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Aliases for GUCY2F Gene

Aliases for GUCY2F Gene

  • Guanylate Cyclase 2F, Retinal 2 3 4 5
  • Guanylate Cyclase 2D-Like, Membrane (Retina-Specific) 2 3
  • Rod Outer Segment Membrane Guanylate Cyclase 2 3 4
  • Guanylate Cyclase F 3 4
  • EC 4 61
  • RETGC-2 3 4
  • ROS-GC2 3 4
  • GUC2F 3 4
  • GC-F 3 4
  • Retinal Guanylyl Cyclase 2 3
  • EC 4.6.1 61
  • GUC2DL 3
  • RETGC2 4
  • CYGF 3

External Ids for GUCY2F Gene

Previous GeneCards Identifiers for GUCY2F Gene

  • GC0XM103919
  • GC0XM105762
  • GC0XM106641
  • GC0XM107380
  • GC0XM108422
  • GC0XM108616
  • GC0XM098238

Summaries for GUCY2F Gene

Entrez Gene Summary for GUCY2F Gene

  • The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa. [provided by RefSeq, Dec 2008]

GeneCards Summary for GUCY2F Gene

GUCY2F (Guanylate Cyclase 2F, Retinal) is a Protein Coding gene. Diseases associated with GUCY2F include Leber Congenital Amaurosis and Retinitis Pigmentosa. Among its related pathways are Metabolism of fat-soluble vitamins and Phototransduction. GO annotations related to this gene include protein homodimerization activity and protein kinase activity. An important paralog of this gene is GUCY2D.

UniProtKB/Swiss-Prot for GUCY2F Gene

  • Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GUCY2F Gene

Genomics for GUCY2F Gene

Regulatory Elements for GUCY2F Gene

Enhancers for GUCY2F Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG109472 0.9 Ensembl ENCODE 0.4 +9.0 8998 1.4 SOX5 SOX13 CTCF ZNF654 RAD21 ZFP69B JUND FOS NXT2 GUCY2F ENSG00000215000
GH0XG109475 0.9 Ensembl ENCODE 0.4 +6.5 6472 0.8 CTCF PKNOX1 TFAP4 MXI1 L3MBTL2 MAX ELF4 RAD21 GATA3 POLR2A KCNE5 GUCY2F ENSG00000215000
GH0XG109533 0.6 ENCODE 0.2 -51.1 -51135 0.2 SRF RFX1 MTA2 TRIM22 TBX21 ZNF664 CBX5 TCF7 SPI1 NXT2 GUCY2F
GH0XG109534 0.6 Ensembl 0.2 -51.4 -51429 0.2 RFX1 MTA2 TRIM22 TBX21 ZNF664 CBX5 GATA2 TCF7 NXT2 GUCY2F
GH0XG109503 0.3 FANTOM5 0.3 -21.4 -21422 0.2 NXT2 GUCY2F
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GUCY2F on UCSC Golden Path with GeneCards custom track

Genomic Location for GUCY2F Gene

109,372,017 bp from pter
109,482,072 bp from pter
110,056 bases
Minus strand

Genomic View for GUCY2F Gene

Genes around GUCY2F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GUCY2F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GUCY2F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GUCY2F Gene

Proteins for GUCY2F Gene

  • Protein details for GUCY2F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Retinal guanylyl cyclase 2
    Protein Accession:
    Secondary Accessions:
    • Q9UJF1

    Protein attributes for GUCY2F Gene

    1108 amino acids
    Molecular mass:
    124850 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GUCY2F Gene

Selected DME Specific Peptides for GUCY2F Gene


Post-translational modifications for GUCY2F Gene

  • There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GUCY2F Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for GUCY2F Gene

Gene Families for GUCY2F Gene

Suggested Antigen Peptide Sequences for GUCY2F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
  • The protein kinase domain is predicted to be catalytically inactive.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with GUCY2F: view

Function for GUCY2F Gene

Molecular function for GUCY2F Gene

GENATLAS Biochemistry:
guanylate cyclase 2F,membrane form expressed in the retina,homolog to murine Gucyf
UniProtKB/Swiss-Prot CatalyticActivity:
GTP = 3,5-cyclic GMP + diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by GCAP-1; inhibited by calcium.
UniProtKB/Swiss-Prot Function:
Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.

