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Aliases for SH3KBP1 Gene

Aliases for SH3KBP1 Gene

  • SH3-Domain Kinase Binding Protein 1 2 3
  • CIN85 3 4 6
  • Human Src Family Kinase-Binding Protein 1 3 4
  • Cbl-Interacting Protein Of 85 KDa 3 4
  • CD2-Binding Protein 3 3 4
  • CD2BP3 3 4
  • HSB-1 3 4
  • SH3 Domain-Containing Kinase-Binding Protein 1 3
  • Src-Related Kinase Binding Protein-1 3
  • Src Family Kinase-Binding Protein 1 3
  • Migration-Inducing Gene 18 3
  • C-Cbl-Interacting Protein 3
  • GIG10 3
  • MIG18 3
  • HSB1 3

External Ids for SH3KBP1 Gene

Summaries for SH3KBP1 Gene

Entrez Gene Summary for SH3KBP1 Gene

  • This gene encodes an adapter protein that contains three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

GeneCards Summary for SH3KBP1 Gene

SH3KBP1 (SH3-Domain Kinase Binding Protein 1) is a Protein Coding gene. Diseases associated with SH3KBP1 include mast-cell leukemia. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include SH3 domain binding. An important paralog of this gene is CD2AP.

UniProtKB/Swiss-Prot for SH3KBP1 Gene

  • Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration.

Gene Wiki entry for SH3KBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SH3KBP1 Gene

Genomics for SH3KBP1 Gene

Genomic Location for SH3KBP1 Gene

Start:
19,533,965 bp from pter
End:
19,887,626 bp from pter
Size:
353,662 bases
Orientation:
Minus strand

Genomic View for SH3KBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SH3KBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SH3KBP1 Gene

Regulatory Elements for SH3KBP1 Gene

Proteins for SH3KBP1 Gene

  • Protein details for SH3KBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B97-SH3K1_HUMAN
    Recommended name:
    SH3 domain-containing kinase-binding protein 1
    Protein Accession:
    Q96B97
    Secondary Accessions:
    • B7Z1D5
    • Q5JPT4
    • Q5JPT5
    • Q8IWX6
    • Q8IX98
    • Q96RN4
    • Q9NYR0

    Protein attributes for SH3KBP1 Gene

    Size:
    665 amino acids
    Molecular mass:
    73126 Da
    Quaternary structure:
    • Can self-associate and form homotetramers. Interacts with CD2, F-actin capping protein, PIK3R3, GRB2, EGFR, MET, BLNK, MAP3K4, PDCD6IP, SPRY2, ARHGAP17, ARHGAP27, MAGI2, CRK, BCAR1, SOS1, ASAP1, ARAP3, HIP1R, SYNJ2, INPP5D and STAP1. Interacts with CBL and CBLB, but does not interact with CBLC. Two molecules of SH3KBP1 seem to bind through their respective SH3 1 domain to one molecule of CBLB. The interaction with CBL or CBLB and EGFR is increased upon EGF stimulation. The interaction with CBL is attenuated by PDCD6IP. Interacts through its proline-rich region with the SH3 domain of endophilins SH3GL1, SH3GL2 and SH3GL3. The SH3KBP1-endophilin complex seems to associate with a complex containing the phosphorylated receptor (EGFR or MET) and phosphorylated CBL. Probably associates with ASAP1 and phosphorylated EGFR. Probably part of a complex consisting of at least SH3KBP1, ASAP1 and ARAP3. Interacts with focal adhesion kinases PTK2/FAK1 AND PTK2B/PYK2, probably as a dimer. Interacts with DAB2 and probably associates with chathrin through its interaction with DAB2. Part of a complex consisting of SH3KBP1, DAB2, and clathrin heavy chain. DAB2 and clathrin dissociate from SH3KBP1 following growth factor treatment, enabling interaction with CBL. Interacts with DDN and probably associates with MAGI2 through its interaction with DDN. Interacts with the SH3 domains of SRC tyrosine-protein kinases SRC, LCK, LYN, FGR, FYN and HCK. Interacts with TRADD, BIRC2, TRAF1, TRAF2 and TNFR1, and the association with a TNFR1-associated complex upon stimulation with TNF-alpha seems to be mediated by SRC. Probably interacts with SH3KBP1.
    SequenceCaution:
    • Sequence=AAH50663.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SH3KBP1 Gene

