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Aliases for ANXA3 Gene

Aliases for ANXA3 Gene

  • Annexin A3 2 3
  • ANX3 3 4 6
  • Inositol 1,2-Cyclic Phosphate 2-Phosphohydrolase 3 4
  • Placental Anticoagulant Protein III 3 4
  • 35-Alpha Calcimedin 3 4
  • Lipocortin III 3 4
  • Annexin-3 3 4
  • PAP-III 3 4
  • Annexin III (Lipocortin III, 1,2-Cyclic-Inositol-Phosphate Phosphodiesterase, Placental Anticoagulant Protein III, Calcimedin 35-Alpha) 3
  • Annexin III (Lipocortin III) 3
  • Calcimedin 35-Alpha 3
  • Annexin III 4

External Ids for ANXA3 Gene

Previous Symbols for ANXA3 Gene

  • ANX3

Summaries for ANXA3 Gene

Entrez Gene Summary for ANXA3 Gene

  • This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANXA3 Gene

ANXA3 (Annexin A3) is a Protein Coding gene. Among its related pathways are Prostaglandin Synthesis and Regulation. GO annotations related to this gene include calcium ion binding and phospholipase A2 inhibitor activity. An important paralog of this gene is ANXA9.

UniProtKB/Swiss-Prot for ANXA3 Gene

  • Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate

Gene Wiki entry for ANXA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA3 Gene

Genomics for ANXA3 Gene

Genomic Location for ANXA3 Gene

Start:
78,551,519 bp from pter
End:
78,610,451 bp from pter
Size:
58,933 bases
Orientation:
Plus strand

Genomic View for ANXA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANXA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA3 Gene

Regulatory Elements for ANXA3 Gene

Proteins for ANXA3 Gene

  • Protein details for ANXA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12429-ANXA3_HUMAN
    Recommended name:
    Annexin A3
    Protein Accession:
    P12429
    Secondary Accessions:
    • B2R9W6
    • Q6LET2

    Protein attributes for ANXA3 Gene

    Size:
    323 amino acids
    Molecular mass:
    36375 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ANXA3 Gene

neXtProt entry for ANXA3 Gene

Proteomics data for ANXA3 Gene at MOPED

Post-translational modifications for ANXA3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys210

Other Protein References for ANXA3 Gene

No data available for DME Specific Peptides for ANXA3 Gene

Domains for ANXA3 Gene

Gene Families for ANXA3 Gene

HGNC:

Protein Domains for ANXA3 Gene

UniProtKB/Swiss-Prot:

ANXA3_HUMAN
Domain:
  • A pair of annexin repeats may form one binding site for calcium and phospholipid:
    • P12429
Family:
  • Belongs to the annexin family.:
    • P12429
Similarity:
  • Contains 4 annexin repeats.:
    • P12429
genes like me logo Genes that share domains with ANXA3: view

Function for ANXA3 Gene

Molecular function for ANXA3 Gene

GENATLAS Biochemistry: annexin A3,calelectrin 32.5
UniProtKB/Swiss-Prot Function: Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate

Gene Ontology (GO) - Molecular Function for ANXA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004859 phospholipase inhibitor activity --
GO:0005509 calcium ion binding IEA --
GO:0005544 calcium-dependent phospholipid binding IDA 2138016
GO:0019834 phospholipase A2 inhibitor activity IEA --
GO:0048306 calcium-dependent protein binding IPI 15226301
genes like me logo Genes that share ontologies with ANXA3: view

miRNA for ANXA3 Gene

miRTarBase miRNAs that target ANXA3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ANXA3 Gene

Localization for ANXA3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANXA3 Gene COMPARTMENTS Subcellular localization image for ANXA3 gene
Compartment Confidence
plasma membrane 5
cytosol 3
cytoskeleton 2
nucleus 2
endosome 1

Gene Ontology (GO) - Cellular Components for ANXA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA 7526843
GO:0016020 membrane IDA 17205602
GO:0030670 phagocytic vesicle membrane IDA 7526843
GO:0042581 specific granule IDA 7526843
genes like me logo Genes that share ontologies with ANXA3: view

Pathways for ANXA3 Gene

genes like me logo Genes that share pathways with ANXA3: view

Pathways by source for ANXA3 Gene

1 BioSystems pathway for ANXA3 Gene

Gene Ontology (GO) - Biological Process for ANXA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006909 phagocytosis IDA 9497492
GO:0010595 positive regulation of endothelial cell migration IDA 16236264
GO:0042742 defense response to bacterium IDA 9497492
GO:0043086 negative regulation of catalytic activity IEA --
GO:0043312 neutrophil degranulation IDA 9550422
genes like me logo Genes that share ontologies with ANXA3: view

Compounds for ANXA3 Gene

(6) HMDB Compounds for ANXA3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
Glycerol
  • 1,2,3-Trihydroxypropane
56-81-5
Inositol cyclic phosphate
  • 1D-myo-Inositol 1,2-cyclic phosphate
43119-57-9
Inositol phosphate
  • 1D-myo-Inositol 1-monophosphate
15421-51-9
Myo-inositol 1-phosphate
  • 1-(dihydrogen phosphate) DL-myo-Inositol
573-35-3

