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Aliases for GYPE Gene

Aliases for GYPE Gene

  • Glycophorin E (MNS Blood Group) 2 3
  • GPE 3 4
  • Glycophorin E 2
  • MiIX 3
  • MNS 3

External Ids for GYPE Gene

Previous GeneCards Identifiers for GYPE Gene

  • GC04M145588
  • GC04M145167
  • GC04M145369
  • GC04M145149
  • GC04M145011
  • GC04M144792
  • GC04M140521

Summaries for GYPE Gene

Entrez Gene Summary for GYPE Gene

  • The protein encoded by this gene is a sialoglycoprotein and a type I membrane protein. It is a member of a gene family with GPA and GPB genes. This encoded protein might carry the M blood group antigen. GYPA, GYPB, and GYPE are organized in tandem on chromosome 4. This gene might have derived from an ancestral gene common to the GPB gene by gene duplication. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for GYPE Gene

GYPE (Glycophorin E (MNS Blood Group)) is a Protein Coding gene. Diseases associated with GYPE include hemidystonia and myeloid sarcoma. An important paralog of this gene is GYPB.

UniProtKB/Swiss-Prot for GYPE Gene

  • This protein is a minor sialoglycoprotein in human erythrocyte membranes

Gene Wiki entry for GYPE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GYPE Gene

Genomics for GYPE Gene

Regulatory Elements for GYPE Gene

Genomic Location for GYPE Gene

Chromosome:
4
Start:
143,870,866 bp from pter
End:
143,905,563 bp from pter
Size:
34,698 bases
Orientation:
Minus strand

Genomic View for GYPE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GYPE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GYPE Gene

Proteins for GYPE Gene

  • Protein details for GYPE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15421-GLPE_HUMAN
    Recommended name:
    Glycophorin-E
    Protein Accession:
    P15421
    Secondary Accessions:
    • D3DNZ5

    Protein attributes for GYPE Gene

    Size:
    78 amino acids
    Molecular mass:
    8463 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GYPE Gene

Proteomics data for GYPE Gene at MOPED

Post-translational modifications for GYPE Gene

  • The N-terminal extracellular domain is heavily glycosylated on serine and threonine residues.

Other Protein References for GYPE Gene

No data available for DME Specific Peptides for GYPE Gene

Domains & Families for GYPE Gene

Gene Families for GYPE Gene

Protein Domains for GYPE Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for GYPE Gene

Graphical View of Domain Structure for InterPro Entry

P15421

UniProtKB/Swiss-Prot:

GLPE_HUMAN :
  • Belongs to the glycophorin-A family.
Family:
  • Belongs to the glycophorin-A family.
genes like me logo Genes that share domains with GYPE: view

Function for GYPE Gene

Molecular function for GYPE Gene

GENATLAS Biochemistry:
glycophorin E
UniProtKB/Swiss-Prot Function:
This protein is a minor sialoglycoprotein in human erythrocyte membranes

Phenotypes for GYPE Gene

GenomeRNAi human phenotypes for GYPE:
genes like me logo Genes that share phenotypes with GYPE: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GYPE

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GYPE Gene

Localization for GYPE Gene

Subcellular locations from UniProtKB/Swiss-Prot for GYPE Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GYPE Gene COMPARTMENTS Subcellular localization image for GYPE gene
Compartment Confidence
plasma membrane 4
mitochondrion 2
nucleus 2
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for GYPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 2295603
GO:0005887 integral component of plasma membrane TAS 7622054
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with GYPE: view

Pathways & Interactions for GYPE Gene

SuperPathways for GYPE Gene

No Data Available

Interacting Proteins for GYPE Gene

Gene Ontology (GO) - Biological Process for GYPE Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GYPE Gene

Drugs & Compounds for GYPE Gene

(11) Drugs for GYPE Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iron Approved Pharma 957
Phenol Approved, Experimental Pharma 41
Phosphatidylserine Approved Nutra 0
cholesterol Experimental Pharma Agonist 0
lactose Experimental Pharma 0

(21) Additional Compounds for GYPE Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1,2-Dimyristoylamido-1,2-deoxyphosphatidylcholine
23-diphosphoglycerate
Carbohydrates
Cyanogen bromide
dextran sulfate
genes like me logo Genes that share compounds with GYPE: view

Transcripts for GYPE Gene

mRNA/cDNA for GYPE Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(88) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GYPE Gene

Glycophorin E (MNS blood group):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GYPE

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GYPE Gene

No ASD Table

Relevant External Links for GYPE Gene

GeneLoc Exon Structure for
GYPE
ECgene alternative splicing isoforms for
GYPE

Expression for GYPE Gene

mRNA expression in normal human tissues for GYPE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for GYPE Gene

This gene is overexpressed in Whole Blood (x5.1) and Spleen (x4.1).

