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Aliases for SLC39A3 Gene

Aliases for SLC39A3 Gene

  • Solute Carrier Family 39 (Zinc Transporter), Member 3 2 3
  • Solute Carrier Family 39 Member 3 3 4
  • Zrt- And Irt-Like Protein 3 3 4
  • ZIP-3 3 4
  • ZIP3 3 4

External Ids for SLC39A3 Gene

Previous GeneCards Identifiers for SLC39A3 Gene

  • GC19M002795
  • GC19M002672
  • GC19M002683
  • GC19M002502

Summaries for SLC39A3 Gene

GeneCards Summary for SLC39A3 Gene

SLC39A3 (Solute Carrier Family 39 (Zinc Transporter), Member 3) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Metal ion SLC transporters. GO annotations related to this gene include metal ion transmembrane transporter activity and zinc ion transmembrane transporter activity. An important paralog of this gene is SLC39A2.

UniProtKB/Swiss-Prot for SLC39A3 Gene

  • Acts as a zinc-influx transporter.

Gene Wiki entry for SLC39A3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC39A3 Gene

Genomics for SLC39A3 Gene

Regulatory Elements for SLC39A3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SLC39A3 Gene

Chromosome:
19
Start:
2,732,204 bp from pter
End:
2,740,152 bp from pter
Size:
7,949 bases
Orientation:
Minus strand

Genomic View for SLC39A3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC39A3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC39A3 Gene

Proteins for SLC39A3 Gene

  • Protein details for SLC39A3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRY0-S39A3_HUMAN
    Recommended name:
    Zinc transporter ZIP3
    Protein Accession:
    Q9BRY0
    Secondary Accessions:
    • B3KMJ3
    • Q8WUG1

    Protein attributes for SLC39A3 Gene

    Size:
    314 amino acids
    Molecular mass:
    33601 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC39A3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC39A3 Gene

Proteomics data for SLC39A3 Gene at MOPED

Post-translational modifications for SLC39A3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC39A3 Gene

Antibody Products

No data available for DME Specific Peptides for SLC39A3 Gene

Domains & Families for SLC39A3 Gene

Gene Families for SLC39A3 Gene

Protein Domains for SLC39A3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC39A3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRY0

UniProtKB/Swiss-Prot:

S39A3_HUMAN :
  • Belongs to the ZIP transporter (TC 2.A.5) family.
Family:
  • Belongs to the ZIP transporter (TC 2.A.5) family.
genes like me logo Genes that share domains with SLC39A3: view

Function for SLC39A3 Gene

Molecular function for SLC39A3 Gene

UniProtKB/Swiss-Prot Function:
Acts as a zinc-influx transporter.

Gene Ontology (GO) - Molecular Function for SLC39A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005385 zinc ion transmembrane transporter activity IBA --
GO:0046873 metal ion transmembrane transporter activity --
genes like me logo Genes that share ontologies with SLC39A3: view
genes like me logo Genes that share phenotypes with SLC39A3: view

Animal Model Products

CRISPR Products

miRNA for SLC39A3 Gene

miRTarBase miRNAs that target SLC39A3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC39A3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC39A3 Gene

Localization for SLC39A3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC39A3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC39A3 Gene COMPARTMENTS Subcellular localization image for SLC39A3 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for SLC39A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC39A3: view

Pathways & Interactions for SLC39A3 Gene

genes like me logo Genes that share pathways with SLC39A3: view

Interacting Proteins for SLC39A3 Gene

Gene Ontology (GO) - Biological Process for SLC39A3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0001701 in utero embryonic development IEA --
GO:0006829 zinc II ion transport --
GO:0030001 metal ion transport --
GO:0043029 T cell homeostasis IEA --
genes like me logo Genes that share ontologies with SLC39A3: view

No data available for SIGNOR curated interactions for SLC39A3 Gene

Drugs & Compounds for SLC39A3 Gene

(1) Drugs for SLC39A3 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1404
genes like me logo Genes that share compounds with SLC39A3: view

Transcripts for SLC39A3 Gene

Unigene Clusters for SLC39A3 Gene

Solute carrier family 39 (zinc transporter), member 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SLC39A3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A3 Gene

No ASD Table

Relevant External Links for SLC39A3 Gene

GeneLoc Exon Structure for
SLC39A3
ECgene alternative splicing isoforms for
SLC39A3

Expression for SLC39A3 Gene

mRNA expression in normal human tissues for SLC39A3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC39A3 Gene

This gene is overexpressed in Testis (x5.7).

