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Aliases for HAS2 Gene

Aliases for HAS2 Gene

  • Hyaluronan Synthase 2 2 3
  • Hyaluronic Acid Synthase 2 4
  • Hyaluronate Synthase 2 4
  • HA Synthase 2 4
  • EC 2.4.1.212 4

External Ids for HAS2 Gene

Summaries for HAS2 Gene

Entrez Gene Summary for HAS2 Gene

  • Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for HAS2 Gene

HAS2 (Hyaluronan Synthase 2) is a Protein Coding gene. Diseases associated with HAS2 include rheumatoid arthritis and lipoblastoma. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include hyaluronan synthase activity. An important paralog of this gene is HAS3.

UniProtKB/Swiss-Prot for HAS2 Gene

  • Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity).

Gene Wiki entry for HAS2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAS2 Gene

Genomics for HAS2 Gene

Genomic Location for HAS2 Gene

Start:
121,612,116 bp from pter
End:
121,641,390 bp from pter
Size:
29,275 bases
Orientation:
Minus strand

Genomic View for HAS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HAS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAS2 Gene

Regulatory Elements for HAS2 Gene

Proteins for HAS2 Gene

  • Protein details for HAS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92819-HYAS2_HUMAN
    Recommended name:
    Hyaluronan synthase 2
    Protein Accession:
    Q92819
    Secondary Accessions:
    • Q32MM3

    Protein attributes for HAS2 Gene

    Size:
    552 amino acids
    Molecular mass:
    63566 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

neXtProt entry for HAS2 Gene

Proteomics data for HAS2 Gene at MOPED

Post-translational modifications for HAS2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HAS2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for HAS2 Gene

Domains for HAS2 Gene

Gene Families for HAS2 Gene

HGNC:
  • GLT2 :Glycosyltransferase family 2 domain containing

Protein Domains for HAS2 Gene

UniProtKB/Swiss-Prot:

HYAS2_HUMAN
Family:
  • Belongs to the NodC/HAS family.:
    • Q92819
genes like me logo Genes that share domains with HAS2: view

Function for HAS2 Gene

Molecular function for HAS2 Gene

GENATLAS Biochemistry: hyaluronan synthase gene 2
UniProtKB/Swiss-Prot CatalyticActivity: UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan)
UniProtKB/Swiss-Prot CatalyticActivity: UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan)
UniProtKB/Swiss-Prot Function: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan. Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development. May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix (By similarity).

Enzyme Numbers (IUBMB) for HAS2 Gene

Gene Ontology (GO) - Molecular Function for HAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050501 hyaluronan synthase activity ISS --
genes like me logo Genes that share ontologies with HAS2: view
genes like me logo Genes that share phenotypes with HAS2: view

Animal Models for HAS2 Gene

MGI Knock Outs for HAS2:

miRNA for HAS2 Gene

miRTarBase miRNAs that target HAS2

No data available for Transcription Factor Targeting and HOMER Transcription for HAS2 Gene

Localization for HAS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for HAS2 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HAS2 Gene COMPARTMENTS Subcellular localization image for HAS2 gene
Compartment Confidence
plasma membrane 4
extracellular 2
golgi apparatus 2
cytoskeleton 1
nucleus 1

Gene Ontology (GO) - Cellular Components for HAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IDA 20522558
genes like me logo Genes that share ontologies with HAS2: view

Pathways for HAS2 Gene

genes like me logo Genes that share pathways with HAS2: view

Pathways by source for HAS2 Gene

UniProtKB/Swiss-Prot Q92819-HYAS2_HUMAN

  • Pathway: Glycan biosynthesis; hyaluronan biosynthesis

Gene Ontology (GO) - Biological Process for HAS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001570 vasculogenesis ISS --
GO:0001822 kidney development ISS --
GO:0008284 positive regulation of cell proliferation IMP 22016393
GO:0030212 hyaluronan metabolic process --
GO:0030213 hyaluronan biosynthetic process ISS --
genes like me logo Genes that share ontologies with HAS2: view

Compounds for HAS2 Gene

(6) HMDB Compounds for HAS2 Gene

Compound Synonyms Cas Number PubMed IDs
Hyaluronan
  • hyaluronic acid
9004-61-9
Hyaluronic acid
  • hyaluronic acid
9004-61-9
Magnesium
  • Magnesium
7439-95-4
Uridine 5'-diphosphate
  • 5'-UDP
58-98-0
Uridine diphosphate glucuronic acid
  • UDP glucuronate
2616-64-0

(19) Novoseek inferred chemical compound relationships for HAS2 Gene

Compound -log(P) Hits PubMed IDs
glycosaminoglycan 77.7 1
hyaluronic acid 69.1 19
4-methylumbelliferone 65.1 3
udp glucuronic acid 55.7 2
iloprost 41.2 3
genes like me logo Genes that share compounds with HAS2: view

