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Aliases for GULOP Gene

Aliases for GULOP Gene

  • Gulonolactone (L-) Oxidase, Pseudogene 2 3 5
  • SCURVY 3
  • GULO 3

External Ids for GULOP Gene

Previous GeneCards Identifiers for GULOP Gene

  • GC08U990039
  • GC08P027255
  • GC08P027457
  • GC08P027491
  • GC08P027418

Summaries for GULOP Gene

Entrez Gene Summary for GULOP Gene

  • This gene is nonfunctional in humans and other primates. In most mammalian species the corresponding gene encodes L-gulono-gamma-lactone oxidase which catalyzes the last step of ascorbic acid biosynthesis. The human gene is a remnant that lacks five of twelve exons found in functional rodent genes. The loss of enzyme activity results in hypoascorbemia or the inability to synthesize vitamin C. [provided by RefSeq, Nov 2010]

GeneCards Summary for GULOP Gene

GULOP (Gulonolactone (L-) Oxidase, Pseudogene) is a Pseudogene. Diseases associated with GULOP include scurvy.

Gene Wiki entry for GULOP Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GULOP Gene

Genomics for GULOP Gene

Genomic Location for GULOP Gene

Chromosome:
8
Start:
27,560,274 bp from pter
End:
27,589,073 bp from pter
Size:
28,800 bases
Orientation:
Plus strand

Genomic View for GULOP Gene

Genes around GULOP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GULOP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GULOP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GULOP Gene

No data available for Regulatory Elements for GULOP Gene

Proteins for GULOP Gene

Post-translational modifications for GULOP Gene

No Post-translational modifications

No data available for DME Specific Peptides for GULOP Gene

Domains & Families for GULOP Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for GULOP Gene

Function for GULOP Gene

Molecular function for GULOP Gene

GENATLAS Biochemistry:
gulono-gamma oxidase,non functional

Phenotypes for GULOP Gene

GenomeRNAi human phenotypes for GULOP:
genes like me logo Genes that share phenotypes with GULOP: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GULOP Gene

Localization for GULOP Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for GULOP Gene

Pathways & Interactions for GULOP Gene

SuperPathways for GULOP Gene

No Data Available

Interacting Proteins for GULOP Gene

Gene Ontology (GO) - Biological Process for GULOP Gene

None

No data available for Pathways by source and SIGNOR curated interactions for GULOP Gene

Drugs & Compounds for GULOP Gene

No Compound Related Data Available

Transcripts for GULOP Gene

mRNA/cDNA for GULOP Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for GULOP Gene

No ASD Table

Relevant External Links for GULOP Gene

GeneLoc Exon Structure for
GULOP
ECgene alternative splicing isoforms for
GULOP

Expression for GULOP Gene

mRNA expression in normal human tissues for GULOP Gene

mRNA differential expression in normal tissues according to GTEx for GULOP Gene

This gene is overexpressed in Pancreas (x5.2).
genes like me logo Genes that share expression patterns with GULOP: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for GULOP Gene

Orthologs for GULOP Gene

Evolution for GULOP Gene

ENSEMBL:
Gene Tree for GULOP (if available)
TreeFam:
Gene Tree for GULOP (if available)

No data available for Orthologs for GULOP Gene

Paralogs for GULOP Gene

No data available for Paralogs for GULOP Gene

Variants for GULOP Gene

Relevant External Links for GULOP Gene

HapMap Linkage Disequilibrium report
GULOP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for GULOP Gene

Disorders for GULOP Gene

MalaCards: The human disease database

(1) MalaCards diseases for GULOP Gene - From: OMIM and GeneCards

Disorder Aliases PubMed IDs
scurvy
  • deficiency of vitamin c
- elite association - COSMIC cancer census association via MalaCards
Search GULOP in MalaCards View complete list of genes associated with diseases

Relevant External Links for GULOP

Genetic Association Database (GAD)
GULOP
genes like me logo Genes that share disorders with GULOP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GULOP Gene

Publications for GULOP Gene

  1. Cloning and chromosomal mapping of the human nonfunctional gene for L-gulono-gamma-lactone oxidase, the enzyme for L-ascorbic acid biosynthesis missing in man. (PMID: 8175804) Nishikimi M. … Yagi K. (J. Biol. Chem. 1994) 2 3 67
  2. Occurrence in humans and guinea pigs of the gene related to their missing enzyme L-gulono-gamma-lactone oxidase. (PMID: 3214183) Nishikimi M. … Yagi K. (Arch. Biochem. Biophys. 1988) 2 3
  3. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  4. Conserved or lost: molecular evolution of the key gene GULO in vertebrate vitamin C biosynthesis. (PMID: 23404229) Yang H. (Biochem. Genet. 2013) 3
  5. Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. (PMID: 20210993) Zhang Z.D. … Gerstein M. (Genome Biol. 2010) 3

Products for GULOP Gene

Sources for GULOP Gene

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