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Aliases for ANXA3 Gene

Aliases for ANXA3 Gene

  • Annexin A3 2 3 5
  • Inositol 1,2-Cyclic Phosphate 2-Phosphohydrolase 3 4
  • Placental Anticoagulant Protein III 3 4
  • 35-Alpha Calcimedin 3 4
  • Lipocortin III 3 4
  • Annexin-3 3 4
  • PAP-III 3 4
  • ANX3 3 4
  • Annexin III (Lipocortin III, 1,2-Cyclic-Inositol-Phosphate Phosphodiesterase, Placental Anticoagulant Protein III, Calcimedin 35-Alpha) 3
  • Annexin III (Lipocortin III) 3
  • Calcimedin 35-Alpha 3
  • Annexin III 4

External Ids for ANXA3 Gene

Previous HGNC Symbols for ANXA3 Gene

  • ANX3

Previous GeneCards Identifiers for ANXA3 Gene

  • GC04P079403
  • GC04P079746
  • GC04P079865
  • GC04P079933
  • GC04P079925
  • GC04P079830
  • GC04P075219
  • GC04P079472

Summaries for ANXA3 Gene

Entrez Gene Summary for ANXA3 Gene

  • This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANXA3 Gene

ANXA3 (Annexin A3) is a Protein Coding gene. Among its related pathways are Prostaglandin Synthesis and Regulation. GO annotations related to this gene include calcium ion binding and calcium-dependent phospholipid binding. An important paralog of this gene is ANXA4.

UniProtKB/Swiss-Prot for ANXA3 Gene

  • Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.

Gene Wiki entry for ANXA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA3 Gene

Genomics for ANXA3 Gene

Regulatory Elements for ANXA3 Gene

Enhancers for ANXA3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ANXA3 on UCSC Golden Path with GeneCards custom track

Promoters for ANXA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ANXA3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ANXA3 Gene

Chromosome:
4
Start:
78,551,519 bp from pter
End:
78,610,451 bp from pter
Size:
58,933 bases
Orientation:
Plus strand

Genomic View for ANXA3 Gene

Genes around ANXA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ANXA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ANXA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA3 Gene

Proteins for ANXA3 Gene

  • Protein details for ANXA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P12429-ANXA3_HUMAN
    Recommended name:
    Annexin A3
    Protein Accession:
    P12429
    Secondary Accessions:
    • B2R9W6
    • Q6LET2

    Protein attributes for ANXA3 Gene

    Size:
    323 amino acids
    Molecular mass:
    36375 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ANXA3 Gene

neXtProt entry for ANXA3 Gene

Proteomics data for ANXA3 Gene at MOPED

Post-translational modifications for ANXA3 Gene

  • Ubiquitination at Lys 210
  • Modification sites at PhosphoSitePlus

Other Protein References for ANXA3 Gene

No data available for DME Specific Peptides for ANXA3 Gene

Domains & Families for ANXA3 Gene

Gene Families for ANXA3 Gene

Protein Domains for ANXA3 Gene

Suggested Antigen Peptide Sequences for ANXA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P12429

UniProtKB/Swiss-Prot:

ANXA3_HUMAN :
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
  • Belongs to the annexin family.
  • Contains 4 annexin repeats.
Domain:
  • A pair of annexin repeats may form one binding site for calcium and phospholipid.
Family:
  • Belongs to the annexin family.
Similarity:
  • Contains 4 annexin repeats.
genes like me logo Genes that share domains with ANXA3: view

Function for ANXA3 Gene

Molecular function for ANXA3 Gene

GENATLAS Biochemistry:
annexin A3,calelectrin 32.5
UniProtKB/Swiss-Prot Function:
Inhibitor of phospholipase A2, also possesses anti-coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.

Gene Ontology (GO) - Molecular Function for ANXA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0048306 calcium-dependent protein binding IPI 15226301
genes like me logo Genes that share ontologies with ANXA3: view
genes like me logo Genes that share phenotypes with ANXA3: view

Animal Models for ANXA3 Gene

MGI Knock Outs for ANXA3:

Animal Model Products

miRNA for ANXA3 Gene

miRTarBase miRNAs that target ANXA3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ANXA3 Gene

Localization for ANXA3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANXA3 Gene COMPARTMENTS Subcellular localization image for ANXA3 gene
Compartment Confidence
cytosol 5
extracellular 5
plasma membrane 5
nucleus 3
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 1
endosome 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ANXA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 17205602
GO:0016020 membrane IDA 17205602
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with ANXA3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ANXA3 Gene

Pathways & Interactions for ANXA3 Gene

genes like me logo Genes that share pathways with ANXA3: view

Pathways by source for ANXA3 Gene

1 BioSystems pathway for ANXA3 Gene

Gene Ontology (GO) - Biological Process for ANXA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010595 positive regulation of endothelial cell migration IDA 16236264
GO:0042742 defense response to bacterium IDA 9497492
GO:0051054 positive regulation of DNA metabolic process IEA --
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IDA 16236264
GO:0070848 response to growth factor IEA --
genes like me logo Genes that share ontologies with ANXA3: view

No data available for SIGNOR curated interactions for ANXA3 Gene

Drugs & Compounds for ANXA3 Gene

(5) Drugs for ANXA3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ethanolamine Experimental Pharma Target 0
Glycerol Experimental Pharma 205
calcium Nutra 0

