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Aliases for ANXA2 Gene

Aliases for ANXA2 Gene

  • Annexin A2 2 3
  • Annexin II 2 3 4
  • Placental Anticoagulant Protein IV 3 4
  • Calpactin I Heavy Chain 3 4
  • Calpactin-1 Heavy Chain 3 4
  • Chromobindin-8 3 4
  • Lipocortin II 3 4
  • Protein I 3 4
  • Annexin-2 3 4
  • ANX2L4 3 4
  • PAP-IV 3 4
  • CAL1H 3 4
  • LPC2D 3 4
  • ANX2 3 4
  • P36 3 4
  • Epididymis Secretory Protein Li 270 3
  • Calpactin I Heavy Polypeptide 3
  • Chromobindin 8 3
  • HEL-S-270 3
  • LIP2 3
  • LPC2 3

External Ids for ANXA2 Gene

Previous HGNC Symbols for ANXA2 Gene

  • ANX2
  • ANX2L4
  • CAL1H
  • LPC2D

Previous GeneCards Identifiers for ANXA2 Gene

  • GC15M056197
  • GC15M053687
  • GC15M058218
  • GC15M058355
  • GC15M058426
  • GC15M060639
  • GC15M037461

Summaries for ANXA2 Gene

Entrez Gene Summary for ANXA2 Gene

  • This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANXA2 Gene

ANXA2 (Annexin A2) is a Protein Coding gene. Diseases associated with ANXA2 include keloid formation and endocervicitis. Among its related pathways are Tyrosine Kinases / Adaptors and Hemostasis. GO annotations related to this gene include poly(A) RNA binding and Rab GTPase binding. An important paralog of this gene is ANXA9.

UniProtKB/Swiss-Prot for ANXA2 Gene

  • Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640).

Gene Wiki entry for ANXA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA2 Gene

Genomics for ANXA2 Gene

Regulatory Elements for ANXA2 Gene

Genomic Location for ANXA2 Gene

Chromosome:
15
Start:
60,347,134 bp from pter
End:
60,402,883 bp from pter
Size:
55,750 bases
Orientation:
Minus strand

Genomic View for ANXA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANXA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA2 Gene

Proteins for ANXA2 Gene

  • Protein details for ANXA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07355-ANXA2_HUMAN
    Recommended name:
    Annexin A2
    Protein Accession:
    P07355
    Secondary Accessions:
    • Q567R4
    • Q6N0B3
    • Q8TBV2
    • Q96DD5
    • Q9UDH8

    Protein attributes for ANXA2 Gene

    Size:
    339 amino acids
    Molecular mass:
    38604 Da
    Quaternary structure:
    • Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF (By similarity). Interacts with COCH (PubMed:21886777). Interacts (via repeat Annexin 1) with PCSK9 (via the C-terminal domain); the interaction inhibits the degradation of LDLR (PubMed:18799458). Interacts with human cytomegalovirus (HCMV) (PubMed:8117306).
    Miscellaneous:
    • It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis
    SequenceCaution:
    • Sequence=AAH66955.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANXA2 Gene

    Alternative splice isoforms for ANXA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ANXA2 Gene

Proteomics data for ANXA2 Gene at MOPED

Post-translational modifications for ANXA2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ANXA2 (ANXA2)

No data available for DME Specific Peptides for ANXA2 Gene

Domains & Families for ANXA2 Gene

Gene Families for ANXA2 Gene

Protein Domains for ANXA2 Gene

Suggested Antigen Peptide Sequences for ANXA2 Gene

Graphical View of Domain Structure for InterPro Entry

P07355

UniProtKB/Swiss-Prot:

ANXA2_HUMAN :
  • A pair of annexin repeats may form one binding site for calcium and phospholipid
  • Belongs to the annexin family.
  • Contains 4 annexin repeats.
Domain:
  • A pair of annexin repeats may form one binding site for calcium and phospholipid
Family:
  • Belongs to the annexin family.
Similarity:
  • Contains 4 annexin repeats.
genes like me logo Genes that share domains with ANXA2: view

Function for ANXA2 Gene

Molecular function for ANXA2 Gene

GENATLAS Biochemistry:
annexin A2,calcium and phospholipid binding protein,calpactin 1,involved in exocytosis,overexpressed in small cell lung carcinoma
UniProtKB/Swiss-Prot Function:
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:24808179, PubMed:22848640).

