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Aliases for GUCY1B3 Gene

Aliases for GUCY1B3 Gene

  • Guanylate Cyclase 1 Soluble Subunit Beta 2 3 5
  • Guanylate Cyclase Soluble Subunit Beta-3 3 4
  • Soluble Guanylate Cyclase Small Subunit 3 4
  • Guanylate Cyclase 1, Soluble, Beta 3 2 3
  • GCS-Beta-1 3 4
  • GCS-Beta-3 3 4
  • EC 4 58
  • GUCY1B1 3 4
  • GUC1B3 3 4
  • GUCSB3 3 4
  • Guanylate Cyclase Soluble Subunit Beta-1 3
  • GC-S-Beta-1 3
  • GC-SB3 3
  • GUCB3 3

External Ids for GUCY1B3 Gene

Previous HGNC Symbols for GUCY1B3 Gene

  • GUC1B3

Previous GeneCards Identifiers for GUCY1B3 Gene

  • GC04P157568
  • GC04P157108
  • GC04P157257
  • GC04P157246
  • GC04P157037
  • GC04P156888
  • GC04P156680
  • GC04P152419

Summaries for GUCY1B3 Gene

Entrez Gene Summary for GUCY1B3 Gene

  • This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for GUCY1B3 Gene

GUCY1B3 (Guanylate Cyclase 1 Soluble Subunit Beta) is a Protein Coding gene. Among its related pathways are Nanog in Mammalian ESC Pluripotency and Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include protein heterodimerization activity and GTP binding. An important paralog of this gene is GUCY1A2.

UniProtKB/Swiss-Prot for GUCY1B3 Gene

  • Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.

Tocris Summary for GUCY1B3 Gene

  • Guanylyl Cyclases (GC) are a group of enzymes that, in the presence of a metal ion co-factor such as Mg2+ or Mn2+, convert guanosine-5'-triphosphate (GTP) into 3',5'-guanosine monophosphate (cGMP) and pyrophosphate. There are two main groups of guanylyl cyclase.

Gene Wiki entry for GUCY1B3 Gene

Additional gene information for GUCY1B3 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GUCY1B3 Gene

Genomics for GUCY1B3 Gene

Regulatory Elements for GUCY1B3 Gene

Enhancers for GUCY1B3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H155675 1.4 Ensembl ENCODE dbSUPER 11.2 -82.7 -82657 1.5 PKNOX1 INSM2 FEZF1 ZNF2 ZNF366 ZSCAN5C ZNF391 OVOL3 TSHZ1 ZEB2 GUCY1B3 GUCY1A3 ENSG00000260244
GH04H155679 0.8 dbSUPER 11.4 -77.9 -77933 3.4 ZSCAN4 ZNF121 ZNF366 ZSCAN5C ZNF350 ZNF600 PRDM10 L3MBTL2 ZNF10 GFI1B GUCY1B3 GUCY1A3 ENSG00000260244
GH04H155628 0.8 Ensembl ENCODE 10.7 -129.5 -129520 1.8 PRDM6 JUN IKZF1 GFI1B MLLT1 GUCY1B3 GUCY1A3 LOC105377504
GH04H155525 0.7 Ensembl ENCODE 10.8 -232.3 -232261 1.4 PRDM1 NR2F2 GUCY1B3 GUCY1A3 LOC105377504
GH04H155683 0.6 dbSUPER 11.4 -74.5 -74483 2 FOXM1 PKNOX1 CTBP1 PRDM6 ZNF680 ELF1 GUCY1B3 GUCY1A3 ENSG00000260244
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GUCY1B3 on UCSC Golden Path with GeneCards custom track

Promoters for GUCY1B3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000175189 627 1600 HDGF PKNOX1 RB1 GLI4 ZNF2 RAD21 RFX5 GLIS2 ZNF143 ATF7

Genomic Locations for GUCY1B3 Gene

Genomic Locations for GUCY1B3 Gene
48,670 bases
Plus strand

Genomic View for GUCY1B3 Gene

Genes around GUCY1B3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GUCY1B3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GUCY1B3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GUCY1B3 Gene

Proteins for GUCY1B3 Gene

  • Protein details for GUCY1B3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Guanylate cyclase soluble subunit beta-1
    Protein Accession:
    Secondary Accessions:
    • B7Z426
    • Q86WY5

    Protein attributes for GUCY1B3 Gene

    619 amino acids
    Molecular mass:
    70514 Da
    Name=heme; Xref=ChEBI:CHEBI:30413;
    Quaternary structure:
    • The active enzyme is formed by a heterodimer of an alpha and a beta subunit. Heterodimer with GUCY1A3 (PubMed:1352257, PubMed:23505436, PubMed:24669844). Can also form inactive homodimers in vitro (PubMed:23505436, PubMed:24669844).
    • There are two types of guanylate cyclases: soluble forms and membrane-associated receptor forms.

