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Aliases for ANXA5 Gene

Aliases for ANXA5 Gene

  • Annexin A5 2 3 5
  • Placental Anticoagulant Protein 4 3 4
  • Placental Anticoagulant Protein I 3 4
  • Vascular Anticoagulant-Alpha 3 4
  • Thromboplastin Inhibitor 3 4
  • Calphobindin I 3 4
  • Anchorin CII 3 4
  • Endonexin II 3 4
  • Lipocortin V 3 4
  • Annexin V 3 4
  • Annexin-5 3 4
  • VAC-Alpha 3 4
  • CBP-I 3 4
  • PAP-I 3 4
  • ANX5 3 4
  • ENX2 3 4
  • PP4 3 4
  • Epididymis Secretory Protein Li 7 3
  • HEL-S-7 3
  • RPRGL3 3

External Ids for ANXA5 Gene

Previous HGNC Symbols for ANXA5 Gene

  • ENX2
  • ANX5

Previous GeneCards Identifiers for ANXA5 Gene

  • GC04M123513
  • GC04M122868
  • GC04M122982
  • GC04M123047
  • GC04M122946
  • GC04M122589
  • GC04M118316

Summaries for ANXA5 Gene

Entrez Gene Summary for ANXA5 Gene

  • The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANXA5 Gene

ANXA5 (Annexin A5) is a Protein Coding gene. Diseases associated with ANXA5 include Pregnancy Loss, Recurrent 3 and Pregnancy Loss, Recurrent, Susceptibility 3. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is ANXA4.

UniProtKB/Swiss-Prot for ANXA5 Gene

  • This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

Gene Wiki entry for ANXA5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA5 Gene

Genomics for ANXA5 Gene

Regulatory Elements for ANXA5 Gene

Enhancers for ANXA5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G121688 1.7 FANTOM5 ENCODE dbSUPER 33.5 +6.6 6645 4.6 FOXA2 ARID4B SIN3A FEZF1 DMAP1 GATA2 ELK1 FOS SP5 JUNB ANXA5 GC04M121669 GC04M121668
GH04G121674 1.1 ENCODE dbSUPER 42.7 +20.6 20565 3.4 FOXA2 MLX ARID4B RARA CREM MIXL1 SP5 CEBPB KAT8 MIER3 ANXA5 TMEM155 PP12613 ENSG00000237868 GC04M121668 GC04M121669
GH04G121694 1.3 ENCODE dbSUPER 26.5 +0.5 536 3.6 CREB3L1 SIN3A DMAP1 YY1 ZNF766 ZNF143 KLF13 ZHX2 REST SMARCB1 ANXA5 GC04M121669 GC04M121668
GH04G121667 0.8 ENCODE dbSUPER 40.3 +27.8 27824 3.5 JUND BHLHE40 ZNF223 FOS ANXA5 TMEM155 PP12613 ENSG00000237868 GC04M121669 GC04M121668
GH04G121727 1.1 Ensembl ENCODE dbSUPER 25.2 -31.3 -31278 2.3 CTCF JUND GATA2 ZFP3 BHLHE40 CEBPB FOS KDM1A MAFK ANXA5 TMEM155 PP12613 QRFPR
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ANXA5 on UCSC Golden Path with GeneCards custom track

Promoters for ANXA5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000172643 813 3001 CREB3L1 SIN3A DMAP1 YY1 ZNF766 ZNF143 ZHX2 REST SMARCB1 TBX21

Genomic Location for ANXA5 Gene

121,667,955 bp from pter
121,697,113 bp from pter
29,159 bases
Minus strand

Genomic View for ANXA5 Gene

Genes around ANXA5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA5 Gene

Proteins for ANXA5 Gene

  • Protein details for ANXA5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Annexin A5
    Protein Accession:
    Secondary Accessions:
    • D3DNW7
    • Q6FHB3
    • Q6FI16
    • Q8WV69
    • Q9UDH9

    Protein attributes for ANXA5 Gene

    320 amino acids
    Molecular mass:
    35937 Da
    Quaternary structure:
    • Monomer. Binds ATRX and EIF5B (By similarity). Interacts with hepatitis B virus (HBV).