Gene Ontology (GO) - Molecular Function for ANXA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 22848640
GO:0004859 phospholipase inhibitor activity --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 18799458
GO:0005544 calcium-dependent phospholipid binding IDA 2138016
genes like me logo Genes that share ontologies with ANXA2: view
genes like me logo Genes that share phenotypes with ANXA2: view

Animal Models for ANXA2 Gene

MGI Knock Outs for ANXA2:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ANXA2 Gene

Localization for ANXA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANXA2 Gene

Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ANXA2 Gene COMPARTMENTS Subcellular localization image for ANXA2 gene
Compartment Confidence
endosome 5
extracellular 5
lysosome 5
nucleus 5
vacuole 5
plasma membrane 4
cytoskeleton 2
cytosol 2
mitochondrion 2
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ANXA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005604 basement membrane IEA --
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with ANXA2: view

Pathways & Interactions for ANXA2 Gene

genes like me logo Genes that share pathways with ANXA2: view

Pathways by source for ANXA2 Gene

2 Cell Signaling Technology pathways for ANXA2 Gene
1 BioSystems pathway for ANXA2 Gene
3 Reactome pathways for ANXA2 Gene
1 GeneGo (Thomson Reuters) pathway for ANXA2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for ANXA2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ANXA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEP 11866539
GO:0001765 membrane raft assembly IMP 23861394
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0002091 negative regulation of receptor internalization IDA 22848640
GO:0006900 membrane budding IMP 23861394
genes like me logo Genes that share ontologies with ANXA2: view

Drugs & Compounds for ANXA2 Gene

(26) Drugs for ANXA2 Gene - From: NovoSeek, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tenecteplase Approved Pharma Target 38
deoxycholic acid Approved Pharma Antagonist 40
Heparin Approved, Investigational Pharma Antagonist 672,226
Iron Approved Pharma 957
Nitric Oxide Approved Pharma 540

(37) Additional Compounds for ANXA2 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-MERCAPTOETHANOL
3-phosphoglycerate
ACTOMYOSIN
adenylate
arsenite
  • AArsenite (AsO33-)
  • Arsenic (III) oxide
  • Arsenic (III) trioxide
  • Arsenic sesquioxide
  • Arsenic trioxide
15502-74-6
genes like me logo Genes that share compounds with ANXA2: view

Transcripts for ANXA2 Gene

Unigene Clusters for ANXA2 Gene

Annexin A2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5:
SP6: - - - - - - - -
SP7:
SP8: - - -
SP9: - - - - - - -
SP10:

Relevant External Links for ANXA2 Gene

GeneLoc Exon Structure for
ANXA2
ECgene alternative splicing isoforms for
ANXA2

Expression for ANXA2 Gene

mRNA expression in normal human tissues for ANXA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANXA2 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.9).

Protein differential expression in normal tissues from HIPED for ANXA2 Gene

This gene is overexpressed in Adipocyte (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANXA2 Gene



SOURCE GeneReport for Unigene cluster for ANXA2 Gene Hs.511605

genes like me logo Genes that share expression patterns with ANXA2: view

Protein tissue co-expression partners for ANXA2 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ANXA2 Gene

Orthologs for ANXA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ANXA2 35
  • 93.02 (n)
  • 98.23 (a)
ANXA2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ANXA2 35
  • 93.31 (n)
  • 98.82 (a)
ANXA2 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Anxa2 35
  • 89.58 (n)
  • 97.64 (a)
Anxa2 16
Anxa2 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ANXA2 35
  • 99.21 (n)
  • 100 (a)
-- 36
  • 100 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Anxa2 35
  • 89.58 (n)
  • 96.76 (a)
oppossum
(Monodelphis domestica)
Mammalia ANXA2 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ANXA2 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves ANXA2 35
  • 81.22 (n)
  • 89.68 (a)
ANXA2 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ANXA2 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa2 35
  • 74.04 (n)
  • 81.71 (a)
MGC76145 35
African clawed frog
(Xenopus laevis)
Amphibia LOC397754 35
zebrafish
(Danio rerio)
Actinopterygii anxa2a 35
  • 67.26 (n)
  • 67.36 (a)
anxa2a 36
  • 67 (a)
OneToMany
anxa2b 36
  • 64 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8679 35
worm
(Caenorhabditis elegans)
Secernentea nex-3 37
  • 36 (a)
nex-1 36
  • 38 (a)
ManyToMany
nex-3 36
  • 36 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7864 36
  • 16 (a)
ManyToMany
Species with no ortholog for ANXA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA2 Gene