    Three dimensional structures from OCA and Proteopedia for GUCY1B3 Gene

    Alternative splice isoforms for GUCY1B3 Gene


neXtProt entry for GUCY1B3 Gene

Selected DME Specific Peptides for GUCY1B3 Gene


Post-translational modifications for GUCY1B3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for GUCY1B3 Gene

Gene Families for GUCY1B3 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with GUCY1B3: view

Function for GUCY1B3 Gene

Molecular function for GUCY1B3 Gene

GENATLAS Biochemistry:
guanylate cyclase,soluble,beta-1 subunit,73kDa,heterodimerizing with GUCY1A3,preferentially expressed in lung and brain
UniProtKB/Swiss-Prot CatalyticActivity:
GTP = 3,5-cyclic GMP + diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by nitric oxide in the presence of magnesium or manganese ions.
UniProtKB/Swiss-Prot Function:
Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.

Enzyme Numbers (IUBMB) for GUCY1B3 Gene

Gene Ontology (GO) - Molecular Function for GUCY1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004016 NOT adenylate cyclase activity IEA,IBA --
GO:0004383 guanylate cyclase activity IEA,IDA 23505436
GO:0004872 receptor activity TAS 9742212
GO:0005515 protein binding IPI 23505436
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with GUCY1B3: view
genes like me logo Genes that share phenotypes with GUCY1B3: view

Animal Models for GUCY1B3 Gene

MGI Knock Outs for GUCY1B3:

Animal Model Products

miRNA for GUCY1B3 Gene

miRTarBase miRNAs that target GUCY1B3

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for GUCY1B3 Gene

Localization for GUCY1B3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GUCY1B3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GUCY1B3 gene
Compartment Confidence
cytosol 5
plasma membrane 4
cytoskeleton 1
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for GUCY1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane IBA --
GO:0008074 guanylate cyclase complex, soluble IDA 23505436
GO:0043234 protein complex IEA --
genes like me logo Genes that share ontologies with GUCY1B3: view

Pathways & Interactions for GUCY1B3 Gene

genes like me logo Genes that share pathways with GUCY1B3: view

Gene Ontology (GO) - Biological Process for GUCY1B3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006171 cAMP biosynthetic process IEA --
GO:0006182 cGMP biosynthetic process IEA,IDA 23505436
GO:0007263 nitric oxide mediated signal transduction TAS 9742212
GO:0008015 blood circulation TAS 9742212
GO:0009190 cyclic nucleotide biosynthetic process IEA --
genes like me logo Genes that share ontologies with GUCY1B3: view

No data available for SIGNOR curated interactions for GUCY1B3 Gene

Drugs & Compounds for GUCY1B3 Gene

(15) Drugs for GUCY1B3 Gene - From: ApexBio, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Riociguat Approved Pharma Soluble guanylate cyclase (sGC) stimulator 0
Phosphoric acid Approved Pharma 0
Manganese Approved Nutra 35
Cyclic GMP Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(1) Additional Compounds for GUCY1B3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi

(5) Tocris Compounds for GUCY1B3 Gene

Compound Action Cas Number
A 350619 hydrochloride Soluble guanylyl cyclase (sGC) activator 1217201-17-6
BAY 41-2272 Soluble guanylyl cyclase (sGC) activator 256376-24-6
BPIPP Non-competitive GC inhibitor. Also AC inhibitor 325746-94-9
CFM 1571 hydrochloride Soluble guanylyl cyclase (sGC) activator 1215548-30-3
YC 1 Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest 170632-47-0

(8) ApexBio Compounds for GUCY1B3 Gene

Compound Action Cas Number
A 350619 hydrochloride Activator of soluble guanylyl cyclase (sGC) 1217201-17-6
BAY 41-2272 Activator of soluble guanylyl cyclase (sGC) 256376-24-6
BPIPP 325746-94-9
CFM 1571 hydrochloride sGC activator 1215548-30-3
Cinaciguat Soluble guanylate cyclase (sGC) activators 329773-35-5
Guanylin (human) 183200-12-6
NS 2028 204326-43-2
Riociguat Soluble guanylate cyclase (sGC) stimulator 625115-55-1
genes like me logo Genes that share compounds with GUCY1B3: view

Drug Products

Transcripts for GUCY1B3 Gene

Unigene Clusters for GUCY1B3 Gene

Guanylate cyclase 1, soluble, beta 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for GUCY1B3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: - - - -
SP6: -

Relevant External Links for GUCY1B3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GUCY1B3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GUCY1B3 Gene

mRNA differential expression in normal tissues according to GTEx for GUCY1B3 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.0).

