Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HCRTR2 Gene

Aliases for HCRTR2 Gene

  • Hypocretin (Orexin) Receptor 2 2 3
  • Hypocretin Receptor Type 2 3 4
  • Ox-2-R 3 4
  • Ox2-R 3 4
  • OX2R 3 4
  • Orexin Type-2 Receptor 3

External Ids for HCRTR2 Gene

Previous GeneCards Identifiers for HCRTR2 Gene

  • GC06P055041
  • GC06P055085
  • GC06P055147
  • GC06P054873

Summaries for HCRTR2 Gene

Entrez Gene Summary for HCRTR2 Gene

  • The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]

GeneCards Summary for HCRTR2 Gene

HCRTR2 (Hypocretin (Orexin) Receptor 2) is a Protein Coding gene. Diseases associated with HCRTR2 include cluster headache and sleep disorder. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include G-protein coupled receptor activity and peptide hormone binding. An important paralog of this gene is NPFFR1.

UniProtKB/Swiss-Prot for HCRTR2 Gene

  • Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides

Tocris Summary for HCRTR2 Gene

  • The OX2 receptors, also known as hypocretin receptor 2, are located primarily in the cerebral cortex, paraventricular hypothalamus, nucleus accumbens, subthalamic and paraventricular thalamus where they are thought to regulate sleep-wakefulness.

Gene Wiki entry for HCRTR2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HCRTR2 Gene

Genomics for HCRTR2 Gene

Regulatory Elements for HCRTR2 Gene

Genomic Location for HCRTR2 Gene

Chromosome:
6
Start:
55,106,460 bp from pter
End:
55,282,620 bp from pter
Size:
176,161 bases
Orientation:
Plus strand

Genomic View for HCRTR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HCRTR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HCRTR2 Gene

Proteins for HCRTR2 Gene

  • Protein details for HCRTR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43614-OX2R_HUMAN
    Recommended name:
    Orexin receptor type 2
    Protein Accession:
    O43614
    Secondary Accessions:
    • Q5VTM0

    Protein attributes for HCRTR2 Gene

    Size:
    444 amino acids
    Molecular mass:
    50694 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for HCRTR2 Gene

neXtProt entry for HCRTR2 Gene

Proteomics data for HCRTR2 Gene at MOPED

Post-translational modifications for HCRTR2 Gene

  • Glycosylation at Asn 14, Asn 22, and Asn 202
  • Modification sites at PhosphoSitePlus

Other Protein References for HCRTR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for HCRTR2 (Orexin R2/HCRTR2)

No data available for DME Specific Peptides for HCRTR2 Gene

Domains & Families for HCRTR2 Gene

Gene Families for HCRTR2 Gene

Protein Domains for HCRTR2 Gene

Suggested Antigen Peptide Sequences for HCRTR2 Gene

Graphical View of Domain Structure for InterPro Entry

O43614

UniProtKB/Swiss-Prot:

OX2R_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with HCRTR2: view

Function for HCRTR2 Gene

Molecular function for HCRTR2 Gene

GENATLAS Biochemistry:
hypocretin receptor 2,G protein coupled receptor superfamily binding both HCRT isoforms A and B
UniProtKB/Swiss-Prot Function:
Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides

Gene Ontology (GO) - Molecular Function for HCRTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0008188 neuropeptide receptor activity TAS 9491897
GO:0016499 orexin receptor activity IBA --
GO:0017046 peptide hormone binding IEA --
GO:0042277 peptide binding IBA --
genes like me logo Genes that share ontologies with HCRTR2: view

Phenotypes for HCRTR2 Gene

MGI mutant phenotypes for HCRTR2:
inferred from 2 alleles
GenomeRNAi human phenotypes for HCRTR2:
genes like me logo Genes that share phenotypes with HCRTR2: view

Animal Model Products

miRNA for HCRTR2 Gene

miRTarBase miRNAs that target HCRTR2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HCRTR2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for HCRTR2 Gene

Localization for HCRTR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HCRTR2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HCRTR2 Gene COMPARTMENTS Subcellular localization image for HCRTR2 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for HCRTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9491897
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with HCRTR2: view

Pathways & Interactions for HCRTR2 Gene

genes like me logo Genes that share pathways with HCRTR2: view

Pathways by source for HCRTR2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for HCRTR2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for HCRTR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway IEA --
GO:0007268 synaptic transmission TAS 9491897
GO:0007631 feeding behavior IEA --
genes like me logo Genes that share ontologies with HCRTR2: view

Drugs & Compounds for HCRTR2 Gene

(25) Drugs for HCRTR2 Gene - From: NovoSeek, IUPHAR, DGIdb, Tocris, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
suvorexant Approved Pharma Antagonist 0
Allopurinol Approved Pharma 125
Norepinephrine Approved Pharma 206
SB-649868 Experimental Pharma Antagonist, antagonist 0
Acetylcholine Experimental Pharma Full agonist, Agonist 104

