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Aliases for ICOS Gene

Aliases for ICOS Gene

  • Inducible T-Cell Co-Stimulator 2 3
  • Activation-Inducible Lymphocyte Immunomediatory Molecule 2 3 4
  • AILIM 3 4 6
  • CVID1 3 6
  • Inducible T-Cell Costimulator 3
  • Inducible Costimulator 3
  • CD278 Antigen 4
  • CD278 3

External Ids for ICOS Gene

Summaries for ICOS Gene

Entrez Gene Summary for ICOS Gene

  • The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]

GeneCards Summary for ICOS Gene

ICOS (Inducible T-Cell Co-Stimulator) is a Protein Coding gene. Diseases associated with ICOS include immunodeficiency, common variable, 1 and autoimmune myocarditis. Among its related pathways are Class I MHC mediated antigen processing and presentation and B cell receptor signaling pathway (KEGG).

UniProtKB/Swiss-Prot for ICOS Gene

  • Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).

Gene Wiki entry for ICOS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ICOS Gene

Genomics for ICOS Gene

Genomic Location for ICOS Gene

Start:
203,936,731 bp from pter
End:
203,961,579 bp from pter
Size:
24,849 bases
Orientation:
Plus strand

Genomic View for ICOS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ICOS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ICOS Gene

Regulatory Elements for ICOS Gene

Proteins for ICOS Gene

  • Protein details for ICOS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6W8-ICOS_HUMAN
    Recommended name:
    Inducible T-cell costimulator
    Protein Accession:
    Q9Y6W8
    Secondary Accessions:
    • Q8N6W8

    Protein attributes for ICOS Gene

    Size:
    199 amino acids
    Molecular mass:
    22625 Da
    Quaternary structure:
    • Homodimer; disulfide-linked.

    Alternative splice isoforms for ICOS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ICOS Gene

Proteomics data for ICOS Gene at MOPED

Post-translational modifications for ICOS Gene

Other Protein References for ICOS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ICOS Gene

Domains for ICOS Gene

Gene Families for ICOS Gene

HGNC:
  • CD :CD molecules

Protein Domains for ICOS Gene

ProtoNet:

UniProtKB/Swiss-Prot:

ICOS_HUMAN
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • Q9Y6W8
genes like me logo Genes that share domains with ICOS: view

Function for ICOS Gene

Molecular function for ICOS Gene

UniProtKB/Swiss-Prot Function: Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity).
UniProtKB/Swiss-Prot Induction: By phorbol myristate acetate (PMA) and ionomycin. Up-regulated early on T-cells and continues to be expressed into the later phases of T-cell activation.

Gene Ontology (GO) - Molecular Function for ICOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ICOS: view
genes like me logo Genes that share phenotypes with ICOS: view

Animal Models for ICOS Gene

MGI Knock Outs for ICOS:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ICOS Gene

Localization for ICOS Gene

Subcellular locations from UniProtKB/Swiss-Prot for ICOS Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ICOS Gene COMPARTMENTS Subcellular localization image for ICOS gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ICOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0009897 external side of plasma membrane IEA --
genes like me logo Genes that share ontologies with ICOS: view

Pathways for ICOS Gene

genes like me logo Genes that share pathways with ICOS: view

Pathways by source for ICOS Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for ICOS Gene
1 Qiagen pathway for ICOS Gene
1 BioSystems pathway for ICOS Gene

Gene Ontology (GO) - Biological Process for ICOS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002517 T cell tolerance induction IEA --
GO:0006955 immune response NAS 9930702
GO:0016337 single organismal cell-cell adhesion IEA --
GO:0031295 T cell costimulation TAS --
genes like me logo Genes that share ontologies with ICOS: view

Compounds for ICOS Gene

(1) Novoseek inferred chemical compound relationships for ICOS Gene

Compound -log(P) Hits PubMed IDs
cytidine 46.1 2
genes like me logo Genes that share compounds with ICOS: view

Transcripts for ICOS Gene

mRNA/cDNA for ICOS Gene

Unigene Clusters for ICOS Gene

Inducible T-cell co-stimulator:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ICOS Gene

ExUns: 1 ^ 2 ^ 3 ^ 4
SP1:
SP2: -

Relevant External Links for ICOS Gene

GeneLoc Exon Structure for
ICOS
ECgene alternative splicing isoforms for
ICOS

Expression for ICOS Gene

mRNA expression in normal human tissues for ICOS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ICOS Gene

This gene is overexpressed in Whole Blood (15.2), Small Intestine - Terminal Ileum (7.1), Spleen (6.0), and Lung (4.2).