Transcripts for HAS2 Gene

Unigene Clusters for HAS2 Gene

Hyaluronan synthase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HAS2 Gene

No ASD Table

Relevant External Links for HAS2 Gene

GeneLoc Exon Structure for
HAS2
ECgene alternative splicing isoforms for
HAS2

Expression for HAS2 Gene

mRNA expression in normal human tissues for HAS2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for HAS2 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for HAS2 Gene

SOURCE GeneReport for Unigene cluster for HAS2 Gene Hs.159226

mRNA Expression by UniProt/SwissProt for HAS2 Gene

Q92819-HYAS2_HUMAN
Tissue specificity: Expressed in fibroblasts
genes like me logo Genes that share expressions with HAS2: view

Orthologs for HAS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HAS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HAS2 36
  • 99.88 (n)
  • 100 (a)
HAS2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HAS2 36
  • 93.66 (n)
  • 98.73 (a)
HAS2 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HAS2 36
  • 93.9 (n)
  • 99.46 (a)
HAS2 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Has2 36
  • 90.94 (n)
  • 98.91 (a)
Has2 16
Has2 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HAS2 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HAS2 37
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Has2 36
  • 91.49 (n)
  • 98.37 (a)
chicken
(Gallus gallus)
Aves HAS2 36
  • 84.78 (n)
  • 93.3 (a)
HAS2 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 85 (a)
OneToMany
-- 37
  • 95 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.608 36
tropical clawed frog
(Silurana tropicalis)
Amphibia has2 36
  • 79.23 (n)
  • 89.67 (a)
zebrafish
(Danio rerio)
Actinopterygii has2 36
  • 73.67 (n)
  • 81.34 (a)
has2 37
  • 81 (a)
OneToOne
Species with no ortholog for HAS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HAS2 Gene

ENSEMBL:
Gene Tree for HAS2 (if available)
TreeFam:
Gene Tree for HAS2 (if available)

Paralogs for HAS2 Gene

Paralogs for HAS2 Gene

Selected SIMAP similar genes for HAS2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with HAS2: view

Variants for HAS2 Gene

Sequence variations from dbSNP and Humsavar for HAS2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1057311 -- 121,613,832(-) TTTTG(C/G)CCTAT utr-variant-3-prime
rs1057315 -- 121,613,592(-) AAATT(C/G/T)TGTAT utr-variant-3-prime
rs1871884 -- 121,618,590(+) GAAAA(A/G)AAAGT intron-variant
rs1905095 -- 121,615,607(+) CGTGA(C/G)CCACT intron-variant
rs2385924 -- 121,615,940(+) ATTTT(G/T)CCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HAS2 Gene

Variant ID Type Subtype PubMed ID
nsv831446 CNV Loss 17160897

Relevant External Links for HAS2 Gene

HapMap Linkage Disequilibrium report
HAS2
Human Gene Mutation Database (HGMD)
HAS2

Disorders for HAS2 Gene

UniProtKB/Swiss-Prot

HYAS2_HUMAN
  • Note=A chromosomal aberration involving HAS2 may be a cause of lipoblastomas, which are benign tumors resulting from transformation of adipocytes, usually diagnosed in children. 8q12.1 to 8q24.1 intrachromosomal rearrangement with PLAG1.

(15) Novoseek inferred disease relationships for HAS2 Gene

Disease -log(P) Hits PubMed IDs
colon carcinoma 47.6 1
osteosarcoma 38.3 7
tumors 28.2 9
metastasis 22.5 1
atherosclerosis 17.5 1

Relevant External Links for HAS2

Genetic Association Database (GAD)
HAS2
Human Genome Epidemiology (HuGE) Navigator
HAS2
genes like me logo Genes that share disorders with HAS2: view

Publications for HAS2 Gene

  1. Chromosomal localization of the human and mouse hyaluronan synthase genes. (PMID: 9169154) Spicer A.P. … McDonald J.A. (Genomics 1997) 2 3 23
  2. Molecular identification of a putative human hyaluronan synthase. (PMID: 8798477) Watanabe K. … Yamaguchi Y. (J. Biol. Chem. 1996) 3 4 23
  3. Expression of hyaluronan synthase in intraocular proliferative diseases: regulation of expression in human vascular endothelial cells by transforming growth factor-beta. (PMID: 14636845) Suzuki K. … Yamashita H. (Jpn. J. Ophthalmol. 2003) 3 23
  4. Induction of hyaluronic acid synthase 2 (HAS2) in human vascular smooth muscle cells by vasodilatory prostaglandins. (PMID: 14752026) Sussmann M. … Fischer J.W. (Circ. Res. 2004) 3 23
  5. Identification and analysis of the promoter region of the human hyaluronan synthase 2 gene. (PMID: 14988410) Monslow J. … Bowen T. (J. Biol. Chem. 2004) 3 23

Products for HAS2 Gene

Sources for HAS2 Gene

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