    Alternative splice isoforms for SH3KBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SH3KBP1 Gene

Proteomics data for SH3KBP1 Gene at MOPED

Post-translational modifications for SH3KBP1 Gene

  • Monoubiquitinated by CBL and CBLB after EGF stimulation; probably on its C-terminus
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SH3KBP1 Gene

No data available for DME Specific Peptides for SH3KBP1 Gene

Domains for SH3KBP1 Gene

Protein Domains for SH3KBP1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SH3K1_HUMAN
Domain:
  • The SH3 domains mediate interaction with SHKBP1.:
    • Q96B97
  • Contains 3 SH3 domains.:
    • Q96B97
genes like me logo Genes that share domains with SH3KBP1: view

No data available for Gene Families for SH3KBP1 Gene

Function for SH3KBP1 Gene

Molecular function for SH3KBP1 Gene

UniProtKB/Swiss-Prot Function: Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration.

Gene Ontology (GO) - Molecular Function for SH3KBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10679202
GO:0017124 SH3 domain binding IEA --
genes like me logo Genes that share ontologies with SH3KBP1: view
genes like me logo Genes that share phenotypes with SH3KBP1: view

Animal Models for SH3KBP1 Gene

MGI Knock Outs for SH3KBP1:

miRNA for SH3KBP1 Gene

miRTarBase miRNAs that target SH3KBP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SH3KBP1 Gene

Localization for SH3KBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SH3KBP1 Gene

Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Cell junction, focal adhesion. Note=Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SH3KBP1 Gene COMPARTMENTS Subcellular localization image for SH3KBP1 gene
Compartment Confidence
cytoskeleton 5
cytosol 4
plasma membrane 4
nucleus 3
endosome 2
lysosome 2
vacuole 2

Gene Ontology (GO) - Cellular Components for SH3KBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane TAS --
GO:0005911 cell-cell junction IEA --
GO:0005925 focal adhesion IEA --
genes like me logo Genes that share ontologies with SH3KBP1: view

Pathways for SH3KBP1 Gene

genes like me logo Genes that share pathways with SH3KBP1: view

Interacting Proteins for SH3KBP1 Gene

Gene Ontology (GO) - Biological Process for SH3KBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0006915 apoptotic process IEA --
GO:0007010 cytoskeleton organization IMP 21834987
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007267 cell-cell signaling NAS 10679202
genes like me logo Genes that share ontologies with SH3KBP1: view

Compounds for SH3KBP1 Gene

(2) Novoseek inferred chemical compound relationships for SH3KBP1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 51.6 12
phosphatidylinositol 19.2 1
genes like me logo Genes that share compounds with SH3KBP1: view

Transcripts for SH3KBP1 Gene

Unigene Clusters for SH3KBP1 Gene

SH3-domain kinase binding protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SH3KBP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20 ^ 21
SP1: - - - -
SP2: - - -
SP3:
SP4:
SP5:
SP6: -

Relevant External Links for SH3KBP1 Gene

GeneLoc Exon Structure for
SH3KBP1
ECgene alternative splicing isoforms for
SH3KBP1

Expression for SH3KBP1 Gene

mRNA expression in normal human tissues for SH3KBP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SH3KBP1 Gene

This gene is overexpressed in Whole Blood (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SH3KBP1 Gene

SOURCE GeneReport for Unigene cluster for SH3KBP1 Gene Hs.726365

mRNA Expression by UniProt/SwissProt for SH3KBP1 Gene

Q96B97-SH3K1_HUMAN
Tissue specificity: Ubiquitously expressed. Also expressed in some cancer cell lines
genes like me logo Genes that share expressions with SH3KBP1: view