Protein differential expression in normal tissues from HIPED for SLC39A3 Gene

This gene is overexpressed in Ovary (47.7), Testis (14.0), and Platelet (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SLC39A3 Gene



SOURCE GeneReport for Unigene cluster for SLC39A3 Gene Hs.515046

genes like me logo Genes that share expression patterns with SLC39A3: view

Protein tissue co-expression partners for SLC39A3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for SLC39A3 Gene

Orthologs for SLC39A3 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC39A3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SLC39A3 35
  • 88.85 (n)
  • 90.45 (a)
SLC39A3 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC39A3 35
  • 89.38 (n)
  • 92.04 (a)
SLC39A3 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc39a3 35
  • 81.74 (n)
  • 84.08 (a)
Slc39a3 16
Slc39a3 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SLC39A3 35
  • 99.36 (n)
  • 100 (a)
SLC39A3 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc39a3 35
  • 81.74 (n)
  • 84.39 (a)
oppossum
(Monodelphis domestica)
Mammalia SLC39A3 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC39A3 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC39A3 35
  • 76.78 (n)
  • 73.16 (a)
SLC39A3 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc39a3 35
  • 62.83 (n)
  • 67.09 (a)
Str.17341 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011178 35
  • 46.38 (n)
  • 33.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta Zip3 35
  • 49.83 (n)
  • 35.45 (a)
ZIP1 36
  • 26 (a)
OneToMany
Zip3 36
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C18A3.2 36
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for SLC39A3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC39A3 Gene

ENSEMBL:
Gene Tree for SLC39A3 (if available)
TreeFam:
Gene Tree for SLC39A3 (if available)

Paralogs for SLC39A3 Gene

Paralogs for SLC39A3 Gene

(2) SIMAP similar genes for SLC39A3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SLC39A3: view

Variants for SLC39A3 Gene

Sequence variations from dbSNP and Humsavar for SLC39A3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs9160 -- 2,732,743(+) ATGGC(A/G)AGGCC utr-variant-3-prime
rs741106 -- 2,732,477(+) CCGCC(C/T)GTGGG downstream-variant-500B
rs759073 -- 2,732,988(+) GCGCT(C/G/T)ACGGT reference, synonymous-codon
rs2302490 -- 2,740,231(+) GAAAC(C/T)CGGAT upstream-variant-2KB
rs4806874 -- 2,738,354(+) AGAAC(A/G)TGCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC39A3 Gene

Variant ID Type Subtype PubMed ID
nsv509714 CNV Insertion 20534489
nsv910675 CNV Loss 21882294
nsv910676 CNV Loss 21882294
dgv3641n71 CNV Loss 21882294
nsv910678 CNV Loss 21882294
nsv910680 CNV Loss 21882294
nsv828397 CNV Gain 20364138
nsv910681 CNV Loss 21882294
dgv3642n71 CNV Loss 21882294
dgv3643n71 CNV Loss 21882294
nsv910689 CNV Loss 21882294

Variation tolerance for SLC39A3 Gene

Residual Variation Intolerance Score: 20.55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.87; 34.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC39A3 Gene

HapMap Linkage Disequilibrium report
SLC39A3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC39A3 Gene

Disorders for SLC39A3 Gene

Relevant External Links for SLC39A3

Genetic Association Database (GAD)
SLC39A3
Human Genome Epidemiology (HuGE) Navigator
SLC39A3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC39A3
genes like me logo Genes that share disorders with SLC39A3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC39A3 Gene

Publications for SLC39A3 Gene

  1. hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands. (PMID: 17550612) Desouki M.M. … Costello L.C. (Mol. Cancer 2007) 23 67
  2. Decreased intracellular zinc in human tumorigenic prostate epithelial cells: a possible role in prostate cancer progression. (PMID: 16579854) Huang L. … Zhang Y. (Cancer Cell Int. 2006) 23 67
  3. Bioinformatic analyses implicate the collaborating meiotic crossover/chiasma proteins Zip2, Zip3, and Spo22/Zip4 in ubiquitin labeling. (PMID: 16314568) Perry J. … BAPrner G.V. (Proc. Natl. Acad. Sci. U.S.A. 2005) 23 67
  4. Structure, function, and regulation of a subfamily of mouse zinc transporter genes. (PMID: 14525987) Dufner-Beattie J. … Andrews G.K. (J. Biol. Chem. 2003) 23 67
  5. Functional expression of the human hZIP2 zinc transporter. (PMID: 10681536) Gaither L.A. … Eide D.J. (J. Biol. Chem. 2000) 2 67

Products for SLC39A3 Gene

Sources for SLC39A3 Gene

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