(1) Drugbank Compounds for ANXA3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Ethanolamine
141-43-5 target

(9) Novoseek inferred chemical compound relationships for ANXA3 Gene

Compound -log(P) Hits PubMed IDs
inositol 1,2-cyclic phosphate 81.8 4
isocitrate 51.9 3
phosphatidylethanolamine 36.5 2
phospholipid 33.8 2
calcium 32.4 6
genes like me logo Genes that share compounds with ANXA3: view

Transcripts for ANXA3 Gene

Unigene Clusters for ANXA3 Gene

Annexin A3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - - -
SP6:

Relevant External Links for ANXA3 Gene

GeneLoc Exon Structure for
ANXA3
ECgene alternative splicing isoforms for
ANXA3

Expression for ANXA3 Gene

mRNA expression in normal human tissues for ANXA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANXA3 Gene

This gene is overexpressed in Whole Blood (16.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANXA3 Gene

SOURCE GeneReport for Unigene cluster for ANXA3 Gene Hs.480042

genes like me logo Genes that share expressions with ANXA3: view

Orthologs for ANXA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ANXA3 36
  • 98.66 (n)
  • 98.45 (a)
ANXA3 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ANXA3 36
  • 88.03 (n)
  • 88.24 (a)
ANXA3 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANXA3 36
  • 89.16 (n)
  • 90.4 (a)
ANXA3 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anxa3 36
  • 84.73 (n)
  • 89.78 (a)
Anxa3 16
Anxa3 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ANXA3 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anxa3 36
  • 83.95 (n)
  • 85.4 (a)
lizard
(Anolis carolinensis)
Reptilia ANXA3 37
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3863 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5303 36
zebrafish
(Danio rerio)
Actinopterygii anxa3a 37
  • 49 (a)
OneToMany
anxa3b 36
  • 60.08 (n)
  • 56.37 (a)
anxa3b 37
  • 53 (a)
OneToMany
wufb60b03 36
fruit fly
(Drosophila melanogaster)
Insecta Anxb11 38
  • 43 (a)
AnnX 38
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea nex-2 37
  • 28 (a)
OneToMany
nex-3 38
  • 35 (a)
nex-2 38
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 27 (a)
OneToMany
Species with no ortholog for ANXA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA3 Gene

ENSEMBL:
Gene Tree for ANXA3 (if available)
TreeFam:
Gene Tree for ANXA3 (if available)

Paralogs for ANXA3 Gene

Paralogs for ANXA3 Gene

genes like me logo Genes that share paralogs with ANXA3: view

Variants for ANXA3 Gene

Sequence variations from dbSNP and Humsavar for ANXA3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs4612 -- 78,610,154(+) GCTTT(C/T)CCAAC utr-variant-3-prime
rs5941 - 78,604,359(+) AGAGT(C/T)CAAGA missense, reference
rs5942 -- 78,604,250(+) TTTGT(A/G)TTGTG intron-variant
rs5943 -- 78,601,491(+) AACAT(C/T)ATTTG intron-variant
rs5944 -- 78,610,032(+) TTGTT(C/T)TTCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA3 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER Inversion 18451855
esv273006 CNV Insertion 20981092
esv271571 CNV Insertion 20981092

Relevant External Links for ANXA3 Gene

HapMap Linkage Disequilibrium report
ANXA3

Disorders for ANXA3 Gene

(5) Novoseek inferred disease relationships for ANXA3 Gene

Disease -log(P) Hits PubMed IDs
ovarian cancer 23.9 4
prostate cancer 22.8 6
cancer 11 6
shock 7.38 3
tuberculosis 0 1

Relevant External Links for ANXA3

Genetic Association Database (GAD)
ANXA3
Human Genome Epidemiology (HuGE) Navigator
ANXA3
genes like me logo Genes that share disorders with ANXA3: view

No data available for UniProtKB/Swiss-Prot for ANXA3 Gene

Publications for ANXA3 Gene

  1. Chromosomal localization of the human annexin III (ANX3) gene. (PMID: 1830024) Tait J.F. … Disteche C.M. (Genomics 1991) 2 3 4 23
  2. Purification and characterization of an abundant cytosolic protein from human neutrophils that promotes Ca2(+)-dependent aggregation of isolated specific granules. (PMID: 2138632) Ernst J.D. … Jaye D. (J. Clin. Invest. 1990) 3 4 23
  3. Identity of inositol 1,2-cyclic phosphate 2-phosphohydrolase with lipocortin III. (PMID: 2159184) Ross T.S. … Majerus P.W. (Science 1990) 3 4 23
  4. Structure and polymorphisms of the human annexin III (ANX3) gene. (PMID: 8276419) Tait J.F. … Cookson B.T. (Genomics 1993) 3 4 23
  5. The high-resolution crystal structure of human annexin III shows subtle differences with annexin V. (PMID: 8639653) Favier-Perron B. … Russo-Marie F. (Biochemistry 1996) 3 4 23

Products for ANXA3 Gene

Sources for ANXA3 Gene

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