SOURCE GeneReport for Unigene cluster for ICOS Gene Hs.56247

mRNA Expression by UniProt/SwissProt for ICOS Gene

Q9Y6W8-ICOS_HUMAN
Tissue specificity: Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus.
genes like me logo Genes that share expressions with ICOS: view

Orthologs for ICOS Gene

This gene was present in the common ancestor of chordates.

Orthologs for ICOS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ICOS 36
  • 99.16 (n)
  • 99.5 (a)
ICOS 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ICOS 36
  • 83.67 (n)
  • 73.74 (a)
ICOS 37
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ICOS 36
  • 84.26 (n)
  • 71.57 (a)
ICOS 37
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Icos 36
  • 77.44 (n)
  • 69.7 (a)
Icos 16
Icos 37
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ICOS 37
  • 43 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ICOS 37
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Icos 36
  • 77.54 (n)
  • 68.95 (a)
chicken
(Gallus gallus)
Aves ICOS 37
  • 29 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ICOS 37
  • 22 (a)
OneToOne
Species with no ortholog for ICOS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ICOS Gene

ENSEMBL:
Gene Tree for ICOS (if available)
TreeFam:
Gene Tree for ICOS (if available)

Paralogs for ICOS Gene

No data available for Paralogs for ICOS Gene

Variants for ICOS Gene

Sequence variations from dbSNP and Humsavar for ICOS Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1559931 -- 203,961,006(+) AATAT(A/G)TGGAA utr-variant-3-prime
rs4264550 -- 203,956,771(+) GTAAG(C/G/T)GATTT intron-variant
rs4270326 -- 203,956,891(+) CCCCC(C/G)AAGAC intron-variant
rs4355090 -- 203,951,659(+) CGTCT(A/G)TGTCT intron-variant
rs4389322 -- 203,941,111(+) TTTAT(C/T)ATTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ICOS Gene

Variant ID Type Subtype PubMed ID
nsv875720 CNV Gain 21882294

Relevant External Links for ICOS Gene

HapMap Linkage Disequilibrium report
ICOS
Human Gene Mutation Database (HGMD)
ICOS
Locus Specific Mutation Databases (LSDB)
ICOS

Disorders for ICOS Gene

(1) OMIM Diseases for ICOS Gene (604558)

UniProtKB/Swiss-Prot

ICOS_HUMAN
  • Immunodeficiency, common variable, 1 (CVID1) [MIM:607594]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269 PubMed:12577056}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(8) Novoseek inferred disease relationships for ICOS Gene

Disease -log(P) Hits PubMed IDs
icos deficiency 92.3 6
common variable immunodeficiency 75.8 3
autoimmune diseases 29.8 3
lupus erythematosus systemic 22.4 1
autoimmunity 6.47 1

Relevant External Links for ICOS

GeneTests
ICOS
GeneReviews
ICOS
Genetic Association Database (GAD)
ICOS
Human Genome Epidemiology (HuGE) Navigator
ICOS
genes like me logo Genes that share disorders with ICOS: view

Publications for ICOS Gene

  1. T-cell co-stimulation through B7RP-1 and ICOS. (PMID: 10617205) Yoshinaga S.K. … Senaldi G. (Nature 1999) 2 3 23
  2. Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. (PMID: 12577056) Grimbacher B. … Peter H.H. (Nat. Immunol. 2003) 3 4 23
  3. Allelic variation of the inducible costimulator (ICOS) gene: detection of polymorphisms, analysis of the promoter region, and extended haplotype estimation. (PMID: 12753665) Haaning Andersen A.D. … Lillevang S.T. (Tissue Antigens 2003) 3 4 23
  4. Inducible CO-stimulator molecule, a candidate gene for defective isotype switching, is normal in patients with hyper-IgM syndrome of unknown molecular diagnosis. (PMID: 14610488) Lee W.I. … Ochs H.D. (J. Allergy Clin. Immunol. 2003) 3 23 49
  5. Characterization of CD28, CTLA4, and ICOS polymorphisms in three Brazilian ethnic groups. (PMID: 16112024) Guzman V.B. … Gerbase-Delima M. (Hum. Immunol. 2005) 3 23 49

Products for ICOS Gene

Sources for ICOS Gene

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