(8) Additional Compounds for HCRTR2 Gene - From: IUPHAR, Tocris, and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-(2,4-dibromo-phenyl)-3-((4S,5S)-2,2-dimethyl-4-phenyl-[1,3]dioxan-5-yl)-urea
Antagonist
ACT-078573
Antagonist
MK-6096
Antagonist
N-ethyl-2-[(6-methoxy-pyridin-3-yl)-(toluene-2-sulphonyl)-amino]-N-pyridin-3-ylmethyl-acetamide
Antagonist
[Ala11,D-Leu15]-Orexin B
532932-99-3
genes like me logo Genes that share compounds with HCRTR2: view

Transcripts for HCRTR2 Gene

mRNA/cDNA for HCRTR2 Gene

(2) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for HCRTR2 Gene

Hypocretin (orexin) receptor 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HCRTR2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HCRTR2 Gene

No ASD Table

Relevant External Links for HCRTR2 Gene

GeneLoc Exon Structure for
HCRTR2
ECgene alternative splicing isoforms for
HCRTR2

Expression for HCRTR2 Gene

mRNA expression in normal human tissues for HCRTR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HCRTR2 Gene

This gene is overexpressed in Brain - Hypothalamus (x9.4), Brain - Substantia nigra (x5.6), and Brain - Anterior cingulate cortex (BA24) (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HCRTR2 Gene



SOURCE GeneReport for Unigene cluster for HCRTR2 Gene Hs.151624

genes like me logo Genes that share expression patterns with HCRTR2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HCRTR2 Gene

Orthologs for HCRTR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for HCRTR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HCRTR2 35
  • 89.86 (n)
  • 96.85 (a)
HCRTR2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HCRTR2 35
  • 93.09 (n)
  • 97.75 (a)
HCRTR2 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hcrtr2 35
  • 87.96 (n)
  • 94.58 (a)
Hcrtr2 16
Hcrtr2 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HCRTR2 35
  • 99.55 (n)
  • 99.1 (a)
HCRTR2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hcrtr2 35
  • 88.04 (n)
  • 94.58 (a)
oppossum
(Monodelphis domestica)
Mammalia HCRTR2 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves HCRTR2 35
  • 80.2 (n)
  • 86.93 (a)
HCRTR2 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HCRTR2 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hcrtr2 35
  • 75.09 (n)
  • 84.05 (a)
zebrafish
(Danio rerio)
Actinopterygii hcrtr2 35
  • 68.88 (n)
  • 71.56 (a)
hcrtr2 36
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta NepYr 37
  • 31 (a)
SIFR 36
  • 17 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea npr-2 35
  • 42.7 (n)
  • 29.43 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for HCRTR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HCRTR2 Gene

ENSEMBL:
Gene Tree for HCRTR2 (if available)
TreeFam:
Gene Tree for HCRTR2 (if available)

Paralogs for HCRTR2 Gene

(16) SIMAP similar genes for HCRTR2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with HCRTR2: view

Variants for HCRTR2 Gene

Sequence variations from dbSNP and Humsavar for HCRTR2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1013624 -- 55,269,804(-) ttttt(A/G)tgttt intron-variant
rs1027650 -- 55,276,386(-) TGTTG(A/C)TTTTT intron-variant
rs1502195 -- 55,282,900(-) TTTTT(A/T)TAAAA downstream-variant-500B
rs1502209 -- 55,267,693(-) CCTGA(A/G)AAGCT intron-variant
rs1553332 -- 55,269,685(-) CAATC(A/G)AGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HCRTR2 Gene

Variant ID Type Subtype PubMed ID
dgv6849n71 CNV Gain 21882294

Variation tolerance for HCRTR2 Gene

Residual Variation Intolerance Score: 65.38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HCRTR2 Gene

HapMap Linkage Disequilibrium report
HCRTR2
Human Gene Mutation Database (HGMD)
HCRTR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HCRTR2 Gene

Disorders for HCRTR2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for HCRTR2 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
cluster headache
sleep disorder
  • non-organic sleep disorder
hallucinogen dependence
narcolepsy
  • paroxysmal sleep
- elite association

Relevant External Links for HCRTR2

Genetic Association Database (GAD)
HCRTR2
Human Genome Epidemiology (HuGE) Navigator
HCRTR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HCRTR2
genes like me logo Genes that share disorders with HCRTR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for HCRTR2 Gene

Publications for HCRTR2 Gene

  1. Orexins/hypocretins and orexin receptors in apoptosis: a mini-review. (PMID: 19719798) Laburthe M. … El Firar A. (Acta Physiol (Oxf) 2010) 23 67
  2. Orexin receptor antagonism prevents transcriptional and behavioral plasticity resulting from stimulant exposure. (PMID: 19596018) Winrow C.J. … Renger J.J. (Neuropharmacology 2010) 23 67
  3. Hypocretin/orexin and energy expenditure. (PMID: 20070282) Teske J.A. … Kotz C.M. (Acta Physiol (Oxf) 2010) 23 67
  4. Genomic organization and regulation of the human orexin (hypocretin) receptor 2 gene: identification of alternative promoters. (PMID: 20156195) Chen J. … Randeva H.S. (Biochem. J. 2010) 23 67
  5. Role of orexin in the regulation of glucose homeostasis. (PMID: 19489767) Tsuneki H. … Sasaoka T. (Acta Physiol (Oxf) 2010) 23 67

Products for HCRTR2 Gene

Sources for HCRTR2 Gene

Back to Top

Content