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Aliases for ERO1L Gene

Aliases for ERO1L Gene

  • ERO1-Like (S. Cerevisiae) 2 3
  • Endoplasmic Oxidoreductin-1-Like Protein 3 4
  • Oxidoreductin-1-L-Alpha 3 4
  • ERO1-L-Alpha 3 4
  • ERO1LA 3 6
  • ERO1-L 3 4
  • ERO1 (S. Cerevisiae)-Like 2
  • ERO1-Like Protein Alpha 3
  • ERO1-Alpha 3
  • EC 1.8.4.- 4
  • EC 1.8.4 63
  • ERO1A 3

External Ids for ERO1L Gene

Previous GeneCards Identifiers for ERO1L Gene

  • GC14M050431
  • GC14M046904
  • GC14M051098
  • GC14M052178
  • GC14M053106
  • GC14M033269

Summaries for ERO1L Gene

GeneCards Summary for ERO1L Gene

ERO1L (ERO1-Like (S. Cerevisiae)) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Cellular Senescence. GO annotations related to this gene include oxidoreductase activity and protein disulfide isomerase activity. An important paralog of this gene is ERO1LB.

UniProtKB/Swiss-Prot for ERO1L Gene

  • Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1.

Gene Wiki entry for ERO1L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ERO1L Gene

Genomics for ERO1L Gene

Regulatory Elements for ERO1L Gene

Genomic Location for ERO1L Gene

Start:
52,639,916 bp from pter
End:
52,695,900 bp from pter
Size:
55,985 bases
Orientation:
Minus strand

Genomic View for ERO1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ERO1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ERO1L Gene

Proteins for ERO1L Gene

  • Protein details for ERO1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HE7-ERO1A_HUMAN
    Recommended name:
    ERO1-like protein alpha
    Protein Accession:
    Q96HE7
    Secondary Accessions:
    • A8K9X4
    • A8MYW1
    • Q7LD45
    • Q9P1Q9
    • Q9UKV6

    Protein attributes for ERO1L Gene

    Size:
    468 amino acids
    Molecular mass:
    54393 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Predominantly monomer. May function both as a monomer and a homodimer. Interacts with PDILT.

    Three dimensional structures from OCA and Proteopedia for ERO1L Gene

neXtProt entry for ERO1L Gene

Proteomics data for ERO1L Gene at MOPED

Post-translational modifications for ERO1L Gene

  • N-glycosylated.
  • The Cys-94/Cys-99 and Cys-394/Cys-397 disulfide bonds constitute the redox-active center. The Cys-94/Cys-99 disulfide bond may accept electron from P4HB and funnel them to the active site disulfide Cys-394/Cys-397 (By similarity). The regulatory Cys-99/Cys-104 disulfide bond stabilizes the other regulatory bond Cys-94/Cys-131 (PubMed:23027870).
  • Glycosylation at Asn280 and Asn384
  • Modification sites at PhosphoSitePlus

Other Protein References for ERO1L Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ERO1L (ERO1L)

Domains for ERO1L Gene

Protein Domains for ERO1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ERO1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96HE7

UniProtKB/Swiss-Prot:

ERO1A_HUMAN :
  • Q96HE7
Family:
  • Belongs to the EROs family.
genes like me logo Genes that share domains with ERO1L: view

No data available for Gene Families for ERO1L Gene

Function for ERO1L Gene

Molecular function for ERO1L Gene

UniProtKB/Swiss-Prot EnzymeRegulation: Enzyme activity is tightly regulated to prevent the accumulation of reactive oxygen species in the endoplasmic reticulum. Reversibly down-regulated by the formation of disulfide bonds between the active site Cys-94 and Cys-131, and between Cys-99 and Cys-104. Glutathione may be required to regulate its activity in the endoplasmic reticulum.
UniProtKB/Swiss-Prot Function: Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin. Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1.
UniProtKB/Swiss-Prot Induction: Stimulated by hypoxia; suggesting that it is regulated via the HIF-pathway.

Enzyme Numbers (IUBMB) for ERO1L Gene

Gene Ontology (GO) - Molecular Function for ERO1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003756 protein disulfide isomerase activity IEA --
GO:0005515 protein binding IPI 17170699
GO:0015035 protein disulfide oxidoreductase activity IEA --
GO:0016491 oxidoreductase activity IDA 11707400
GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA --
genes like me logo Genes that share ontologies with ERO1L: view
genes like me logo Genes that share phenotypes with ERO1L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ERO1L

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ERO1L Gene

Localization for ERO1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for ERO1L Gene

Endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side. Note=The association with ERP44 is essential for its retention in the endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ERO1L Gene COMPARTMENTS Subcellular localization image for ERO1L gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 3
cytosol 1
lysosome 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ERO1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA 10671517
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IDA 19946888
GO:0043231 intracellular membrane-bounded organelle TAS 10671517
genes like me logo Genes that share ontologies with ERO1L: view

Pathways for ERO1L Gene

genes like me logo Genes that share pathways with ERO1L: view

Pathways by source for ERO1L Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ERO1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000302 response to reactive oxygen species TAS --
GO:0006457 protein folding TAS 10671517
GO:0006464 cellular protein modification process TAS 10671517
GO:0009266 response to temperature stimulus TAS 10671517
GO:0019471 4-hydroxyproline metabolic process IEA --
genes like me logo Genes that share ontologies with ERO1L: view

