Aliases for PADI1 Gene
External Ids for PADI1 Gene
Previous GeneCards Identifiers for PADI1 Gene
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]
GeneCards Summary for PADI1 Gene
PADI1 (Peptidyl Arginine Deiminase, Type I) is a Protein Coding gene. Among its related pathways are Chromatin organization and protein citrullination. GO annotations related to this gene include calcium ion binding and protein-arginine deiminase activity. An important paralog of this gene is PADI3.
UniProtKB/Swiss-Prot for PADI1 Gene
Catalyzes the deimination of arginine residues of proteins.