Aliases for UBQLN2 Gene
External Ids for UBQLN2 Gene
This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein. [provided by RefSeq, Oct 2009]
GeneCards Summary for UBQLN2 Gene
UBQLN2 (Ubiquilin 2) is a Protein Coding gene. Diseases associated with UBQLN2 include amyotrophic lateral sclerosis 15, with or without frontotemporal dementia and ubqln2-related amyotrophic lateral sclerosis/frontotemporal dementia. Among its related pathways are Protein processing in endoplasmic reticulum. An important paralog of this gene is UBQLN3.
UniProtKB/Swiss-Prot for UBQLN2 Gene
Increases the half-life of proteins destined to be degraded by the proteasome; may modulate proteasome-mediated protein degradation.