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Aliases for TRPM5 Gene

Aliases for TRPM5 Gene

  • Transient Receptor Potential Cation Channel Subfamily M Member 5 2 3 5
  • Long Transient Receptor Potential Channel 5 3 4
  • MLSN1- And TRP-Related Gene 1 Protein 3 4
  • LTrpC-5 3 4
  • LTRPC5 3 4
  • MTr1 3 4
  • Transient Receptor Potential Cation Channel, Subfamily M, Member 5 2
  • MLSN1 And TRP-Related 3

External Ids for TRPM5 Gene

Previous GeneCards Identifiers for TRPM5 Gene

  • GC11M002487
  • GC11M002626
  • GC11M002385
  • GC11M002390
  • GC11M002382
  • GC11M002216

Summaries for TRPM5 Gene

Entrez Gene Summary for TRPM5 Gene

  • This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. [provided by RefSeq, Oct 2010]

GeneCards Summary for TRPM5 Gene

TRPM5 (Transient Receptor Potential Cation Channel Subfamily M Member 5) is a Protein Coding gene. Diseases associated with TRPM5 include Beckwith-Wiedemann Syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. GO annotations related to this gene include ion channel activity and voltage-gated ion channel activity. An important paralog of this gene is TRPM4.

UniProtKB/Swiss-Prot for TRPM5 Gene

  • Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.

Gene Wiki entry for TRPM5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRPM5 Gene

Genomics for TRPM5 Gene

Regulatory Elements for TRPM5 Gene

Enhancers for TRPM5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G002511 1.3 Ensembl dbSUPER 17.4 -76.6 -76584 1.2 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A ZNF2 GLIS2 CBX5 ZNF143 TRPM5 ENSG00000199550 CD81 GC11M002505 GC11P002446
GH11G002480 1.3 FANTOM5 Ensembl ENCODE dbSUPER 11.6 -46.0 -46006 1.6 ZNF707 PKNOX1 MNT FOS TRPM5 TSSC2 KCNQ1 GC11M002505 GC11P002446
GH11G002483 1.1 FANTOM5 ENCODE dbSUPER 11.6 -48.7 -48720 0.4 E2F1 ESRRA GATA3 TCF7L2 ZNF7 KCNQ1 TRPM5 GC11M002505 GC11P002446
GH11G002509 0.7 dbSUPER 17.4 -74.6 -74638 0.9 HDGF ZNF263 CTCF HLF ZMYM3 MNT RAD21 GLIS2 GLIS1 ZNF143 TRPM5 CD81 ENSG00000199550 IGF2-AS GC11M002505 GC11P002446
GH11G002881 1.1 ENCODE 11 -449.3 -449290 5.7 CREB3L1 SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 KLF13 SP5 REST PHLDA2 TRPM5 KCNQ1OT1 RNU1-91P SLC22A18 CDKN1C ENSG00000274740
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRPM5 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRPM5 Gene

Chromosome:
11
Start:
2,403,952 bp from pter
End:
2,435,017 bp from pter
Size:
31,066 bases
Orientation:
Minus strand

Genomic View for TRPM5 Gene

Genes around TRPM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRPM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRPM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRPM5 Gene

Proteins for TRPM5 Gene

  • Protein details for TRPM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NZQ8-TRPM5_HUMAN
    Recommended name:
    Transient receptor potential cation channel subfamily M member 5
    Protein Accession:
    Q9NZQ8
    Secondary Accessions:
    • A6NHS0
    • Q52LU2
    • Q9NY34

    Protein attributes for TRPM5 Gene

    Size:
    1165 amino acids
    Molecular mass:
    131451 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRPM5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRPM5 Gene

Post-translational modifications for TRPM5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRPM5 Gene

No data available for DME Specific Peptides for TRPM5 Gene

Domains & Families for TRPM5 Gene

Gene Families for TRPM5 Gene

Protein Domains for TRPM5 Gene

Suggested Antigen Peptide Sequences for TRPM5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NZQ8

UniProtKB/Swiss-Prot:

TRPM5_HUMAN :
  • Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM5 sub-subfamily.
Family:
  • Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM5 sub-subfamily.
genes like me logo Genes that share domains with TRPM5: view

Function for TRPM5 Gene

Molecular function for TRPM5 Gene

UniProtKB/Swiss-Prot Function:
Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent-specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+). Also activated by a fast intracellular Ca(2+) increase in response to inositol 1,4,5-triphosphate-producing receptor agonists. The channel is blocked by extracellular acidification. External acidification has 2 effects, a fast reversible block of the current and a slower irreversible enhancement of current inactivation. Is a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. Activated by arachidonic acid in vitro. May be involved in perception of bitter, sweet and umami tastes. May also be involved in sensing semiochemicals.

Gene Ontology (GO) - Molecular Function for TRPM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity TAS 10607831
GO:0005227 calcium activated cation channel activity IEA --
GO:0005244 voltage-gated ion channel activity IEA --
GO:0005267 potassium channel activity IEA --
GO:0005272 sodium channel activity TAS --
genes like me logo Genes that share ontologies with TRPM5: view
genes like me logo Genes that share phenotypes with TRPM5: view

Animal Models for TRPM5 Gene

MGI Knock Outs for TRPM5:

Animal Model Products

miRNA for TRPM5 Gene

miRTarBase miRNAs that target TRPM5

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRPM5 Gene

Localization for TRPM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRPM5 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRPM5 gene
Compartment Confidence
plasma membrane 5
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TRPM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with TRPM5: view

Pathways & Interactions for TRPM5 Gene

genes like me logo Genes that share pathways with TRPM5: view

Pathways by source for TRPM5 Gene

1 Qiagen pathway for TRPM5 Gene

Gene Ontology (GO) - Biological Process for TRPM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006812 cation transport IEA --
GO:0034220 ion transmembrane transport IEA --
GO:0034765 regulation of ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with TRPM5: view

No data available for SIGNOR curated interactions for TRPM5 Gene

Drugs & Compounds for TRPM5 Gene

(6) Drugs for TRPM5 Gene - From: ApexBio, DGIdb, and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rosiglitazone Approved, Investigational Pharma Full agonist, Agonist, agonist Potent PPARγ agonist, Potent and selective PPARgamma agonist; antidiabetic agent. 220
spermine Approved Nutra Full agonist, Agonist 0
Flufenamic Acid Experimental Pharma Channel blocker 0
HC-030031 Pharma TRPA1 channel blocker,potent and selective, Selective TRPA1 blocker 0
H<SUP>+</SUP> Pharma 0

(1) Additional Compounds for TRPM5 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
H<sup>+</sup> (extracellular)
Activator

(1) ApexBio Compounds for TRPM5 Gene

Compound Action Cas Number
HC-030031 TRPA1 channel blocker,potent and selective 349085-38-7
genes like me logo Genes that share compounds with TRPM5: view

Transcripts for TRPM5 Gene

mRNA/cDNA for TRPM5 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRPM5 Gene

Transient receptor potential cation channel, subfamily M, member 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRPM5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24
SP1:
SP2:

Relevant External Links for TRPM5 Gene

GeneLoc Exon Structure for
TRPM5
ECgene alternative splicing isoforms for
TRPM5

Expression for TRPM5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRPM5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRPM5 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x12.0), Colon - Transverse (x9.6), Pancreas (x8.2), and Thyroid (x4.9).

Protein differential expression in normal tissues from HIPED for TRPM5 Gene

This gene is overexpressed in Pancreas (59.0) and CD8 Tcells (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRPM5 Gene



Protein tissue co-expression partners for TRPM5 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRPM5 Gene:

TRPM5

SOURCE GeneReport for Unigene cluster for TRPM5 Gene:

Hs.272287

mRNA Expression by UniProt/SwissProt for TRPM5 Gene:

Q9NZQ8-TRPM5_HUMAN
Tissue specificity: Strongly expressed in fetal brain, liver and kidney, and in adult prostate, testis, ovary, colon and peripheral blood leukocytes. Also expressed in a large proportion of Wilms tumors and rhabdomyosarcomas. In monochromosomal cell lines shows exclusive paternal expression.