Compounds for ERO1L Gene

(1) HMDB Compounds for ERO1L Gene

Compound Synonyms Cas Number PubMed IDs
FAD
  • 1H-Purin-6-amine flavin dinucleotide
146-14-5
genes like me logo Genes that share compounds with ERO1L: view

Transcripts for ERO1L Gene

Unigene Clusters for ERO1L Gene

ERO1-like (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ERO1L

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ERO1L Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: -
SP2:
SP3:
SP4:
SP5: - -

Relevant External Links for ERO1L Gene

GeneLoc Exon Structure for
ERO1L
ECgene alternative splicing isoforms for
ERO1L

Expression for ERO1L Gene

mRNA expression in normal human tissues for ERO1L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ERO1L Gene

This gene is overexpressed in Esophagus - Mucosa (8.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ERO1L Gene

SOURCE GeneReport for Unigene cluster for ERO1L Gene Hs.592304

mRNA Expression by UniProt/SwissProt for ERO1L Gene

Q96HE7-ERO1A_HUMAN
Tissue specificity: Widely expressed at low level. Expressed at high level in upper digestive tract. Highly expressed in esophagus. Weakly expressed in stomach and duodenum.
genes like me logo Genes that share expressions with ERO1L: view

In Situ Assay Products

Orthologs for ERO1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ERO1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ERO1L 35
  • 99.64 (n)
  • 99.57 (a)
ERO1L 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ERO1L 35
  • 93.45 (n)
  • 95.3 (a)
ERO1L 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ERO1L 35
  • 92.88 (n)
  • 96.37 (a)
ERO1L 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ero1l 35
  • 87.14 (n)
  • 92.67 (a)
Ero1l 16
Ero1l 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ERO1L 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ero1l 35
  • 86.28 (n)
  • 92.03 (a)
chicken
(Gallus gallus)
Aves ERO1L 35
  • 73.23 (n)
  • 78.57 (a)
ERO1L 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 73 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ero1lb 35
  • 71.26 (n)
  • 72.22 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
ero1l 35
  • 66.02 (n)
  • 71.22 (a)
ero1l 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ero1L 36
  • 43 (a)
OneToMany
Ero1L 37
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea ero-1 36
  • 36 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL348W 35
  • 44.64 (n)
  • 37.87 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERO1 35
  • 49.3 (n)
  • 38.44 (a)
ERO1 36
  • 23 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D10241g 35
  • 51 (n)
  • 40.46 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ERO1 35
  • 51.98 (n)
  • 44.86 (a)
rice
(Oryza sativa)
Liliopsida Os03g0733800 35
  • 54.34 (n)
  • 47.26 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.1995 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02074 35
  • 44.98 (n)
  • 38.55 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ero12 35
  • 48.33 (n)
  • 37.75 (a)
Species with no ortholog for ERO1L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ERO1L Gene

ENSEMBL:
Gene Tree for ERO1L (if available)
TreeFam:
Gene Tree for ERO1L (if available)

Paralogs for ERO1L Gene

Paralogs for ERO1L Gene

Selected SIMAP similar genes for ERO1L Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ERO1L Gene

genes like me logo Genes that share paralogs with ERO1L: view

Variants for ERO1L Gene

Sequence variations from dbSNP and Humsavar for ERO1L Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs716404 -- 52,679,601(-) ggcca(A/G)catgg intron-variant
rs743259 -- 52,684,690(+) CAAAT(A/G)TTTAA intron-variant
rs1033766 -- 52,675,064(+) ACAGA(C/T)ATGTG intron-variant
rs1058946 -- 52,642,064(-) CTTTA(A/C)ATATG utr-variant-3-prime
rs1570255 -- 52,684,427(+) GGGGG(C/G)CAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ERO1L Gene

Variant ID Type Subtype PubMed ID
nsv832796 CNV Loss 17160897

Relevant External Links for ERO1L Gene

HapMap Linkage Disequilibrium report
ERO1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ERO1L Gene

Disorders for ERO1L Gene

Relevant External Links for ERO1L

Genetic Association Database (GAD)
ERO1L
Human Genome Epidemiology (HuGE) Navigator
ERO1L
genes like me logo Genes that share disorders with ERO1L: view

No data available for UniProtKB/Swiss-Prot for ERO1L Gene

Publications for ERO1L Gene

  1. ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum. (PMID: 10671517) Cabibbo A. … Sitia R. (J. Biol. Chem. 2000) 2 3 4 23
  2. The cellular oxygen tension regulates expression of the endoplasmic oxidoreductase ERO1-Lalpha. (PMID: 12752442) Gess B. … Kurtz A. (Eur. J. Biochem. 2003) 3 4 23
  3. The Ero1alpha-PDI redox cycle regulates retro-translocation of cholera toxin. (PMID: 20130085) Moore P. … Tsai B. (Mol. Biol. Cell 2010) 3 23
  4. Endoplasmic reticulum oxidoreductin 1-lbeta (ERO1-Lbeta), a human gene induced in the course of the unfolded protein response. (PMID: 10818100) Pagani M. … Sitia R. (J. Biol. Chem. 2000) 3 4
  5. The CXXCXXC motif determines the folding, structure and stability of human Ero1-Lalpha. (PMID: 10970843) Benham A.M. … Braakman I. (EMBO J. 2000) 3 4

Products for ERO1L Gene

Sources for ERO1L Gene

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