Enzyme Numbers (IUBMB) for GUCY2F Gene

Gene Ontology (GO) - Molecular Function for GUCY2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004016 NOT adenylate cyclase activity IBA --
GO:0004383 guanylate cyclase activity TAS --
GO:0004672 protein kinase activity IEA --
GO:0004872 receptor activity TAS 7777544
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with GUCY2F: view
genes like me logo Genes that share phenotypes with GUCY2F: view

Animal Models for GUCY2F Gene

MGI Knock Outs for GUCY2F:

Animal Model Products

  • Taconic Biosciences Mouse Models for GUCY2F

CRISPR Products

miRNA for GUCY2F Gene

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GUCY2F Gene

Localization for GUCY2F Gene

Subcellular locations from UniProtKB/Swiss-Prot for GUCY2F Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GUCY2F gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 4
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for GUCY2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005640 nuclear outer membrane TAS 7777544
GO:0005887 integral component of plasma membrane TAS 7777544
GO:0008074 guanylate cyclase complex, soluble IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GUCY2F: view

Pathways & Interactions for GUCY2F Gene

genes like me logo Genes that share pathways with GUCY2F: view

Gene Ontology (GO) - Biological Process for GUCY2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006182 cGMP biosynthetic process IBA --
GO:0006468 protein phosphorylation IEA --
GO:0007165 signal transduction IBA --
GO:0007168 receptor guanylyl cyclase signaling pathway TAS 7777544
GO:0007601 visual perception TAS 7777544
genes like me logo Genes that share ontologies with GUCY2F: view

No data available for SIGNOR curated interactions for GUCY2F Gene

Drugs & Compounds for GUCY2F Gene

(5) Drugs for GUCY2F Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Cyclic GMP Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
calcium Nutra 0

(2) Additional Compounds for GUCY2F Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
genes like me logo Genes that share compounds with GUCY2F: view

Transcripts for GUCY2F Gene

mRNA/cDNA for GUCY2F Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GUCY2F Gene

Guanylate cyclase 2F, retinal:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GUCY2F Gene

No ASD Table

Relevant External Links for GUCY2F Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GUCY2F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GUCY2F Gene

mRNA differential expression in normal tissues according to GTEx for GUCY2F Gene

This gene is overexpressed in Testis (x13.6) and Cervix - Endocervix (x5.9).

Protein differential expression in normal tissues from HIPED for GUCY2F Gene

This gene is overexpressed in Cervix (66.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for GUCY2F Gene

Protein tissue co-expression partners for GUCY2F Gene

NURSA nuclear receptor signaling pathways regulating expression of GUCY2F Gene:


SOURCE GeneReport for Unigene cluster for GUCY2F Gene:


mRNA Expression by UniProt/SwissProt for GUCY2F Gene:

Tissue specificity: Retina. Localized exclusively in the outer nuclear layer and inner segments of the rod and cone photoreceptor cells.

Evidence on tissue expression from TISSUES for GUCY2F Gene

  • Eye(4.5)
genes like me logo Genes that share expression patterns with GUCY2F: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for GUCY2F Gene

Orthologs for GUCY2F Gene

This gene was present in the common ancestor of animals.

