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Aliases for ANXA2 Gene

Aliases for ANXA2 Gene

  • Annexin A2 2 3
  • Annexin II 2 3 4
  • ANX2L4 3 4 6
  • LPC2D 3 4 6
  • Placental Anticoagulant Protein IV 3 4
  • Calpactin I Heavy Chain 3 4
  • Calpactin-1 Heavy Chain 3 4
  • Chromobindin-8 3 4
  • Lipocortin II 3 4
  • Protein I 3 4
  • Annexin-2 3 4
  • PAP-IV 3 4
  • CAL1H 3 4
  • LIP2 3 6
  • ANX2 3 4
  • P36 3 4
  • Epididymis Secretory Protein Li 270 3
  • Calpactin I Heavy Polypeptide 3
  • Chromobindin 8 3
  • HEL-S-270 3
  • LPC2 3

External Ids for ANXA2 Gene

Previous HGNC Symbols for ANXA2 Gene

  • ANX2
  • ANX2L4
  • CAL1H
  • LPC2D

Previous GeneCards Identifiers for ANXA2 Gene

  • GC15M056197
  • GC15M053687
  • GC15M058218
  • GC15M058355
  • GC15M058426
  • GC15M060639
  • GC15M037461

Summaries for ANXA2 Gene

Entrez Gene Summary for ANXA2 Gene

  • This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ANXA2 Gene

ANXA2 (Annexin A2) is a Protein Coding gene. Among its related pathways are Tyrosine Kinases / Adaptors and Ca, cAMP and Lipid Signaling. GO annotations related to this gene include calcium ion binding and cytoskeletal protein binding. An important paralog of this gene is ANXA9.

UniProtKB/Swiss-Prot for ANXA2 Gene

  • Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response

Gene Wiki entry for ANXA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ANXA2 Gene

Genomics for ANXA2 Gene

Regulatory Elements for ANXA2 Gene

Genomic Location for ANXA2 Gene

60,347,134 bp from pter
60,402,883 bp from pter
55,750 bases
Minus strand

Genomic View for ANXA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ANXA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ANXA2 Gene

Proteins for ANXA2 Gene

  • Protein details for ANXA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Annexin A2
    Protein Accession:
    Secondary Accessions:
    • Q567R4
    • Q6N0B3
    • Q8TBV2
    • Q96DD5
    • Q9UDH8

    Protein attributes for ANXA2 Gene

    339 amino acids
    Molecular mass:
    38604 Da
    Quaternary structure:
    • Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF (By similarity). Interacts with human cytomegalovirus (HCMV). Interacts with COCH.
    • It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis
    • Sequence=AAH66955.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ANXA2 Gene

    Alternative splice isoforms for ANXA2 Gene


neXtProt entry for ANXA2 Gene

Proteomics data for ANXA2 Gene at MOPED

Post-translational modifications for ANXA2 Gene

  • ISGylated.
  • Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface.
  • Ubiquitination at Lys49, Lys104, Lys157, Lys227, Lys313, and Lys324
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ANXA2 (ANXA2)

No data available for DME Specific Peptides for ANXA2 Gene

Domains for ANXA2 Gene

Gene Families for ANXA2 Gene

Protein Domains for ANXA2 Gene

Suggested Antigen Peptide Sequences for ANXA2 Gene

Graphical View of Domain Structure for InterPro Entry



  • A pair of annexin repeats may form one binding site for calcium and phospholipid
  • Belongs to the annexin family.
  • Contains 4 annexin repeats.
  • A pair of annexin repeats may form one binding site for calcium and phospholipid
  • Belongs to the annexin family.
  • Contains 4 annexin repeats.
genes like me logo Genes that share domains with ANXA2: view

Function for ANXA2 Gene

Molecular function for ANXA2 Gene

GENATLAS Biochemistry:
annexin A2,calcium and phospholipid binding protein,calpactin 1,involved in exocytosis,overexpressed in small cell lung carcinoma
UniProtKB/Swiss-Prot Function:
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response