Orthologs for SH3KBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SH3KBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SH3KBP1 36
  • 93.6 (n)
  • 92.72 (a)
cow
(Bos Taurus)
Mammalia SH3KBP1 36
  • 91.28 (n)
  • 95.79 (a)
SH3KBP1 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SH3KBP1 36
  • 92.42 (n)
  • 95.93 (a)
SH3KBP1 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sh3kbp1 36
  • 90.93 (n)
  • 94.14 (a)
Sh3kbp1 16
Sh3kbp1 37
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 85 (a)
OneToMany
-- 37
  • 86 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SH3KBP1 37
  • 40 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sh3kbp1 36
  • 90.38 (n)
  • 93.53 (a)
chicken
(Gallus gallus)
Aves SH3KBP1 36
  • 76.05 (n)
  • 79 (a)
SH3KBP1 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SH3KBP1 37
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sh3kbp1 36
  • 68.2 (n)
  • 66.56 (a)
Str.9067 36
zebrafish
(Danio rerio)
Actinopterygii sh3kbp1 36
  • 62.3 (n)
  • 59.71 (a)
sh3kbp1 37
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta cindr 37
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y44E3A.4 37
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 37 (a)
OneToMany
Species with no ortholog for SH3KBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SH3KBP1 Gene

ENSEMBL:
Gene Tree for SH3KBP1 (if available)
TreeFam:
Gene Tree for SH3KBP1 (if available)

Paralogs for SH3KBP1 Gene

Paralogs for SH3KBP1 Gene

Selected SIMAP similar genes for SH3KBP1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with SH3KBP1: view

Variants for SH3KBP1 Gene

Sequence variations from dbSNP and Humsavar for SH3KBP1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs724923 -- 19,553,065(-) CATTC(C/G)AGCCT intron-variant
rs729135 -- 19,614,996(-) ATGTT(A/T)GAAAG intron-variant
rs747638 -- 19,736,123(-) TATGG(A/G)AAATA intron-variant
rs767386 -- 19,776,132(-) GAGGT(A/C)TTTCT intron-variant
rs767821 -- 19,792,254(-) GCTGT(G/T)ATAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SH3KBP1 Gene

Variant ID Type Subtype PubMed ID
nsv6824 CNV Loss 18451855
nsv6825 CNV Insertion 18451855
nsv6826 CNV Insertion 18451855

Relevant External Links for SH3KBP1 Gene

HapMap Linkage Disequilibrium report
SH3KBP1
Locus Specific Mutation Databases (LSDB)
SH3KBP1

Disorders for SH3KBP1 Gene

(1) MalaCards Diseases for SH3KBP1 Gene

Search for SH3KBP1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SH3KBP1 Gene

(1) Novoseek inferred disease relationships for SH3KBP1 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1
genes like me logo Genes that share disorders with SH3KBP1: view

No data available for UniProtKB/Swiss-Prot for SH3KBP1 Gene

Publications for SH3KBP1 Gene

  1. Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors. (PMID: 11894095) Soubeyran P. … Dikic I. (Nature 2002) 3 4 23
  2. The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met. (PMID: 11894096) Petrelli A. … Giordano S. (Nature 2002) 3 4 23
  3. CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases. (PMID: 12177062) Szymkiewicz I. … Dikic I. (J. Biol. Chem. 2002) 3 4 23
  4. Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors. (PMID: 12218189) Haglund K. … Dikic I. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4 23
  5. CD2BP3, CIN85 and the structurally related adaptor protein CMS bind to the same CD2 cytoplasmic segment but elicit divergent functional activities. (PMID: 12618476) Tibaldi E.V. … Reinherz E.L. (Int. Immunol. 2003) 3 4 23

Products for SH3KBP1 Gene

Sources for SH3KBP1 Gene

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