Aliases for TBX21 Gene
External Ids for TBX21 Gene
Previous GeneCards Identifiers for TBX21 Gene
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]
GeneCards Summary for TBX21 Gene
TBX21 (T-Box 21) is a Protein Coding gene. Diseases associated with TBX21 include asthma, aspirin-induced and acute necrotizing encephalitis. Among its related pathways are Glucocorticoid receptor regulatory network and NF-kappaB Signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is MGA.
UniProtKB/Swiss-Prot for TBX21 Gene
Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs