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Aliases for PKN3 Gene

Aliases for PKN3 Gene

  • Protein Kinase N3 2 3
  • Protein-Kinase C-Related Kinase 3 3 4
  • Protein Kinase PKN-Beta 3 4
  • EC 4 63
  • Serine/Threonine-Protein Kinase N3 3
  • EC 2.7.11 63
  • UTDP4-1 3

External Ids for PKN3 Gene

Previous GeneCards Identifiers for PKN3 Gene

  • GC09P126841
  • GC09P128544
  • GC09P130504
  • GC09P131464
  • GC09P101074

Summaries for PKN3 Gene

GeneCards Summary for PKN3 Gene

PKN3 (Protein Kinase N3) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and Salmonella infection (KEGG). GO annotations related to this gene include protein kinase activity and protein kinase C activity. An important paralog of this gene is PRKCB.

UniProtKB/Swiss-Prot for PKN3 Gene

  • Contributes to invasiveness in malignant prostate cancer.

Gene Wiki entry for PKN3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PKN3 Gene

Genomics for PKN3 Gene

Regulatory Elements for PKN3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PKN3 Gene

128,702,235 bp from pter
128,720,920 bp from pter
18,686 bases
Plus strand

Genomic View for PKN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PKN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PKN3 Gene

Proteins for PKN3 Gene

  • Protein details for PKN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase N3
    Protein Accession:
    Secondary Accessions:
    • Q9UM03

    Protein attributes for PKN3 Gene

    889 amino acids
    Molecular mass:
    99421 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PKN3 Gene

Proteomics data for PKN3 Gene at MOPED

Post-translational modifications for PKN3 Gene

Other Protein References for PKN3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for PKN3 Gene

Suggested Antigen Peptide Sequences for PKN3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q6P5Z2
  • The C1 domain does not bind the diacylglycerol (DAG)
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
  • Contains 3 REM (Hr1) repeats.
genes like me logo Genes that share domains with PKN3: view

Function for PKN3 Gene

Molecular function for PKN3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation:
Two specific sites, Thr-718 (activation loop of the kinase domain) and Thr-860 (turn motif), need to be phosphorylated for its full activation.
UniProtKB/Swiss-Prot Function:
Contributes to invasiveness in malignant prostate cancer.

Enzyme Numbers (IUBMB) for PKN3 Gene

Gene Ontology (GO) - Molecular Function for PKN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 10441506
GO:0004674 protein serine/threonine kinase activity --
GO:0004697 protein kinase C activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 11432776
genes like me logo Genes that share ontologies with PKN3: view
genes like me logo Genes that share phenotypes with PKN3: view

Animal Model Products

miRNA for PKN3 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PKN3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PKN3 Gene

Localization for PKN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PKN3 Gene

Nucleus. Cytoplasm, perinuclear region. Note=Nuclear and perinuclear Golgi region.

Subcellular locations from

Jensen Localization Image for PKN3 Gene COMPARTMENTS Subcellular localization image for PKN3 gene
Compartment Confidence
nucleus 5
golgi apparatus 4
cytosol 3
chloroplast 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PKN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005794 Golgi apparatus TAS 10441506
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with PKN3: view

Pathways for PKN3 Gene

genes like me logo Genes that share pathways with PKN3: view

Pathways by source for PKN3 Gene

2 KEGG pathways for PKN3 Gene

Gene Ontology (GO) - Biological Process for PKN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction IEA --
GO:0010631 epithelial cell migration IDA 21754995
genes like me logo Genes that share ontologies with PKN3: view

Compounds for PKN3 Gene

(2) HMDB Compounds for PKN3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
genes like me logo Genes that share compounds with PKN3: view

Transcripts for PKN3 Gene

Unigene Clusters for PKN3 Gene

Protein kinase N3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PKN3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PKN3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
SP2: -
SP4: -

Relevant External Links for PKN3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PKN3 Gene

mRNA expression in normal human tissues for PKN3 Gene

Protein differential expression in normal tissues for PKN3 Gene

This gene is overexpressed in Heart (67.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PKN3 Gene

SOURCE GeneReport for Unigene cluster for PKN3 Gene Hs.300485

mRNA Expression by UniProt/SwissProt for PKN3 Gene

Tissue specificity: Expressed in prostate tumors and various cancer cell lines. Not expressed in adult tissues.
genes like me logo Genes that share expressions with PKN3: view

Expression partners for PKN3 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PKN3 Gene

Orthologs for PKN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PKN3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PKN3 35
  • 87.96 (n)
  • 90.1 (a)
PKN3 36
  • 90 (a)
(Canis familiaris)
Mammalia PKN3 35
  • 86.8 (n)
  • 89.78 (a)
PKN3 36
  • 90 (a)
(Mus musculus)
Mammalia Pkn3 35
  • 82.07 (n)
  • 84.44 (a)
Pkn3 16
Pkn3 36
  • 84 (a)
(Pan troglodytes)
Mammalia PKN3 35
  • 99.48 (n)
  • 99.55 (a)
PKN3 36
  • 99 (a)
(Monodelphis domestica)
Mammalia PKN3 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia PKN3 36
  • 69 (a)
(Gallus gallus)
Aves PKN3 35
  • 61.44 (n)
  • 62.28 (a)
PKN3 36
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100145241 35
  • 62.27 (n)
  • 59.49 (a)
(Danio rerio)
Actinopterygii pkn3 36
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pkn 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea pkn-1 36
  • 30 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PKC1 36
  • 22 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
Species with no ortholog for PKN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PKN3 Gene

Gene Tree for PKN3 (if available)
Gene Tree for PKN3 (if available)

Paralogs for PKN3 Gene

Paralogs for PKN3 Gene

genes like me logo Genes that share paralogs with PKN3: view

Variants for PKN3 Gene

Sequence variations from dbSNP and Humsavar for PKN3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs12932 - 128,713,616(+) GCCTG(G/T)TACCG reference, missense
rs1572915 -- 128,702,888(+) GAGAG(A/G)AGGGC upstream-variant-2KB, utr-variant-5-prime
rs1572916 -- 128,705,972(+) ACCAT(C/T)CCAGC intron-variant
rs2417123 -- 128,716,364(-) TGCTT(C/T)GGCCT intron-variant
rs2417124 -- 128,713,926(-) CAGAA(A/G)GACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PKN3 Gene

Variant ID Type Subtype PubMed ID
nsv893900 CNV Loss 21882294
nsv416266 CNV Loss 16902084

Relevant External Links for PKN3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PKN3 Gene

Disorders for PKN3 Gene

No disorders were found for PKN3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for PKN3 Gene

Publications for PKN3 Gene

  1. Identification and characterization of PKNbeta, a novel isoform of protein kinase PKN: expression and arachidonic acid dependency are different from those of PKNalpha. (PMID: 10441506) Oishi K. … Ono Y. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23
  2. PKN regulates phospholipase D1 through direct interaction. (PMID: 11259428) Oishi K. … Ono Y. (J. Biol. Chem. 2001) 3 23
  3. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  4. PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase. (PMID: 15282551) Leenders F. … Klippel A. (EMBO J. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PKN3 Gene

Sources for PKN3 Gene

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