Gene Ontology (GO) - Molecular Function for ANXA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004859 phospholipase inhibitor activity --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 18799458
GO:0005544 calcium-dependent phospholipid binding IDA 2138016
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IMP 23861394
genes like me logo Genes that share ontologies with ANXA2: view
genes like me logo Genes that share phenotypes with ANXA2: view

Animal Models for ANXA2 Gene

MGI Knock Outs for ANXA2:

Animal Model Products

miRNA for ANXA2 Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ANXA2 Gene

Localization for ANXA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ANXA2 Gene

Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.

Subcellular locations from

Jensen Localization Image for ANXA2 Gene COMPARTMENTS Subcellular localization image for ANXA2 gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 3
cytoskeleton 2
endosome 2
nucleus 2
endoplasmic reticulum 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ANXA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005604 basement membrane IEA --
GO:0005615 extracellular space IDA 22664934
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with ANXA2: view

Pathways for ANXA2 Gene

genes like me logo Genes that share pathways with ANXA2: view

Pathways by source for ANXA2 Gene

2 Cell Signaling Technology pathways for ANXA2 Gene
1 BioSystems pathway for ANXA2 Gene
1 GeneGo (Thomson Reuters) pathway for ANXA2 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ANXA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEP 11866539
GO:0001765 membrane raft assembly IMP 23861394
GO:0001934 positive regulation of protein phosphorylation IEA --
GO:0002091 negative regulation of receptor internalization IDA 22848640
GO:0006900 membrane budding IMP 23861394
genes like me logo Genes that share ontologies with ANXA2: view

Drugs for ANXA2 Gene

(1) Drugbank Compounds for ANXA2 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • t- PA
191588-94-0 Target approved

(1) HMDB Compounds for ANXA2 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(62) Novoseek inferred chemical compound relationships for ANXA2 Gene

Compound -log(P) Hits PubMed IDs
phospholipid 57.7 28
calcium 45.7 67
epsilon aminocaproic acid 41.6 1
phosphatidylserine 40.8 7
tyrosine 39.8 28
genes like me logo Genes that share compounds with ANXA2: view

Transcripts for ANXA2 Gene

Unigene Clusters for ANXA2 Gene

Annexin A2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ANXA2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP6: - - - - - - - -
SP8: - - -
SP9: - - - - - - -

Relevant External Links for ANXA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ANXA2 Gene

mRNA expression in normal human tissues for ANXA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ANXA2 Gene

This gene is overexpressed in Esophagus - Mucosa (4.9).

Protein differential expression in normal tissues for ANXA2 Gene

This gene is overexpressed in Adipocyte (8.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ANXA2 Gene

SOURCE GeneReport for Unigene cluster for ANXA2 Gene Hs.511605

genes like me logo Genes that share expressions with ANXA2: view

Expression partners for ANXA2 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ANXA2 Gene

Orthologs for ANXA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ANXA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ANXA2 35
  • 93.02 (n)
  • 98.23 (a)
ANXA2 36
  • 98 (a)
(Canis familiaris)
Mammalia ANXA2 35
  • 93.31 (n)
  • 98.82 (a)
ANXA2 36
  • 69 (a)
(Mus musculus)
Mammalia Anxa2 35
  • 89.58 (n)
  • 97.64 (a)
Anxa2 16
Anxa2 36
  • 98 (a)
(Pan troglodytes)
Mammalia ANXA2 35
  • 99.21 (n)
  • 100 (a)
-- 36
  • 100 (a)
-- 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Anxa2 35
  • 89.58 (n)
  • 96.76 (a)
(Monodelphis domestica)
Mammalia ANXA2 36
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia ANXA2 36
  • 94 (a)
(Gallus gallus)
Aves ANXA2 35
  • 81.22 (n)
  • 89.68 (a)
ANXA2 36
  • 90 (a)
(Anolis carolinensis)
Reptilia ANXA2 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia anxa2 35
  • 74.04 (n)
  • 81.71 (a)
MGC76145 35
African clawed frog
(Xenopus laevis)
Amphibia LOC397754 35
(Danio rerio)
Actinopterygii anxa2a 35
  • 67.26 (n)
  • 67.36 (a)
anxa2a 36
  • 67 (a)
anxa2b 36
  • 64 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8679 35
(Caenorhabditis elegans)
Secernentea nex-3 37
  • 36 (a)
nex-1 36
  • 38 (a)
nex-3 36
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7864 36
  • 16 (a)
Species with no ortholog for ANXA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ANXA2 Gene