Orthologs for GUCY2F Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GUCY2F 34 35
  • 97.71 (n)
(Bos Taurus)
Mammalia GUCY2F 34 35
  • 91.26 (n)
(Canis familiaris)
Mammalia GUCY2F 34 35
  • 91.16 (n)
(Mus musculus)
Mammalia Gucy2f 34 16 35
  • 89.05 (n)
(Rattus norvegicus)
Mammalia Gucy2f 34
  • 88.63 (n)
(Monodelphis domestica)
Mammalia GUCY2F 35
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia GUCY2F 35
  • 50 (a)
(Gallus gallus)
Aves GUCY2F 35 34
  • 63.03 (n)
(Anolis carolinensis)
Reptilia GUCY2F 35
  • 58 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gucy2f 34
  • 70.18 (n)
(Danio rerio)
Actinopterygii gc2 34 35
  • 63.37 (n)
gucy2f 34
fruit fly
(Drosophila melanogaster)
Insecta CG9783 36
  • 56 (a)
CG5719 36
  • 52 (a)
Gyc32E 36
  • 33 (a)
Gyc76C 36
  • 33 (a)
CG34357 35
  • 22 (a)
(Caenorhabditis elegans)
Secernentea gcy-21 36
  • 43 (a)
gcy-22 36
  • 43 (a)
gcy-6 36
  • 43 (a)
gcy-14 36
  • 42 (a)
gcy-19 36
  • 42 (a)
gcy-2 36
  • 42 (a)
gcy-31 36
  • 42 (a)
gcy-13 36
  • 41 (a)
gcy-15 36 35
  • 41 (a)
gcy-11 36
  • 39 (a)
gcy-20 36
  • 39 (a)
gcy-4 36
  • 39 (a)
gcy-23 36
  • 38 (a)
gcy-8 36
  • 38 (a)
gcy-3 36
  • 37 (a)
odr-1 36
  • 33 (a)
gcy-12 36
  • 31 (a)
gcy-27 36
  • 31 (a)
daf-11 36
  • 30 (a)
gcy-5 36
  • 30 (a)
Species where no ortholog for GUCY2F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GUCY2F Gene

Gene Tree for GUCY2F (if available)
Gene Tree for GUCY2F (if available)

Paralogs for GUCY2F Gene

Paralogs for GUCY2F Gene

(3) SIMAP similar genes for GUCY2F Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GUCY2F: view

Variants for GUCY2F Gene

Sequence variations from dbSNP and Humsavar for GUCY2F Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs755991142 A breast cancer sample 109,475,908(+) CAAGG(C/G)GAGAA nc-transcript-variant, reference, missense
rs779221554 A glioblastoma multiforme sample 109,430,395(+) AATCA(A/C/T)CCTAG nc-transcript-variant, reference, missense
VAR_042242 A lung adenocarcinoma sample
VAR_042243 A lung squamous cell carcinoma sample
rs1000020826 -- 109,433,825(+) CCTGG(C/T)CCTGC intron-variant

Variation tolerance for GUCY2F Gene

Residual Variation Intolerance Score: 98.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.19; 87.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GUCY2F Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for GUCY2F Gene

Disorders for GUCY2F Gene

MalaCards: The human disease database

(2) MalaCards diseases for GUCY2F Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
leber congenital amaurosis
  • lca
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for GUCY2F

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with GUCY2F: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GUCY2F Gene

Publications for GUCY2F Gene

  1. Cloning and expression of a second photoreceptor-specific membrane retina guanylyl cyclase (RetGC), RetGC-2. (PMID: 7777544) Lowe D.G. … Hurley J.B. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 22 64
  2. Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. (PMID: 8838319) Yang R.B. … Garbers D.L. (Genomics 1996) 2 3 22 64
  3. Genetic mutations associated with cigarette smoking in pancreatic cancer. (PMID: 19351817) Blackford A. … Hruban R.H. (Cancer Res. 2009) 3 46 64
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  5. The kinase homology domain of retinal guanylyl cyclases 1 and 2 specifies the affinity and cooperativity of interaction with guanylyl cyclase activating protein-2. (PMID: 9698373) Laura R.P. … Hurley J.B. (Biochemistry 1998) 3 22 64

Products for GUCY2F Gene

Sources for GUCY2F Gene

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