Evidence on tissue expression from TISSUES for TRPM5 Gene

  • Lung(2.1)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with TRPM5: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TRPM5 Gene

Orthologs for TRPM5 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRPM5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRPM5 34 35
  • 98.04 (n)
dog
(Canis familiaris)
Mammalia TRPM5 34 35
  • 86.81 (n)
cow
(Bos Taurus)
Mammalia TRPM5 34 35
  • 84.66 (n)
mouse
(Mus musculus)
Mammalia Trpm5 34 16 35
  • 82.54 (n)
rat
(Rattus norvegicus)
Mammalia Trpm5 34
  • 82.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TRPM5 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRPM5 34 35
  • 65.47 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 65 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.13379 34
zebrafish
(Danio rerio)
Actinopterygii trpm5 34 35
  • 64.19 (n)
fruit fly
(Drosophila melanogaster)
Insecta trpm 35
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gtl-2 35
  • 19 (a)
ManyToMany
gtl-1 35
  • 16 (a)
ManyToMany
gon-2 35
  • 15 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 32 (a)
OneToMany
Species where no ortholog for TRPM5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRPM5 Gene

ENSEMBL:
Gene Tree for TRPM5 (if available)
TreeFam:
Gene Tree for TRPM5 (if available)

Paralogs for TRPM5 Gene

Paralogs for TRPM5 Gene

(5) SIMAP similar genes for TRPM5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TRPM5: view

Variants for TRPM5 Gene

Sequence variations from dbSNP and Humsavar for TRPM5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000067819 -- 2,413,681(+) TGGCC(C/T)ACGTG intron-variant
rs1000182251 -- 2,413,477(+) CCACC(C/T)GAAGG reference, missense
rs1000202516 -- 2,416,992(+) GGACA(C/T)GAAAT intron-variant
rs1000328464 -- 2,409,987(+) CAAGA(A/C)AGAGG intron-variant
rs1000334351 -- 2,421,169(+) GCCCA(C/T)GCGGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TRPM5 Gene

Variant ID Type Subtype PubMed ID
dgv1569n54 CNV loss 21841781
dgv1570n54 CNV loss 21841781
dgv1571n54 CNV loss 21841781
dgv189n67 CNV gain 20364138
esv25890 CNV gain 19812545
esv2744007 CNV deletion 23290073
nsv1037537 CNV gain 25217958
nsv467645 CNV gain 19166990
nsv469928 CNV loss 18288195
nsv473212 CNV novel sequence insertion 20440878
nsv509382 CNV insertion 20534489
nsv553047 CNV gain 21841781
nsv553100 CNV loss 21841781
nsv553102 CNV loss 21841781
nsv825714 CNV gain 20364138
nsv951287 CNV deletion 24416366

Variation tolerance for TRPM5 Gene

Residual Variation Intolerance Score: 89.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.09; 75.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRPM5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRPM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRPM5 Gene

Disorders for TRPM5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRPM5 Gene - From: GeneCards

Disorder Aliases PubMed IDs
beckwith-wiedemann syndrome
  • wiedemann-beckwith syndrome
- elite association - COSMIC cancer census association via MalaCards
Search TRPM5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRPM5

Genetic Association Database (GAD)
TRPM5
Human Genome Epidemiology (HuGE) Navigator
TRPM5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRPM5
genes like me logo Genes that share disorders with TRPM5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRPM5 Gene

Publications for TRPM5 Gene

  1. Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele- specific expression. (PMID: 10607831) Prawitt D. … Zabel B. (Hum. Mol. Genet. 2000) 2 3 4 64
  2. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 46 64
  3. International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels. (PMID: 16382100) Clapham D.E. … Schultz G. (Pharmacol. Rev. 2005) 2 3 64
  4. TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i. (PMID: 14634208) Prawitt D. … Penner R. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 64
  5. GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation. (PMID: 26571400) Shigeto M. … Rorsman P. (J. Clin. Invest. 2015) 3 64

Products for TRPM5 Gene

Sources for TRPM5 Gene

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