    Three dimensional structures from OCA and Proteopedia for ANXA5 Gene

neXtProt entry for ANXA5 Gene

Post-translational modifications for ANXA5 Gene

  • S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.
  • Ubiquitination at posLast=2929, posLast=7676, Lys79, Lys108, posLast=193193, Lys290, and Lys301
  • Modification sites at PhosphoSitePlus

Other Protein References for ANXA5 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ANXA5 (ANXA5)

No data available for DME Specific Peptides for ANXA5 Gene

Domains & Families for ANXA5 Gene

Gene Families for ANXA5 Gene

Protein Domains for ANXA5 Gene

Suggested Antigen Peptide Sequences for ANXA5 Gene

Graphical View of Domain Structure for InterPro Entry



  • The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
  • Belongs to the annexin family.
  • The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
genes like me logo Genes that share domains with ANXA5: view

Function for ANXA5 Gene

Molecular function for ANXA5 Gene

GENATLAS Biochemistry:
annexin A5,calcium and phospholipid binding protein,endonexin 2,placental protein 4,anchorin CII collagen receptor of chondrocytes,predominantly expressed in major constituent of growth plate chondrocytes,down-regulated in adult articular cartilage
UniProtKB/Swiss-Prot Function:
This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

Gene Ontology (GO) - Molecular Function for ANXA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004859 phospholipase inhibitor activity TAS 2967495
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 21044950
GO:0005543 phospholipid binding TAS 2967291
GO:0005544 calcium-dependent phospholipid binding IEA,IDA 2138016
genes like me logo Genes that share ontologies with ANXA5: view
genes like me logo Genes that share phenotypes with ANXA5: view

Animal Models for ANXA5 Gene

MGI Knock Outs for ANXA5:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANXA5 Gene

Localization for ANXA5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ANXA5 gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 4
nucleus 4
mitochondrion 3
cytoskeleton 2
endoplasmic reticulum 2
lysosome 2
endosome 1

Gene Ontology (GO) - Cellular Components for ANXA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005622 intracellular IDA --
GO:0005737 cytoplasm TAS 16130169
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with ANXA5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANXA5 Gene

Pathways & Interactions for ANXA5 Gene

genes like me logo Genes that share pathways with ANXA5: view

Gene Ontology (GO) - Biological Process for ANXA5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0007165 signal transduction TAS 16130169
GO:0007596 blood coagulation IEA --
GO:0007599 hemostasis IEA --
GO:0010033 response to organic substance IEA --
genes like me logo Genes that share ontologies with ANXA5: view

No data available for SIGNOR curated interactions for ANXA5 Gene

Drugs & Compounds for ANXA5 Gene

(81) Drugs for ANXA5 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid Experimental Pharma Target 0
1,4-Dideoxy-O2-Sulfo-Glucuronic Acid Experimental Pharma Target 0
K201 Experimental Pharma Target 0
L-Alpha-Glycerophosphorylethanolamine Experimental Pharma Target 0
L-Alpha-Glycerophosphorylserine Experimental Pharma Target 0

(76) Additional Compounds for ANXA5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ANXA5: view

Transcripts for ANXA5 Gene

Unigene Clusters for ANXA5 Gene

Annexin A5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA5 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - - -
SP2: - -
SP3: - -
SP4: - - - - -
SP5: - - -
SP6: - -
SP8: - - - - - - - - - - -
SP9: - -

Relevant External Links for ANXA5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANXA5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ANXA5 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ANXA5 Gene

Protein tissue co-expression partners for ANXA5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ANXA5 Gene:


SOURCE GeneReport for Unigene cluster for ANXA5 Gene:


Evidence on tissue expression from TISSUES for ANXA5 Gene

  • Lung(4.9)
  • Skin(4.9)
  • Liver(4.8)
  • Nervous system(4.8)
  • Muscle(4.7)
  • Intestine(4.1)
  • Blood(3.7)
  • Heart(3.6)
  • Pancreas(3.5)
  • Bone marrow(3.3)
  • Eye(3.3)
  • Kidney(3.3)
  • Spleen(3.3)
  • Bone(3.2)
  • Stomach(3.2)
  • Adrenal gland(3)
  • Lymph node(3)
  • Thyroid gland(2.6)
  • Gall bladder(2.3)
genes like me logo Genes that share expression patterns with ANXA5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ANXA5 Gene

