA --
GO:0043066 negative regulation of apoptotic process TAS 16130169
genes like me logo Genes that share ontologies with ANXA5: view

Compounds for ANXA5 Gene

(1) HMDB Compounds for ANXA5 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(150) Novoseek inferred chemical compound relationships for ANXA5 Gene

Compound -log(P) Hits PubMed IDs
phosphatidylserine 93.2 195
7-aminoactinomycin d 81.1 41
phospholipid 75.4 179
fluo 3 74.4 10
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide 72.9 17
genes like me logo Genes that share compounds with ANXA5: view

Transcripts for ANXA5 Gene

Unigene Clusters for ANXA5 Gene

Annexin A5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ANXA5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - - -
SP2: - -
SP3: - -
SP4: - - - - -
SP5: - - -
SP6: - -
SP8: - - - - - - - - - - -
SP9: - -

Relevant External Links for ANXA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANXA5 Gene

mRNA expression in normal human tissues for ANXA5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANXA5 Gene

SOURCE GeneReport for Unigene cluster for ANXA5 Gene Hs.480653

genes like me logo Genes that share expressions with ANXA5: view

Expression partners for ANXA5 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ANXA5 Gene

Orthologs for ANXA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ANXA5 35
  • 92.08 (n)
  • 96.56 (a)
ANXA5 36
  • 97 (a)
(Canis familiaris)
Mammalia ANXA5 35
  • 93.44 (n)
  • 97.19 (a)
ANXA5 36
  • 98 (a)
(Mus musculus)
Mammalia Anxa5 35
  • 86.98 (n)
  • 93.65 (a)
Anxa5 16
Anxa5 36
  • 93 (a)
(Pan troglodytes)
Mammalia ANXA5 35
  • 99.79 (n)
  • 100 (a)
ANXA5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Anxa5 35
  • 85.44 (n)
  • 91.77 (a)
(Monodelphis domestica)
Mammalia ANXA5 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia ANXA5 36
  • 89 (a)
(Gallus gallus)
Aves ANXA5 35
  • 74.9 (n)
  • 78.44 (a)
ANXA5 36
  • 78 (a)
(Anolis carolinensis)
Reptilia ANXA5 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa5 35
  • 72.59 (n)
  • 74.6 (a)
Str.8395 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398472 35
(Danio rerio)
Actinopterygii anxa5b 35
  • 62.19 (n)
  • 64.86 (a)
anxa5a 36
  • 59 (a)
anxa5b 36
  • 64 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9774 35
fruit fly
(Drosophila melanogaster)
Insecta AnnIX 37
  • 48 (a)
AnnX 37
  • 46 (a)
Anxb11 37
  • 43 (a)
(Caenorhabditis elegans)
Secernentea nex-1 37
  • 39 (a)
nex-2 37
  • 46 (a)
nex-3 37
  • 38 (a)
Species with no ortholog for ANXA5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA5 Gene

Gene Tree for ANXA5 (if available)
Gene Tree for ANXA5 (if available)

Paralogs for ANXA5 Gene

Paralogs for ANXA5 Gene

genes like me logo Genes that share paralogs with ANXA5: view

Variants for ANXA5 Gene

Sequence variations from dbSNP and Humsavar for ANXA5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs9611 -- 121,668,041(-) TGATT(A/G)TATTC utr-variant-3-prime
rs17718 -- 121,668,128(-) TTAAT(C/T)AGAAG utr-variant-3-prime
rs1050606 -- 121,696,891(-) CGGGG(G/T)TTCGG utr-variant-5-prime
rs1131239 -- 121,696,590(-) GTCGC(A/C/G/T)ATGGC utr-variant-5-prime
rs1383232 -- 121,691,268(-) AGCCA(A/G)CAAAA intron-variant

Relevant External Links for ANXA5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ANXA5 Gene

Disorders for ANXA5 Gene

(1) OMIM Diseases for ANXA5 Gene (131230)


  • Pregnancy loss, recurrent, 3 (RPRGL3) [MIM:614391]: A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions. {ECO:0000269 PubMed:17339269}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(91) Novoseek inferred disease relationships for ANXA5 Gene

Disease -log(P) Hits PubMed IDs
necrosis 68.4 100
antiphospholipid syndrome 64.2 32
tumors 58.4 60
cancer 56.3 23
promyelocytic leukemia 52.4 2

Relevant External Links for ANXA5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ANXA5: view

No data available for Genatlas for ANXA5 Gene

Publications for ANXA5 Gene

  1. A common haplotype of the annexin A5 (ANXA5) gene promoter is associated with recurrent pregnancy loss. (PMID: 17339269) Bogdanova N. … Markoff A. (Hum. Mol. Genet. 2007) 3 4 23 48
  2. Annexin A5 polymorphism (-1C-->T) and the presence of anti-annexin A5 antibodies in the antiphospholipid syndrome. (PMID: 16449315) de Laat B. … van Heerde W.L. (Ann. Rheum. Dis. 2006) 3 23 48
  3. Matrix metalloproteinase-9 gene -1562C/T polymorphism mitigates preeclampsia. (PMID: 17137622) Coolman M. … de Groot C.J. (Placenta 2007) 3 23 48
  4. Crystal and molecular structure of human annexin V after refinement. Implications for structure, membrane binding and ion channel formation of the annexin family of proteins. (PMID: 1311770) Huber R. … Paques E.-P. (J. Mol. Biol. 1992) 3 4 23
  5. Organization of the human annexin V (ANX5) gene. (PMID: 8034319) Cookson B.T. … Tait J.F. (Genomics 1994) 3 4 23

Products for ANXA5 Gene

  • Addgene plasmids for ANXA5

Sources for ANXA5 Gene

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