Gene Tree for ANXA2 (if available)
Gene Tree for ANXA2 (if available)

Paralogs for ANXA2 Gene

Paralogs for ANXA2 Gene Pseudogenes for ANXA2 Gene

genes like me logo Genes that share paralogs with ANXA2: view

Variants for ANXA2 Gene

Sequence variations from dbSNP and Humsavar for ANXA2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs3582 -- 60,347,469(-) CTGGC(C/T)TTCCT utr-variant-3-prime
rs1065180 -- 60,385,143(-) GAATT(G/T)AGAAC intron-variant
rs1065181 -- 60,385,074(-) TCTTT(C/T)TTTTA intron-variant
rs1377790 -- 60,388,939(+) CGTTA(C/T)CTTGC intron-variant
rs1377791 -- 60,388,940(+) GTTAC(A/C/G)TTGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ANXA2 Gene

Variant ID Type Subtype PubMed ID
nsv7266 OTHER Inversion 18451855
esv1071950 CNV Insertion 17803354
esv2592269 CNV Insertion 19546169
esv271908 CNV Insertion 20981092
esv273112 CNV Insertion 20981092
esv1613497 CNV Insertion 17803354
esv2656603 CNV Deletion 23128226
dgv2392n71 CNV Loss 21882294

Relevant External Links for ANXA2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ANXA2 Gene

Disorders for ANXA2 Gene

(2) University of Copenhagen DISEASES for ANXA2 Gene

(58) Novoseek inferred disease relationships for ANXA2 Gene

Disease -log(P) Hits PubMed IDs
antiphospholipid syndrome 53.3 2
leukemia promyelocytic acute 51.3 8
pancreatic cancer 31.9 17
disseminated intravascular coagulation 27.8 2
carcinoma squamous cell 27 10

Relevant External Links for ANXA2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ANXA2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot and Genatlas for ANXA2 Gene

Publications for ANXA2 Gene

  1. The crystal structure and ion channel activity of human annexin II, a peripheral membrane protein. (PMID: 8636985) Burger A. … Weber K. (J. Mol. Biol. 1996) 3 4 23
  2. An endothelial cell-surface form of annexin II binds human cytomegalovirus. (PMID: 8117306) Wright J.F. … Wasi S. (Biochem. Biophys. Res. Commun. 1994) 3 4 23
  3. The protein-tyrosine kinase substrate, calpactin I heavy chain (p36), is part of the primer recognition protein complex that interacts with DNA polymerase alpha. (PMID: 1825830) Jindal H.K. … Vishwanatha J.K. (J. Biol. Chem. 1991) 3 4 23
  4. Phospholipid-associated annexin A2-S100A10 heterotetramer and its subunits: characterization of the interaction with tissue plasminogen activator, plasminogen, and plasmin. (PMID: 12730231) MacLeod T.J. … Waisman D.M. (J. Biol. Chem. 2003) 3 23 25
  5. Angiostatin binds ATP synthase on the surface of human endothelial cells. (PMID: 10077593) Moser T.L. … Pizzo S.V. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 23

Products for ANXA2 Gene

Sources for ANXA2 Gene

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