Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PKN3 Gene

Aliases for PKN3 Gene

  • Protein Kinase N3 2 3 5
  • Protein-Kinase C-Related Kinase 3 3 4
  • Protein Kinase PKN-Beta 3 4
  • EC 2.7.11.13 4 63
  • EC 2.7.11 63
  • UTDP4-1 3
  • PKNBETA 4

External Ids for PKN3 Gene

Previous GeneCards Identifiers for PKN3 Gene

  • GC09P126841
  • GC09P128544
  • GC09P130504
  • GC09P131464
  • GC09P101074

Summaries for PKN3 Gene

GeneCards Summary for PKN3 Gene

PKN3 (Protein Kinase N3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKCB.

UniProtKB/Swiss-Prot for PKN3 Gene

  • Contributes to invasiveness in malignant prostate cancer.

Gene Wiki entry for PKN3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PKN3 Gene

Genomics for PKN3 Gene

Regulatory Elements for PKN3 Gene

Promoters for PKN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PKN3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PKN3 Gene

Chromosome:
9
Start:
128,702,499 bp from pter
End:
128,720,920 bp from pter
Size:
18,422 bases
Orientation:
Plus strand

Genomic View for PKN3 Gene

Genes around PKN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PKN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PKN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PKN3 Gene

Proteins for PKN3 Gene

  • Protein details for PKN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P5Z2-PKN3_HUMAN
    Recommended name:
    Serine/threonine-protein kinase N3
    Protein Accession:
    Q6P5Z2
    Secondary Accessions:
    • Q9UM03

    Protein attributes for PKN3 Gene

    Size:
    889 amino acids
    Molecular mass:
    99421 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PKN3 Gene

Proteomics data for PKN3 Gene at MOPED

Post-translational modifications for PKN3 Gene

Other Protein References for PKN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PKN3 Gene

Suggested Antigen Peptide Sequences for PKN3 Gene

Graphical View of Domain Structure for InterPro Entry

Q6P5Z2

UniProtKB/Swiss-Prot:

PKN3_HUMAN :
  • The C1 domain does not bind the diacylglycerol (DAG).
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
  • Contains 3 REM (Hr1) repeats.
Domain:
  • The C1 domain does not bind the diacylglycerol (DAG).
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Similarity:
  • Contains 3 REM (Hr1) repeats.
genes like me logo Genes that share domains with PKN3: view

Function for PKN3 Gene

Molecular function for PKN3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Two specific sites, Thr-718 (activation loop of the kinase domain) and Thr-860 (turn motif), need to be phosphorylated for its full activation.
UniProtKB/Swiss-Prot Function:
Contributes to invasiveness in malignant prostate cancer.

Enzyme Numbers (IUBMB) for PKN3 Gene

Gene Ontology (GO) - Molecular Function for PKN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004697 protein kinase C activity IEA --
genes like me logo Genes that share ontologies with PKN3: view
genes like me logo Genes that share phenotypes with PKN3: view

Animal Models for PKN3 Gene

MGI Knock Outs for PKN3:

Animal Model Products

  • Taconic Biosciences Mouse Models for PKN3

miRNA for PKN3 Gene

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PKN3 Gene

Localization for PKN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PKN3 Gene

Nucleus. Cytoplasm, perinuclear region. Note=Nuclear and perinuclear Golgi region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PKN3 Gene COMPARTMENTS Subcellular localization image for PKN3 gene
Compartment Confidence
nucleus 5
golgi apparatus 4
cytosol 3
chloroplast 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PKN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PKN3: view

Pathways & Interactions for PKN3 Gene

genes like me logo Genes that share pathways with PKN3: view

Pathways by source for PKN3 Gene

Gene Ontology (GO) - Biological Process for PKN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,TAS 10441506
genes like me logo Genes that share ontologies with PKN3: view

