Aliases for SLC39A2 Gene
External Ids for SLC39A2 Gene
Previous GeneCards Identifiers for SLC39A2 Gene
This gene encodes a member of the ZIP family of metal ion transporters. The encoded protein functions as a zinc transporter. Mutations in this gene may be associated with susceptibility to carotid artery disease. Multiple transcript variants have been described. [provided by RefSeq, Mar 2010]
GeneCards Summary for SLC39A2 Gene
SLC39A2 (Solute Carrier Family 39 Member 2) is a Protein Coding gene. Diseases associated with SLC39A2 include Carotid Artery Disease and Artery Disease. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Senescence and Autophagy in Cancer. GO annotations related to this gene include metal ion transmembrane transporter activity and zinc ion transmembrane transporter activity. An important paralog of this gene is SLC39A1.
UniProtKB/Swiss-Prot for SLC39A2 Gene
Mediates zinc uptake. Zinc uptake may be mediated by a Zn(2+)-HCO(3)(-) symport mechanism and can function in the presence of albumin. May also transport other divalent cations. May be important in contact inhibition of normal epithelial cells and loss of its expression may play a role in tumorigenesis.