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Aliases for HAL Gene

Aliases for HAL Gene

  • Histidine Ammonia-Lyase 2 3
  • EC 4.3.1.3 4 63
  • Histidase 3 4
  • HIS 3 4
  • EC 4.3.1 63
  • HSTD 3

External Ids for HAL Gene

Previous HGNC Symbols for HAL Gene

  • HIS

Previous GeneCards Identifiers for HAL Gene

  • GC12M095787
  • GC12M096730
  • GC12M096300
  • GC12M094869
  • GC12M093429
  • GC12M096366

Summaries for HAL Gene

Entrez Gene Summary for HAL Gene

  • Histidine ammonia-lyase is a cytosolic enzyme catalyzing the first reaction in histidine catabolism, the nonoxidative deamination of L-histidine to trans-urocanic acid. Histidine ammonia-lyase defects cause histidinemia which is characterized by increased histidine and histamine and decreased urocanic acid in body fluids. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

GeneCards Summary for HAL Gene

HAL (Histidine Ammonia-Lyase) is a Protein Coding gene. Diseases associated with HAL include histidinemia and histidine metabolism disease. Among its related pathways are Metabolism and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include histidine ammonia-lyase activity and ammonia-lyase activity.

Gene Wiki entry for HAL Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HAL Gene

Genomics for HAL Gene

Regulatory Elements for HAL Gene

Genomic Location for HAL Gene

Chromosome:
12
Start:
95,972,662 bp from pter
End:
95,996,365 bp from pter
Size:
23,704 bases
Orientation:
Minus strand

Genomic View for HAL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HAL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HAL Gene

Proteins for HAL Gene

  • Protein details for HAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42357-HUTH_HUMAN
    Recommended name:
    Histidine ammonia-lyase
    Protein Accession:
    P42357
    Secondary Accessions:
    • B4DQC1
    • B4E0V8
    • F5GXF2
    • F5H1U5
    • Q4VB92
    • Q4VB93

    Protein attributes for HAL Gene

    Size:
    657 amino acids
    Molecular mass:
    72698 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for HAL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for HAL Gene

Proteomics data for HAL Gene at MOPED

Post-translational modifications for HAL Gene

  • Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for HAL Gene

Protein Domains for HAL Gene

Graphical View of Domain Structure for InterPro Entry

P42357

UniProtKB/Swiss-Prot:

HUTH_HUMAN :
  • Belongs to the PAL/histidase family.
Family:
  • Belongs to the PAL/histidase family.
genes like me logo Genes that share domains with HAL: view

No data available for Gene Families for HAL Gene

Function for HAL Gene

Molecular function for HAL Gene

GENATLAS Biochemistry:
histidine ammonia lyase (histidase),histidine catabolism
UniProtKB/Swiss-Prot CatalyticActivity:
L-histidine = urocanate + NH(3).

Enzyme Numbers (IUBMB) for HAL Gene

Gene Ontology (GO) - Molecular Function for HAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004397 histidine ammonia-lyase activity IEA --
GO:0016841 ammonia-lyase activity --
genes like me logo Genes that share ontologies with HAL: view
genes like me logo Genes that share phenotypes with HAL: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HAL

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for HAL Gene

Localization for HAL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HAL Gene COMPARTMENTS Subcellular localization image for HAL gene
Compartment Confidence
cytosol 4
mitochondrion 2

Gene Ontology (GO) - Cellular Components for HAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with HAL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for HAL Gene

Pathways & Interactions for HAL Gene

genes like me logo Genes that share pathways with HAL: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot P42357-HUTH_HUMAN

  • Pathway: Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3

Interacting Proteins for HAL Gene

Gene Ontology (GO) - Biological Process for HAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006548 histidine catabolic process TAS --
GO:0008152 metabolic process --
GO:0009058 biosynthetic process --
GO:0019556 histidine catabolic process to glutamate and formamide IEA --
GO:0019557 histidine catabolic process to glutamate and formate IEA --
genes like me logo Genes that share ontologies with HAL: view

No data available for SIGNOR curated interactions for HAL Gene

Drugs & Compounds for HAL Gene

(10) Drugs for HAL Gene - From: NovoSeek, HMDB, DrugBank, and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Histidine Approved Nutra Target 0
urocanic acid Experimental Pharma 0
Methyl 5-aminolevulinate Pharma 47
cinnamic acid Pharma Full agonist, Agonist 0
Imidazole Pharma 30

(4) Additional Compounds for HAL Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
Dehydroalanine
histidinol-phosphate
hydrogen
  • Dihydrogen
  • Hydrogen gas
1333-74-0
genes like me logo Genes that share compounds with HAL: view

Transcripts for HAL Gene

Unigene Clusters for HAL Gene

Histidine ammonia-lyase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for HAL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for HAL Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b ^
SP1: - -
SP2: - - - -
SP3: -
SP4:

ExUns: 22a · 22b
SP1:
SP2:
SP3:
SP4:

Relevant External Links for HAL Gene

GeneLoc Exon Structure for
HAL
ECgene alternative splicing isoforms for
HAL

Expression for HAL Gene

mRNA expression in normal human tissues for HAL Gene

mRNA differential expression in normal tissues according to GTEx for HAL Gene

This gene is overexpressed in Liver (x27.8), Whole Blood (x12.2), and Skin - Sun Exposed (Lower leg) (x5.0).