(10) Additional Compounds for ANXA3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Inositol cyclic phosphate
  • 1D-Myo-Inositol 1,2-cyclic phosphate
  • D-Myo-Inositol 1,2-cyclic phosphate
  • Inositol 1,2-cyclic phosphate
  • Inositol cyclic phosphate
  • Inositol cyclic-1,2-monophosphate
43119-57-9
Inositol phosphate
  • 1D-Myo-Inositol 1-monophosphate
  • 1D-Myo-Inositol 1-phosphate
  • D-Myo-Inositol-1-Phosphate
  • Inositol 1-monophosphate
15421-51-9
Myo-inositol 1-phosphate
  • 1-(Dihydrogen phosphate) DL-myo-Inositol
  • 1-(Dihydrogen phosphate) myo-Inositol
  • DL-myo-Inositol 1-phosphate
  • Myo-Inositol 1-monophosphate
  • Myo-Inositol 1-phosphate
573-35-3
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with ANXA3: view

Transcripts for ANXA3 Gene

Unigene Clusters for ANXA3 Gene

Annexin A3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - - -
SP6:

Relevant External Links for ANXA3 Gene

GeneLoc Exon Structure for
ANXA3
ECgene alternative splicing isoforms for
ANXA3

Expression for ANXA3 Gene

mRNA expression in normal human tissues for ANXA3 Gene

mRNA differential expression in normal tissues according to GTEx for ANXA3 Gene

This gene is overexpressed in Whole Blood (x16.5).

Protein differential expression in normal tissues from HIPED for ANXA3 Gene

This gene is overexpressed in Neutrophil (12.0) and Nasal epithelium (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANXA3 Gene



SOURCE GeneReport for Unigene cluster for ANXA3 Gene Hs.480042

genes like me logo Genes that share expression patterns with ANXA3: view

Protein tissue co-expression partners for ANXA3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ANXA3 Gene

Orthologs for ANXA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANXA3 35
  • 88.03 (n)
  • 88.24 (a)
ANXA3 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANXA3 35
  • 89.16 (n)
  • 90.4 (a)
ANXA3 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anxa3 35
  • 84.73 (n)
  • 89.78 (a)
Anxa3 16
Anxa3 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANXA3 35
  • 98.66 (n)
  • 98.45 (a)
ANXA3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Anxa3 35
  • 83.95 (n)
  • 85.4 (a)
oppossum
(Monodelphis domestica)
Mammalia ANXA3 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANXA3 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5303 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3863 35
zebrafish
(Danio rerio)
Actinopterygii anxa3b 35
  • 60.08 (n)
  • 56.37 (a)
wufb60b03 35
anxa3a 36
  • 49 (a)
OneToMany
anxa3b 36
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta AnnX 37
  • 44 (a)
Anxb11 37
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea nex-2 37
  • 44 (a)
nex-3 37
  • 35 (a)
nex-2 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
Species with no ortholog for ANXA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA3 Gene

ENSEMBL:
Gene Tree for ANXA3 (if available)
TreeFam:
Gene Tree for ANXA3 (if available)

Paralogs for ANXA3 Gene

genes like me logo Genes that share paralogs with ANXA3: view

Variants for ANXA3 Gene

Sequence variations from dbSNP and Humsavar for ANXA3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs5951 - 78,573,220(+) CTTTA(A/G)CCCAT nc-transcript-variant, reference, missense, utr-variant-5-prime
rs5948 - 78,597,340(+) AAATA(A/T)CAGCC nc-transcript-variant, reference, missense
rs5949 - 78,601,531(+) CACGC(C/T)GGCCT nc-transcript-variant, reference, missense
rs5941 - 78,604,359(+) AGAGT(C/T)CAAGA reference, missense
rs4612 -- 78,610,154(+) GCTTT(C/T)CCAAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ANXA3 Gene

Variant ID Type Subtype PubMed ID
nsv7363 OTHER Inversion 18451855
esv273006 CNV Insertion 20981092
esv271571 CNV Insertion 20981092

Variation tolerance for ANXA3 Gene

Residual Variation Intolerance Score: 85.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.82; 58.54% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ANXA3 Gene

Disorders for ANXA3 Gene

Relevant External Links for ANXA3

Genetic Association Database (GAD)
ANXA3
Human Genome Epidemiology (HuGE) Navigator
ANXA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANXA3

No disorders were found for ANXA3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ANXA3 Gene

Publications for ANXA3 Gene

  1. Chromosomal localization of the human annexin III (ANX3) gene. (PMID: 1830024) Tait J.F. … Disteche C.M. (Genomics 1991) 2 3 4 23 67
  2. Increased expression of annexin A3 is a mechanism of platinum resistance in ovarian cancer. (PMID: 20103635) Yan X. … Pan L. (Cancer Res. 2010) 3 23
  3. Primary cell cultures from human renal cortex and renal-cell carcinoma evidence a differential expression of two spliced isoforms of Annexin A3. (PMID: 20167856) Bianchi C. … Perego R.A. (Am. J. Pathol. 2010) 3 23
  4. Differential radioactive quantification of protein abundance ratios between benign and malignant prostate tissues: cancer association of annexin A3. (PMID: 17205602) Wozny W. … Cahill M.A. (Proteomics 2007) 3 23
  5. Annexin A3 is a potential angiogenic mediator. (PMID: 16236264) Park J.E. … Cho S. (Biochem. Biophys. Res. Commun. 2005) 3 23

Products for ANXA3 Gene

Sources for ANXA3 Gene

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