SOURCE GeneReport for Unigene cluster for GYPE Gene Hs.728753

mRNA Expression by UniProt/SwissProt for GYPE Gene

P15421-GLPE_HUMAN
Tissue specificity: Erythrocytes
genes like me logo Genes that share expression patterns with GYPE: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for GYPE Gene

Orthologs for GYPE Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for GYPE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GYPE2 35
  • 99.15 (n)
  • 98.72 (a)
GYPE 36
  • 75 (a)
OneToOne
Species with no ortholog for GYPE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for GYPE Gene

ENSEMBL:
Gene Tree for GYPE (if available)
TreeFam:
Gene Tree for GYPE (if available)

Paralogs for GYPE Gene

Paralogs for GYPE Gene

genes like me logo Genes that share paralogs with GYPE: view

Variants for GYPE Gene

Sequence variations from dbSNP and Humsavar for GYPE Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_053111 -
VAR_062006 -

Structural Variations from Database of Genomic Variants (DGV) for GYPE Gene

Variant ID Type Subtype PubMed ID
dgv1683e1 CNV Complex 17122850
dgv1684e1 CNV Complex 17122850
nsv428452 CNV Loss 18775914
dgv1685e1 CNV Complex 17122850
dgv1686e1 CNV Complex 17122850
dgv4n29 CNV Loss 16826518
esv2728476 CNV Deletion 23290073
dgv978e199 CNV Deletion 23128226
dgv898e201 CNV Deletion 23290073
dgv979e199 CNV Deletion 23128226
nsv436452 CNV Deletion 17901297
esv2752026 CNV Gain 17911159
dgv189e55 CNV Gain 17911159
nsv880178 CNV Gain 21882294
nsv528303 CNV Gain 19592680
dgv667n27 CNV Gain 19166990
dgv5767n71 CNV Gain 21882294
nsv517006 CNV Gain+Loss 19592680
nsv436078 CNV Insertion 17901297
nsv461664 CNV Gain 19166990
nsv461665 CNV Loss 19166990
nsv10584 CNV Gain+Loss 18304495
nsv880181 CNV Gain+Loss 21882294
nsv880182 CNV Gain 21882294
dgv980e199 CNV Deletion 23128226
nsv880185 CNV Loss 21882294
dgv5768n71 CNV Gain 21882294
dgv5769n71 CNV Gain 21882294
nsv435790 CNV Deletion 17901297
dgv1687e1 CNV Complex 17122850
esv2752030 CNV Gain 17911159
dgv1688e1 CNV Complex 17122850
nsv880191 CNV Gain+Loss 21882294
nsv436411 CNV Deletion 17901297
esv2728480 CNV Deletion 23290073
dgv5770n71 CNV Gain 21882294
esv2668125 CNV Deletion 23128226
dgv5771n71 CNV Gain 21882294

Variation tolerance for GYPE Gene

Residual Variation Intolerance Score: 76.52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GYPE Gene

HapMap Linkage Disequilibrium report
GYPE
Human Gene Mutation Database (HGMD)
GYPE
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GYPE Gene

Disorders for GYPE Gene

MalaCards: The human disease database

(3) MalaCards diseases for GYPE Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hemidystonia
myeloid sarcoma
  • chloroma
multifocal dystonia
- elite association
Search GYPE in MalaCards View complete list of genes associated with diseases

Relevant External Links for GYPE

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GYPE
genes like me logo Genes that share disorders with GYPE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GYPE Gene

Publications for GYPE Gene

  1. Erythrocyte aggregability and AB0 blood groups. (PMID: 19136744) VayA! A. … Romagnoli M. (Clin. Hemorheol. Microcirc. 2009) 23 67
  2. Helix-helix interactions in membrane proteins: coarse-grained simulations of glycophorin a helix dimerization. (PMID: 18783247) Psachoulia E. … Sansom M.S. (Biochemistry 2008) 23 67
  3. Receptor-based identification of an inhibitory peptide against blood stage malaria. (PMID: 18793615) Li X. … Chishti A.H. (Biochem. Biophys. Res. Commun. 2008) 23 67
  4. Loss of phospholipid membrane asymmetry and sialylated glycoconjugates from erythrocyte surface in haemoglobin E beta-thalassaemia. (PMID: 18324971) Basu S. … Chakrabarti A. (Br. J. Haematol. 2008) 23 67
  5. Mass spectral imaging of glycophospholipids, cholesterol, and glycophorin a in model cell membranes. (PMID: 18788765) Baker M.J. … Vickerman J.C. (Langmuir 2008) 23 67

Products for GYPE Gene

Sources for GYPE Gene

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