Protein differential expression in normal tissues from HIPED for HAL Gene

This gene is overexpressed in Fetal Liver (29.3), Saliva (20.6), and Liver (12.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for HAL Gene



SOURCE GeneReport for Unigene cluster for HAL Gene Hs.190783

genes like me logo Genes that share expression patterns with HAL: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for HAL Gene

Orthologs for HAL Gene

This gene was present in the common ancestor of animals.

Orthologs for HAL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia HAL 35
  • 90.01 (n)
  • 95.13 (a)
HAL 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HAL 35
  • 90.01 (n)
  • 94.98 (a)
HAL 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hal 35
  • 87.42 (n)
  • 93.76 (a)
Hal 16
Hal 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia HAL 35
  • 99.39 (n)
  • 99.24 (a)
HAL 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hal 35
  • 87.67 (n)
  • 93.91 (a)
oppossum
(Monodelphis domestica)
Mammalia HAL 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HAL 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves HAL 35
  • 78.29 (n)
  • 89.04 (a)
HAL 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HAL 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia hal.1 35
  • 72.98 (n)
  • 80.46 (a)
Str.16849 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.2256 35
zebrafish
(Danio rerio)
Actinopterygii hal 35
  • 71.97 (n)
  • 82.06 (a)
hal 36
  • 80 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F47B10.2 37
  • 54 (a)
haly-1 35
  • 56.03 (n)
  • 57 (a)
haly-1 36
  • 53 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11334 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
OneToOne
Species with no ortholog for HAL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for HAL Gene

ENSEMBL:
Gene Tree for HAL (if available)
TreeFam:
Gene Tree for HAL (if available)

Paralogs for HAL Gene

No data available for Paralogs for HAL Gene

Variants for HAL Gene

Sequence variations from dbSNP and Humsavar for HAL Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs721199 -- 95,980,279(-) TGCAT(A/G)TGAAC intron-variant
rs1059844 -- 95,972,991(-) GCTGC(A/C)CACAG utr-variant-3-prime
rs1059845 -- 95,972,920(-) TATTC(C/T)TTGTC utr-variant-3-prime
rs1108405 -- 95,975,662(-) GTATA(A/C)GAGAG intron-variant
rs2068662 -- 95,974,477(-) GTGTC(C/T)GGTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HAL Gene

Variant ID Type Subtype PubMed ID
nsv7234 OTHER Inversion 18451855
nsv523292 CNV Gain 19592680

Variation tolerance for HAL Gene

Residual Variation Intolerance Score: 82.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for HAL Gene

HapMap Linkage Disequilibrium report
HAL
Human Gene Mutation Database (HGMD)
HAL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for HAL Gene

Disorders for HAL Gene

MalaCards: The human disease database

(2) MalaCards diseases for HAL Gene - From: GeneTests, Orphanet, Swiss-Prot, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
histidinemia
  • histidinuria
histidine metabolism disease
  • disturbances of histidine metabolism
- elite association
Search HAL in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

HUTH_HUMAN
  • Histidinemia (HISTID) [MIM:235800]: Autosomal recessive disease characterized by increased histidine and histamine as well as decreased urocanic acid in body fluids. {ECO:0000269 PubMed:15806399}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for HAL Gene

histidinemia

Relevant External Links for HAL

Genetic Association Database (GAD)
HAL
Human Genome Epidemiology (HuGE) Navigator
HAL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
HAL
genes like me logo Genes that share disorders with HAL: view

Publications for HAL Gene

  1. Discovery of a substrate selectivity switch in tyrosine ammonia-lyase, a member of the aromatic amino acid lyase family. (PMID: 17185227) Watts K.T. … Schmidt-Dannert C. (Chem. Biol. 2006) 23 25 26 67
  2. Inhibition of histidine ammonia lyase by heteroaryl-alanines and acrylates. (PMID: 17193285) Katona A. … RActey J. (Chem. Biodivers. 2006) 23 25 26 67
  3. Kinetic analysis of the reactions catalyzed by histidine and phenylalanine ammonia lyases. (PMID: 17191848) Viergutz S. … RActey J. (Chem. Biodivers. 2004) 23 25 26 67
  4. Histidase expression in human epidermal keratinocytes: regulation by differentiation status and all-trans retinoic acid. (PMID: 18280705) Eckhart L. … Tschachler E. (J. Dermatol. Sci. 2008) 23 67
  5. A role for ultraviolet radiation immunosuppression in non-melanoma skin cancer as evidenced by gene-environment interactions. (PMID: 18641401) Welsh M.M. … Nelson H.H. (Carcinogenesis 2008) 23 67

Products for HAL Gene

Sources for HAL Gene

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