No data available for SIGNOR curated interactions for PKN3 Gene

Drugs & Compounds for PKN3 Gene

(3) Drugs for PKN3 Gene - From: HMDB and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
ATU027 Pharma 0
sophoretin Pharma inhibitor Kinase Inhibitors 0

(1) Additional Compounds for PKN3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with PKN3: view

Transcripts for PKN3 Gene

Unigene Clusters for PKN3 Gene

Protein kinase N3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PKN3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
SP1:
SP2: -
SP3:
SP4: -
SP5:

Relevant External Links for PKN3 Gene

GeneLoc Exon Structure for
PKN3
ECgene alternative splicing isoforms for
PKN3

Expression for PKN3 Gene

mRNA expression in normal human tissues for PKN3 Gene

Protein differential expression in normal tissues from HIPED for PKN3 Gene

This gene is overexpressed in Heart (67.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PKN3 Gene



SOURCE GeneReport for Unigene cluster for PKN3 Gene Hs.300485

mRNA Expression by UniProt/SwissProt for PKN3 Gene

Q6P5Z2-PKN3_HUMAN
Tissue specificity: Expressed in prostate tumors and various cancer cell lines. Not expressed in adult tissues.
genes like me logo Genes that share expression patterns with PKN3: view

Protein tissue co-expression partners for PKN3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PKN3 Gene

Orthologs for PKN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PKN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PKN3 35
  • 87.96 (n)
  • 90.1 (a)
PKN3 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PKN3 35
  • 86.8 (n)
  • 89.78 (a)
PKN3 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pkn3 35
  • 82.07 (n)
  • 84.44 (a)
Pkn3 16
Pkn3 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PKN3 35
  • 99.48 (n)
  • 99.55 (a)
PKN3 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PKN3 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PKN3 36
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves PKN3 35
  • 61.44 (n)
  • 62.28 (a)
PKN3 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145241 35
  • 62.27 (n)
  • 59.49 (a)
zebrafish
(Danio rerio)
Actinopterygii pkn3 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pkn 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pkn-1 36
  • 30 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PKC1 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for PKN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PKN3 Gene

ENSEMBL:
Gene Tree for PKN3 (if available)
TreeFam:
Gene Tree for PKN3 (if available)

Paralogs for PKN3 Gene

Paralogs for PKN3 Gene

genes like me logo Genes that share paralogs with PKN3: view

Variants for PKN3 Gene

Sequence variations from dbSNP and Humsavar for PKN3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs56251280 - 128,706,911(+) GCTGG(A/C)GGAGG reference, missense
rs12932 - 128,713,616(+) GCCTG(G/T)TACCG reference, missense
rs1572915 -- 128,702,888(+) GAGAG(A/G)AGGGC upstream-variant-2KB, utr-variant-5-prime
rs1572916 -- 128,705,972(+) ACCAT(C/T)CCAGC intron-variant
rs2417123 -- 128,716,364(-) TGCTT(C/T)GGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PKN3 Gene

Variant ID Type Subtype PubMed ID
nsv893900 CNV Loss 21882294
nsv416266 CNV Loss 16902084

Variation tolerance for PKN3 Gene

Residual Variation Intolerance Score: 48.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.61; 56.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PKN3 Gene

HapMap Linkage Disequilibrium report
PKN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PKN3 Gene

Disorders for PKN3 Gene

Relevant External Links for PKN3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PKN3

No disorders were found for PKN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PKN3 Gene

Publications for PKN3 Gene

  1. Identification and characterization of PKNbeta, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKNalpha. (PMID: 10441506) Oishi K. … Ono Y. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23 67
  2. PKN regulates phospholipase D1 through direct interaction. (PMID: 11259428) Oishi K. … Ono Y. (J. Biol. Chem. 2001) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3
  5. Genetic variants associated with disordered eating. (PMID: 23568457) Wade T.D. … Martin N.G. (Int J Eat Disord 2013) 3

Products for PKN3 Gene

Sources for PKN3 Gene

Back to Top

Content