Aliases for HCRTR2 Gene
External Ids for HCRTR2 Gene
Previous GeneCards Identifiers for HCRTR2 Gene
The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]
GeneCards Summary for HCRTR2 Gene
HCRTR2 (Hypocretin (Orexin) Receptor 2) is a Protein Coding gene. Diseases associated with HCRTR2 include cluster headache and headache. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include peptide hormone binding and orexin receptor activity. An important paralog of this gene is NPFFR1.
UniProtKB/Swiss-Prot for HCRTR2 Gene
Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides
The OX2 receptors, also known as hypocretin receptor 2, are located primarily in the cerebral cortex, paraventricular hypothalamus, nucleus accumbens, subthalamic and paraventricular thalamus where they are thought to regulate sleep-wakefulness. The OX2 receptor displays equal affinity for Orexin A and Orexin B. The human OX2 receptor gene has been localized to chromosome 6 (6p11-q11).