Orthologs for ANXA5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ANXA5 34 35
  • 99.79 (n)
(Canis familiaris)
Mammalia ANXA5 34 35
  • 93.44 (n)
(Bos Taurus)
Mammalia ANXA5 34 35
  • 92.08 (n)
(Monodelphis domestica)
Mammalia ANXA5 35
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia ANXA5 35
  • 89 (a)
(Mus musculus)
Mammalia Anxa5 34 16 35
  • 86.98 (n)
(Rattus norvegicus)
Mammalia Anxa5 34
  • 85.44 (n)
(Gallus gallus)
Aves ANXA5 34 35
  • 74.9 (n)
(Anolis carolinensis)
Reptilia ANXA5 35
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa5 34
  • 72.59 (n)
Str.8395 34
African clawed frog
(Xenopus laevis)
Amphibia LOC398472 34
(Danio rerio)
Actinopterygii anxa5b 34 35
  • 62.19 (n)
anxa5a 35
  • 59 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9774 34
fruit fly
(Drosophila melanogaster)
Insecta AnnIX 36
  • 48 (a)
AnnX 36
  • 46 (a)
Anxb11 36
  • 43 (a)
(Caenorhabditis elegans)
Secernentea nex-2 36
  • 46 (a)
nex-1 36
  • 39 (a)
nex-3 36
  • 38 (a)
Species where no ortholog for ANXA5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA5 Gene

Gene Tree for ANXA5 (if available)
Gene Tree for ANXA5 (if available)

Paralogs for ANXA5 Gene

genes like me logo Genes that share paralogs with ANXA5: view

Variants for ANXA5 Gene

Sequence variations from dbSNP and Humsavar for ANXA5 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000010176 -- 121,668,238(+) ATTAA(A/C)CTTAG utr-variant-3-prime
rs1000422058 -- 121,694,677(+) CATGC(A/C)TGGCC intron-variant
rs1000502929 -- 121,697,883(+) GTAGA(C/T)AGAAG upstream-variant-2KB
rs1000510467 -- 121,680,425(+) AATGC(A/G)TTATT intron-variant, utr-variant-3-prime
rs10006900 -- 121,694,152(+) aaata(A/T)tgagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA5 Gene

Variant ID Type Subtype PubMed ID
esv3447335 CNV insertion 20981092
nsv1013073 CNV gain 25217958
nsv473255 CNV novel sequence insertion 20440878
nsv595356 CNV gain 21841781
nsv997539 CNV gain 25217958
nsv999788 CNV gain 25217958

Variation tolerance for ANXA5 Gene

Residual Variation Intolerance Score: 51.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANXA5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA5 Gene

Disorders for ANXA5 Gene

MalaCards: The human disease database

(31) MalaCards diseases for ANXA5 Gene - From: OMIM, ClinVar, GeneTests, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
pregnancy loss, recurrent 3
  • pregnancy loss, recurrent, 3
pregnancy loss, recurrent, susceptibility 3
antiphospholipid syndrome
  • acromegaloid facial appearance syndrome
indolent myeloma
  • indolent multiple myeloma
israeli tick typhus
  • israeli spotted fever
- elite association - COSMIC cancer census association via MalaCards
Search ANXA5 in MalaCards View complete list of genes associated with diseases


  • Pregnancy loss, recurrent, 3 (RPRGL3) [MIM:614391]: A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions. {ECO:0000269 PubMed:17339269}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for ANXA5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ANXA5: view

No data available for Genatlas for ANXA5 Gene

Publications for ANXA5 Gene

  1. A common haplotype of the annexin A5 (ANXA5) gene promoter is associated with recurrent pregnancy loss. (PMID: 17339269) Bogdanova N. … Markoff A. (Hum. Mol. Genet. 2007) 3 4 46 64
  2. Crystal structure of annexin V with its ligand K-201 as a calcium channel activity inhibitor. (PMID: 9398511) Kaneko N. … Miyano M. (J. Mol. Biol. 1997) 3 4 22 64
  3. The gene encoding human annexin V has a TATA-less promoter with a high G+C content. (PMID: 7958998) Fernandez M.-P. … Carcedo M.-T. (Gene 1994) 3 4 22 64
  4. Organization of the human annexin V (ANX5) gene. (PMID: 8034319) Cookson B.T. … Tait J.F. (Genomics 1994) 3 4 22 64
  5. Crystal and molecular structure of human annexin V after refinement. Implications for structure, membrane binding and ion channel formation of the annexin family of proteins. (PMID: 1311770) Huber R. … Paques E.-P. (J. Mol. Biol. 1992) 3 4 22 64

Products for ANXA5 Gene

Sources for ANXA5 Gene

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