Protein differential expression in normal tissues from HIPED for GUCY1B3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (19.8), Platelet (9.2), Frontal cortex (8.8), and Fetal gut (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for GUCY1B3 Gene

NURSA nuclear receptor signaling pathways regulating expression of GUCY1B3 Gene:


SOURCE GeneReport for Unigene cluster for GUCY1B3 Gene:


mRNA Expression by UniProt/SwissProt for GUCY1B3 Gene:

Tissue specificity: Detected in brain cortex and cerebellum (at protein level).

Evidence on tissue expression from TISSUES for GUCY1B3 Gene

  • Nervous system(4.9)
  • Kidney(4.4)
  • Lung(4.4)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with GUCY1B3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for GUCY1B3 Gene

Orthologs for GUCY1B3 Gene

This gene was present in the common ancestor of animals.

Orthologs for GUCY1B3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GUCY1B3 33 34
  • 99.78 (n)
(Bos Taurus)
Mammalia GUCY1B1 34
  • 99 (a)
GUCY1B3 33
  • 90.41 (n)
(Monodelphis domestica)
Mammalia GUCY1B3 34
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia GUCY1B3 34
  • 97 (a)
(Canis familiaris)
Mammalia GUCY1B3 33 34
  • 92.84 (n)
(Mus musculus)
Mammalia Gucy1b3 33 16 34
  • 88.69 (n)
(Rattus norvegicus)
Mammalia Gucy1b3 33
  • 88.42 (n)
(Gallus gallus)
Aves GUCY1B3 33 34
  • 83.98 (n)
(Anolis carolinensis)
Reptilia GUCY1B3 34
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gucy1b3 33
  • 80.53 (n)
(Danio rerio)
Actinopterygii gucy1b3 33 34
  • 77.21 (n)
fruit fly
(Drosophila melanogaster)
Insecta Gycbeta100B 33 34
  • 58.57 (n)
Gycbgr100B 35
  • 58 (a)
CG14886 35
  • 37 (a)
CG4154 35
  • 35 (a)
CG14885 35
  • 28 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000214 33
  • 57.91 (n)
(Caenorhabditis elegans)
Secernentea gcy-34 35 33
  • 48.04 (n)
gcy-31 35 34
  • 36 (a)
gcy-35 35
  • 34 (a)
gcy-32 35
  • 33 (a)
gcy-37 35 34
  • 29 (a)
gcy-33 34
  • 18 (a)
acy-3 34
  • 9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 51 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13250 33
Species where no ortholog for GUCY1B3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for GUCY1B3 Gene

Gene Tree for GUCY1B3 (if available)
Gene Tree for GUCY1B3 (if available)

Paralogs for GUCY1B3 Gene

Paralogs for GUCY1B3 Gene

(7) SIMAP similar genes for GUCY1B3 Gene using alignment to 5 proteins: Pseudogenes for GUCY1B3 Gene

genes like me logo Genes that share paralogs with GUCY1B3: view

Variants for GUCY1B3 Gene

Sequence variations from dbSNP and Humsavar for GUCY1B3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000028198 -- 155,767,712(+) CTTGG(C/T)AGCTC intron-variant
rs1000181745 -- 155,789,242(+) TGCTT(A/C)TGTTT intron-variant
rs1000214956 -- 155,795,901(+) TTTAG(A/G)TAGTG intron-variant
rs1000241336 -- 155,788,301(+) TCAGC(A/G)GGCAG intron-variant
rs10003470 -- 155,788,060(+) ttgct(A/G)ccata intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GUCY1B3 Gene

Variant ID Type Subtype PubMed ID
nsv818286 CNV gain 17921354
nsv521382 CNV loss 19592680
nsv1029122 CNV gain 25217958

Variation tolerance for GUCY1B3 Gene

Residual Variation Intolerance Score: 17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.21; 24.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GUCY1B3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GUCY1B3 Gene

Disorders for GUCY1B3 Gene

Relevant External Links for GUCY1B3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for GUCY1B3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GUCY1B3 Gene

Publications for GUCY1B3 Gene

  1. Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain. (PMID: 1352257) Giuili G … Guellaën G (FEBS letters 1992) 2 3 4 60
  2. Crystal structures of the catalytic domain of human soluble guanylate cyclase. (PMID: 23505436) Allerston CK … Gileadi O (PloS one 2013) 3 4 60
  3. Soluble guanylate cyclase beta1-subunit expression is increased in mononuclear cells from patients with erectile dysfunction. (PMID: 16528291) Mateos-Cáceres PJ … López-Farré AJ (International journal of impotence research 2006) 3 22 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Heterogeneity in human soluble guanylate cyclase due to alternative splicing. (PMID: 1680753) Chhajlani V … Wikberg JE (FEBS letters 1991) 3 4 60

Products for GUCY1B3 Gene

Sources for GUCY1B3 Gene

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