ENSEMBL:
Gene Tree for ANXA2 (if available)
TreeFam:
Gene Tree for ANXA2 (if available)

Paralogs for ANXA2 Gene

Paralogs for ANXA2 Gene

Pseudogenes.org Pseudogenes for ANXA2 Gene

genes like me logo Genes that share paralogs with ANXA2: view

Variants for ANXA2 Gene

Sequence variations from dbSNP and Humsavar for ANXA2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs3582 -- 60,347,469(-) CTGGC(C/T)TTCCT utr-variant-3-prime
rs1065180 -- 60,385,143(-) GAATT(G/T)AGAAC intron-variant
rs1065181 -- 60,385,074(-) TCTTT(C/T)TTTTA intron-variant
rs1377790 -- 60,388,939(+) CGTTA(C/T)CTTGC intron-variant
rs1377791 -- 60,388,940(+) GTTAC(A/C/G)TTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA2 Gene

Variant ID Type Subtype PubMed ID
nsv7266 OTHER Inversion 18451855
esv1071950 CNV Insertion 17803354
esv2592269 CNV Insertion 19546169
esv271908 CNV Insertion 20981092
esv273112 CNV Insertion 20981092
esv1613497 CNV Insertion 17803354
esv2656603 CNV Deletion 23128226
dgv2392n71 CNV Loss 21882294

Variation tolerance for ANXA2 Gene

Residual Variation Intolerance Score: 27.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.52; 64.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ANXA2 Gene

HapMap Linkage Disequilibrium report
ANXA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA2 Gene

Disorders for ANXA2 Gene

MalaCards: The human disease database

(9) MalaCards diseases for ANXA2 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
keloid formation
endocervicitis
  • endocervicitis unspecified
papillary hidradenoma
deep angioma
  • deep hemangioma
intramuscular hemangioma
  • intramuscular angioma
- elite association
Search ANXA2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ANXA2

Genetic Association Database (GAD)
ANXA2
Human Genome Epidemiology (HuGE) Navigator
ANXA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ANXA2
genes like me logo Genes that share disorders with ANXA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ANXA2 Gene

Publications for ANXA2 Gene

  1. Specific interaction of tissue-type plasminogen activator (t-PA) with annexin II on the membrane of pancreatic cancer cells activates plasminogen and promotes invasion in vitro. (PMID: 15194650) DA-az V.M. … Paciucci R. (Gut 2004) 23 25 67
  2. Phospholipid-associated annexin A2-S100A10 heterotetramer and its subunits: characterization of the interaction with tissue plasminogen activator, plasminogen, and plasmin. (PMID: 12730231) MacLeod T.J. … Waisman D.M. (J. Biol. Chem. 2003) 23 25 67
  3. Breast cancer cell surface annexin II induces cell migration and neoangiogenesis via tPA dependent plasmin generation. (PMID: 20079732) Sharma M. … Sharma M.C. (Exp. Mol. Pathol. 2010) 23 67
  4. Silencing of the annexin II gene down-regulates the levels of S100A10, c-Myc, and plasmin and inhibits breast cancer cell proliferation and invasion. (PMID: 20383413) Zhang J. … Chen T. (Saudi Med J 2010) 23 67
  5. Annexin II promotes invasion and migration of human hepatocellular carcinoma cells in vitro via its interaction with HAb18G/CD147. (PMID: 20047591) Zhao P. … Chen Z.N. (Cancer Sci. 2010) 23 67

Products for ANXA2 Gene

Sources for ANXA2 Gene

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